| Title : Competitive displacement of lipoprotein lipase from heparan sulfate is orchestrated by a disordered acidic cluster in GPIHBP1 - Biswas_2025_J.Lipid.Res__100745 |
| Author(s) : Biswas A , Arshid S , Kristensen KK , Jorgensen TJD , Ploug M |
| Ref : J Lipid Res , :100745 , 2025 |
| Abstract : |
| PubMedSearch : Biswas_2025_J.Lipid.Res__100745 |
| PubMedID: 39814316 |
| Gene_locus related to this paper: human-LPL |
| Title : ANGPTL3\/8 is an atypical unfoldase that regulates intravascular lipolysis by catalyzing unfolding of lipoprotein lipase - Kumari_2025_Proc.Natl.Acad.Sci.U.S.A_122_e2420721122 |
| Author(s) : Kumari A , Larsen SWR , Bondesen S , Qian Y , Tian HD , Walker SG , Davies BSJ , Remaley AT , Young SG , Konrad RJ , Jorgensen TJD , Ploug M |
| Ref : Proc Natl Acad Sci U S A , 122 :e2420721122 , 2025 |
| Abstract : |
| PubMedSearch : Kumari_2025_Proc.Natl.Acad.Sci.U.S.A_122_e2420721122 |
| PubMedID: 40112106 |
| Gene_locus related to this paper: human-LPL |
| Title : Distinct strategies for intravascular triglyceride metabolism in hearts of mammals and lower vertebrate species - Nguyen_2024_JCI.Insight_9_ |
| Author(s) : Nguyen LP , Song W , Yang Y , Tran AP , Weston TA , Jung H , Tu Y , Kim PH , Kim JR , Xie K , Yu RG , Scheithauer J , Presnell AM , Ploug M , Birrane G , Arnold H , Koltowska K , Mae MA , Betsholtz C , He L , Goodwin JL , Beigneux AP , Fong LG , Young SG |
| Ref : JCI Insight , 9 : , 2024 |
| Abstract : |
| PubMedSearch : Nguyen_2024_JCI.Insight_9_ |
| PubMedID: 39435661 |
| Title : Carboxyl-terminal sequences in APOA5 are important for suppressing ANGPTL3\/8 activity - Chen_2024_Proc.Natl.Acad.Sci.U.S.A_121_e2322332121 |
| Author(s) : Chen YQ , Yang Y , Zhen EY , Beyer TP , Li H , Wen Y , Ehsani M , Jackson N , Xie K , Jung H , Scheithauer JL , Kumari A , Birrane G , Russell AM , Balasubramaniam D , Liao Z , Siegel RW , Qian Y , Ploug M , Young SG , Konrad RJ |
| Ref : Proc Natl Acad Sci U S A , 121 :e2322332121 , 2024 |
| Abstract : |
| PubMedSearch : Chen_2024_Proc.Natl.Acad.Sci.U.S.A_121_e2322332121 |
| PubMedID: 38625948 |
| Gene_locus related to this paper: human-LPL |
| Title : Quantification of lipoprotein lipase in mouse plasma with a sandwich enzyme-linked immunosorbent assay - Kimura_2024_J.Lipid.Res_65_100532 |
| Author(s) : Kimura T , Miyashita K , Fukamachi I , Fukamachi K , Ogura K , Yokoyama E , Tsunekawa K , Nagasawa T , Ploug M , Yang Y , Song W , Young SG , Beigneux AP , Nakajima K , Murakami M |
| Ref : J Lipid Res , 65 :100532 , 2024 |
| Abstract : |
| PubMedSearch : Kimura_2024_J.Lipid.Res_65_100532 |
| PubMedID: 38608546 |
| Gene_locus related to this paper: mouse-lipli |
| Title : The lipoprotein lipase that is shuttled into capillaries by GPIHBP1 enters the glycocalyx where it mediates lipoprotein processing - Song_2023_Proc.Natl.Acad.Sci.U.S.A_120_e2313825120 |
| Author(s) : Song W , Beigneux AP , Weston TA , Chen K , Yang Y , Nguyen LP , Guagliardo P , Jung H , Tran AP , Tu Y , Tran C , Birrane G , Miyashita K , Nakajima K , Murakami M , Tontonoz P , Jiang H , Ploug M , Fong LG , Young SG |
| Ref : Proc Natl Acad Sci U S A , 120 :e2313825120 , 2023 |
| Abstract : |
| PubMedSearch : Song_2023_Proc.Natl.Acad.Sci.U.S.A_120_e2313825120 |
| PubMedID: 37871217 |
| Title : Inverse effects of APOC2 and ANGPTL4 on the conformational dynamics of lid-anchoring structures in lipoprotein lipase - Kumari_2023_Proc.Natl.Acad.Sci.U.S.A_120_e2221888120 |
