strve-PIKAIV
Streptomyces venezuelae type I polyketide synthase PikAIV
Comment
Relationship
Family : Thioesterase
Block : X
Position in NCBI Life Tree : Streptomyces venezuelae
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Bacteria N E > Terrabacteria group N E > Actinobacteria [phylum] N E > Actinobacteria [class] N E > Streptomycetales N E > Streptomycetaceae N E > Streptomyces N E > Streptomyces venezuelae N EMolecular evidence
No mutation
1MN6 - Thioesterase Domain from Picromycin Polyketide Synthase, pH 7.6
1MNA - Thioesterase Domain of Picromycin Polyketide Synthase (PICS TE), pH 8.0
1MNQ - Thioesterase Domain of Picromycin Polyketide Synthase (PICS TE), pH 8.4
2H7X - Pikromycin Thioesterase adduct with reduced triketide affinity label
2H7Y - Pikromycin Thioesterase with covalent affinity label
2HFJ - Pikromycin thioesterase with covalent pentaketide affinity label
2HFK - Pikromycin thioesterase in complex with product 10-deoxymethynolide
9CBD - Streptomyces venezuelae Pikromycin Thioesterase Domain
9CGL - Streptomyces venezuelae Pikromycin Thioesterase Doubly Protected DAP (Narbonolide\/10-deoxymethynolide synthase PikA4, module 6)
9CGN - Streptomyces venezuelae Pikromycin Thioesterase Domain with heptaketide adduct
No kinetic
No disease
Sequence
Peptide
SGADTGAGAG MFRALFRQAV EDDRYGEFLD VLAEASAFRP QFASPEACSE RLDPVLLAGG PTDRAEGRAV LVGCTGTAAN GGPHEFLRLS TSFQEERDFL AVPLPGYGTG TGTGTALLPA DLDTALDAQA RAILRAAGDA PVVLLGHSGG ALLAHELAFR LERAHGAPPA GIVLVDPYPP GHQEPIEVWS RQLGEGLFAG ELEPMSDARL LAMGRYARFL AGPRPGRSSA PVLLVRASEP LGDWQEERGD WRAHWDLPHT VADVPGDHFT MMRDHAPAVA EAVLSWLDAI EGIEGAGK
References (14)
| Title : Substrate Trapping in Polyketide Synthase Thioesterase Domains: Structural Basis for Macrolactone Formation - McCullough_2024_ACS.Catal_14_12551 |
| Author(s) : McCullough TM , Choudhary V , Akey DL , Skiba MA , Bernard SM , Kittendorf JD , Schmidt JJ , Sherman DH , Smith JL |
| Ref : ACS Catal , 14 :12551 , 2024 |
| Abstract : |
| PubMedSearch : McCullough_2024_ACS.Catal_14_12551 |
| PubMedID: 39927088 |
| Gene_locus related to this paper: 9actn-k4i6l4 , micch-a0a1z1mz81 , strve-PIKAIV |
| Title : Probing Selectivity and Creating Structural Diversity Through Hybrid Polyketide Synthases - Koch_2020_Angew.Chem.Int.Ed.Engl_59_13575 |
| Author(s) : Koch AA , Schmidt JJ , Lowell AN , Hansen DA , Coburn KM , Chemler JA , Sherman DH |
| Ref : Angew Chem Int Ed Engl , 59 :13575 , 2020 |
| Abstract : |
| PubMedSearch : Koch_2020_Angew.Chem.Int.Ed.Engl_59_13575 |
| PubMedID: 32357274 |
| Gene_locus related to this paper: strve-PIKAIV |
| Title : Identification of a Thioesterase Bottleneck in the Pikromycin Pathway through Full-Module Processing of Unnatural Pentaketides - Hansen_2017_J.Am.Chem.Soc_139_13450 |
| Author(s) : Hansen DA , Koch AA , Sherman DH |
| Ref : Journal of the American Chemical Society , 139 :13450 , 2017 |
| Abstract : |
| PubMedSearch : Hansen_2017_J.Am.Chem.Soc_139_13450 |
| PubMedID: 28836772 |
| Gene_locus related to this paper: strve-PIKAIV |
| Title : A Single Active Site Mutation in the Pikromycin Thioesterase Generates a More Effective Macrocyclization Catalyst - Koch_2017_J.Am.Chem.Soc_139_13456 |
| Author(s) : Koch AA , Hansen DA , Shende VV , Furan LR , Houk KN , Jimenez-Oses G , Sherman DH |
| Ref : Journal of the American Chemical Society , 139 :13456 , 2017 |
| Abstract : |
| PubMedSearch : Koch_2017_J.Am.Chem.Soc_139_13456 |
| PubMedID: 28836768 |
| Gene_locus related to this paper: strve-PIKAIV |
| Title : Structural basis for binding specificity between subclasses of modular polyketide synthase docking domains - Buchholz_2009_ACS.Chem.Biol_4_41 |
| Author(s) : Buchholz TJ , Geders TW , Bartley FE, 3rd , Reynolds KA , Smith JL , Sherman DH |
| Ref : ACS Chemical Biology , 4 :41 , 2009 |
| Abstract : |
| PubMedSearch : Buchholz_2009_ACS.Chem.Biol_4_41 |
| PubMedID: 19146481 |
| Gene_locus related to this paper: strve-PIKAIV |
| Title : The methymycin\/pikromycin pathway: a model for metabolic diversity in natural product biosynthesis - Kittendorf_2009_Bioorg.Med.Chem_17_2137 |
| Author(s) : Kittendorf JD , Sherman DH |
| Ref : Bioorganic & Medicinal Chemistry , 17 :2137 , 2009 |
| Abstract : |
| PubMedSearch : Kittendorf_2009_Bioorg.Med.Chem_17_2137 |
| PubMedID: 19027305 |
| Gene_locus related to this paper: strve-PIKAIV |
| Title : Interrogating the molecular basis for multiple macrolactone ring formation by the pikromycin polyketide synthase - Kittendorf_2007_Chem.Biol_14_944 |
| Author(s) : Kittendorf JD , Beck BJ , Buchholz TJ , Seufert W , Sherman DH |
| Ref : Chemical Biology , 14 :944 , 2007 |
| Abstract : |
| PubMedSearch : Kittendorf_2007_Chem.Biol_14_944 |
| PubMedID: 17719493 |
| Gene_locus related to this paper: strve-PIKAIV |
| Title : Structural and mechanistic insights into polyketide macrolactonization from polyketide-based affinity labels - Giraldes_2006_Nat.Chem.Biol_2_531 |
| Author(s) : Giraldes JW , Akey DL , Kittendorf JD , Sherman DH , Smith JL , Fecik RA |
| Ref : Nat Chemical Biology , 2 :531 , 2006 |
| Abstract : |
| PubMedSearch : Giraldes_2006_Nat.Chem.Biol_2_531 |
| PubMedID: 16969373 |
| Gene_locus related to this paper: strve-PIKAIV |
| Title : Structural basis for macrolactonization by the pikromycin thioesterase - Akey_2006_Nat.Chem.Biol_2_537 |
| Author(s) : Akey DL , Kittendorf JD , Giraldes JW , Fecik RA , Sherman DH , Smith JL |
| Ref : Nat Chemical Biology , 2 :537 , 2006 |
| Abstract : |
| PubMedSearch : Akey_2006_Nat.Chem.Biol_2_537 |
| PubMedID: 16969372 |
| Gene_locus related to this paper: strve-PIKAIV |
| Title : Developing tools for engineering hybrid polyketide synthetic pathways - Kittendorf_2006_Curr.Opin.Biotechnol_17_597 |
| Author(s) : Kittendorf JD , Sherman DH |
| Ref : Curr Opin Biotechnol , 17 :597 , 2006 |
| Abstract : |
| PubMedSearch : Kittendorf_2006_Curr.Opin.Biotechnol_17_597 |
| PubMedID: 17046237 |
| Gene_locus related to this paper: strve-PIKAIV |
| Title : Neopikromycin and novapikromycin from the pikromycin biosynthetic pathway of Streptomyces venezuelae - Lee_2006_J.Nat.Prod_69_847 |
| Author(s) : Lee SK , Park JW , Kim JW , Jung WS , Park SR , Choi CY , Kim ES , Kim BS , Ahn JS , Sherman DH , Yoon YJ |
| Ref : Journal of Natural Products , 69 :847 , 2006 |
| Abstract : |
| PubMedSearch : Lee_2006_J.Nat.Prod_69_847 |
| PubMedID: 16724858 |
| Gene_locus related to this paper: strve-PIKAIV |
| Title : Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases - Tsai_2002_Biochemistry_41_12598 |
| Author(s) : Tsai SC , Lu H , Cane DE , Khosla C , Stroud RM |
| Ref : Biochemistry , 41 :12598 , 2002 |
| Abstract : |
| PubMedSearch : Tsai_2002_Biochemistry_41_12598 |
| PubMedID: 12379102 |
| Gene_locus related to this paper: sacer-ery3 , strve-PIKAIV |
| Title : Expression, site-directed mutagenesis, and steady state kinetic analysis of the terminal thioesterase domain of the methymycin\/picromycin polyketide synthase - Lu_2002_Biochemistry_41_12590 |
| Author(s) : Lu H , Tsai SC , Khosla C , Cane DE |
| Ref : Biochemistry , 41 :12590 , 2002 |
| Abstract : |
| PubMedSearch : Lu_2002_Biochemistry_41_12590 |
| PubMedID: 12379101 |
| Gene_locus related to this paper: strve-PIKAIV |
| Title : A gene cluster for macrolide antibiotic biosynthesis in streptomyces venezuelae: architecture of metabolic diversity. - |
| Author(s) : Xue Y , Zhao L , Liu Hw , Sherman DH |
| Ref : Proceedings of the National Academy of Sciences of the United States of America , 95 :12111 , 1998 |
| PubMedID: 9770448 |
| Gene_locus related to this paper: strve-PIKAIV , strve-PIKAV |