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| Title : Synthesis and in vitro activity of N-benzyl-1-(2,3-dichlorophenyl)-1H-tetrazol-5-amine P2X(7) antagonists - Perez-Medrano_2011_Bioorg.Med.Chem.Lett_21_3297 |
| Author(s) : Perez-Medrano A , Donnelly-Roberts D , Florjancic AS , Nelson DW , Li T , Namovic MT , Peddi S , Faltynek CR , Jarvis MF , Carroll WA |
| Ref : Bioorganic & Medicinal Chemistry Lett , 21 :3297 , 2011 |
| Abstract : Perez-Medrano_2011_Bioorg.Med.Chem.Lett_21_3297 |
| ESTHER : Perez-Medrano_2011_Bioorg.Med.Chem.Lett_21_3297 |
| PubMedSearch : Perez-Medrano_2011_Bioorg.Med.Chem.Lett_21_3297 |
| PubMedID: 21536435 |
| Title : Discovery and biological evaluation of novel cyanoguanidine P2X(7) antagonists with analgesic activity in a rat model of neuropathic pain - Perez-Medrano_2009_J.Med.Chem_52_3366 |
| Author(s) : Perez-Medrano A , Donnelly-Roberts D , Honore P , Hsieh GC , Namovic MT , Peddi S , Shuai Q , Wang Y , Faltynek CR , Jarvis MF , Carroll WA |
| Ref : Journal of Medicinal Chemistry , 52 :3366 , 2009 |
| Abstract : Perez-Medrano_2009_J.Med.Chem_52_3366 |
| ESTHER : Perez-Medrano_2009_J.Med.Chem_52_3366 |
| PubMedSearch : Perez-Medrano_2009_J.Med.Chem_52_3366 |
| PubMedID: 19397270 |
| Title : Structure-activity relationship studies on N'-aryl carbohydrazide P2X7 antagonists - Nelson_2008_J.Med.Chem_51_3030 |
| Author(s) : Nelson DW , Sarris K , Kalvin DM , Namovic MT , Grayson G , Donnelly-Roberts D , Harris R , Honore P , Jarvis MF , Faltynek CR , Carroll WA |
| Ref : Journal of Medicinal Chemistry , 51 :3030 , 2008 |
| Abstract : Nelson_2008_J.Med.Chem_51_3030 |
| ESTHER : Nelson_2008_J.Med.Chem_51_3030 |
| PubMedSearch : Nelson_2008_J.Med.Chem_51_3030 |
| PubMedID: 18438986 |
| Title : P2X7-related modulation of pathological nociception in rats - McGaraughty_2007_Neurosci_146_1817 |
| Author(s) : McGaraughty S , Chu KL , Namovic MT , Donnelly-Roberts D , Harris RR , Zhang XF , Shieh CC , Wismer CT , Zhu CZ , Gauvin DM , Fabiyi AC , Honore P , Gregg RJ , Kort ME , Nelson DW , Carroll WA , Marsh K , Faltynek CR , Jarvis MF |
| Ref : Neuroscience , 146 :1817 , 2007 |
| Abstract : McGaraughty_2007_Neurosci_146_1817 |
| ESTHER : McGaraughty_2007_Neurosci_146_1817 |
| PubMedSearch : McGaraughty_2007_Neurosci_146_1817 |
| PubMedID: 17478048 |
| Title : A-740003 [N-(1-{[(cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a novel and selective P2X7 receptor antagonist, dose-dependently reduces neuropathic pain in the rat - Honore_2006_J.Pharmacol.Exp.Ther_319_1376 |
| Author(s) : Honore P , Donnelly-Roberts D , Namovic MT , Hsieh G , Zhu CZ , Mikusa JP , Hernandez G , Zhong C , Gauvin DM , Chandran P , Harris R , Medrano AP , Carroll W , Marsh K , Sullivan JP , Faltynek CR , Jarvis MF |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 319 :1376 , 2006 |
| Abstract : Honore_2006_J.Pharmacol.Exp.Ther_319_1376 |
| ESTHER : Honore_2006_J.Pharmacol.Exp.Ther_319_1376 |
| PubMedSearch : Honore_2006_J.Pharmacol.Exp.Ther_319_1376 |
| PubMedID: 16982702 |
| Title : Structure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists - Nelson_2006_J.Med.Chem_49_3659 |
| Author(s) : Nelson DW , Gregg RJ , Kort ME , Perez-Medrano A , Voight EA , Wang Y , Grayson G , Namovic MT , Donnelly-Roberts D , Niforatos W , Honore P , Jarvis MF , Faltynek CR , Carroll WA |
| Ref : Journal of Medicinal Chemistry , 49 :3659 , 2006 |
| Abstract : Nelson_2006_J.Med.Chem_49_3659 |
| ESTHER : Nelson_2006_J.Med.Chem_49_3659 |
| PubMedSearch : Nelson_2006_J.Med.Chem_49_3659 |
| PubMedID: 16759108 |
| Title : Mitogen-activated protein kinase and caspase signaling pathways are required for P2X7 receptor (P2X7R)-induced pore formation in human THP-1 cells - Donnelly-Roberts_2004_J.Pharmacol.Exp.Ther_308_1053 |
| Author(s) : Donnelly-Roberts D , Namovic MT , Faltynek CR , Jarvis MF |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 308 :1053 , 2004 |
| Abstract : Donnelly-Roberts_2004_J.Pharmacol.Exp.Ther_308_1053 |
| ESTHER : Donnelly-Roberts_2004_J.Pharmacol.Exp.Ther_308_1053 |
| PubMedSearch : Donnelly-Roberts_2004_J.Pharmacol.Exp.Ther_308_1053 |
| PubMedID: 14634045 |