| Author(s) : Kumari A , Gronnemose AL , Kristensen KK , Winther AL , Young SG , Jorgensen TJD , Ploug M |
| Ref : Proc Natl Acad Sci U S A , 120 :e2221888120 , 2023 |
| Abstract : |
| PubMedSearch : Kumari_2023_Proc.Natl.Acad.Sci.U.S.A_120_e2221888120 |
| PubMedID: 37094117 |
| Gene_locus related to this paper: human-LPL |
| Title : Intracapillary LPL levels in brown adipose tissue, visualized with an antibody-based approach, are regulated by ANGPTL4 at thermoneutral temperatures - Song_2023_Proc.Natl.Acad.Sci.U.S.A_120_e2219833120 |
| Author(s) : Song W , Yang Y , Heizer P , Tu Y , Weston TA , Kim JR , Munguia P , Jung H , Fong JL , Tran C , Ploug M , Beigneux AP , Young SG , Fong LG |
| Ref : Proc Natl Acad Sci U S A , 120 :e2219833120 , 2023 |
| Abstract : |
| PubMedSearch : Song_2023_Proc.Natl.Acad.Sci.U.S.A_120_e2219833120 |
| PubMedID: 36787365 |
| Title : A protein of capillary endothelial cells, GPIHBP1, is crucial for plasma triglyceride metabolism - Young_2022_Proc.Natl.Acad.Sci.U.S.A_119_e2211136119 |
| Author(s) : Young SG , Song W , Yang Y , Birrane G , Jiang H , Beigneux AP , Ploug M , Fong LG |
| Ref : Proc Natl Acad Sci U S A , 119 :e2211136119 , 2022 |
| Abstract : |
| PubMedSearch : Young_2022_Proc.Natl.Acad.Sci.U.S.A_119_e2211136119 |
| PubMedID: 36037340 |
| Title : Electrostatic sheathing of lipoprotein lipase is essential for its movement across capillary endothelial cells - Song_2022_J.Clin.Invest_132_ |
| Author(s) : Song W , Beigneux AP , Winther AL , Kristensen KK , Gronnemose AL , Yang Y , Tu Y , Munguia P , Morales J , Jung H , de Jong PJ , Jung CJ , Miyashita K , Kimura T , Nakajima K , Murakami M , Birrane G , Jiang H , Tontonoz P , Ploug M , Fong LG , Young SG |
| Ref : J Clinical Investigation , 132 : , 2022 |
| Abstract : |
| PubMedSearch : Song_2022_J.Clin.Invest_132_ |
| PubMedID: 35229724 |
| Title : ANGPTL4: a new mode in the regulation of intravascular lipolysis - Ploug_2021_Curr.Opin.Lipidol__ |
| Author(s) : Ploug M |
| Ref : Curr Opin Lipidol , : , 2021 |
| Abstract : |
| PubMedSearch : Ploug_2021_Curr.Opin.Lipidol__ |
| PubMedID: 34860701 |
| Title : GPIHBP1 and ANGPTL4 Utilize Protein Disorder to Orchestrate Order in Plasma Triglyceride Metabolism and Regulate Compartmentalization of LPL Activity - Kristensen_2021_Front.Cell.Dev.Biol_9_702508 |
| Author(s) : Kristensen KK , Leth-Espensen KZ , Kumari A , Gronnemose AL , Lund-Winther AM , Young SG , Ploug M |
| Ref : Front Cell Developmental Biology , 9 :702508 , 2021 |
| Abstract : |
| PubMedSearch : Kristensen_2021_Front.Cell.Dev.Biol_9_702508 |
| PubMedID: 34336854 |
| Title : The Importance of Lipoprotein Lipase Regulation in Atherosclerosis - Kumari_2021_Biomedicines_9_ |
| Author(s) : Kumari A , Kristensen KK , Ploug M , Winther AL |
| Ref : Biomedicines , 9 : , 2021 |
| Abstract : |
| PubMedSearch : Kumari_2021_Biomedicines_9_ |
| PubMedID: 34356847 |
| Title : The intrinsic instability of the hydrolase domain of lipoprotein lipase facilitates its inactivation by ANGPTL4-catalyzed unfolding - Leth-Espensen_2021_Proc.Natl.Acad.Sci.U.S.A_118_e2026650118 |
| Author(s) : Leth-Espensen KZ , Kristensen KK , Kumari A , Winther AL , Young SG , Jorgensen TJD , Ploug M |
| Ref : Proc Natl Acad Sci U S A , 118 : , 2021 |
| Abstract : |
| PubMedSearch : Leth-Espensen_2021_Proc.Natl.Acad.Sci.U.S.A_118_e2026650118 |
| PubMedID: 33723082 |
