| Title : A neutralizing APOA5 monoclonal antibody reduces amounts of lipoprotein lipase in capillaries and triggers hypertriglyceridemia - Yang_2026_Proc.Natl.Acad.Sci.U.S.A_123_e2528664123 |
| Author(s) : Yang Y , Beigneux AP , Lowe TL , Chen YQ , Xie K , Jung H , Tu Y , Yu RG , Scheithauer JL , Mehta S , Wu J , Alvarez L , Davidson WS , Birrane G , Remaley AT , Sviridov D , Ploug M , Zhen EY , Qian Y , Sloan JH , Siegel RW , Konrad RJ , Fong LG , Young SG |
| Ref : Proc Natl Acad Sci U S A , 123 :e2528664123 , 2026 |
| Abstract : |
| PubMedSearch : Yang_2026_Proc.Natl.Acad.Sci.U.S.A_123_e2528664123 |
| PubMedID: 41481469 |
| Title : A neutralizing APOA5 monoclonal antibody reduces amounts of lipoprotein lipase in capillaries and triggers hypertriglyceridemia - Yang_2026_Proc.Natl.Acad.Sci.U.S.A_123_e2528664123 |
| Author(s) : Yang Y , Beigneux AP , Lowe TL , Chen YQ , Xie K , Jung H , Tu Y , Yu RG , Scheithauer JL , Mehta S , Wu J , Alvarez L , Davidson WS , Birrane G , Remaley AT , Sviridov D , Ploug M , Zhen EY , Qian Y , Sloan JH , Siegel RW , Konrad RJ , Fong LG , Young SG |
| Ref : Proc Natl Acad Sci U S A , 123 :e2528664123 , 2026 |
| Abstract : |
| PubMedSearch : Yang_2026_Proc.Natl.Acad.Sci.U.S.A_123_e2528664123 |
| PubMedID: 41481469 |
| Title : A neutralizing APOA5 monoclonal antibody reduces amounts of lipoprotein lipase in capillaries and triggers hypertriglyceridemia - Yang_2026_Proc.Natl.Acad.Sci.U.S.A_123_e2528664123 |
| Author(s) : Yang Y , Beigneux AP , Lowe TL , Chen YQ , Xie K , Jung H , Tu Y , Yu RG , Scheithauer JL , Mehta S , Wu J , Alvarez L , Davidson WS , Birrane G , Remaley AT , Sviridov D , Ploug M , Zhen EY , Qian Y , Sloan JH , Siegel RW , Konrad RJ , Fong LG , Young SG |
| Ref : Proc Natl Acad Sci U S A , 123 :e2528664123 , 2026 |
| Abstract : |
| PubMedSearch : Yang_2026_Proc.Natl.Acad.Sci.U.S.A_123_e2528664123 |
| PubMedID: 41481469 |
| Title : ANGPTL3\/8 is an atypical unfoldase that regulates intravascular lipolysis by catalyzing unfolding of lipoprotein lipase - Kumari_2025_Proc.Natl.Acad.Sci.U.S.A_122_e2420721122 |
| Author(s) : Kumari A , Larsen SWR , Bondesen S , Qian Y , Tian HD , Walker SG , Davies BSJ , Remaley AT , Young SG , Konrad RJ , Jorgensen TJD , Ploug M |
| Ref : Proc Natl Acad Sci U S A , 122 :e2420721122 , 2025 |
| Abstract : |
| PubMedSearch : Kumari_2025_Proc.Natl.Acad.Sci.U.S.A_122_e2420721122 |
| PubMedID: 40112106 |
| Gene_locus related to this paper: human-LPL |
| Title : Circulating ANGPTL3\/8 Concentrations Are Associated With an Atherogenic Lipoprotein Profile and Increased CHD Risk in Swedish Population-Based Studies - Leander_2025_Arterioscler.Thromb.Vasc.Biol__ |
| Author(s) : Leander K , Chen YQ , Vikstrom M , Silveira A , Fisher RM , Konrad RJ , van 't Hooft FM |
| Ref : Arterioscler Thromb Vasc Biol , : , 2025 |
| Abstract : |
| PubMedSearch : Leander_2025_Arterioscler.Thromb.Vasc.Biol__ |
| PubMedID: 39882603 |
| Title : Angiopoietin-like 3 monomers are abundant in human plasma but are unable to inhibit endothelial lipase - Walker_2025_JCI.Insight__ |
| Author(s) : Walker SG , Chen YQ , Sylvers-Davie KL , Dou A , Zhen EY , Qian Y , Wen Y , Ehsani ME , Smith SA , Thapa R , Mercer MJ , Langmack L , Bhattarai BR , Ploug M , Konrad RJ , Davies BS |
