| Title : Identification of key metabolic enzymes involved in the activation of obeldesivir and remdesivir to the active triphosphate metabolite - Xu_2026_Antimicrob.Agents.Chemother__e0005526 |
| Author(s) : Xu Y , Liclican A , Zhao X , Chen C , Ortega JT , Chuang HC , Soulette C , Chaudhuri S , Zhang J , Wang T , Babusis D , Marchand B , Sun KH , Ramirez R , Ma B , Nayak A , Wang L , Menon S , Belzile JP , Lai Y , Li L , Mackman RL , Bilello JP , Cihlar T , Feng JY , Lad L |
| Ref : Antimicrobial Agents & Chemotherapy , :e0005526 , 2026 |
| Abstract : |
| PubMedSearch : Xu_2026_Antimicrob.Agents.Chemother__e0005526 |
| PubMedID: 42363837 |
| Title : The oral nucleoside prodrug GS-5245 is efficacious against SARS-CoV-2 and other endemic, epidemic, and enzootic coronaviruses - Martinez_2024_Sci.Transl.Med_16_eadj4504 |
| Author(s) : Martinez DR , Moreira FR , Catanzaro NJ , Diefenbacher MV , Zweigart MR , Gully KL , De la Cruz G , Brown AJ , Adams LE , Yount B , Baric TJ , Mallory ML , Conrad H , May SR , Dong S , Scobey DT , Nguyen C , Montgomery SA , Perry JK , Babusis D , Barrett KT , Nguyen AH , Nguyen AQ , Kalla R , Bannister R , Feng JY , Cihlar T , Baric RS , Mackman RL , Bilello JP , Schafer A , Sheahan TP |
| Ref : Sci Transl Med , 16 :eadj4504 , 2024 |
| Abstract : |
| PubMedSearch : Martinez_2024_Sci.Transl.Med_16_eadj4504 |
| PubMedID: 38776389 |
| Title : Discovery of GS-5245 (Obeldesivir), an Oral Prodrug of Nucleoside GS-441524 That Exhibits Antiviral Efficacy in SARS-CoV-2-Infected African Green Monkeys - Mackman_2023_J.Med.Chem_66_11701 |
| Author(s) : Mackman RL , Kalla RV , Babusis D , Pitts J , Barrett KT , Chun K , Du Pont V , Rodriguez L , Moshiri J , Xu Y , Lee M , Lee G , Bleier B , Nguyen AQ , O'Keefe BM , Ambrosi A , Cook M , Yu J , Dempah KE , Bunyan E , Riola NC , Lu X , Liu R , Davie A , Hsiang TY , Dearing J , Vermillion M , Gale M, Jr. , Niedziela-Majka A , Feng JY , Hedskog C , Bilello JP , Subramanian R , Cihlar T |
| Ref : Journal of Medicinal Chemistry , 66 :11701 , 2023 |
| Abstract : |
| PubMedSearch : Mackman_2023_J.Med.Chem_66_11701 |
| PubMedID: 37596939 |
| Title : Time-dependent effects of storage at -80 C on the stability of butyrylcholinesterase activity in human serum - Huang_2022_Pract.Lab.Med_31_e00298 |
| Author(s) : Huang CH , Chang YT , Severance S , Feng JY , Hou SY , Gong MM , Hwang CC , Dai CY , Wang JJ , Wang TP |
| Ref : Pract Lab Med , 31 :e00298 , 2022 |
| Abstract : |
| PubMedSearch : Huang_2022_Pract.Lab.Med_31_e00298 |
| PubMedID: 35880118 |
| Title : Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung Cells - Li_2021_Antimicrob.Agents.Chemother__AAC0060221 |
| Author(s) : Li R , Liclican A , Xu Y , Pitts J , Niu C , Zhang J , Kim C , Zhao X , Soohoo D , Babusis D , Yue Q , Ma B , Murray BP , Subramanian R , Xie X , Zou J , Bilello JP , Li L , Schultz BE , Sakowicz R , Smith BJ , Shi PY , Murakami E , Feng JY |
| Ref : Antimicrobial Agents & Chemotherapy , :AAC0060221 , 2021 |
| Abstract : |
| PubMedSearch : Li_2021_Antimicrob.Agents.Chemother__AAC0060221 |
| PubMedID: 34125594 |
| Title : Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV - Sheahan_2020_Nat.Commun_11_222 |
| Author(s) : Sheahan TP , Sims AC , Leist SR , Schafer A , Won J , Brown AJ , Montgomery SA , Hogg A , Babusis D , Clarke MO , Spahn JE , Bauer L , Sellers S , Porter D , Feng JY , Cihlar T , Jordan R , Denison MR , Baric RS |
| Ref : Nat Commun , 11 :222 , 2020 |
| Abstract : |
| PubMedSearch : Sheahan_2020_Nat.Commun_11_222 |
| PubMedID: 31924756 |
| Title : Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease - Agostini_2018_mBio_9_ |
| Author(s) : Agostini ML , Andres EL , Sims AC , Graham RL , Sheahan TP , Lu X , Smith EC , Case JB , Feng JY , Jordan R , Ray AS , Cihlar T , Siegel D , Mackman RL , Clarke MO , Baric RS , Denison MR |
| Ref : MBio , 9 : , 2018 |
| Abstract : |
| PubMedSearch : Agostini_2018_mBio_9_ |
| PubMedID: 29511076 |
| Title : Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys - Warren_2016_Nature_531_381 |
| Author(s) : Warren TK , Jordan R , Lo MK , Ray AS , Mackman RL , Soloveva V , Siegel D , Perron M , Bannister R , Hui HC , Larson N , Strickley R , Wells J , Stuthman KS , Van Tongeren SA , Garza NL , Donnelly G , Shurtleff AC , Retterer CJ , Gharaibeh D , Zamani R , Kenny T , Eaton BP , Grimes E , Welch LS , Gomba L , Wilhelmsen CL , Nichols DK , Nuss JE , Nagle ER , Kugelman JR , Palacios G , Doerffler E , Neville S , Carra E , Clarke MO , Zhang L , Lew W , Ross B , Wang Q , Chun K , Wolfe L , Babusis D , Park Y , Stray KM , Trancheva I , Feng JY , Barauskas O , Xu Y , Wong P , Braun MR , Flint M , McMullan LK , Chen SS , Fearns R , Swaminathan S , Mayers DL , Spiropoulou CF , Lee WA , Nichol ST , Cihlar T , Bavari S |
| Ref : Nature , 531 :381 , 2016 |
| Abstract : |
| PubMedSearch : Warren_2016_Nature_531_381 |
| PubMedID: 26934220 |