Prentki R

References (1)

Title : alpha\/beta-Hydrolase Domain 6 Deletion Induces Adipose Browning and Prevents Obesity and Type 2 Diabetes - Zhao_2016_Cell.Rep_14_2872
Author(s) : Zhao S , Mugabo Y , Ballentine G , Attane C , Iglesias J , Poursharifi P , Zhang D , Nguyen TA , Erb H , Prentki R , Peyot ML , Joly E , Tobin S , Fulton S , Brown JM , Madiraju SR , Prentki M
Ref : Cell Rep , 14 :2872 , 2016
Abstract : Suppression of alpha/beta-domain hydrolase-6 (ABHD6), a monoacylglycerol (MAG) hydrolase, promotes glucose-stimulated insulin secretion by pancreatic beta cells. We report here that high-fat-diet-fed ABHD6-KO mice show modestly reduced food intake, decreased body weight gain and glycemia, improved glucose tolerance and insulin sensitivity, and enhanced locomotor activity. ABHD6-KO mice also show increased energy expenditure, cold-induced thermogenesis, brown adipose UCP1 expression, fatty acid oxidation, and white adipose browning. Adipose browning and cold-induced thermogenesis are replicated by the ABHD6 inhibitor WWL70 and by antisense oligonucleotides targeting ABHD6. Our evidence suggests that one mechanism by which the lipolysis derived 1-MAG signals intrinsic and cell-autonomous adipose browning is via PPARalpha and PPARgamma activation, and that ABHD6 regulates adipose browning by controlling signal competent 1-MAG levels. Thus, ABHD6 regulates energy homeostasis, brown adipose function, and white adipose browning and is a potential therapeutic target for obesity and type 2 diabetes.
ESTHER : Zhao_2016_Cell.Rep_14_2872
PubMedSearch : Zhao_2016_Cell.Rep_14_2872
PubMedID: 26997277
Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6