Sullivan JP

General

Full name : Sullivan James P

First name : James P

Mail : Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064

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Country : USA

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References (34)

Title : Broad-spectrum efficacy across cognitive domains by alpha7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1\/2 and CREB phosphorylation pathways - Bitner_2007_J.Neurosci_27_10578
Author(s) : Bitner RS , Bunnelle WH , Anderson DJ , Briggs CA , Buccafusco JJ , Curzon P , Decker MW , Frost JM , Gronlien JH , Gubbins E , Li J , Malysz J , Markosyan S , Marsh K , Meyer MD , Nikkel AL , Radek RJ , Robb HM , Timmermann DB , Sullivan JP , Gopalakrishnan M
Ref : Journal of Neuroscience , 27 :10578 , 2007
PubMedID: 17898229

Title : A-740003 [N-(1-{[(cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a novel and selective P2X7 receptor antagonist, dose-dependently reduces neuropathic pain in the rat - Honore_2006_J.Pharmacol.Exp.Ther_319_1376
Author(s) : Honore P , Donnelly-Roberts D , Namovic MT , Hsieh G , Zhu CZ , Mikusa JP , Hernandez G , Zhong C , Gauvin DM , Chandran P , Harris R , Medrano AP , Carroll W , Marsh K , Sullivan JP , Faltynek CR , Jarvis MF
Ref : Journal of Pharmacology & Experimental Therapeutics , 319 :1376 , 2006
PubMedID: 16982702

Title : Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzam ide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction - Patel_2006_J.Med.Chem_49_7450
Author(s) : Patel MV , Kolasa T , Mortell K , Matulenko MA , Hakeem AA , Rohde JJ , Nelson SL , Cowart MD , Nakane M , Miller LN , Uchic ME , Terranova MA , El-Kouhen OF , Donnelly-Roberts D , Namovic MT , Hollingsworth PR , Chang R , Martino BR , Wetter JM , Marsh KC , Martin R , Darbyshire JF , Gintant G , Hsieh GC , Moreland RB , Sullivan JP , Brioni JD , Stewart AO
Ref : Journal of Medicinal Chemistry , 49 :7450 , 2006
PubMedID: 17149874

Title : ABT-089: pharmacological properties of a neuronal nicotinic acetylcholine receptor agonist for the potential treatment of cognitive disorders - Rueter_2004_CNS.Drug.Rev_10_167
Author(s) : Rueter LE , Anderson DJ , Briggs CA , Donnelly-Roberts D , Gintant GA , Gopalakrishnan M , Lin NH , Osinski MA , Reinhart GA , Buckley MJ , Martin RL , McDermott JS , Preusser LC , Seifert TR , Su Z , Cox BF , Decker MW , Sullivan JP
Ref : CNS Drug Rev , 10 :167 , 2004
PubMedID: 15179445

Title : Dopamine D4 ligands and models of receptor activation: 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and related heteroarylmethylarylpiperazines exhibit a substituent effect responsible for additional efficacy tuning - Stewart_2004_J.Med.Chem_47_2348
Author(s) : Stewart AO , Cowart MD , Moreland RB , Latshaw SP , Matulenko MA , Bhatia PA , Wang X , Daanen JF , Nelson SL , Terranova MA , Namovic MT , Donnelly-Roberts D , Miller LN , Nakane M , Sullivan JP , Brioni JD
Ref : Journal of Medicinal Chemistry , 47 :2348 , 2004
PubMedID: 15084133

Title : Central mechanisms regulating penile erection in conscious rats: the dopaminergic systems related to the proerectile effect of apomorphine - Hsieh_2004_J.Pharmacol.Exp.Ther_308_330
Author(s) : Hsieh GC , Hollingsworth PR , Martino B , Chang R , Terranova MA , O'Neill AB , Lynch JJ , Moreland RB , Donnelly-Roberts D , Kolasa T , Mikusa JP , McVey JM , Marsh KC , Sullivan JP , Brioni JD
Ref : Journal of Pharmacology & Experimental Therapeutics , 308 :330 , 2004
PubMedID: 14569075

Title : Activation of dopamine D4 receptors by ABT-724 induces penile erection in rats - Brioni_2004_Proc.Natl.Acad.Sci.U.S.A_101_6758
Author(s) : Brioni JD , Moreland RB , Cowart M , Hsieh GC , Stewart AO , Hedlund P , Donnelly-Roberts D , Nakane M , Lynch JJ, 3rd , Kolasa T , Polakowski JS , Osinski MA , Marsh K , Andersson KE , Sullivan JP
Ref : Proc Natl Acad Sci U S A , 101 :6758 , 2004
PubMedID: 15087502

Title : Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction - Cowart_2004_J.Med.Chem_47_3853
Author(s) : Cowart M , Latshaw SP , Bhatia P , Daanen JF , Rohde J , Nelson SL , Patel M , Kolasa T , Nakane M , Uchic ME , Miller LN , Terranova MA , Chang R , Donnelly-Roberts D , Namovic MT , Hollingsworth PR , Martino BR , Lynch JJ, 3rd , Sullivan JP , Hsieh GC , Moreland RB , Brioni JD , Stewart AO
Ref : Journal of Medicinal Chemistry , 47 :3853 , 2004
PubMedID: 15239663

Title : Alkaloids from frog skin: the discovery of epibatidine and the potential for developing novel non-opioid analgesics -
Author(s) : Daly JW , Garraffo HM , Spande TF , Decker MW , Sullivan JP , Williams M
Ref : Nat Prod Rep , 17 :131 , 2000
PubMedID: 10821107

Title : The identification of novel structural compound classes exhibiting high affinity for neuronal nicotinic acetylcholine receptors and analgesic efficacy in preclinical models of pain - Meyer_2000_Eur.J.Pharmacol_393_171
Author(s) : Meyer MD , Decker MW , Rueter LE , Anderson DJ , Dart MJ , Kim KH , Sullivan JP , Williams M
Ref : European Journal of Pharmacology , 393 :171 , 2000
PubMedID: 10771011

Title : Gain of function mutation of the alpha7 nicotinic receptor: distinct pharmacology of the human alpha7V274T variant - Briggs_1999_Eur.J.Pharmacol_366_301
Author(s) : Briggs CA , McKenna DG , Monteggia LM , Touma E , Roch JM , Arneric SP , Gopalakrishnan M , Sullivan JP
Ref : European Journal of Pharmacology , 366 :301 , 1999
PubMedID: 10082212

Title : Structure-activity studies related to ABT-594, a potent nonopioid analgesic agent: effect of pyridine and azetidine ring substitutions on nicotinic acetylcholine receptor binding affinity and analgesic activity in mice - Holladay_1998_Bioorg.Med.Chem.Lett_8_2797
Author(s) : Holladay MW , Bai H , Li Y , Lin NH , Daanen JF , Ryther KB , Wasicak JT , Kincaid JF , He Y , Hettinger AM , Huang P , Anderson DJ , Bannon AW , Buckley MJ , Campbell JE , Donnelly-Roberts D , Gunther KL , Kim DJ , Kuntzweiler TA , Sullivan JP , Decker MW , Arneric SP
Ref : Bioorganic & Medicinal Chemistry Lett , 8 :2797 , 1998
PubMedID: 9873625

Title : Synthesis and structure-activity relationships of pyridine-modified analogs of 3-[2-((S)-pyrrolidinyl)methoxy]pyridine, A-84543, a potent nicotinic acetylcholine receptor agonist - Lin_1998_Bioorg.Med.Chem.Lett_8_249
Author(s) : Lin NH , Gunn DE , Li Y , He Y , Bai H , Ryther KB , Kuntzweiler T , Donnelly-Roberts D , Anderson DJ , Campbell JE , Sullivan JP , Arneric SP , Holladay MW
Ref : Bioorganic & Medicinal Chemistry Lett , 8 :249 , 1998
PubMedID: 9871663

Title : Up-regulation of human alpha7 nicotinic receptors by chronic treatment with activator and antagonist ligands - Molinari_1998_Eur.J.Pharmacol_347_131
Author(s) : Molinari EJ , Delbono O , Messi ML , Renganathan M , Arneric SP , Sullivan JP , Gopalakrishnan M
Ref : European Journal of Pharmacology , 347 :131 , 1998
PubMedID: 9650859

Title : Regulation of human alpha4beta2 neuronal nicotinic acetylcholine receptors by cholinergic channel ligands and second messenger pathways - Gopalakrishnan_1997_Mol.Pharmacol_52_524
Author(s) : Gopalakrishnan M , Molinari EJ , Sullivan JP
Ref : Molecular Pharmacology , 52 :524 , 1997
PubMedID: 9281615

Title : ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine]: I. A potent and selective cholinergic channel modulator with neuroprotective properties - Sullivan_1997_J.Pharmacol.Exp.Ther_283_235
Author(s) : Sullivan JP , Donnelly-Roberts D , Briggs CA , Anderson DJ , Gopalakrishnan M , Xue IC , Piattoni-Kaplan M , Molinari E , Campbell JE , McKenna DG , Gunn DE , Lin NH , Ryther KB , He Y , Holladay MW , Wonnacott S , Williams M , Arneric SP
Ref : Journal of Pharmacology & Experimental Therapeutics , 283 :235 , 1997
PubMedID: 9336329

Title : Functional characterization of the novel neuronal nicotinic acetylcholine receptor ligand GTS-21 in vitro and in vivo - Briggs_1997_Pharmacol.Biochem.Behav_57_231
Author(s) : Briggs CA , Anderson DJ , Brioni JD , Buccafusco JJ , Buckley MJ , Campbell JE , Decker MW , Donnelly-Roberts D , Elliott RL , Gopalakrishnan M , Holladay MW , Hui YH , Jackson WJ , Kim DJ , Marsh KC , O'Neill A , Prendergast MA , Ryther KB , Sullivan JP , Arneric SP
Ref : Pharmacol Biochem Behav , 57 :231 , 1997
PubMedID: 9164577

Title : Structure-activity studies on 2-methyl-3-(2(S)-pyrrolidinylmethoxy) pyridine (ABT-089): an orally bioavailable 3-pyridyl ether nicotinic acetylcholine receptor ligand with cognition-enhancing properties - Lin_1997_J.Med.Chem_40_385
Author(s) : Lin NH , Gunn DE , Ryther KB , Garvey DS , Donnelly-Roberts D , Decker MW , Brioni JD , Buckley MJ , Rodrigues AD , Marsh KG , Anderson DJ , Buccafusco JJ , Prendergast MA , Sullivan JP , Williams M , Arneric SP , Holladay MW
Ref : Journal of Medicinal Chemistry , 40 :385 , 1997
PubMedID: 9022806

Title : Activation of the recombinant human alpha 7 nicotinic acetylcholine receptor significantly raises intracellular free calcium - Delbono_1997_J.Pharmacol.Exp.Ther_280_428
Author(s) : Delbono O , Gopalakrishnan M , Renganathan M , Monteggia LM , Messi ML , Sullivan JP
Ref : Journal of Pharmacology & Experimental Therapeutics , 280 :428 , 1997
PubMedID: 8996225

Title : Stable expression, pharmacologic properties and regulation of the human neuronal nicotinic acetylcholine alpha 4 beta 2 receptor - Gopalakrishnan_1996_J.Pharmacol.Exp.Ther_276_289
Author(s) : Gopalakrishnan M , Monteggia LM , Anderson DJ , Molinari EJ , Piattoni-Kaplan M , Donnelly-Roberts D , Arneric SP , Sullivan JP
Ref : Journal of Pharmacology & Experimental Therapeutics , 276 :289 , 1996
PubMedID: 8558445

Title : Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors - Abreo_1996_J.Med.Chem_39_817
Author(s) : Abreo MA , Lin NH , Garvey DS , Gunn DE , Hettinger AM , Wasicak JT , Pavlik PA , Martin YC , Donnelly-Roberts D , Anderson DJ , Sullivan JP , Williams M , Arneric SP , Holladay MW
Ref : Journal of Medicinal Chemistry , 39 :817 , 1996
PubMedID: 8632405

Title : Pharmacological characterization of a nicotinic autoreceptor in rat hippocampal synaptosomes - Wilkie_1996_Neurochem.Res_21_1141
Author(s) : Wilkie GI , Hutson P , Sullivan JP , Wonnacott S
Ref : Neurochem Res , 21 :1141 , 1996
PubMedID: 8897478

Title : A-85380 [3-(2(S)-azetidinylmethoxy) pyridine]: in vitro pharmacological properties of a novel, high affinity alpha 4 beta 2 nicotinic acetylcholine receptor ligand - Sullivan_1996_Neuropharmacol_35_725
Author(s) : Sullivan JP , Donnelly-Roberts D , Briggs CA , Anderson DJ , Gopalakrishnan M , Piattoni-Kaplan M , Campbell JE , McKenna DG , Molinari E , Hettinger AM , Garvey DS , Wasicak JT , Holladay MW , Williams M , Arneric SP
Ref : Neuropharmacology , 35 :725 , 1996
PubMedID: 8887981

Title : Human alpha4beta2 neuronal nicotinic acetylcholine receptor in HEK 293 cells: A patch-clamp study - Buisson_1996_J.Neurosci_16_7880
Author(s) : Buisson B , Gopalakrishnan M , Arneric SP , Sullivan JP , Bertrand D
Ref : Journal of Neuroscience , 16 :7880 , 1996
PubMedID: 8987816

