Title : Design, Synthesis, and Structure-Activity Relationship Studies of Dual Inhibitors of Soluble Epoxide Hydrolase and 5-Lipoxygenase - Hiesinger_2020_J.Med.Chem_63_11498 |
Author(s) : Hiesinger K , Kramer JS , Beyer S , Eckes T , Brunst S , Flauaus C , Wittmann SK , Weizel L , Kaiser A , Kretschmer SBM , George S , Angioni C , Heering J , Geisslinger G , Schubert-Zsilavecz M , Schmidtko A , Pogoryelov D , Pfeilschifter J , Hofmann B , Steinhilber D , Schwalm S , Proschak E |
Ref : Journal of Medicinal Chemistry , 63 :11498 , 2020 |
Abstract : |
PubMedSearch : Hiesinger_2020_J.Med.Chem_63_11498 |
PubMedID: 33044073 |
Gene_locus related to this paper: human-EPHX2 |
Title : Zafirlukast Is a Dual Modulator of Human Soluble Epoxide Hydrolase and Peroxisome Proliferator-Activated Receptor gamma - Gobel_2019_Front.Pharmacol_10_263 |
Author(s) : Gobel T , Diehl O , Heering J , Merk D , Angioni C , Wittmann SK , Buscato E , Kottke R , Weizel L , Schader T , Maier TJ , Geisslinger G , Schubert-Zsilavecz M , Steinhilber D , Proschak E , Kahnt AS |
Ref : Front Pharmacol , 10 :263 , 2019 |
Abstract : |
PubMedSearch : Gobel_2019_Front.Pharmacol_10_263 |
PubMedID: 30949053 |
Title : N-Benzylbenzamides: A Novel Merged Scaffold for Orally Available Dual Soluble Epoxide Hydrolase\/Peroxisome Proliferator-Activated Receptor gamma Modulators - Blocher_2016_J.Med.Chem_59_61 |
Author(s) : Blocher R , Lamers C , Wittmann SK , Merk D , Hartmann M , Weizel L , Diehl O , Bruggerhoff A , Boss M , Kaiser A , Schader T , Gobel T , Grundmann M , Angioni C , Heering J , Geisslinger G , Wurglics M , Kostenis E , Brune B , Steinhilber D , Schubert-Zsilavecz M , Kahnt AS , Proschak E |
Ref : Journal of Medicinal Chemistry , 59 :61 , 2016 |
Abstract : |
PubMedSearch : Blocher_2016_J.Med.Chem_59_61 |
PubMedID: 26595749 |
Title : A novel class of oxylipins, sn1-O-(12-oxophytodienoyl)-sn2-O-(hexadecatrienoyl)-monogalactosyl Diglyceride, from Arabidopsis thaliana - Stelmach_2001_J.Biol.Chem_276_12832 |
Author(s) : Stelmach BA , Muller A , Hennig P , Gebhardt S , Schubert-Zsilavecz M , Weiler EW |
Ref : Journal of Biological Chemistry , 276 :12832 , 2001 |
Abstract : |
PubMedSearch : Stelmach_2001_J.Biol.Chem_276_12832 |
PubMedID: 11278736 |