Khan SB

References (5)

Title : Withanolides: Biologically Active Constituents in the Treatment of Alzheimer's Disease - Khan_2016_Med.Chem_12_238
Author(s) : Khan SA , Khan SB , Shah Z , Asiri AM
Ref : Med Chem , 12 :238 , 2016
Abstract : The use of natural products in drug discovery and development have an important history. Several therapeutic agents have been investigated during the biological screenings of natural compounds. It is well documented that plants are possibly the core of novel substances that led to the discovery of new, novel, and effective therapeutic agents. Therefore, in the last few decades, scientists were thoroughly attempting for the search of benevolent drugs to protect mankind from various diseases and discomforts. The diverse chemical structures of natural products are the key element of their success in modern drug discovery. Cholinesterase enzyme inhibitors (ChEI) are chemicals which inhibit the splitting of cholinesterase enzymes (acetylcholinesterase and butyrylcholinesterase). Acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) are two types of cholinesterase enzymes that have been identified in vertebrates that are responsible for Alzheimer's disease and related dementia. Withanolides are affective plant secondary metabolites which inhibit acetylcholinesterase and butyrylcholinesterase enzyme and thus possibly will be the future drug for Alzheimer's disease. By viewing the importance of natural products in drug discovery and development, we present here, the importance of withanolides in the treatment of Alzheimer's disease. In this article, we also describe the classification and structural characterization of withanolides. This review comprises of 114 compounds.
ESTHER : Khan_2016_Med.Chem_12_238
PubMedSearch : Khan_2016_Med.Chem_12_238
PubMedID: 26527154

Title : Leufolins A and B, potent butyrylcholinesterase-inhibiting flavonoid glucosides from Leucas urticifolia - Atia_2007_Molecules_12_1447
Author(s) : Atia tun N , Fatima I , Ahmad I , Malik A , Afza N , Iqbal L , Latif M , Khan SB
Ref : Molecules , 12 :1447 , 2007
Abstract : New flavonoidal glucosides leufolins A (1) and B (2), have been isolated from the ethyl acetate soluble fraction of the whole plants of Leucas urticifolia. Their structures were elucidated on the basis of extensive analysis of nuclear magnetic resonance (1D and 2D NMR) spectral data. Both of these compounds exhibited significant inhibitory potential against the enzyme butyrylcholinesterase.
ESTHER : Atia_2007_Molecules_12_1447
PubMedSearch : Atia_2007_Molecules_12_1447
PubMedID: 17909500

Title : Phenolic constituents from Perovskia atriplicifolia - Perveen_2006_Nat.Prod.Res_20_347
Author(s) : Perveen S , Khan SB , Malik A , Tareen RB , Nawaz SA , Choudhary MI
Ref : Nat Prod Res , 20 :347 , 2006
Abstract : Perovskoate, an isorinic acid derivative (1) and perovskoside, the catechol derivative (2) have been isolated from the ethyl acetate soluble fraction of the whole plant of Perovskia atriplicifolia and assigned the structure 3(7-hydroxyphenyl)-2-hydroxy propanoic acid; (R)-form, 2-O-(6',7'-dihydroxy-E-cinnamoyl) (1) and 2-methoxy-4-(undecyl-4'-O-beta-D-glucopyranosyl) phenol (2). In addition, caffeic acid (3) and ferulic acid (4) have been reported for the first time from this species. The structures of these compounds were assigned on the basis of 1D and 2D NMR techniques. The compound 1 showed significant inhibitory activity against lipoxygenase and weak to moderate activity against cholinesterases.
ESTHER : Perveen_2006_Nat.Prod.Res_20_347
PubMedSearch : Perveen_2006_Nat.Prod.Res_20_347
PubMedID: 16644529

Title : Butyrylcholinesterase inhibitory guaianolides from Amberboa ramosa - Khan_2005_Arch.Pharm.Res_28_172
Author(s) : Khan SB , Azhar Ul H , Perveen S , Afza N , Malik A , Nawaz SA , Shah MR , Choudhary MI
Ref : Arch Pharm Res , 28 :172 , 2005
Abstract : Phytochemical investigation of the whole plant of Amberboa ramosa led to the isolation of six sesquiterpene lactones which could be identified as 8alpha-hydroxy-11beta-methyl-1alphaH, 5alphaH, 6betaH, 7alphaH, 11alphaH-guai-10(14), 4(15)-dien-6, 12-olide(1), 3beta, 8alpha-dihydroxy-11alpha-methyl-1alphaH, 5alphaH, 6betaH, 7alphaH, 11betaH-guai-10(14), 4 (15)-dien-6, 12-olide (2), 3beta, 4alpha, 8alpha-trihydroxy-4beta-(hydroxymethyl)-1alphaH, 5alphaH, 6betaH, 7alphaH-guai-10(14), 11(13)-dien-6, 12-olide (3), 3beta, 4alpha, 8alpha-trihydroxy-4beta-(chloromethyl)-1alphaH, 5alphaH, 6betaH, 7alphaH-guai-10(14),11(13)-dien-6, 12-olide(4), 3beta, 4alpha, dihydroxy-4beta-(hydroxymethyl)-1alphaH, 5alphaH, 6betaH, 7alphaH-guai-10(14),11(13)-dien-6, 12-olide(5), 3beta, 4alpha-dihydroxy-4beta-(chloromethyl)-8alpha-(4-hydroxymethacrylate)-1alphaH, 5alphaH, 6betaH, 7alphaH-guai-10(14),11 (13)-dien-6,12-olide (6) by spectroscopic methods. All of them showed inhibitory potential against butyrylcholinesterase.
ESTHER : Khan_2005_Arch.Pharm.Res_28_172
PubMedSearch : Khan_2005_Arch.Pharm.Res_28_172
PubMedID: 15789746

Title : Enzyme inhibiting lignans from Vitex negundo - Azhar_2004_Chem.Pharm.Bull.(Tokyo)_52_1269
Author(s) : Azhar Ul H , Malik A , Anis I , Khan SB , Ahmed E , Ahmed Z , Nawaz SA , Choudhary MI
Ref : Chem Pharm Bull (Tokyo) , 52 :1269 , 2004
Abstract : Two new lignans trivially named negundins A (1) and B (2), were isolated along with (+)-diasyringaresinol (3), (+)-lyoniresinol (4), vitrofolal E (5) and vitrofolal F (6), reported for the first time from this species. The structures of the new compounds were established through spectral studies. Compound 2 showed potent inhibitory activity against lipoxygenase enzyme, while 5 showed moderate activity against butyryl-cholinesterase.
ESTHER : Azhar_2004_Chem.Pharm.Bull.(Tokyo)_52_1269
PubMedSearch : Azhar_2004_Chem.Pharm.Bull.(Tokyo)_52_1269
PubMedID: 15520511