Title : In vitro neuroprotective properties of the novel cholinergic channel activator (ChCA), ABT-418 - Donnelly-Roberts_1996_Brain.Res_719_36
Author(s) : Donnelly-Roberts D , Xue IC , Arneric SP , Sullivan JP
Ref : Brain Research , 719 :36 , 1996
PubMedID: 8782861

Title : Stable expression and pharmacological properties of the human alpha 7 nicotinic acetylcholine receptor - Gopalakrishnan_1995_Eur.J.Pharmacol_290_237
Author(s) : Gopalakrishnan M , Buisson B , Touma E , Giordano T , Campbell JE , Hu IC , Donnelly-Roberts D , Arneric SP , Bertrand D , Sullivan JP
Ref : European Journal of Pharmacology , 290 :237 , 1995
PubMedID: 7589218

Title : Cholinergic channel activators: novel opportunities for the treatment of CNS disorders - Sullivan_1995_Proc.West.Pharmacol.Soc_38_127
Author(s) : Sullivan JP , Decker MW , Donnelly-Roberts D , Brioni JD , Bannon AW , Holladay MW , Anderson DJ , Briggs CA , Williams M , Arneric SP
Ref : Proc West Pharmacol Soc , 38 :127 , 1995
PubMedID: 7480004

Title : Potential treatment of Alzheimer disease using cholinergic channel activators (ChCAs) with cognitive enhancement, anxiolytic-like, and cytoprotective properties - Arneric_1995_Alzheimer.Dis.Assoc.Disord_9 Suppl 2_50
Author(s) : Arneric SP , Sullivan JP , Decker MW , Brioni JD , Bannon AW , Briggs CA , Donnelly-Roberts D , Radek RJ , Marsh KC , Kyncl J , Williams M , Buccafusco JJ
Ref : Alzheimer Disease & Associated Disorders , 9 Suppl 2 :50 , 1995
PubMedID: 8534424

Title : Erysodine, a competitive antagonist at neuronal nicotinic acetylcholine receptors - Decker_1995_Eur.J.Pharmacol_280_79
Author(s) : Decker MW , Anderson DJ , Brioni JD , Donnelly-Roberts D , Kang CH , O'Neill AB , Piattoni-Kaplan M , Swanson S , Sullivan JP
Ref : European Journal of Pharmacology , 280 :79 , 1995
PubMedID: 7498257

Title : Cloning and transient expression of genes encoding the human alpha 4 and beta 2 neuronal nicotinic acetylcholine receptor (nAChR) subunits - Monteggia_1995_Gene_155_189
Author(s) : Monteggia LM , Gopalakrishnan M , Touma E , Idler KB , Nash N , Arneric SP , Sullivan JP , Giordano T
Ref : Gene , 155 :189 , 1995
PubMedID: 7721089

Title : Functional modulation of human ganglionic-like neuronal nicotinic acetylcholine receptors (nAChRs) by L-type calcium channel antagonists - Donnelly-Roberts_1995_Biochem.Biophys.Res.Commun_213_657
Author(s) : Donnelly-Roberts D , Arneric SP , Sullivan JP
Ref : Biochemical & Biophysical Research Communications , 213 :657 , 1995
PubMedID: 7544126

Title : Novel isoxazoles which interact with brain cholinergic channel receptors have intrinsic cognitive enhancing and anxiolytic activities -
Author(s) : Garvey DS , Wasicak JT , Decker MW , Brioni JD , Buckley MJ , Sullivan JP , Carrera GM , Holladay MW , Arneric SP , Williams M
Ref : Journal of Medicinal Chemistry , 37 :1055 , 1994
PubMedID: 7909335

Title : (+\/-)-Epibatidine elicits a diversity of in vitro and in vivo effects mediated by nicotinic acetylcholine receptors - Sullivan_1994_J.Pharmacol.Exp.Ther_271_624
Author(s) : Sullivan JP , Decker MW , Brioni JD , Donnelly-Roberts D , Anderson DJ , Bannon AW , Kang CH , Adams P , Piattoni-Kaplan M , Buckley MJ
Ref : Journal of Pharmacology & Experimental Therapeutics , 271 :624 , 1994
PubMedID: 7965777

Title : (S)-3-methyl-5-(1-methyl-2-pyrrolidinyl) isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: I. In vitro characterization - Arneric_1994_J.Pharmacol.Exp.Ther_270_310
Author(s) : Arneric SP , Sullivan JP , Briggs CA , Donnelly-Roberts D , Anderson DJ , Raszkiewicz JL , Hughes ML , Cadman ED , Adams P , Garvey DS
Ref : Journal of Pharmacology & Experimental Therapeutics , 270 :310 , 1994
PubMedID: 7518514