Freedman SB

General

Full name : Freedman Stephen B

First name : Stephen B

Mail : Merck, Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex

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Country : United Kingdom

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References (17)

Title : The design of novel muscarinic partial agonists that have functional selectivity in pharmacological preparations in vitro and reduced side-effect profile in vivo - Freedman_1993_Life.Sci_52(5-6)_489
Author(s) : Freedman SB , Dawson GR , Iversen LL , Baker R , Hargreaves RJ
Ref : Life Sciences , 52 :489 , 1993
Abstract :
PubMedSearch : Freedman_1993_Life.Sci_52(5-6)_489
PubMedID: 8441329

Title : Synthesis and muscarinic activity of quinuclidinyl- and (1-azanorbornyl)pyrazine derivatives - Street_1992_J.Med.Chem_35_295
Author(s) : Street LJ , Baker R , Book T , Reeve AJ , Saunders J , Willson T , Marwood RS , Patel S , Freedman SB
Ref : Journal of Medicinal Chemistry , 35 :295 , 1992
Abstract :
PubMedSearch : Street_1992_J.Med.Chem_35_295
PubMedID: 1732546

Title : L-687,306: a functionally selective and potent muscarinic M1 receptor agonist - Freedman_1992_Eur.J.Pharmacol_215_135
Author(s) : Freedman SB , Patel S , Harley EA , Iversen LL , Baker R , Showell GA , Saunders J , McKnight A , Newberry N , Scholey K , Hargreaves R
Ref : European Journal of Pharmacology , 215 :135 , 1992
Abstract :
PubMedSearch : Freedman_1992_Eur.J.Pharmacol_215_135
PubMedID: 1516645

Title : Tetrahydropyridyloxadiazoles: semirigid muscarinic ligands - Showell_1991_J.Med.Chem_34_1086
Author(s) : Showell GA , Gibbons TL , Kneen CO , MacLeod AM , Merchant K , Saunders J , Freedman SB , Patel S , Baker R
Ref : Journal of Medicinal Chemistry , 34 :1086 , 1991
Abstract :
PubMedSearch : Showell_1991_J.Med.Chem_34_1086
PubMedID: 2002451

Title : Novel quinuclidine-based ligands for the muscarinic cholinergic receptor - Saunders_1990_J.Med.Chem_33_1128
Author(s) : Saunders J , Cassidy M , Freedman SB , Harley EA , Iversen LL , Kneen C , MacLeod AM , Merchant KJ , Snow RJ , Baker R
Ref : Journal of Medicinal Chemistry , 33 :1128 , 1990
Abstract :
PubMedSearch : Saunders_1990_J.Med.Chem_33_1128
PubMedID: 2319559

Title : Synthesis and biological activity of 1,2,4-oxadiazole derivatives: highly potent and efficacious agonists for cortical muscarinic receptors - Street_1990_J.Med.Chem_33_2690
Author(s) : Street LJ , Baker R , Book T , Kneen CO , MacLeod AM , Merchant KJ , Showell GA , Saunders J , Herbert RH , Freedman SB , Harley EA
Ref : Journal of Medicinal Chemistry , 33 :2690 , 1990
Abstract :
PubMedSearch : Street_1990_J.Med.Chem_33_2690
PubMedID: 2213823

Title : Synthesis and muscarinic activities of 1,2,4-thiadiazoles - MacLeod_1990_J.Med.Chem_33_2052
Author(s) : MacLeod AM , Baker R , Freedman SB , Patel S , Merchant KJ , Roe M , Saunders J
Ref : Journal of Medicinal Chemistry , 33 :2052 , 1990
Abstract :
PubMedSearch : MacLeod_1990_J.Med.Chem_33_2052
PubMedID: 2362286

Title : Poster: Tetrahydropyridyl-oxadiazoles: ligands used to map the muscarinic receptor -
Author(s) : Showell GA , Merchant K , Baker R , Freedman SB , Saunders J
Ref : Trends in Pharmacological Sciences , Suppl :112 , 1989
PubMedID:

Title : Poster: 5-Hydroxyquinuclidine oxadiazoles: stereochemical probes for the agonist binding state of the muscarinic receptor -
Author(s) : Snow RJ , Freedman SB , Baker R , Saunders J
Ref : Trends in Pharmacological Sciences , Suppl :112 , 1989
PubMedID:

Title : Poster: Direct measurement of muscannic agonists and antagonists in the mouse central nervous system ratio -
Author(s) : Freedman SB , Harley EA , Patel S
Ref : Trends in Pharmacological Sciences , Suppl :114 , 1989
PubMedID:

Title : The design of full agonists for the cortical muscarinic receptor - Saunders_1989_Trends.Pharmacol.Sci_Suppl_70
Author(s) : Saunders J , Freedman SB
Ref : Trends in Pharmacological Sciences , Suppl :70 , 1989
Abstract :
PubMedSearch : Saunders_1989_Trends.Pharmacol.Sci_Suppl_70
PubMedID: 2694527

Title : 2-Methyl-1,3-dioxaazaspiro[4.5]decanes as novel muscarinic cholinergic agonists - Saunders_1988_J.Med.Chem_31_486
Author(s) : Saunders J , Showell GA , Snow RJ , Baker R , Harley EA , Freedman SB
Ref : Journal of Medicinal Chemistry , 31 :486 , 1988
Abstract :
PubMedSearch : Saunders_1988_J.Med.Chem_31_486
PubMedID: 3339620

Title : Biochemical measurement of muscarinic receptor efficacy and its role in receptor regulation -
Author(s) : Freedman SB , Harley EA , Iversen LL
Ref : Trends in Pharmacological Sciences , Suppl :54 , 1988
PubMedID: 3074538

Title : Bioisosteres of arecoline as novel CNS-active muscarinic agonists -
Author(s) : Krogsgaard-Larsen P , Falch E , Sauerberg P , Freedman SB , Lembol HL , Meier E
Ref : Trends in Pharmacological Sciences , Suppl :69 , 1988
PubMedID: 3074541

Title : Synthesis and characterization of all four isomers of the muscarinic agonist 2'-methylspiro[1-azabicyclo[2.2.2]octane-3,4'-[1,3]dioxolane] - Saunders_1987_J.Med.Chem_30_969
Author(s) : Saunders J , Showell GA , Baker R , Freedman SB , Hill D , McKnight A , Newberry N , Salamone JD , Hirshfield J , Springer JP
Ref : Journal of Medicinal Chemistry , 30 :969 , 1987
Abstract :
PubMedSearch : Saunders_1987_J.Med.Chem_30_969
PubMedID: 3585909

Title : Poster: Apparent affinities of muscarinic antagonists and agonists at binding sites in rat heart and brain -
Author(s) : Freedman SB , Beer MS , Harley EA
Ref : Trends in Pharmacological Sciences , Suppl :79 , 1986
PubMedID:

Title : Poster: Allosteric regulation of muscarinic receptors from rat brain -
Author(s) : Freedman SB , Harley EA , Iversen LL
Ref : Trends in Pharmacological Sciences , Suppl :80 , 1986
PubMedID: