| Title : Mechanism of Action of Prolyl Oligopeptidase (PREP) in Degenerative Brain Diseases: Has Peptidase Activity Only a Modulatory Role on the Interactions of PREP with Proteins? - Mannisto_2017_Front.Aging.Neurosci_9_27 |
| Author(s) : Mannisto PT , Garcia-Horsman JA |
| Ref : Front Aging Neurosci , 9 :27 , 2017 |
| Abstract : |
| PubMedSearch : Mannisto_2017_Front.Aging.Neurosci_9_27 |
| PubMedID: 28261087 |
| Title : The beneficial effect of a prolyl oligopeptidase inhibitor, KYP-2047, on alpha-synuclein clearance and autophagy in A30P transgenic mouse - Savolainen_2014_Neurobiol.Dis_68_1 |
| Author(s) : Savolainen MH , Richie CT , Harvey BK , Mannisto PT , Maguire-Zeiss KA , Myohanen TT |
| Ref : Neurobiol Dis , 68 :1 , 2014 |
| Abstract : |
| PubMedSearch : Savolainen_2014_Neurobiol.Dis_68_1 |
| PubMedID: 24746855 |
| Title : Alteration of prolyl oligopeptidase and activated alpha-2-macroglobulin in multiple sclerosis subtypes and in the clinically isolated syndrome - Tenorio-Laranga_2013_Biochem.Pharmacol_85_1783 |
| Author(s) : Tenorio-Laranga J , Peltonen I , Keskitalo S , Duran-Torres G , Natarajan R , Mannisto PT , Nurmi A , Vartiainen N , Airas L , Elovaara I , Garcia-Horsman JA |
| Ref : Biochemical Pharmacology , 85 :1783 , 2013 |
| Abstract : |
| PubMedSearch : Tenorio-Laranga_2013_Biochem.Pharmacol_85_1783 |
| PubMedID: 23643808 |
| Title : A prolyl oligopeptidase inhibitor, KYP-2047, reduces alpha-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease - Myohanen_2012_Br.J.Pharmacol_166_1097 |
| Author(s) : Myohanen TT , Hannula MJ , Van Elzen R , Gerard M , Van der Veken P , Garcia-Horsman JA , Baekelandt V , Mannisto PT , Lambeir AM |
| Ref : British Journal of Pharmacology , 166 :1097 , 2012 |
| Abstract : |
| PubMedSearch : Myohanen_2012_Br.J.Pharmacol_166_1097 |
| PubMedID: 22233220 |
| Title : Molecular dynamics, crystallography and mutagenesis studies on the substrate gating mechanism of prolyl oligopeptidase. - Kaszuba_2012_Biochimie_94_1398 |
| Author(s) : Kaszuba K , Rog T , Danne R , Canning P , Fulop V , Juhasz T , Szeltner Z , St Pierre JF , Garcia-Horsman A , Mannisto PT , Karttunen M , Hokkanen J , Bunker A |
| Ref : Biochimie , 94 :1398 , 2012 |
| Abstract : |
| PubMedSearch : Kaszuba_2012_Biochimie_94_1398 |
| PubMedID: 22484394 |
| Gene_locus related to this paper: pig-ppce |
| Title : Distribution of prolyl oligopeptidase in human peripheral tissues and in ovarian and colorectal tumors - Myohanen_2012_J.Histochem.Cytochem_60_706 |
| Author(s) : Myohanen TT , Pyykko E , Mannisto PT , Carpen O |
| Ref : Journal of Histochemistry & Cytochemistry , 60 :706 , 2012 |
| Abstract : |
| PubMedSearch : Myohanen_2012_J.Histochem.Cytochem_60_706 |
| PubMedID: 22740343 |
| Title : Association of prolyl oligopeptidase with conventional neurotransmitters in the brain - Peltonen_2011_CNS.Neurol.Disord.Drug.Targets_10_311 |
| Author(s) : Peltonen I , Myohanen TT , Mannisto PT |
| Ref : CNS Neurol Disord Drug Targets , 10 :311 , 2011 |
| Abstract : |
| PubMedSearch : Peltonen_2011_CNS.Neurol.Disord.Drug.Targets_10_311 |
| PubMedID: 21222629 |
| Title : Effects of diverse psychopharmacological substances on the activity of brain prolyl oligopeptidase - Peltonen_2011_Basic.Clin.Pharmacol.Toxicol_108_46 |
| Author(s) : Peltonen I , Mannisto PT |
| Ref : Basic Clin Pharmacol Toxicol , 108 :46 , 2011 |
| Abstract : |
| PubMedSearch : Peltonen_2011_Basic.Clin.Pharmacol.Toxicol_108_46 |
| PubMedID: 20825390 |
| Title : Prolyl oligopeptidase induces angiogenesis both in vitro and in vivo in a novel regulatory manner - Myohanen_2011_Br.J.Pharmacol_163_1666 |
| Author(s) : Myohanen TT , Tenorio-Laranga J , Jokinen B , Vazquez-Sanchez R , Moreno-Baylach MJ , Garcia-Horsman JA , Mannisto PT |
| Ref : British Journal of Pharmacology , 163 :1666 , 2011 |
| Abstract : |
| PubMedSearch : Myohanen_2011_Br.J.Pharmacol_163_1666 |
| PubMedID: 21133893 |
| Title : Hunting for peptide substrates of prolyl oligopeptidase: classical versus non-classical bioactive peptides - Tenorio-Laranga_2011_CNS.Neurol.Disord.Drug.Targets_10_319 |
| Author(s) : Tenorio-Laranga J , Mannisto PT , Garcia-Horsman JA |
| Ref : CNS Neurol Disord Drug Targets , 10 :319 , 2011 |
| Abstract : |
| PubMedSearch : Tenorio-Laranga_2011_CNS.Neurol.Disord.Drug.Targets_10_319 |
| PubMedID: 21222622 |
| Title : Characterization of membrane-bound prolyl endopeptidase from brain - Tenorio-Laranga_2008_FEBS.J_275_4415 |
| Author(s) : Tenorio-Laranga J , Venalainen JI , Mannisto PT , Garcia-Horsman JA |
| Ref : Febs J , 275 :4415 , 2008 |
| Abstract : |
| PubMedSearch : Tenorio-Laranga_2008_FEBS.J_275_4415 |
| PubMedID: 18657187 |
| Title : On the role of prolyl oligopeptidase in health and disease - Garcia-Horsman_2007_Neuropeptides_41_1 |
| Author(s) : Garcia-Horsman JA , Mannisto PT , Venalainen JI |
| Ref : Neuropeptides , 41 :1 , 2007 |
| Abstract : |
| PubMedSearch : Garcia-Horsman_2007_Neuropeptides_41_1 |
| PubMedID: 17196652 |
| Title : Deficient activity of mammalian prolyl oligopeptidase on the immunoactive peptide digestion in coeliac disease - Garcia-Horsman_2007_Scand.J.Gastroenterol_42_562 |
| Author(s) : Garcia-Horsman JA , Venalainen JI , Lohi O , Auriola IS , Korponay-Szabo IR , Kaukinen K , Maki M , Mannisto PT |
| Ref : Scand J Gastroenterol , 42 :562 , 2007 |
| Abstract : |
| PubMedSearch : Garcia-Horsman_2007_Scand.J.Gastroenterol_42_562 |
| PubMedID: 17454876 |
| Title : Dicarboxylic acid azacycle l-prolyl-pyrrolidine amides as prolyl oligopeptidase inhibitors and three-dimensional quantitative structure-activity relationship of the enzyme-inhibitor interactions - Jarho_2005_J.Med.Chem_48_4772 |
| Author(s) : Jarho EM , Wallen EA , Christiaans JA , Forsberg MM , Venalainen JI , Mannisto PT , Gynther J , Poso A |
| Ref : Journal of Medicinal Chemistry , 48 :4772 , 2005 |
| Abstract : |
| PubMedSearch : Jarho_2005_J.Med.Chem_48_4772 |
| PubMedID: 16033257 |
| Title : Evolutionary relationships of the prolyl oligopeptidase family enzymes - Venalainen_2004_Eur.J.Biochem_271_2705 |
| Author(s) : Venalainen JI , Juvonen RO , Mannisto PT |
| Ref : European Journal of Biochemistry , 271 :2705 , 2004 |
| Abstract : |
| PubMedSearch : Venalainen_2004_Eur.J.Biochem_271_2705 |
| PubMedID: 15206935 |
| Title : Substrate-dependent, non-hyperbolic kinetics of pig brain prolyl oligopeptidase and its tight binding inhibition by JTP-4819 - Venalainen_2002_Biochem.Pharmacol_64_463 |
| Author(s) : Venalainen JI , Juvonen RO , Forsberg MM , Garcia-Horsman A , Poso A , Wallen EA , Gynther J , Mannisto PT |
| Ref : Biochemical Pharmacology , 64 :463 , 2002 |
| Abstract : |
| PubMedSearch : Venalainen_2002_Biochem.Pharmacol_64_463 |
| PubMedID: 12147298 |