| Title : Design, Synthesis, and Structure-Activity Relationship Studies of Dual Inhibitors of Soluble Epoxide Hydrolase and 5-Lipoxygenase - Hiesinger_2020_J.Med.Chem_63_11498 |
| Author(s) : Hiesinger K , Kramer JS , Beyer S , Eckes T , Brunst S , Flauaus C , Wittmann SK , Weizel L , Kaiser A , Kretschmer SBM , George S , Angioni C , Heering J , Geisslinger G , Schubert-Zsilavecz M , Schmidtko A , Pogoryelov D , Pfeilschifter J , Hofmann B , Steinhilber D , Schwalm S , Proschak E |
| Ref : Journal of Medicinal Chemistry , 63 :11498 , 2020 |
| Abstract : |
| PubMedSearch : Hiesinger_2020_J.Med.Chem_63_11498 |
| PubMedID: 33044073 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : The histone demethylase Jarid1b mediates angiotensin II-induced endothelial dysfunction by controlling the 3'UTR of soluble epoxide hydrolase - Vasconez_2019_Acta.Physiol.(Oxf)_225_e13168 |
| Author(s) : Vasconez AE , Janetzko P , Oo JA , Pfluger-Muller B , Ratiu C , Gu L , Helin K , Geisslinger G , Fleming I , Schroder K , Fork C , Brandes RP , Leisegang MS |
| Ref : Acta Physiol (Oxf) , 225 :e13168 , 2019 |
| Abstract : |
| PubMedSearch : Vasconez_2019_Acta.Physiol.(Oxf)_225_e13168 |
| PubMedID: 30076673 |
| Title : Zafirlukast Is a Dual Modulator of Human Soluble Epoxide Hydrolase and Peroxisome Proliferator-Activated Receptor gamma - Gobel_2019_Front.Pharmacol_10_263 |
| Author(s) : Gobel T , Diehl O , Heering J , Merk D , Angioni C , Wittmann SK , Buscato E , Kottke R , Weizel L , Schader T , Maier TJ , Geisslinger G , Schubert-Zsilavecz M , Steinhilber D , Proschak E , Kahnt AS |
| Ref : Front Pharmacol , 10 :263 , 2019 |
| Abstract : |
| PubMedSearch : Gobel_2019_Front.Pharmacol_10_263 |
| PubMedID: 30949053 |
| Title : Computer-Aided Selective Optimization of Side Activities of Talinolol - Hiesinger_2019_ACS.Med.Chem.Lett_10_899 |
| Author(s) : Hiesinger K , Kramer JS , Achenbach J , Moser D , Weber J , Wittmann SK , Morisseau C , Angioni C , Geisslinger G , Kahnt AS , Kaiser A , Proschak A , Steinhilber D , Pogoryelov D , Wagner K , Hammock BD , Proschak E |
| Ref : ACS Med Chem Lett , 10 :899 , 2019 |
| Abstract : |
| PubMedSearch : Hiesinger_2019_ACS.Med.Chem.Lett_10_899 |
| PubMedID: 31223445 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : The oxidized linoleic acid metabolite 12,13-DiHOME mediates thermal hyperalgesia during inflammatory pain - Zimmer_2018_Biochim.Biophys.Acta_1863_669 |
| Author(s) : Zimmer B , Angioni C , Osthues T , Toewe A , Thomas D , Pierre SC , Geisslinger G , Scholich K , Sisignano M |
| Ref : Biochimica & Biophysica Acta , 1863 :669 , 2018 |
| Abstract : |
| PubMedSearch : Zimmer_2018_Biochim.Biophys.Acta_1863_669 |
| PubMedID: 29625231 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : A Dual Modulator of Farnesoid X Receptor and Soluble Epoxide Hydrolase To Counter Nonalcoholic Steatohepatitis - Schmidt_2017_J.Med.Chem_60_7703 |
| Author(s) : Schmidt J , Rotter M , Weiser T , Wittmann S , Weizel L , Kaiser A , Heering J , Goebel T , Angioni C , Wurglics M , Paulke A , Geisslinger G , Kahnt A , Steinhilber D , Proschak E , Merk D |
| Ref : Journal of Medicinal Chemistry , 60 :7703 , 2017 |
| Abstract : |
| PubMedSearch : Schmidt_2017_J.Med.Chem_60_7703 |
| PubMedID: 28845983 |
| Title : N-Benzylbenzamides: A Novel Merged Scaffold for Orally Available Dual Soluble Epoxide Hydrolase\/Peroxisome Proliferator-Activated Receptor gamma Modulators - Blocher_2016_J.Med.Chem_59_61 |
| Author(s) : Blocher R , Lamers C , Wittmann SK , Merk D , Hartmann M , Weizel L , Diehl O , Bruggerhoff A , Boss M , Kaiser A , Schader T , Gobel T , Grundmann M , Angioni C , Heering J , Geisslinger G , Wurglics M , Kostenis E , Brune B , Steinhilber D , Schubert-Zsilavecz M , Kahnt AS , Proschak E |
| Ref : Journal of Medicinal Chemistry , 59 :61 , 2016 |
| Abstract : |
| PubMedSearch : Blocher_2016_J.Med.Chem_59_61 |
| PubMedID: 26595749 |
| Title : Design, Synthesis and Cellular Characterization of a Dual Inhibitor of 5-Lipoxygenase and Soluble Epoxide Hydrolase - Meirer_2016_Molecules_22_ |
| Author(s) : Meirer K , Glatzel D , Kretschmer S , Wittmann SK , Hartmann M , Blocher R , Angioni C , Geisslinger G , Steinhilber D , Hofmann B , Furst R , Proschak E |
| Ref : Molecules , 22 : , 2016 |
| Abstract : |
| PubMedSearch : Meirer_2016_Molecules_22_ |
| PubMedID: 28036068 |
| Title : Intrinsic up-regulation of 2-AG favors an area specific neuronal survival in different in vitro models of neuronal damage - Kallendrusch_2012_PLoS.One_7_e51208 |
| Author(s) : Kallendrusch S , Hobusch C , Ehrlich A , Nowicki M , Ziebell S , Bechmann I , Geisslinger G , Koch M , Dehghani F |
| Ref : PLoS ONE , 7 :e51208 , 2012 |
| Abstract : |
| PubMedSearch : Kallendrusch_2012_PLoS.One_7_e51208 |
| PubMedID: 23284665 |
| Title : Inhibition of the soluble epoxide hydrolase promotes albuminuria in mice with progressive renal disease - Jung_2010_PLoS.One_5_e11979 |
| Author(s) : Jung O , Jansen F , Mieth A , Barbosa-Sicard E , Pliquett RU , Babelova A , Morisseau C , Hwang SH , Tsai C , Hammock BD , Schaefer L , Geisslinger G , Amann K , Brandes RP |
| Ref : PLoS ONE , 5 :e11979 , 2010 |
| Abstract : |
| PubMedSearch : Jung_2010_PLoS.One_5_e11979 |
| PubMedID: 20694143 |
| Title : Soluble epoxide hydrolase deficiency attenuates neointima formation in the femoral cuff model of hyperlipidemic mice - Revermann_2010_Arterioscler.Thromb.Vasc.Biol_30_909 |
| Author(s) : Revermann M , Schloss M , Barbosa-Sicard E , Mieth A , Liebner S , Morisseau C , Geisslinger G , Schermuly RT , Fleming I , Hammock BD , Brandes RP |
| Ref : Arterioscler Thromb Vasc Biol , 30 :909 , 2010 |
| Abstract : |
| PubMedSearch : Revermann_2010_Arterioscler.Thromb.Vasc.Biol_30_909 |
| PubMedID: 20224052 |
| Title : Isolation and pharmacological characterization of microsomal human liver flumazenil carboxylesterase - Kleingeist_1998_J.Pharm.Pharm.Sci_1_38 |
| Author(s) : Kleingeist B , Bocker R , Geisslinger G , Brugger R |
| Ref : J Pharm Pharm Sci , 1 :38 , 1998 |
| Abstract : |
| PubMedSearch : Kleingeist_1998_J.Pharm.Pharm.Sci_1_38 |
| PubMedID: 10942971 |