| Title : Potent acetylcholinesterase inhibitors: design, synthesis and structure-activity relationships of alkylene linked bis-galanthamine and galanthamine-galanthaminium salts - Guillou_2000_Bioorg.Med.Chem.Lett_10_637 |
| Author(s) : Guillou C , Mary A , Renko DZ , Gras E , Thal C |
| Ref : Bioorganic & Medicinal Chemistry Lett , 10 :637 , 2000 |
|
Abstract :
The syntheses, the anticholinesterase activities and structure-activity relationships of homodimeric (3a-c) and heterodimeric (6a-c) alkylene linked bis-galanthamine are reported. Compounds 6b-c were found to be more potent than galanthamine and tacrine in inhibiting AChE. |
| PubMedSearch : Guillou_2000_Bioorg.Med.Chem.Lett_10_637 |
| PubMedID: 10762042 |
| Inhibitor | Galanthamine Bis-galanthamine |
Guillou C, Mary A, Renko DZ, Gras E, Thal C (2000)
Potent acetylcholinesterase inhibitors: design, synthesis and structure-activity relationships of alkylene linked bis-galanthamine and galanthamine-galanthaminium salts
Bioorganic & Medicinal Chemistry Lett
10 :637
Guillou C, Mary A, Renko DZ, Gras E, Thal C (2000)
Bioorganic & Medicinal Chemistry Lett
10 :637