Mary_1998_Bioorg.Med.Chem_6_1835

Reference

Title : Potent acetylcholinesterase inhibitors: design, synthesis, and structure-activity relationships of bis-interacting ligands in the galanthamine series - Mary_1998_Bioorg.Med.Chem_6_1835
Author(s) : Mary A , Renko DZ , Guillou C , Thal C
Ref : Bioorganic & Medicinal Chemistry , 6 :1835 , 1998
Abstract : New galanthamine derivatives, especially bis-interacting ligands 3-5 and 7-9 were prepared in order to interact with the catalytic and the peripheral sites of acetylcholinesterase (AChE). The synthesis, the anticholinesterase activities, and the structure-activity relationships of bis-interacting ligands are reported. Compounds 4d-e were found to be more potent than galanthamine and tacrine in inhibiting AChE.
ESTHER : Mary_1998_Bioorg.Med.Chem_6_1835
PubMedSearch : Mary_1998_Bioorg.Med.Chem_6_1835
PubMedID: 9839013

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Citations formats

Mary A, Renko DZ, Guillou C, Thal C (1998)
Potent acetylcholinesterase inhibitors: design, synthesis, and structure-activity relationships of bis-interacting ligands in the galanthamine series
Bioorganic & Medicinal Chemistry 6 :1835

Mary A, Renko DZ, Guillou C, Thal C (1998)
Bioorganic & Medicinal Chemistry 6 :1835