| Title : Target cell activation of a structurally novel NLRP3 inhibitor NT-0796 enhances potency - Smolak_2024_J.Pharmacol.Exp.Ther__ |
| Author(s) : Smolak P , Nguyen M , Diamond C , Wescott H , Doedens JR , Schooley K , Snouwaert JN , Bock MG , Harrison D , Watt AP , Koller BH , Gabel CA |
| Ref : Journal of Pharmacology & Experimental Therapeutics , : , 2024 |
| Abstract : |
| PubMedSearch : Smolak_2024_J.Pharmacol.Exp.Ther__ |
| PubMedID: 38253384 |
| Title : The ester-containing prodrug NT-0796 enhances delivery of the NLRP3 inflammasome inhibitor NDT-19795 to monocytic cells expressing carboxylesterase-1 - Doedens_2024_Biochem.Pharmacol__116455 |
| Author(s) : Doedens JR , Diamond C , Harrison D , Bock MG , Clarke N , Watt AP , Gabel CA |
| Ref : Biochemical Pharmacology , :116455 , 2024 |
| Abstract : |
| PubMedSearch : Doedens_2024_Biochem.Pharmacol__116455 |
| PubMedID: 39069136 |
| Title : Discovery of Clinical Candidate NT-0796, a Brain-Penetrant and Highly Potent NLRP3 Inflammasome Inhibitor for Neuroinflammatory Disorders - Harrison_2023_J.Med.Chem_66_14897 |
| Author(s) : Harrison D , Billinton A , Bock MG , Doedens JR , Gabel CA , Holloway MK , Porter RA , Reader V , Scanlon J , Schooley K , Watt AP |
| Ref : Journal of Medicinal Chemistry , 66 :14897 , 2023 |
| Abstract : |
| PubMedSearch : Harrison_2023_J.Med.Chem_66_14897 |
| PubMedID: 37874905 |
| Title : Discovery of a Series of Ester-substituted NLRP3 Inflammasome Inhibitors - Harrison_2020_Bioorg.Med.Chem.Lett__127560 |
| Author(s) : Harrison D , Boutard N , Brzozka K , Bugaj M , Chmielewski S , Cierpich A , Doedens JR , CH RYF , Gabel CA , Galezowski M , Kowalczyk P , Levenets O , Mroczkowska M , Palica K , Porter RA , Schultz D , Sowinska M , Topolnicki G , Urbanski P , Woyciechowski J , Watt AP |
| Ref : Bioorganic & Medicinal Chemistry Lett , :127560 , 2020 |
| Abstract : |
| PubMedSearch : Harrison_2020_Bioorg.Med.Chem.Lett__127560 |
| PubMedID: 32956781 |
| Title : Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics - Smith_1997_J.Bacteriol_179_7135 |
| Author(s) : Smith DR , Doucette-Stamm LA , Deloughery C , Lee H , Dubois J , Aldredge T , Bashirzadeh R , Blakely D , Cook R , Gilbert K , Harrison D , Hoang L , Keagle P , Lumm W , Pothier B , Qiu D , Spadafora R , Vicaire R , Wang Y , Wierzbowski J , Gibson R , Jiwani N , Caruso A , Bush D , Reeve JN , et al. |
| Ref : Journal of Bacteriology , 179 :7135 , 1997 |
| Abstract : |
| PubMedSearch : Smith_1997_J.Bacteriol_179_7135 |
| PubMedID: 9371463 |
| Gene_locus related to this paper: metth-metx , metth-MTH354 |
| Title : Insights into interfacial activation from an open structure of Candida rugosa lipase - Grochulski_1993_J.Biol.Chem_268_12843 |
| Author(s) : Grochulski P , Li Y , Schrag JD , Bouthillier F , Smith P , Harrison D , Rubin B , Cygler M |
| Ref : Journal of Biological Chemistry , 268 :12843 , 1993 |
| Abstract : |
| PubMedSearch : Grochulski_1993_J.Biol.Chem_268_12843 |
| PubMedID: 8509417 |
| Gene_locus related to this paper: canru-1lipa , geoca-1lipa |