Full name : Aldridge W.Norman
First name : W.Norman
Mail : Robens Institute of Health and Safety, University of Surrey, Woodmansterne Road, Carsha1ton, Surrey SM5 4EF Guildford
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Country : United Kingdom
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Website : \/\/toxsci.oxfordjournals.org\/content\/59\/1\/3.full
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Comment
W. Norman Aldridge was born in 1919 and died in 1996. He established much of the basic enzymology on the interaction of organophosphorus esters with esterases. He classified these into A, B, or C esterases according to whether organophosphorus esters were hydrolyzed by them, were inhibited, or did not interact either way. A tribute to his work was published by Martin K. Johnson obituary paper.
| Title : The esterases: perspectives and problems - Aldridge_1993_Chem.Biol.Interact_87_5 |
| Author(s) : Aldridge WN |
| Ref : Chemico-Biological Interactions , 87 :5 , 1993 |
| Abstract : |
| PubMedSearch : Aldridge_1993_Chem.Biol.Interact_87_5 |
| PubMedID: 8344005 |
| Title : Mechanism of Substrate Inhibition of Acetylcholinesterase - |
| Author(s) : Reiner E , Aldridge WN , Simeon-Rudolf V , Radic Z , Taylor P |
| Ref : In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology , (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC :227 , 1991 |
| PubMedID: |
| Title : Studies on the metabolism of the pneumotoxin O,S,S-trimethyl phosphorodithioate--I. Lung and liver microsomes - Nemery_1988_Biochem.Pharmacol_37_3709 |
| Author(s) : Nemery B , Aldridge WN |
| Ref : Biochemical Pharmacology , 37 :3709 , 1988 |
| Abstract : |
| PubMedSearch : Nemery_1988_Biochem.Pharmacol_37_3709 |
| PubMedID: 3178882 |
| Title : Studies on the metabolism of the pneumotoxin O,S,S-trimethyl phosphorodithioate--II. Lung and liver slices - Nemery_1988_Biochem.Pharmacol_37_3717 |
| Author(s) : Nemery B , Aldridge WN |
| Ref : Biochemical Pharmacology , 37 :3717 , 1988 |
| Abstract : |
| PubMedSearch : Nemery_1988_Biochem.Pharmacol_37_3717 |
| PubMedID: 3178883 |
| Title : The interaction between phosphorothionate insecticides, pneumotoxic trialkyl phosphorothiolates and effects on lung 7-ethoxycoumarin O-deethylase activity - Verschoyle_1987_Arch.Toxicol_60_311 |
| Author(s) : Verschoyle RD , Aldridge WN |
| Ref : Archives of Toxicology , 60 :311 , 1987 |
| Abstract : |
| PubMedSearch : Verschoyle_1987_Arch.Toxicol_60_311 |
| PubMedID: 3498466 |
| Title : Some aspects of the toxicology of trimethyl and triethyl phosphorothioates - Aldridge_1985_Fundam.Appl.Toxicol_5_S47 |
| Author(s) : Aldridge WN , Dinsdale D , Nemery B , Verschoyle RD |
| Ref : Fundamental & Applied Toxicology , 5 :S47 , 1985 |
| Abstract : |
| PubMedSearch : Aldridge_1985_Fundam.Appl.Toxicol_5_S47 |
| PubMedID: 4092896 |
| Title : Trialkyl phosphorothioates and glutathione S-transferases - Aldridge_1985_Chem.Biol.Interact_54_243 |
| Author(s) : Aldridge WN , Grasdalen H , Aarstad K , Street BW , Norkov T |
| Ref : Chemico-Biological Interactions , 54 :243 , 1985 |
| Abstract : |
| PubMedSearch : Aldridge_1985_Chem.Biol.Interact_54_243 |
| PubMedID: 4028290 |
| Title : Toxicology of trialkylphosphorothioates with particular reference to lung toxicity - |
| Author(s) : Aldridge WN , Nemery B |
| Ref : Fundamental & Applied Toxicology , 4 :S215 , 1984 |
| PubMedID: 6724214 |
| Title : Dimethylphosphorothioates. Reaction with malathion and effect on malathion toxicity - Verschoyle_1982_Arch.Toxicol_49_293 |
| Author(s) : Verschoyle RD , Reiner E , Bailey E , Aldridge WN |
| Ref : Archives of Toxicology , 49 :293 , 1982 |
| Abstract : |
| PubMedSearch : Verschoyle_1982_Arch.Toxicol_49_293 |
| PubMedID: 7092568 |
| Title : Organophosphorus compounds: molecular basis for their biological properties - |
| Author(s) : Aldridge WN |
| Ref : Sci Prog , 67 :131 , 1981 |
| PubMedID: 7013066 |
| Title : Metrifonate and dichlorvos: theoretical and practical aspects. History and scope of the conference - |
| Author(s) : Aldridge WN , Holmstedt B |
| Ref : Acta Pharmacologica et Toxicologica (Copenh) , 49 Suppl 5 :3 , 1981 |
| PubMedID: 7046344 |
| Title : Toxicology of trimethyl- and triethyl phosphorothioates - |
| Author(s) : Verschoyle RD , Aldridge WN , Cabral JR |
| Ref : Developments in Toxicology & Environmental Sciences , 8 :631 , 1980 |
| PubMedID: 7308074 |
| Title : Insecticides, past, present and future: practice and the understanding of mechanisms - |
| Author(s) : Aldridge WN |
| Ref : Ann Occup Hyg , 22 :407 , 1979 |
| PubMedID: 398174 |
| Title : The toxicological properties of impurities in malathion - Aldridge_1979_Arch.Toxicol_42_95 |
| Author(s) : Aldridge WN , Miles JW , Mount DL , Verschoyle RD |
| Ref : Archives of Toxicology , 42 :95 , 1979 |
| Abstract : |
| PubMedSearch : Aldridge_1979_Arch.Toxicol_42_95 |
| PubMedID: 755464 |
| Title : General discussion on models for the ligand binding sites of cholinesterase - |
| Author(s) : Reiner E , Aldridge WN , Hopff WH , Taylor P , Krupka RM , Rosenberry TL , Augustinsson KB , Mooser G , O'Brien RD , Brodbeck U , Massoulie J , Maricic S , Eldefrawi ME , Silman I |
| Ref : Croatica Chemica Acta , 47 :499 , 1975 |
| PubMedID: |
| Title : Survey of major points of interest about reactions of cholinesterases - |
| Author(s) : Aldridge WN |
| Ref : Croatica Chemica Acta , 47 :225 , 1975 |
| PubMedID: |
| Title : Nature of the reaction of organophosphorus compounds and carbamates with esterases - |
| Author(s) : Aldridge WN |
| Ref : Hoppe-Seylers Zeitschrift fur physiologische Chemie , 354 :4 , 1973 |
| PubMedID: 4803240 |
| Title : The nature of the reaction of organophosphorus compounds and carbamates with esterases - |
| Author(s) : Aldridge WN |
| Ref : Bulletin of the World Health Organization , 44 :25 , 1971 |
| PubMedID: 5315347 |
| Title : Side effects of organophosphorus compounds: delayed neurotoxicity - |
| Author(s) : Aldridge WN , Johnson MK |
| Ref : Bulletin of the World Health Organization , 44 :259 , 1971 |
| PubMedID: 5315346 |
| Title : Acetylcholinesterase. Two types of inhibition by an organophosphorus compound: one the formation of phosphorylated enzyme and the other analogous to inhibition by substrate - |
| Author(s) : Aldridge WN , Reiner E |
| Ref : Biochemical Journal , 115 :147 , 1969 |
| PubMedID: 5378376 |
| Title : Organophosphorus compounds and carbamates, and their reaction with esterases - |
| Author(s) : Aldridge WN |
| Ref : British Medical Bulletin , 25 :236 , 1969 |
| PubMedID: 5812100 |
| Title : Studies on delayed neurotoxicity produced by some organophosphorus compounds - |
| Author(s) : Aldridge WN , Barnes JM , Johnson MK |
| Ref : Annals of the New York Academy of Sciences , 160 :314 , 1969 |
| PubMedID: 4896090 |
| Title : Effect of pH on inhibition and spontaneous reactivation of acetylcholinesterase treated with esters of phosphorus acids and of carbamic acids - |
| Author(s) : Reiner E , Aldridge WN |
| Ref : Biochemical Journal , 105 :171 , 1967 |
| PubMedID: 6070126 |
| Title : Further observations on the neurotoxicity of organophosphorus compounds - |
| Author(s) : Aldridge WN , Barnes JM |
| Ref : Biochemical Pharmacology , 15 :541 , 1966 |
| PubMedID: 5962859 |
| Title : Esterases and neurotoxicity of some organophosphorus compounds - |
| Author(s) : Aldridge WN , Barnes JM |
| Ref : Biochemical Pharmacology , 15 :549 , 1966 |
| PubMedID: 5961433 |
| Title : The inhibition of enzymes by beryllium - |
| Author(s) : Thomas M , Aldridge WN |
| Ref : Biochemical Journal , 98 :94 , 1966 |
| PubMedID: 4287187 |
| Title : A method for the characterization of two similar B-esterases present in the chicken central nervous system - |
| Author(s) : Aldridge WN |
| Ref : Biochemical Journal , 93 :619 , 1964 |
| PubMedID: 5839196 |
| Title : Studies on esterases in the chicken central nervous system - |
| Author(s) : Poulsen E , Aldridge WN |
| Ref : Biochemical Journal , 90 :182 , 1964 |
| PubMedID: 5832290 |
| Title : Cholinesterase, succinic dehydrogenase, nucleic acids, esterase and glutathione reductase in sub-cellular fractions from rat brain - |
| Author(s) : Aldridge WN , Johnson MK |
| Ref : Biochemical Journal , 73 :270 , 1959 |
| PubMedID: 13792488 |
| Title : Tricresyl phosphates and cholinesterase - |
| Author(s) : Aldridge WN |
| Ref : Biochemical Journal , 56 :185 , 1954 |
| PubMedID: 13140171 |
| Title : Some esterases of the rat - |
| Author(s) : Aldridge WN |
| Ref : Biochemical Journal , 57 :692 , 1954 |
| PubMedID: 13198822 |
| Title : The mechanism of inhibition of cholinesterases by organophosphorus compounds - |
| Author(s) : Aldridge WN , Davison AN |
| Ref : Biochemical Journal , 55 :763 , 1953 |
| PubMedID: 13115369 |
| Title : The inhibition of erythrocyte cholinesterase by tri-esters of phosphoric acid. III. The nature of the inhibitory process - |
| Author(s) : Aldridge WN |
| Ref : Biochemical Journal , 54 :442 , 1953 |
| PubMedID: 13058922 |
| Title : Serum esterases. II. An enzyme hydrolyzing,diethyl p-nitro-phenyl phosphate (E600) and its identity with the esterase of mammalian sera - |
| Author(s) : Aldridge WN |
| Ref : Biochemical Journal , 53 :117 , 1953 |
| PubMedID: 13032042 |
| Title : Serum esterases. I. Two types of esterase (A and B) hydrolyzing p-nitrophenyl acetate, propionate, butyrate and a method for their determination - |
| Author(s) : Aldridge WN |
| Ref : Biochemical Journal , 53 :110 , 1953 |
| PubMedID: 13032041 |
| Title : The differentiation of true and pseudo cholinesterase by organophosphorus compounds - |
| Author(s) : Aldridge WN |
| Ref : Biochemical Journal , 53 :62 , 1953 |
| PubMedID: 13032034 |
| Title : The inhibition of erythrocyte cholinesterase by tri-esters of phosphoric acid. 1. Diethyl p-nitrophenyl phosphate (E600) and analogues - |
| Author(s) : Aldridge WN , Davison AN |
| Ref : Biochemical Journal , 51 :62 , 1952 |
| PubMedID: 14944533 |
| Title : The inhibition of erythrocyte cholinesterase by tri-esters of phosphoric acid. II. Diethyl p-nitrophenyl twophosphate (E605) and analogues - |
| Author(s) : Aldridge WN , Davison AN |
| Ref : Biochemical Journal , 52 :663 , 1952 |
| PubMedID: 13018298 |
| Title : Determination of cholinesterase activity in human blood - |
| Author(s) : Aldridge WN , Davies DR |
| Ref : British Medical Journal , 1 :945 , 1952 |
| PubMedID: 14916207 |
| Title : Some problems in assessing the toxicity of the organophosphorus insecticides towards mammals - |
| Author(s) : Aldridge WN , Barnes JM |
| Ref : Nature , 169 :345 , 1952 |
| PubMedID: 14919566 |
| Title : The enzymic hydrolysis of diethyl p-nitrophenyl phosphate (E 600) - |
| Author(s) : Aldridge WN |
| Ref : J Biochem (Tokyo) , 49 :i , 1951 |
| PubMedID: 14848041 |