Title : Pharmacokinetics of the dipeptidyl peptidase 4 inhibitor saxagliptin in rats, dogs, and monkeys and clinical projections - Fura_2009_Drug.Metab.Dispos_37_1164 |
Author(s) : Fura A , Khanna A , Vyas V , Koplowitz B , Chang SY , Caporuscio C , Boulton DW , Christopher LJ , Chadwick KD , Hamann LG , Humphreys WG , Kirby M |
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 37 :1164 , 2009 |
Abstract : |
PubMedSearch : Fura_2009_Drug.Metab.Dispos_37_1164 |
PubMedID: 19251818 |
Title : Discovery and preclinical profile of Saxagliptin (BMS-477118): a highly potent, long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes - Augeri_2005_J.Med.Chem_48_5025 |
Author(s) : Augeri DJ , Robl JA , Betebenner DA , Magnin DR , Khanna A , Robertson JG , Wang A , Simpkins LM , Taunk P , Huang Q , Han SP , Abboa-Offei B , Cap M , Xin L , Tao L , Tozzo E , Welzel GE , Egan DM , Marcinkeviciene J , Chang SY , Biller SA , Kirby MS , Parker RA , Hamann LG |
Ref : Journal of Medicinal Chemistry , 48 :5025 , 2005 |
Abstract : |
PubMedSearch : Augeri_2005_J.Med.Chem_48_5025 |
PubMedID: 16033281 |
Title : Synthesis of novel potent dipeptidyl peptidase IV inhibitors with enhanced chemical stability: interplay between the N-terminal amino acid alkyl side chain and the cyclopropyl group of alpha-aminoacyl-l-cis-4,5-methanoprolinenitrile-based inhibitors - Magnin_2004_J.Med.Chem_47_2587 |
Author(s) : Magnin DR , Robl JA , Sulsky RB , Augeri DJ , Huang Y , Simpkins LM , Taunk PC , Betebenner DA , Robertson JG , Abboa-Offei BE , Wang A , Cap M , Xin L , Tao L , Sitkoff DF , Malley MF , Gougoutas JZ , Khanna A , Huang Q , Han SP , Parker RA , Hamann LG |
Ref : Journal of Medicinal Chemistry , 47 :2587 , 2004 |
Abstract : |
PubMedSearch : Magnin_2004_J.Med.Chem_47_2587 |
PubMedID: 15115400 |