| Gene_locus related to this paper: human-LPL |
| Title : Chylomicronemia from GPIHBP1 autoantibodies - Miyashita_2020_J.Lipid.Res_61_1365 |
| Author(s) : Miyashita K , Lutz J , Hudgins LC , Toib D , Ashraf AP , Song W , Murakami M , Nakajima K , Ploug M , Fong LG , Young SG , Beigneux AP |
| Ref : J Lipid Res , 61 :1365 , 2020 |
| Abstract : |
| PubMedSearch : Miyashita_2020_J.Lipid.Res_61_1365 |
| PubMedID: 32948662 |
| Title : Unfolding of monomeric lipoprotein lipase by ANGPTL4: Insight into the regulation of plasma triglyceride metabolism - Kristensen_2020_Proc.Natl.Acad.Sci.U.S.A__ |
| Author(s) : Kristensen KK , Leth-Espensen KZ , Mertens HDT , Birrane G , Meiyappan M , Olivecrona G , Jorgensen TJD , Young SG , Ploug M |
| Ref : Proc Natl Acad Sci U S A , : , 2020 |
| Abstract : |
| PubMedSearch : Kristensen_2020_Proc.Natl.Acad.Sci.U.S.A__ |
| PubMedID: 32034094 |
| Gene_locus related to this paper: human-LPL |
| Title : ANGPTL4 inactivates lipoprotein lipase by catalyzing the irreversible unfolding of LPL's hydrolase domain - |
| Author(s) : Kristensen KK , Leth-Espensen KZ , Young SG , Ploug M |
| Ref : J Lipid Res , : , 2020 |
| PubMedID: 32327484 |
| Title : The structural basis for monoclonal antibody 5D2 binding to the tryptophan-rich loop of lipoprotein lipase - Luz_2020_J.Lipid.Res_61_1347 |
| Author(s) : Luz JG , Beigneux AP , Asamoto DK , He C , Song W , Allan CM , Morales J , Tu Y , Kwok A , Cottle T , Meiyappan M , Fong LG , Kim JE , Ploug M , Young SG , Birrane G |
| Ref : J Lipid Res , 61 :1347 , 2020 |
| Abstract : |
| PubMedSearch : Luz_2020_J.Lipid.Res_61_1347 |
| PubMedID: 32690595 |
| Title : Structure of the lipoprotein lipase-GPIHBP1 complex that mediates plasma triglyceride hydrolysis - Birrane_2019_Proc.Natl.Acad.Sci.U.S.A_116_1723 |
| Author(s) : Birrane G , Beigneux AP , Dwyer B , Strack-Logue B , Kristensen KK , Francone OL , Fong LG , Mertens HDT , Pan CQ , Ploug M , Young SG , Meiyappan M |
| Ref : Proc Natl Acad Sci U S A , 116 :1723 , 2019 |
| Abstract : |
| PubMedSearch : Birrane_2019_Proc.Natl.Acad.Sci.U.S.A_116_1723 |
| PubMedID: 30559189 |
| Gene_locus related to this paper: human-LPL |
| Title : GPIHBP1 and Lipoprotein Lipase, Partners in Plasma Triglyceride Metabolism - Young_2019_Cell.Metab_30_51 |
| Author(s) : Young SG , Fong LG , Beigneux AP , Allan CM , He C , Jiang H , Nakajima K , Meiyappan M , Birrane G , Ploug M |
| Ref : Cell Metab , 30 :51 , 2019 |
| Abstract : |
| PubMedSearch : Young_2019_Cell.Metab_30_51 |
| PubMedID: 31269429 |
| Gene_locus related to this paper: human-LPL |
| Title : Lipoprotein lipase is active as a monomer - Beigneux_2019_Proc.Natl.Acad.Sci.U.S.A_116_6319 |
| Author(s) : Beigneux AP , Allan CM , Sandoval NP , Cho GW , Heizer PJ , Jung RS , Stanhope KL , Havel PJ , Birrane G , Meiyappan M , Gill JEt , Murakami M , Miyashita K , Nakajima K , Ploug M , Fong LG , Young SG |
| Ref : Proc Natl Acad Sci U S A , 116 :6319 , 2019 |
| Abstract : |
| PubMedSearch : Beigneux_2019_Proc.Natl.Acad.Sci.U.S.A_116_6319 |
| PubMedID: 30850549 |
| Gene_locus related to this paper: human-LPL |
| Title : A disordered acidic domain in GPIHBP1 harboring a sulfated tyrosine regulates lipoprotein lipase - Kristensen_2018_Proc.Natl.Acad.Sci.U.S.A_115_E6020 |
| Author(s) : Kristensen KK , Midtgaard SR , Mysling S , Kovrov O , Hansen LB , Skar-Gislinge N , Beigneux AP , Kragelund BB , Olivecrona G , Young SG , Jorgensen TJD , Fong LG , Ploug M |
| Ref : Proc Natl Acad Sci U S A , 115 :E6020 , 2018 |
| Abstract : |
| PubMedSearch : Kristensen_2018_Proc.Natl.Acad.Sci.U.S.A_115_E6020 |
| PubMedID: 29899144 |
| Title : GPIHBP1 autoantibodies in a patient with unexplained chylomicronemia - Hu_2017_J.Clin.Lipidol_11_964 |
| Author(s) : Hu X , Dallinga-Thie GM , Hovingh GK , Chang SY , Sandoval NP , Dang TLP , Fukamachi I , Miyashita K , Nakajima K , Murakami M , Fong LG , Ploug M , Young SG , Beigneux AP |
| Ref : J Clin Lipidol , 11 :964 , 2017 |
| Abstract : |
| PubMedSearch : Hu_2017_J.Clin.Lipidol_11_964 |
| PubMedID: 28666713 |
| Title : Mobility of HSPG-bound LPL explains how LPL is able to reach GPIHBP1 on capillaries - Allan_2017_J.Lipid.Res_58_216 |
| Author(s) : Allan CM , Larsson M , Jung RS , Ploug M , Bensadoun A , Beigneux AP , Fong LG , Young SG |
| Ref : J Lipid Res , 58 :216 , 2017 |
| Abstract : |
| PubMedSearch : Allan_2017_J.Lipid.Res_58_216 |
| PubMedID: 27811232 |
| Title : Autoantibodies against GPIHBP1 as a Cause of Hypertriglyceridemia - Beigneux_2017_N.Engl.J.Med_376_1647 |
| Author(s) : Beigneux AP , Miyashita K , Ploug M , Blom DJ , Ai M , Linton MF , Khovidhunkit W , Dufour R , Garg A , McMahon MA , Pullinger CR , Sandoval NP , Hu X , Allan CM , Larsson M , Machida T , Murakami M , Reue K , Tontonoz P , Goldberg IJ , Moulin P , Charriere S , Fong LG , Nakajima K , Young SG |
| Ref : N Engl J Med , 376 :1647 , 2017 |
| Abstract : |
| PubMedSearch : Beigneux_2017_N.Engl.J.Med_376_1647 |
| PubMedID: 28402248 |
| Title : The acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain - Mysling_2016_Elife_5_e12095 |
| Author(s) : Mysling S , Kristensen KK , Larsson M , Beigneux AP , Gardsvoll H , Loren FG , Bensadouen A , Jorgensen TJ , Young SG , Ploug M |
| Ref : Elife , 5 : , 2016 |
| Abstract : |
| PubMedSearch : Mysling_2016_Elife_5_e12095 |
| PubMedID: 26725083 |
| Title : The angiopoietin-like protein ANGPTL4 catalyzes unfolding of the hydrolase domain in lipoprotein lipase and the endothelial membrane protein GPIHBP1 counteracts this unfolding - Mysling_2016_Elife_5_e20958 |
| Author(s) : Mysling S , Kristensen KK , Larsson M , Kovrov O , Bensadouen A , Jorgensen TJ , Olivecrona G , Young SG , Ploug M |
| Ref : Elife , 5 : , 2016 |
| Abstract : |
| PubMedSearch : Mysling_2016_Elife_5_e20958 |
| PubMedID: 27929370 |
| Gene_locus related to this paper: human-LPL |
| Title : GPIHBP1 missense mutations often cause multimerization of GPIHBP1 and thereby prevent lipoprotein lipase binding - Beigneux_2015_Circ.Res_116_624 |
| Author(s) : Beigneux AP , Fong LG , Bensadoun A , Davies BS , Oberer M , Gardsvoll H , Ploug M , Young SG |
| Ref : Circulation Research , 116 :624 , 2015 |
| Abstract : |
| PubMedSearch : Beigneux_2015_Circ.Res_116_624 |
| PubMedID: 25387803 |
| Title : Multimerization of Glycosylphosphatidylinositol-anchored High Density Lipoprotein-binding Protein 1 (GPIHBP1) and Familial Chylomicronemia from a Serine-to-Cysteine Substitution in GPIHBP1 Ly6 Domain - Plengpanich_2014_J.Biol.Chem_289_19491 |
| Author(s) : Plengpanich W , Young SG , Khovidhunkit W , Bensadoun A , Karnman H , Ploug M , Gardsvoll H , Leung CS , Adeyo O , Larsson M , Muanpetch S , Charoen S , Fong LG , Niramitmahapanya S , Beigneux AP |
| Ref : Journal of Biological Chemistry , 289 :19491 , 2014 |
| Abstract : |
| PubMedSearch : Plengpanich_2014_J.Biol.Chem_289_19491 |
| PubMedID: 24847059 |