Shimada M

References (10)

Title : Recovery of nutritional metabolism after liver transplantation - Sugihara_2014_Nutrition_31_105
Author(s) : Sugihara K , Yamanaka-Okumura H , Teramoto A , Urano E , Katayama T , Morine Y , Imura S , Utsunomiya T , Shimada M , Takeda E
Ref : Nutrition , 31 :105 , 2014
Abstract : OBJECTIVE: Perioperative nutritional assessment is critically important to reflect nutritional management because liver transplantation (LTx) often is undertaken in patients with poor nutritional status. The aim of this study was to evaluate nutritional status, including the non-protein respiratory quotient (npRQ), resting energy expenditure (REE), nitrogen balance, and blood biochemical parameters in patients before and after LTx.
METHODS: Fourteen patients undergoing LTx and 10 healthy controls were enrolled in this study. The npRQ and REE were measured using indirect calorimetry before LTx and at 2, 3, and 4 wk after the procedure. Blood biochemistry and nitrogen balance calculated by 24-h urine collection were performed concurrently with indirect calorimetric measurement; the results were compared between the two groups.
RESULTS: Before LTx, npRQ was significantly lower and serum non-esterified fatty acid levels were significantly higher in the patients than in the controls. Furthermore, a negative nitrogen balance was observed in the patients. These, however, improved significantly at 4 wk after LTx. REE did not significantly increase compared with the preoperative values in recipients. Blood biochemistry showed gradually increasing levels of serum cholinesterase and albumin. These failed to reach to normal levels by 4 wk post-transplant.
CONCLUSIONS: The findings revealed that improvement of nutritional metabolism after LTx may require 4 wk. Additional nutritional strategies, therefore, may be needed to minimize catabolic state during the early post-transplant period. Adequate, individualized nutritional guidance before and after LTx should be performed in these patients.
ESTHER : Sugihara_2014_Nutrition_31_105
PubMedSearch : Sugihara_2014_Nutrition_31_105
PubMedID: 25441593

Title : Is acetylcholinesterase activity in neorectum after laparoscopic endorectal pull-through method for Hirschsprung's disease a primary or a secondary condition? - Takehara_2006_J.Med.Invest_53_113
Author(s) : Takehara H , Ishibashi H , Yoshikawa K , Shimada M
Ref : J Med Invest , 53 :113 , 2006
Abstract : Between 1996 and 2002, 22 cases of Hirschsprung's disease were treated laparoscopically by endorectal pull-through operation. The proximal margin of the resected bowel materials from these 22 patients were examined histologically by frozen sections at surgery and also after surgery using H&E staining, and complete resection of the aganglionic segment was confirmed. Eleven patients, in whom an informed consent was obtained at randomly, underwent suction biopsy from the pulled-though neorectum after surgery. Of these 11 patients, 2 revealed many AchE-positive nerve fibers in the lamina propria, the muscularis mucosa and around the ganglion cells in the submucosal plexuses. These structural changes were similar to intestinal neuronal dysplasia that was characterized by hyperganglionosis and other neuronal abnormalities. The remaining 9 revealed no AchE activity. Unexpectedly, the two patients showing AchE activity in their neorectum continued to have persistent constipation and were treated with laxatives or glycerin enema. It was suggested that their persistent constipation was caused by intestinal neuronal dysplasia showing an abnormal increase of AchE activity in spite of presence of ganglion cells of the neorectum after surgery, but it was uncertain that they were primary condition as a HaIND or secondary reactions after surgery.
ESTHER : Takehara_2006_J.Med.Invest_53_113
PubMedSearch : Takehara_2006_J.Med.Invest_53_113
PubMedID: 16538003

