Beppu T

References (3)

Title : Large splenic volume may be a useful predictor for partial splenic embolization-induced liver functional improvement in cirrhotic patients - Hayashi_2014_J.Hepatobiliary.Pancreat.Sci_21_51
Author(s) : Hayashi H , Beppu T , Masuda T , Okabe H , Imai K , Hashimoto D , Ikuta Y , Chikamoto A , Watanabe M , Baba H
Ref : J Hepatobiliary Pancreat Sci , 21 :51 , 2014
Abstract : BACKGROUND: Partial splenic embolization (PSE) for cirrhotic patients has been reported not only to achieve an improvement in thrombocytopenia and portal hypertension, but also to induce PSE-associated fringe benefit such as individual liver functional improvement. The purpose of this study was to clarify the predictive marker of liver functional improvement due from PSE in cirrhotic patients.
METHODS: From April 1999 to January 2009, 83 cirrhotic patients with hypersplenism-induced thrombocytopenia (platelet count <10 x 10(4) /mul) underwent PSE. Of them, 71 patients with follow-up for more than one year after PSE were retrospectively investigated.
RESULTS: In liver tissues after PSE, proliferating cell nuclear antigen (PCNA)-positive hepatocytes were remarkably increased, speculating that PSE induced liver regenerative response. Indeed, serum albumin and cholinesterase levels increased to 104 +/- 14% and 130 +/- 65% each of the pretreatment level at one year after PSE. In a multiple linear regression analysis, preoperative splenic volume was extracted as the predictive factor for the improvement in cholinesterase level after PSE. Cirrhotic patients with preoperative splenic volume >600 ml obtained significantly higher serum albumin and cholinesterase levels at one year after PSE compared to those with less than 600 ml (P-values were 0.029 in both). CONCLUSION: A large preoperative splenic volume was the useful predictive marker for an effective PSE-induced liver functional improvement.
ESTHER : Hayashi_2014_J.Hepatobiliary.Pancreat.Sci_21_51
PubMedSearch : Hayashi_2014_J.Hepatobiliary.Pancreat.Sci_21_51
PubMedID: 23798315

Title : Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium that depends on microbial commensalism - Ueda_2004_Nucleic.Acids.Res_32_4937
Author(s) : Ueda K , Yamashita A , Ishikawa J , Shimada M , Watsuji TO , Morimura K , Ikeda H , Hattori M , Beppu T
Ref : Nucleic Acids Research , 32 :4937 , 2004
Abstract : Symbiobacterium thermophilum is an uncultivable bacterium isolated from compost that depends on microbial commensalism. The 16S ribosomal DNA-based phylogeny suggests that this bacterium belongs to an unknown taxon in the Gram-positive bacterial cluster. Here, we describe the 3.57 Mb genome sequence of S.thermophilum. The genome consists of 3338 protein-coding sequences, out of which 2082 have functional assignments. Despite the high G + C content (68.7%), the genome is closest to that of Firmicutes, a phylum consisting of low G + C Gram-positive bacteria. This provides evidence for the presence of an undefined category in the Gram-positive bacterial group. The presence of both spo and related genes and microscopic observation indicate that S.thermophilum is the first high G + C organism that forms endospores. The S.thermophilum genome is also characterized by the widespread insertion of class C group II introns, which are oriented in the same direction as chromosomal replication. The genome has many membrane transporters, a number of which are involved in the uptake of peptides and amino acids. The genes involved in primary metabolism are largely identified, except those that code several biosynthetic enzymes and carbonic anhydrase. The organism also has a variety of respiratory systems including Nap nitrate reductase, which has been found only in Gram-negative bacteria. Overall, these features suggest that S.thermophilum is adaptable to and thus lives in various environments, such that its growth requirement could be a substance or a physiological condition that is generally available in the natural environment rather than a highly specific substance that is present only in a limited niche. The genomic information from S.thermophilum offers new insights into microbial diversity and evolutionary sciences, and provides a framework for characterizing the molecular basis underlying microbial commensalism.
ESTHER : Ueda_2004_Nucleic.Acids.Res_32_4937
PubMedSearch : Ueda_2004_Nucleic.Acids.Res_32_4937
PubMedID: 15383646
Gene_locus related to this paper: symth-metx , symth-q67kd5 , symth-q67kg6 , symth-q67kl6 , symth-q67km7 , symth-q67lu3 , symth-q67mi3 , symth-q67mk6 , symth-q67mr3 , symth-q67n56 , symth-q67nt3 , symth-q67pl6 , symth-q67qv2 , symth-q67r02 , symth-q67r99 , symth-q67ra1 , symth-q67ri0 , symth-q67rl1 , symth-q67ru9 , symth-q67s20 , symth-q67sr9 , symth-q67sv7 , symth-q67t46

Title : Significant changes in the serum levels of IL-6, h-HGF, and type IV collagen 7S during the perioperative period of a hepatectomy: relevance to SIRS - Namekata_2000_Surg.Today_30_403
Author(s) : Namekata K , Takamori S , Kojima K , Beppu T , Futagawa S
Ref : Surg Today , 30 :403 , 2000
Abstract : We analyzed the changes in the serum levels of both interleukin-6 (IL-6), human hepatocyte growth factor (h-HGF), and type IV collagen 7S (7S) during the perioperative period of a hepatectomy and evaluated their relationship with systemic inflammatory response syndrome (SIRS). The study subjects consisted of 40 patients who underwent a hepatectomy. In 14 out of 40 patients, postoperative SIRS(+) was observed. Between the SIRS(+) and SIRS(-) cases, there were significant differences in the preoperative values of prothrombin time, hepaplastin test, cholinesterase, and indocyanine green retention at 15 min (P < 0.01). Compared with the SIRS(-) cases, the IL-6, h-HGF, and 7S of the SIRS(+) cases fluctuated in a higher range and remained significantly higher after postoperative day 1 (P < 0.05). Eight out of 14 SIRS(+) patients had postoperative complications. In the 8 SIRS(+) patients with postoperative complications and in the 4 patients in which the SIRS(+) state lasted 3 days or longer, the 7S levels were significantly higher during the perioperative period (P < 0.05). In the SIRS(+) cases, the postoperative levels of IL-6 and h-HGF, as well as pre- and postoperative levels of 7S, were elevated. We therefore consider these levels to be risk factors for complications during the perioperative period of a hepatectomy.
ESTHER : Namekata_2000_Surg.Today_30_403
PubMedSearch : Namekata_2000_Surg.Today_30_403
PubMedID: 10819474