Herzberg C

References (3)

Title : The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential - Veith_2004_J.Mol.Microbiol.Biotechnol_7_204
Author(s) : Veith B , Herzberg C , Steckel S , Feesche J , Maurer KH , Ehrenreich P , Baumer S , Henne A , Liesegang H , Merkl R , Ehrenreich A , Gottschalk G
Ref : J Molecular Microbiology Biotechnol , 7 :204 , 2004
Abstract : The genome of Bacillus licheniformis DSM13 consists of a single chromosome that has a size of 4,222,748 base pairs. The average G+C ratio is 46.2%. 4,286 open reading frames, 72 tRNA genes, 7 rRNA operons and 20 transposase genes were identified. The genome shows a marked co-linearity with Bacillus subtilis but contains defined inserted regions that can be identified at the sequence as well as at the functional level. B. licheniformis DSM13 has a well-conserved secretory system, no polyketide biosynthesis, but is able to form the lipopeptide lichenysin. From the further analysis of the genome sequence, we identified conserved regulatory DNA motives, the occurrence of the glyoxylate bypass and the presence of anaerobic ribonucleotide reductase explaining that B. licheniformis is able to grow on acetate and 2,3-butanediol as well as anaerobically on glucose. Many new genes of potential interest for biotechnological applications were found in B. licheniformis; candidates include proteases, pectate lyases, lipases and various polysaccharide degrading enzymes.
ESTHER : Veith_2004_J.Mol.Microbiol.Biotechnol_7_204
PubMedSearch : Veith_2004_J.Mol.Microbiol.Biotechnol_7_204
PubMedID: 15383718
Gene_locus related to this paper: bacld-q62u01 , bacld-q62yz9 , bacld-q65dz7 , bacld-q65e02 , bacld-q65eq1 , bacld-q65fc5 , bacld-q65fg2 , bacld-q65fg3 , bacld-q65fk9 , bacld-q65ft3 , bacld-q65fw3 , bacld-q65fy2 , bacld-q65gx2 , bacld-q65hn8 , bacld-q65hr4 , bacld-q65if8 , bacld-q65iy4 , bacld-q65j72 , bacld-q65le0 , bacld-q65ly2 , bacld-q65m29 , bacld-q65mg8 , bacld-q65my7 , bacld-q65n63 , bacld-q65nk2 , bacld-q65nm7 , bacli-LICC

Title : Complete nucleotide sequence and genetic organization of the 210-kilobase linear plasmid of Rhodococcus erythropolis BD2 - Stecker_2003_J.Bacteriol_185_5269
Author(s) : Stecker C , Johann A , Herzberg C , Averhoff B , Gottschalk G
Ref : Journal of Bacteriology , 185 :5269 , 2003
Abstract : The complete nucleotide sequence of the linear plasmid pBD2 from Rhodococcus erythropolis BD2 comprises 210,205 bp. Sequence analyses of pBD2 revealed 212 putative open reading frames (ORFs), 97 of which had an annotatable function. These ORFs could be assigned to six functional groups: plasmid replication and maintenance, transport and metalloresistance, catabolism, transposition, regulation, and protein modification. Many of the transposon-related sequences were found to flank the isopropylbenzene pathway genes. This finding together with the significant sequence similarities of the ipb genes to genes of the linear plasmid-encoded biphenyl pathway in other rhodococci suggests that the ipb genes were acquired via transposition events and subsequently distributed among the rhodococci via horizontal transfer.
ESTHER : Stecker_2003_J.Bacteriol_185_5269
PubMedSearch : Stecker_2003_J.Bacteriol_185_5269
PubMedID: 12923100
Gene_locus related to this paper: rhoer-q6xn97 , rhosp-EtbD1

Title : The genome sequence of Clostridium tetani, the causative agent of tetanus disease - Bruggemann_2003_Proc.Natl.Acad.Sci.U.S.A_100_1316
Author(s) : Bruggemann H , Baumer S , Fricke WF , Wiezer A , Liesegang H , Decker I , Herzberg C , Martinez-Arias R , Merkl R , Henne A , Gottschalk G
Ref : Proceedings of the National Academy of Sciences of the United States of America , 100 :1316 , 2003
Abstract : Tetanus disease is one of the most dramatic and globally prevalent diseases of humans and vertebrate animals, and has been reported for over 24 centuries. The manifestation of the disease, spastic paralysis, is caused by the second most poisonous substance known, the tetanus toxin, with a human lethal dose of approximately 1 ng/kg. Fortunately, this disease is successfully controlled through immunization with tetanus toxoid; nevertheless, according to the World Health Organization, an estimated 400,000 cases still occur each year, mainly of neonatal tetanus. The causative agent of tetanus disease is Clostridium tetani, an anaerobic spore-forming bacterium, whose natural habitat is soil, dust, and intestinal tracts of various animals. Here we report the complete genome sequence of toxigenic C. tetani E88, a variant of strain Massachusetts. The genome consists of a 2,799,250-bp chromosome encoding 2,372 ORFs. The tetanus toxin and a collagenase are encoded on a 74,082-bp plasmid, containing 61 ORFs. Additional virulence-related factors could be identified, such as an array of surface-layer and adhesion proteins (35 ORFs), some of them unique to C. tetani. Comparative genomics with the genomes of Clostridium perfringens, the causative agent of gas gangrene, and Clostridium acetobutylicum, a nonpathogenic solvent producer, revealed a remarkable capacity of C. tetani: The organism can rely on an extensive sodium ion bioenergetics. Additional candidate genes involved in the establishment and maintenance of a pathogenic lifestyle of C. tetani are presented.
ESTHER : Bruggemann_2003_Proc.Natl.Acad.Sci.U.S.A_100_1316
PubMedSearch : Bruggemann_2003_Proc.Natl.Acad.Sci.U.S.A_100_1316
PubMedID: 12552129
Gene_locus related to this paper: clote-CTC00812 , clote-CTC00947 , clote-CTC01150 , clote-CTC01505 , clote-CTC02183 , clote-CTC02480