Title : Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium that depends on microbial commensalism - Ueda_2004_Nucleic.Acids.Res_32_4937
Author(s) : Ueda K , Yamashita A , Ishikawa J , Shimada M , Watsuji TO , Morimura K , Ikeda H , Hattori M , Beppu T
Ref : Nucleic Acids Research , 32 :4937 , 2004
Abstract : Symbiobacterium thermophilum is an uncultivable bacterium isolated from compost that depends on microbial commensalism. The 16S ribosomal DNA-based phylogeny suggests that this bacterium belongs to an unknown taxon in the Gram-positive bacterial cluster. Here, we describe the 3.57 Mb genome sequence of S.thermophilum. The genome consists of 3338 protein-coding sequences, out of which 2082 have functional assignments. Despite the high G + C content (68.7%), the genome is closest to that of Firmicutes, a phylum consisting of low G + C Gram-positive bacteria. This provides evidence for the presence of an undefined category in the Gram-positive bacterial group. The presence of both spo and related genes and microscopic observation indicate that S.thermophilum is the first high G + C organism that forms endospores. The S.thermophilum genome is also characterized by the widespread insertion of class C group II introns, which are oriented in the same direction as chromosomal replication. The genome has many membrane transporters, a number of which are involved in the uptake of peptides and amino acids. The genes involved in primary metabolism are largely identified, except those that code several biosynthetic enzymes and carbonic anhydrase. The organism also has a variety of respiratory systems including Nap nitrate reductase, which has been found only in Gram-negative bacteria. Overall, these features suggest that S.thermophilum is adaptable to and thus lives in various environments, such that its growth requirement could be a substance or a physiological condition that is generally available in the natural environment rather than a highly specific substance that is present only in a limited niche. The genomic information from S.thermophilum offers new insights into microbial diversity and evolutionary sciences, and provides a framework for characterizing the molecular basis underlying microbial commensalism.
ESTHER : Ueda_2004_Nucleic.Acids.Res_32_4937
PubMedSearch : Ueda_2004_Nucleic.Acids.Res_32_4937
PubMedID: 15383646
Gene_locus related to this paper: symth-metx , symth-q67kd5 , symth-q67kg6 , symth-q67kl6 , symth-q67km7 , symth-q67lu3 , symth-q67mi3 , symth-q67mk6 , symth-q67mr3 , symth-q67n56 , symth-q67nt3 , symth-q67pl6 , symth-q67qv2 , symth-q67r02 , symth-q67r99 , symth-q67ra1 , symth-q67ri0 , symth-q67rl1 , symth-q67ru9 , symth-q67s20 , symth-q67sr9 , symth-q67sv7 , symth-q67t46

Title : Preoperative hyaluronic acid measurement to assess the hepatic functional reserve - Suehiro_2004_Hepatogastroenterology_51_1776
Author(s) : Suehiro T , Matsumata T , Shikada Y , Shimada M , Shirabe K , Sugimachi K
Ref : Hepato-Gastroenterology , 51 :1776 , 2004
Abstract : BACKGROUND/AIMS: With liver surgery, preoperative assessment of the hepatic functional reserve is important for estimating the extent of hepatectomy. Hyaluronic acid (HA) is specifically cleared and metabolized by endothelial cells in the liver. Its half-life time is 2-5 min and HA might be a sensitive liver function marker. We obtained data from 44 patients with liver tumor undergoing liver resection. METHODOLOGY: We studied 44 liver resected patients. Blood samples were obtained before surgery and HA levels and other liver function markers [type IV collagen (IV), procollagen-III-peptide (PIIIP), lecithin-cholesterol acyltransferase (LCAT), cholinesterase (ChE), albumin (Alb), platelets (Plt), prothrombin time (PT%)] levels in the samples were measured. We also performed indocyanine green retention test and calculate R15% (ICG).
RESULTS: HA showed strong positive correlation with ICG, IV and PIIIP, negative correlation with LCAT, ChE, Alb, Plt and PT%. ICG was not correlated with ChE, Plt and PT%. The HA levels and ICG of the patients who had more than 2 segments of the liver resected were below 100 ng/mL and 20%, respectively. In the patients with obstructive jaundice HA levels of the 3 patients with obstructive jaundice who underwent bisegmentectomy were below 100 ng/mL.
CONCLUSIONS: Our findings suggest that HA is a useful preoperative liver function test as well as ICGR15%. Preoperative HA levels <100 ng/mL and ICGR15% <20% might be helpful indicators for major liver resection. We also recommend that HA measurement for evaluating liver function in the patients with obstructive jaundice ICG is not helpful.
ESTHER : Suehiro_2004_Hepatogastroenterology_51_1776
PubMedSearch : Suehiro_2004_Hepatogastroenterology_51_1776
PubMedID: 15532824

Title : Detection of three separate DNA polymorphisms in the human lipoprotein lipase gene by gene amplification and restriction endonuclease digestion - Gotoda_1992_J.Lipid.Res_33_1067
Author(s) : Gotoda T , Yamada N , Murase T , Shimano H , Shimada M , Harada K , Kawamura M , Kozaki K , Yazaki Y
Ref : J Lipid Res , 33 :1067 , 1992
Abstract : A rapid detection method was developed for DNA polymorphisms in the human lipoprotein lipase (LPL) gene. The examined polymorphisms include an A-C transversion in the 5'-region of intron 3, a T-G transversion that occurs within a Hind III site of intron 8, and the previously described C-T transition that causes a Pvu II polymorphism in intron 6. Gene fragments encompassing each polymorphic site were amplified by the polymerase chain reaction (PCR) and digested with an appropriate restriction enzyme whose recognition site was either naturally affected by the polymorphism or artificially created with a mismatched PCR-primer. According to the digestion profiles, genotypes were unambiguously distinguished. With this method, respective allelic frequencies were determined for 50 or 70 normal subjects. The procedure will facilitate LPL genotyping in the large population.
ESTHER : Gotoda_1992_J.Lipid.Res_33_1067
PubMedSearch : Gotoda_1992_J.Lipid.Res_33_1067
PubMedID: 1358995
Gene_locus related to this paper: human-LPL

