Holmstedt B

General

Full name : Holmstedt Bo

First name : Bo

Mail : Toxicology Unit, Institute of Environmental Medicine Karolinska Institute

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Country : Sweden

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Website : \/\/www.eurotox.com\/bhmf\/

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Comment
Bo Holmstedt was born 1919 in the southern part of Sweden, and died in 2002. Bo Holmstedt studied medicine at the Karolinska Institute. He became full professor in toxicology at the Karolinska Institute in 1964. He studied organophosphate compounds. He described the synthesis of tabun. He developed a histochemical method to reveal cholinergic nerves. During the Alpha Helix expedition to the Amazons in 1967, he and his collaborators identified hallucinogens, 5-metoxy-N, -carboline-alkaloids, used by different South and American Indian tribes. A tribute to his work was given at the 11th international symposium on cholinergic mechanisms (St Moritz) in 2002. and an obituary paper by Malmfos T.

References (29)

Title : Chemical methods for the determination of acetylcholine -
Author(s) : Holmstedt B
Ref : Life Sciences , 58 :1917 , 1996
PubMedID: 8637419

Title : Intoxications with anticholinesterases: effect of different combinations of antidotes on the dynamics of acetylcholine in mouse brain - Nordgren_1992_Pharmacol.Toxicol_70_384
Author(s) : Nordgren I , Karlen B , Kimland M , Palmer L , Holmstedt B
Ref : Pharmacol Toxicol , 70 :384 , 1992
Abstract :
PubMedSearch : Nordgren_1992_Pharmacol.Toxicol_70_384
PubMedID: 1608928

Title : Poster: Mechanism of action of the protecting effect of combinations of antidotes in intoxications with anticholinesterases -
Author(s) : Nordgren I , Karlen B , Kimland M , Palmer L , Holmstedt B
Ref : In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology , (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC :301 , 1991
PubMedID:

Title : Acetylcholine Turnover in Mouse Brain: Influence of Cholinesterase Inhibitors -
Author(s) : Karlen B , Lundgren G , Lundin J , Holmstedt B
Ref : Advances in Behavioral Biology , 30 :781 , 1986
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Title : Analysis of succinylcholine in tissues and body fluids by ion-pair extraction and gas chromatography-mass spectrometry - Nordgren_1983_Arch.Toxicol.Suppl_6_339
Author(s) : Nordgren I , Forney RB, Jr. , Carroll FT , Holmstedt B , Jaderholm-Ek I , Pettersson BM
Ref : Archives of Toxicology Suppl , 6 :339 , 1983
Abstract :
PubMedSearch : Nordgren_1983_Arch.Toxicol.Suppl_6_339
PubMedID: 6578742

Title : Extraction, identification and quantitation of succinylcholine in embalmed tissue - Forney_1982_J.Anal.Toxicol_6_115
Author(s) : Forney RB, Jr. , Carroll FT , Nordgren IK , Pettersson BM , Holmstedt B
Ref : J Anal Toxicol , 6 :115 , 1982
Abstract :
PubMedSearch : Forney_1982_J.Anal.Toxicol_6_115
PubMedID: 7109551

Title : Metrifonate and dichlorvos: theoretical and practical aspects. History and scope of the conference -
Author(s) : Aldridge WN , Holmstedt B
Ref : Acta Pharmacologica et Toxicologica (Copenh) , 49 Suppl 5 :3 , 1981
PubMedID: 7046344

Title : Subcellular fractionation of cat submandibular gland: comparative studies on the distribution of acetylcholine and vasoactive intestinal polypeptide (VIP) -
Author(s) : Lundberg JM , Fried G , Fahrenkrug J , Holmstedt B , Hokfelt T , Lagercrantz H , Lundgren G , Anggard A
Ref : Neuroscience , 6 :1001 , 1981
PubMedID: 7279209

Title : Effect of occupational exposure to organophosphorus insecticides on neuromuscular function - Stalberg_1978_Scand.J.Work.Environ.Health_4_255
Author(s) : Stalberg E , Hilton-Brown P , Kolmodin-Hedman B , Holmstedt B , Augustinsson KB
Ref : Scandinavian Journal of Work, Environment & Health , 4 :255 , 1978
Abstract :
PubMedSearch : Stalberg_1978_Scand.J.Work.Environ.Health_4_255
PubMedID: 212825

Title : Effect of Atropine on Acetylcholine Metabolism in the Mouse Brain -
Author(s) : Karlen B , Lundgren G , Miyata T , Lundin J , Holmstedt B
Ref : Advances in Behavioral Biology , 24 :643 , 1978
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Title : Acetylcholine and choline in mouse brain--influence of peripherally acting cholinergic drugs -
Author(s) : Lundgren G , Karlen B , Holmstedt B
Ref : Biochemical Pharmacology , 26 :1607 , 1977
PubMedID: 901579

