Renko DZ

References (2)

Title : Potent acetylcholinesterase inhibitors: design, synthesis and structure-activity relationships of alkylene linked bis-galanthamine and galanthamine-galanthaminium salts - Guillou_2000_Bioorg.Med.Chem.Lett_10_637
Author(s) : Guillou C , Mary A , Renko DZ , Gras E , Thal C
Ref : Bioorganic & Medicinal Chemistry Lett , 10 :637 , 2000
Abstract : The syntheses, the anticholinesterase activities and structure-activity relationships of homodimeric (3a-c) and heterodimeric (6a-c) alkylene linked bis-galanthamine are reported. Compounds 6b-c were found to be more potent than galanthamine and tacrine in inhibiting AChE.
ESTHER : Guillou_2000_Bioorg.Med.Chem.Lett_10_637
PubMedSearch : Guillou_2000_Bioorg.Med.Chem.Lett_10_637
PubMedID: 10762042

Title : Potent acetylcholinesterase inhibitors: design, synthesis, and structure-activity relationships of bis-interacting ligands in the galanthamine series - Mary_1998_Bioorg.Med.Chem_6_1835
Author(s) : Mary A , Renko DZ , Guillou C , Thal C
Ref : Bioorganic & Medicinal Chemistry , 6 :1835 , 1998
Abstract : New galanthamine derivatives, especially bis-interacting ligands 3-5 and 7-9 were prepared in order to interact with the catalytic and the peripheral sites of acetylcholinesterase (AChE). The synthesis, the anticholinesterase activities, and the structure-activity relationships of bis-interacting ligands are reported. Compounds 4d-e were found to be more potent than galanthamine and tacrine in inhibiting AChE.
ESTHER : Mary_1998_Bioorg.Med.Chem_6_1835
PubMedSearch : Mary_1998_Bioorg.Med.Chem_6_1835
PubMedID: 9839013