| Title : Potent acetylcholinesterase inhibitors: design, synthesis, and structure-activity relationships of bis-interacting ligands in the galanthamine series - Mary_1998_Bioorg.Med.Chem_6_1835 |
| Author(s) : Mary A , Renko DZ , Guillou C , Thal C |
| Ref : Bioorganic & Medicinal Chemistry , 6 :1835 , 1998 |
|
Abstract :
New galanthamine derivatives, especially bis-interacting ligands 3-5 and 7-9 were prepared in order to interact with the catalytic and the peripheral sites of acetylcholinesterase (AChE). The synthesis, the anticholinesterase activities, and the structure-activity relationships of bis-interacting ligands are reported. Compounds 4d-e were found to be more potent than galanthamine and tacrine in inhibiting AChE. |
| PubMedSearch : Mary_1998_Bioorg.Med.Chem_6_1835 |
| PubMedID: 9839013 |
Mary A, Renko DZ, Guillou C, Thal C (1998)
Potent acetylcholinesterase inhibitors: design, synthesis, and structure-activity relationships of bis-interacting ligands in the galanthamine series
Bioorganic & Medicinal Chemistry
6 :1835
Mary A, Renko DZ, Guillou C, Thal C (1998)
Bioorganic & Medicinal Chemistry
6 :1835