Title : Pages from the history of research on cholinergic mechanisms -
Author(s) : Holmstedt B
Ref : Cholinergic.Mechanisms, Raven Press :1 , 1975
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Title : Acetylcholine turnover in mouse brain in vivo studied with a mass fragmentographic technique -
Author(s) : Karlen B , Lundgren G , Lundholm B , Nordgren I , Holmstedt B
Ref : Cholinergic.Mechanisms, Raven Press :99 , 1975
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Title : Identification of acetylcholine in fresh rat brain by combined gas chromatography-mass spectrometry -
Author(s) : Hammar CG , Hanin I , Holmstedt B , Kitz RJ , Jenden DJ , Karlen B
Ref : Nature , 220 :915 , 1968
PubMedID: 5722142

Title : Relationship between acetylcholine and cholinesterase activity in the brain following an organophosphorus inhibitor -
Author(s) : Holmstedt B , Harkonen M , Lundgren G , Sundwall A , Sundwali A
Ref : Biochemical Pharmacology , 16 :404 , 1967
PubMedID: 6029922

Title : Determination of cholinesterase in blood samples dried on filter-paper and its practical application -
Author(s) : Augustinsson KB , Holmstedt B
Ref : Scand J Clin Lab Invest , 17 :573 , 1965
PubMedID: 5858749

Title : Tremorine and oxotremorine effects on acetlcholinesterase and choline acetylase from rat brain -
Author(s) : Holmstedt B , Lundgren G , Schuberth J , Sundwall A
Ref : Biochemical Pharmacology , 14 :189 , 1965
PubMedID: 14332469

Title : Anticholinesterase agents -
Author(s) : Koelle GB , Volle RB , Holmstedt B , Karczmar AG , O'Brien RD
Ref : Science , 141 :63 , 1963
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Title : Structure-activity relationships of the organophosphorus anticholinesterase agents -
Author(s) : Holmstedt B
Ref : Handbook of Experimental Pharmacology , 15 :428 , 1963
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Title : Tremorine and atropine effects on rain acetylcholine -
Author(s) : Holmstedt B , Lundgren G , Sundwall A
Ref : Life Sciences , 10 :731 , 1963
PubMedID: 14076593

Title : Some principles about histochemistry of cholinesterase with special reference to the thiocholine method -
Author(s) : Holmstedt B , Sjoqvist F
Ref : Bibliotheca Anat , 2 :1 , 1961
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Title : Effects of sarin in the anesthetized and unanesthetized dog following inhalation, percutaneous absorption and intravenous infusion -
Author(s) : Fredriksson T , Hansson GH , Holmstedt B
Ref : Archives Internationales de Pharmacodynamie et de Therapie , 126 :228 , 1960
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Title : Pharmacology of organophosphorus cholinesterase inhibitors -
Author(s) : Holmstedt B
Ref : Pharmacological Reviews , 11 :567 , 1959
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Title : The pathology of experimental cholinesterase-inhibitor poisoning -
Author(s) : Holmstedt B , Krook L , Rooney JR
Ref : Acta Pharmacologica et Toxicologica (Copenh) , 13 :337 , 1957
PubMedID:

Title : A modification of the thiocholine method for the determination of cholinesterase. I. Biochemical evaluation of selective inhibitors -
Author(s) : Holmstedt B
Ref : Acta Physiologica Scandinavica , 40 :322 , 1957
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Title : A modification of the thiocholine method for the determination of cholinesterase. II. Histochemical application -
Author(s) : Holmstedt B
Ref : Acta Physiologica Scandinavica , 40 :331 , 1957
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Title : Some considerations regarding the nomenclature of organic phosphorus compounds -
Author(s) : Larsson L , Holmstedt B , Tjus E
Ref : Acta Chemica Scandinavica , 8 :1563 , 1954
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Title : Effect of phenothiazine derivatives against poisoning by irreversible cholinesterase inhibitor dimethylamido-ethoxyphosphoryl cyanide (tabun) -
Author(s) : Dahlbom R , Diamant H , Edlund T , Ekstrand T , Holmstedt B
Ref : Acta Pharmacologica et Toxicologica (Copenh) , 9 :163 , 1953
PubMedID: 13079852

Title : Synthesis and pharmacology of dimethylamidoethoxyphosphoryl cyanide (tabun) together with a description of some allied anticholinesterase compounds contamina the N-P bond -
Author(s) : Holmstedt B
Ref : Acta Physiologica Scandinavica , 25 :11 , 1951
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