| Title : Discovery of GS-5245 (Obeldesivir), an Oral Prodrug of Nucleoside GS-441524 That Exhibits Antiviral Efficacy in SARS-CoV-2-Infected African Green Monkeys - Mackman_2023_J.Med.Chem_66_11701 |
| Author(s) : Mackman RL , Kalla RV , Babusis D , Pitts J , Barrett KT , Chun K , Du Pont V , Rodriguez L , Moshiri J , Xu Y , Lee M , Lee G , Bleier B , Nguyen AQ , O'Keefe BM , Ambrosi A , Cook M , Yu J , Dempah KE , Bunyan E , Riola NC , Lu X , Liu R , Davie A , Hsiang TY , Dearing J , Vermillion M , Gale M, Jr. , Niedziela-Majka A , Feng JY , Hedskog C , Bilello JP , Subramanian R , Cihlar T |
| Ref : Journal of Medicinal Chemistry , 66 :11701 , 2023 |
| Abstract : |
| PubMedSearch : Mackman_2023_J.Med.Chem_66_11701 |
| PubMedID: 37596939 |
| Title : Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys - Warren_2016_Nature_531_381 |
| Author(s) : Warren TK , Jordan R , Lo MK , Ray AS , Mackman RL , Soloveva V , Siegel D , Perron M , Bannister R , Hui HC , Larson N , Strickley R , Wells J , Stuthman KS , Van Tongeren SA , Garza NL , Donnelly G , Shurtleff AC , Retterer CJ , Gharaibeh D , Zamani R , Kenny T , Eaton BP , Grimes E , Welch LS , Gomba L , Wilhelmsen CL , Nichols DK , Nuss JE , Nagle ER , Kugelman JR , Palacios G , Doerffler E , Neville S , Carra E , Clarke MO , Zhang L , Lew W , Ross B , Wang Q , Chun K , Wolfe L , Babusis D , Park Y , Stray KM , Trancheva I , Feng JY , Barauskas O , Xu Y , Wong P , Braun MR , Flint M , McMullan LK , Chen SS , Fearns R , Swaminathan S , Mayers DL , Spiropoulou CF , Lee WA , Nichol ST , Cihlar T , Bavari S |
| Ref : Nature , 531 :381 , 2016 |
| Abstract : |
| PubMedSearch : Warren_2016_Nature_531_381 |
| PubMedID: 26934220 |