| Title : Three-dimensional rational approach to the discovery of potent substituted cyclopropyl urea soluble epoxide hydrolase inhibitors - Takai_2015_Bioorg.Med.Chem.Lett_25_1705 |
| Author(s) : Takai K , Chiyo N , Nakajima T , Nariai T , Ishikawa C , Nakatani S , Ikeno A , Yamamoto S , Sone T |
| Ref : Bioorganic & Medicinal Chemistry Lett , 25 :1705 , 2015 |
| Abstract : |
| PubMedSearch : Takai_2015_Bioorg.Med.Chem.Lett_25_1705 |
| PubMedID: 25800114 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Structure-based optimization of cyclopropyl urea derivatives as potent soluble epoxide hydrolase inhibitors for potential decrease of renal injury without hypotensive action - Takai_2014_Bioorg.Med.Chem_22_1548 |
| Author(s) : Takai K , Nakajima T , Takanashi Y , Sone T , Nariai T , Chiyo N , Nakatani S , Ishikawa C , Yamaguchi N , Fujita K , Yamada K |
| Ref : Bioorganic & Medicinal Chemistry , 22 :1548 , 2014 |
| Abstract : |
| PubMedSearch : Takai_2014_Bioorg.Med.Chem_22_1548 |
| PubMedID: 24530032 |
| Title : A practical use of ligand efficiency indices out of the fragment-based approach: ligand efficiency-guided lead identification of soluble epoxide hydrolase inhibitors - Tanaka_2011_J.Med.Chem_54_851 |
| Author(s) : Tanaka D , Tsuda Y , Shiyama T , Nishimura T , Chiyo N , Tominaga Y , Sawada N , Mimoto T , Kusunose N |
| Ref : Journal of Medicinal Chemistry , 54 :851 , 2011 |
| Abstract : |
| PubMedSearch : Tanaka_2011_J.Med.Chem_54_851 |
| PubMedID: 21192659 |
| Gene_locus related to this paper: human-EPHX2 |