| Ref : JCI Insight , : , 2025 |
| Abstract : |
| PubMedSearch : Walker_2025_JCI.Insight__ |
| PubMedID: 41148215 |
| Title : Circulating ANGPTL3\/8 Concentrations Are Associated With an Atherogenic Lipoprotein Profile and Increased CHD Risk in Swedish Population-Based Studies - Leander_2025_Arterioscler.Thromb.Vasc.Biol__ |
| Author(s) : Leander K , Chen YQ , Vikstrom M , Silveira A , Fisher RM , Konrad RJ , van 't Hooft FM |
| Ref : Arterioscler Thromb Vasc Biol , : , 2025 |
| Abstract : |
| PubMedSearch : Leander_2025_Arterioscler.Thromb.Vasc.Biol__ |
| PubMedID: 39882603 |
| Title : Angiopoietin-like 3 monomers are abundant in human plasma but are unable to inhibit endothelial lipase - Walker_2025_JCI.Insight__ |
| Author(s) : Walker SG , Chen YQ , Sylvers-Davie KL , Dou A , Zhen EY , Qian Y , Wen Y , Ehsani ME , Smith SA , Thapa R , Mercer MJ , Langmack L , Bhattarai BR , Ploug M , Konrad RJ , Davies BS |
| Ref : JCI Insight , : , 2025 |
| Abstract : |
| PubMedSearch : Walker_2025_JCI.Insight__ |
| PubMedID: 41148215 |
| Title : Circulating ANGPTL3\/8 Concentrations Are Associated With an Atherogenic Lipoprotein Profile and Increased CHD Risk in Swedish Population-Based Studies - Leander_2025_Arterioscler.Thromb.Vasc.Biol__ |
| Author(s) : Leander K , Chen YQ , Vikstrom M , Silveira A , Fisher RM , Konrad RJ , van 't Hooft FM |
| Ref : Arterioscler Thromb Vasc Biol , : , 2025 |
| Abstract : |
| PubMedSearch : Leander_2025_Arterioscler.Thromb.Vasc.Biol__ |
| PubMedID: 39882603 |
| Title : Angiopoietin-like 3 monomers are abundant in human plasma but are unable to inhibit endothelial lipase - Walker_2025_JCI.Insight__ |
| Author(s) : Walker SG , Chen YQ , Sylvers-Davie KL , Dou A , Zhen EY , Qian Y , Wen Y , Ehsani ME , Smith SA , Thapa R , Mercer MJ , Langmack L , Bhattarai BR , Ploug M , Konrad RJ , Davies BS |
| Ref : JCI Insight , : , 2025 |
| Abstract : |
| PubMedSearch : Walker_2025_JCI.Insight__ |
| PubMedID: 41148215 |
| Title : ANGPTL3\/8 is an atypical unfoldase that regulates intravascular lipolysis by catalyzing unfolding of lipoprotein lipase - Kumari_2025_Proc.Natl.Acad.Sci.U.S.A_122_e2420721122 |
| Author(s) : Kumari A , Larsen SWR , Bondesen S , Qian Y , Tian HD , Walker SG , Davies BSJ , Remaley AT , Young SG , Konrad RJ , Jorgensen TJD , Ploug M |
| Ref : Proc Natl Acad Sci U S A , 122 :e2420721122 , 2025 |
| Abstract : |
| PubMedSearch : Kumari_2025_Proc.Natl.Acad.Sci.U.S.A_122_e2420721122 |
| PubMedID: 40112106 |
| Gene_locus related to this paper: human-LPL |
| Title : ANGPTL3\/8 is an atypical unfoldase that regulates intravascular lipolysis by catalyzing unfolding of lipoprotein lipase - Kumari_2025_Proc.Natl.Acad.Sci.U.S.A_122_e2420721122 |
| Author(s) : Kumari A , Larsen SWR , Bondesen S , Qian Y , Tian HD , Walker SG , Davies BSJ , Remaley AT , Young SG , Konrad RJ , Jorgensen TJD , Ploug M |
| Ref : Proc Natl Acad Sci U S A , 122 :e2420721122 , 2025 |
| Abstract : |
| PubMedSearch : Kumari_2025_Proc.Natl.Acad.Sci.U.S.A_122_e2420721122 |
| PubMedID: 40112106 |
| Gene_locus related to this paper: human-LPL |
| Title : Carboxyl-terminal sequences in APOA5 are important for suppressing ANGPTL3\/8 activity - Chen_2024_Proc.Natl.Acad.Sci.U.S.A_121_e2322332121 |
| Author(s) : Chen YQ , Yang Y , Zhen EY , Beyer TP , Li H , Wen Y , Ehsani M , Jackson N , Xie K , Jung H , Scheithauer JL , Kumari A , Birrane G , Russell AM , Balasubramaniam D , Liao Z , Siegel RW , Qian Y , Ploug M , Young SG , Konrad RJ |
| Ref : Proc Natl Acad Sci U S A , 121 :e2322332121 , 2024 |
| Abstract : |
| PubMedSearch : Chen_2024_Proc.Natl.Acad.Sci.U.S.A_121_e2322332121 |
| PubMedID: 38625948 |
| Gene_locus related to this paper: human-LPL |
| Title : Associations of Circulating ANGPTL3, C-Terminal Domain-Containing ANGPTL4, and ANGPTL3\/8 and ANGPTL4\/8 Complexes with LPL Activity, Diabetes, Inflammation, and Cardiovascular Mortality - Silbernagel_2024_Circulation__ |
| Author(s) : Silbernagel G , Chen YQ , Li H , Lemen D , Wen Y , Zhen EY , Rief M , Kleber ME , Delgado G , Sarzynski MA , Qian YW , Schmidt B , Erbel R , Trampisch U , Moissl AP , Rudolf H , Schunkert H , Stang A , Marz W , Trampisch HJ , Scharnagl H , Konrad RJ |
| Ref : Circulation , : , 2024 |
| Abstract : |
| PubMedSearch : Silbernagel_2024_Circulation__ |
| PubMedID: 39392008 |
| Title : Associations of Circulating ANGPTL3, C-Terminal Domain-Containing ANGPTL4, and ANGPTL3\/8 and ANGPTL4\/8 Complexes with LPL Activity, Diabetes, Inflammation, and Cardiovascular Mortality - Silbernagel_2024_Circulation__ |
| Author(s) : Silbernagel G , Chen YQ , Li H , Lemen D , Wen Y , Zhen EY , Rief M , Kleber ME , Delgado G , Sarzynski MA , Qian YW , Schmidt B , Erbel R , Trampisch U , Moissl AP , Rudolf H , Schunkert H , Stang A , Marz W , Trampisch HJ , Scharnagl H , Konrad RJ |
| Ref : Circulation , : , 2024 |
| Abstract : |
| PubMedSearch : Silbernagel_2024_Circulation__ |
| PubMedID: 39392008 |
| Title : Associations of Circulating ANGPTL3, C-Terminal Domain-Containing ANGPTL4, and ANGPTL3\/8 and ANGPTL4\/8 Complexes with LPL Activity, Diabetes, Inflammation, and Cardiovascular Mortality - Silbernagel_2024_Circulation__ |
| Author(s) : Silbernagel G , Chen YQ , Li H , Lemen D , Wen Y , Zhen EY , Rief M , Kleber ME , Delgado G , Sarzynski MA , Qian YW , Schmidt B , Erbel R , Trampisch U , Moissl AP , Rudolf H , Schunkert H , Stang A , Marz W , Trampisch HJ , Scharnagl H , Konrad RJ |
| Ref : Circulation , : , 2024 |
| Abstract : |
| PubMedSearch : Silbernagel_2024_Circulation__ |
| PubMedID: 39392008 |
| Title : Carboxyl-terminal sequences in APOA5 are important for suppressing ANGPTL3\/8 activity - Chen_2024_Proc.Natl.Acad.Sci.U.S.A_121_e2322332121 |
| Author(s) : Chen YQ , Yang Y , Zhen EY , Beyer TP , Li H , Wen Y , Ehsani M , Jackson N , Xie K , Jung H , Scheithauer JL , Kumari A , Birrane G , Russell AM , Balasubramaniam D , Liao Z , Siegel RW , Qian Y , Ploug M , Young SG , Konrad RJ |
| Ref : Proc Natl Acad Sci U S A , 121 :e2322332121 , 2024 |
| Abstract : |
| PubMedSearch : Chen_2024_Proc.Natl.Acad.Sci.U.S.A_121_e2322332121 |
| PubMedID: 38625948 |
| Gene_locus related to this paper: human-LPL |
| Title : Carboxyl-terminal sequences in APOA5 are important for suppressing ANGPTL3\/8 activity - Chen_2024_Proc.Natl.Acad.Sci.U.S.A_121_e2322332121 |
| Author(s) : Chen YQ , Yang Y , Zhen EY , Beyer TP , Li H , Wen Y , Ehsani M , Jackson N , Xie K , Jung H , Scheithauer JL , Kumari A , Birrane G , Russell AM , Balasubramaniam D , Liao Z , Siegel RW , Qian Y , Ploug M , Young SG , Konrad RJ |
| Ref : Proc Natl Acad Sci U S A , 121 :e2322332121 , 2024 |
| Abstract : |
| PubMedSearch : Chen_2024_Proc.Natl.Acad.Sci.U.S.A_121_e2322332121 |
| PubMedID: 38625948 |
| Gene_locus related to this paper: human-LPL |
| Title : Angiopoietin-like protein 8: a multifaceted protein instrumental in regulating triglyceride metabolism - Wen_2023_Curr.Opin.Lipidol__ |
| Author(s) : Wen Y , Chen YQ , Konrad RJ |
| Ref : Curr Opin Lipidol , : , 2023 |
| Abstract : |
| PubMedSearch : Wen_2023_Curr.Opin.Lipidol__ |
| PubMedID: 37962908 |
| Title : Angiopoietin-like protein 8: a multifaceted protein instrumental in regulating triglyceride metabolism - Wen_2023_Curr.Opin.Lipidol__ |
| Author(s) : Wen Y , Chen YQ , Konrad RJ |
| Ref : Curr Opin Lipidol , : , 2023 |
| Abstract : |
| PubMedSearch : Wen_2023_Curr.Opin.Lipidol__ |
| PubMedID: 37962908 |
| Title : Angiopoietin-like protein 4\/8 complex-mediated plasmin generation leads to cleavage of the complex and restoration of LPL activity - Zhen_2023_Proc.Natl.Acad.Sci.U.S.A_120_e2214081120 |
| Author(s) : Zhen EY , Chen YQ , Russell AM , Ehsani M , Siegel RW , Qian Y , Konrad RJ |
| Ref : Proc Natl Acad Sci U S A , 120 :e2214081120 , 2023 |
| Abstract : |
| PubMedSearch : Zhen_2023_Proc.Natl.Acad.Sci.U.S.A_120_e2214081120 |
| PubMedID: 36763533 |
| Title : Decoding the role of angiopoietin-like protein 4\/8 complex-mediated plasmin generation in the regulation of LPL activity - Chen_2023_J.Lipid.Res__100441 |
| Author(s) : Chen YQ , Zhen EY , Russell AM , Ehsani M , Siegel RW , Qian Y , Konrad RJ |
| Ref : J Lipid Res , :100441 , 2023 |
| Abstract : |
| PubMedSearch : Chen_2023_J.Lipid.Res__100441 |
| PubMedID: 37666362 |
| Title : Angiopoietin-like protein 4\/8 complex-mediated plasmin generation leads to cleavage of the complex and restoration of LPL activity - Zhen_2023_Proc.Natl.Acad.Sci.U.S.A_120_e2214081120 |
| Author(s) : Zhen EY , Chen YQ , Russell AM , Ehsani M , Siegel RW , Qian Y , Konrad RJ |
| Ref : Proc Natl Acad Sci U S A , 120 :e2214081120 , 2023 |
| Abstract : |
| PubMedSearch : Zhen_2023_Proc.Natl.Acad.Sci.U.S.A_120_e2214081120 |
| PubMedID: 36763533 |
| Title : Decoding the role of angiopoietin-like protein 4\/8 complex-mediated plasmin generation in the regulation of LPL activity - Chen_2023_J.Lipid.Res__100441 |
| Author(s) : Chen YQ , Zhen EY , Russell AM , Ehsani M , Siegel RW , Qian Y , Konrad RJ |
| Ref : J Lipid Res , :100441 , 2023 |
| Abstract : |
| PubMedSearch : Chen_2023_J.Lipid.Res__100441 |
| PubMedID: 37666362 |
| Title : Angiopoietin-like protein 4\/8 complex-mediated plasmin generation leads to cleavage of the complex and restoration of LPL activity - Zhen_2023_Proc.Natl.Acad.Sci.U.S.A_120_e2214081120 |
| Author(s) : Zhen EY , Chen YQ , Russell AM , Ehsani M , Siegel RW , Qian Y , Konrad RJ |
| Ref : Proc Natl Acad Sci U S A , 120 :e2214081120 , 2023 |
| Abstract : |
| PubMedSearch : Zhen_2023_Proc.Natl.Acad.Sci.U.S.A_120_e2214081120 |
| PubMedID: 36763533 |
| Title : Decoding the role of angiopoietin-like protein 4\/8 complex-mediated plasmin generation in the regulation of LPL activity - Chen_2023_J.Lipid.Res__100441 |
| Author(s) : Chen YQ , Zhen EY , Russell AM , Ehsani M , Siegel RW , Qian Y , Konrad RJ |
| Ref : J Lipid Res , :100441 , 2023 |
| Abstract : |
| PubMedSearch : Chen_2023_J.Lipid.Res__100441 |
| PubMedID: 37666362 |
| Title : Angiopoietin-like protein 8: a multifaceted protein instrumental in regulating triglyceride metabolism - Wen_2023_Curr.Opin.Lipidol__ |
| Author(s) : Wen Y , Chen YQ , Konrad RJ |
| Ref : Curr Opin Lipidol , : , 2023 |
| Abstract : |
| PubMedSearch : Wen_2023_Curr.Opin.Lipidol__ |
| PubMedID: 37962908 |
| Title : An anti-ANGPTL3\/8 antibody decreases circulating triglycerides by binding to a LPL-inhibitory leucine zipper-like motif - Balasubramaniam_2022_J.Lipid.Res__100198 |
| Author(s) : Balasubramaniam D , Schroeder O , Russell AM , Fitchett JR , Austin AK , Beyer TP , Chen YQ , Day JW , Ehsani M , Heng AR , Zhen EY , Davies J , Glaesner W , Jones BE , Siegel RW , Qian YW , Konrad RJ |
| Ref : J Lipid Res , :100198 , 2022 |
| Abstract : |
| PubMedSearch : Balasubramaniam_2022_J.Lipid.Res__100198 |
| PubMedID: 35307397 |
| Title : An anti-ANGPTL3\/8 antibody decreases circulating triglycerides by binding to a LPL-inhibitory leucine zipper-like motif - Balasubramaniam_2022_J.Lipid.Res__100198 |
| Author(s) : Balasubramaniam D , Schroeder O , Russell AM , Fitchett JR , Austin AK , Beyer TP , Chen YQ , Day JW , Ehsani M , Heng AR , Zhen EY , Davies J , Glaesner W , Jones BE , Siegel RW , Qian YW , Konrad RJ |
| Ref : J Lipid Res , :100198 , 2022 |
| Abstract : |
| PubMedSearch : Balasubramaniam_2022_J.Lipid.Res__100198 |
| PubMedID: 35307397 |
| Title : An anti-ANGPTL3\/8 antibody decreases circulating triglycerides by binding to a LPL-inhibitory leucine zipper-like motif - Balasubramaniam_2022_J.Lipid.Res__100198 |
| Author(s) : Balasubramaniam D , Schroeder O , Russell AM , Fitchett JR , Austin AK , Beyer TP , Chen YQ , Day JW , Ehsani M , Heng AR , Zhen EY , Davies J , Glaesner W , Jones BE , Siegel RW , Qian YW , Konrad RJ |
| Ref : J Lipid Res , :100198 , 2022 |
| Abstract : |
| PubMedSearch : Balasubramaniam_2022_J.Lipid.Res__100198 |
| PubMedID: 35307397 |
| Title : Apolipoprotein A5 lowers triglyceride levels via suppression of ANGPTL3\/8-mediated LPL inhibition - Chen_2021_J.Lipid.Res__100068 |
| Author(s) : Chen YQ , Pottanat TG , Zhen EY , Siegel RW , Ehsani M , Qian YW , Konrad RJ |
| Ref : J Lipid Res , :100068 , 2021 |
| Abstract : |
| PubMedSearch : Chen_2021_J.Lipid.Res__100068 |
| PubMedID: 33762177 |
| Title : Apolipoprotein A5 lowers triglyceride levels via suppression of ANGPTL3\/8-mediated LPL inhibition - Chen_2021_J.Lipid.Res__100068 |
| Author(s) : Chen YQ , Pottanat TG , Zhen EY , Siegel RW , Ehsani M , Qian YW , Konrad RJ |
| Ref : J Lipid Res , :100068 , 2021 |
| Abstract : |
| PubMedSearch : Chen_2021_J.Lipid.Res__100068 |
| PubMedID: 33762177 |
| Title : Apolipoprotein A5 lowers triglyceride levels via suppression of ANGPTL3\/8-mediated LPL inhibition - Chen_2021_J.Lipid.Res__100068 |
| Author(s) : Chen YQ , Pottanat TG , Zhen EY , Siegel RW , Ehsani M , Qian YW , Konrad RJ |
| Ref : J Lipid Res , :100068 , 2021 |
| Abstract : |
| PubMedSearch : Chen_2021_J.Lipid.Res__100068 |
| PubMedID: 33762177 |