Latif M

References (4)

Title : Experimental and Theoretical Biological Probing of Schiff Bases as Esterase Inhibitors: Structural, Spectral and Molecular Insights - Raza_2023_Molecules_28_5703
Author(s) : Raza MA , Mumtaz MW , Ozturk S , Latif M , Aisha , Ashraf A , Dege N , Dogan OE , Agar E , Rehman SU , Noor A
Ref : Molecules , 28 :5703 , 2023
Abstract : The present study was designed to evaluate the in vitro and in silico potential of the Schiff bases (Z)-4-ethoxy-N-((5-nitrothiophen-2-yl)methylene)benzenamine (1) and (Z)-2,4-diiodo-6-((2-methyl-3-nitrophenylimino)methyl)phenol (2). These Schiff bases were synthesized according to a reported method using ethanol as a solvent, and each reaction was monitored on a TLC until completion of the reaction. The structures of both compounds were elucidated using spectroscopic techniques such as UV-Vis, FTIR, (1)H NMR and (13)C NMR. Molecular structure was determined using single-crystal XRD, which revealed that compounds 1 and 2 were monoclinic and triclinic, respectively. Hirshfeld surface analysis (HS) and 2D fingerprint plots were used to determine the intermolecular interactions along the contact contribution in the crystalline molecules. The structures of both compounds were optimized through a hybrid functional method B3LYP using the 6-31G(d,p) basis set, and various structural parameters were studied. The experimental and theoretical parameters (bond angle and bond length) of the compounds were compared with each other and are in close agreement. The in vitro esterase potential of the synthesized compounds was checked using a spectrophotometric model, while in silico molecular docking studies were performed with AutoDock against two enzymes of the esterase family. The docking studies and the in vitro assessment predicted that such molecules could be used as enzyme inhibitors against the tested enzymes: acetylcholine esterase (AChE) and butyrylcholine esterase (BChE).
ESTHER : Raza_2023_Molecules_28_5703
PubMedSearch : Raza_2023_Molecules_28_5703
PubMedID: 37570673

Title : Cholinesterase activity as a potential biomarker for neurotoxicity induced by pesticides in vivo exposed Oreochromis niloticus (Nile tilapia) - Amin_2021_Environ.Technol__1
Author(s) : Amin M , Yousuf M , Attaullah M , Ahmad N , Azra MN , Latif M , Buneri ID , Zekker I , Batiha GE , Aboelenin SM , Zahoor M , Ikram M , Naeem M
Ref : Environ Technol , :1 , 2021
Abstract : Organophosphates (OPs) and synthetic pyrethroids (SPs) are the most popular broad spectrum pesticides, used in agriculture as they have a strong pesticidal activity while also being biodegradable in the environment. The present study aimed to demonstrate the effects of these pesticides on the Acetylcholinesterase (AChE) activity in brain, gills and body muscles of Oreochromis niloticus- an important enzyme for the assessment and biomonitoring pollution caused by neurotoxins in the environment. The fish were exposed for 24 and 48h to the LC(0) concentrations of the malathion (1.425mg/L), the chlorpyrifos (0.125mg/L) and the lambda-cyhalothrin (0.0039mg/L), respectively. The activity of the AChE was significantly increased (p < 0.05) at 24hours and decreased at 48hours (except for the chlorpyrifos- treated brain and gills while tissues had shown no activity at 48 hours' exposure) in all pesticides- treated tissues. The maximum increase in the activity and inhibition in the AChE activity were recorded as +92% and -52% in the chlorpyrifos and the lambda -cyhalothrin exposed brain tissues, respectively. Thus, the alterations in the AChE activities indicated that the applied pesticides are highly neurotoxic to fish and the enzyme (AChE) could be used as a useful biomarker for estimation of water pollution.
ESTHER : Amin_2021_Environ.Technol__1
PubMedSearch : Amin_2021_Environ.Technol__1
PubMedID: 34962184

Title : New butyrylcholinesterase inhibitory steroid and peroxy acid from Leucas urticifolia - Fatima_2008_Arch.Pharm.Res_31_999
Author(s) : Fatima I , Ahmad I , Anis I , Malik A , Afza N , Iqbal L , Latif M
Ref : Arch Pharm Res , 31 :999 , 2008
Abstract : A new steroid leucisterol (1) and a new peroxy acid urticic acid (2) along with methoxybenzyl benzoate (3), 4-hydroxy benzoic acid (4), beta-sitosterol (5), and ursolic acid (6), have been isolated from the chloroform soluble fraction of the whole plant of Leucas urticifolia. Their structures were elucidated on the basis of nuclear magnetic resonance (1D and 2D NMR) spectral data. Leucisterol showed potent inhibitory activity against butyrylcholinesterase enzyme.
ESTHER : Fatima_2008_Arch.Pharm.Res_31_999
PubMedSearch : Fatima_2008_Arch.Pharm.Res_31_999
PubMedID: 18787788

Title : Leufolins A and B, potent butyrylcholinesterase-inhibiting flavonoid glucosides from Leucas urticifolia - Atia_2007_Molecules_12_1447
Author(s) : Atia tun N , Fatima I , Ahmad I , Malik A , Afza N , Iqbal L , Latif M , Khan SB
Ref : Molecules , 12 :1447 , 2007
Abstract : New flavonoidal glucosides leufolins A (1) and B (2), have been isolated from the ethyl acetate soluble fraction of the whole plants of Leucas urticifolia. Their structures were elucidated on the basis of extensive analysis of nuclear magnetic resonance (1D and 2D NMR) spectral data. Both of these compounds exhibited significant inhibitory potential against the enzyme butyrylcholinesterase.
ESTHER : Atia_2007_Molecules_12_1447
PubMedSearch : Atia_2007_Molecules_12_1447
PubMedID: 17909500