Title : A newly identified null allelic mutation in the human lipoprotein lipase (LPL) gene of a compound heterozygote with familial LPL deficiency - Gotoda_1992_Biochim.Biophys.Acta_1138_353
Author(s) : Gotoda T , Yamada N , Murase T , Miyake S , Murakami R , Kawamura M , Kozaki K , Mori N , Shimano H , Shimada M , Yazaki Y
Ref : Biochimica & Biophysica Acta , 1138 :353 , 1992
Abstract : In a Japanese patient with familial LPL deficiency, a new null allelic mutation, one base pair deletion at nucleotide position 916 was identified in exon 5 of one allele. In exon 3 of the other allele, we found the same nonsense mutation as we described previously in other Japanese kindreds. For the deletional mutant allele, we developed a simple detection method and constructed the DNA haplotype.
ESTHER : Gotoda_1992_Biochim.Biophys.Acta_1138_353
PubMedSearch : Gotoda_1992_Biochim.Biophys.Acta_1138_353
PubMedID: 1562620

Title : Diethylcarbamazine: inhibitory effect on acetylcholinesterase of Dirofilaria immitis and Brugia pahangi - Fujimaki_1989_Southeast.Asian.J.Trop.Med.Public.Health_20_179
Author(s) : Fujimaki Y , Sakamoto M , Shimada M , Kimura E , Aoki Y
Ref : Southeast Asian J Trop Med Public Health , 20 :179 , 1989
Abstract : Anti-acetylcholinesterase activity of diethylcarbamazine (DEC) was studied. Acethylcholinesterase (AchE) of adult worms of Dirofilaria immitis, those of the 4th-stage larvae, early 5th-stage larvae and adults worms of Brugia pahangi, and that of hamster brain tissue were all inhibited by DEC. Michaelis constant (Km) of D. immitis and B. pahangi adult worm AchE were 1.47 x 10(-4) and 1.81 x 10(-4) M respectively. DEC was a competitive inhibitor of the filarial AchE. Inhibition constant (Ki) for AchE of D. immitis and B. pahangi adult worms were 2.56 x 10(-4) and 6.39 x 10(-4) M, respectively. DEC is a less potent anticholinesterase inhibitor, because Ki of DEC is 10(4) times higher than that of eserine, a potent anti-cholinesterase agent.
ESTHER : Fujimaki_1989_Southeast.Asian.J.Trop.Med.Public.Health_20_179
PubMedSearch : Fujimaki_1989_Southeast.Asian.J.Trop.Med.Public.Health_20_179
PubMedID: 2609206

Title : Ultrastructural study on a severe infantile sialidosis (beta-galactosidase-alpha-neuraminidase deficiency) - Yamano_1985_Neuropediatrics_16_109
Author(s) : Yamano T , Shimada M , Sugino H , Dezawa T , Koike M , Okada S , Yabuuchi H
Ref : Neuropediatrics , 16 :109 , 1985
Abstract : This study was undertaken to elucidate ultrastructural changes in a severe infantile sialidosis. The materials examined in this study consisted of biopsied rectal mucosa and autopsied small intestine, liver and kidney. In the biopsy sample, axons contained a number of pleomorphic electron dense bodies, and numerous membrane-bound vacuoles were found in Schwann's cells, fibroblasts, endothelial cells, lymphocytes and plasma cells. In autopsy samples, neurons in Auerbach's myenteric plexus of the small intestine were filled with a number of membranous cytoplasmic bodies, pleomorphic dense bodies and vesicles containing dense materials. Hepatocytes in the liver, and glomerular and tubular epithelial cells in the kidney were also extended by a number of membrane-bound vacuoles. These ultrastructural changes in severe infantile sialidosis closely resemble those in GM1-gangliosidosis type 1.
ESTHER : Yamano_1985_Neuropediatrics_16_109
PubMedSearch : Yamano_1985_Neuropediatrics_16_109
PubMedID: 3925363
Gene_locus related to this paper: human-CTSA

Title : Studies on the metabolic pathway of the acetyl group for acetylcholine synthesis -
Author(s) : Gibson GE , Shimada M
Ref : Biochemical Pharmacology , 29 :167 , 1980
PubMedID: 7362632

Title : Alterations in acetylcholine synthesis and cyclic nucleotides in mild cerebral hypoxia -
Author(s) : Gibson GE , Shimada M , Blass JP
Ref : Journal of Neurochemistry , 31 :757 , 1978
PubMedID: 212531