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| Title : Investigation of a Bicyclo[1.1.1]pentane as a Phenyl Replacement within an LpPLA2 Inhibitor - Measom_2017_ACS.Med.Chem.Lett_8_43 |
| Author(s) : Measom ND , Down KD , Hirst DJ , Jamieson C , Manas ES , Patel VK , Somers DO |
| Ref : ACS Med Chem Lett , 8 :43 , 2017 |
| Abstract : Measom_2017_ACS.Med.Chem.Lett_8_43 |
| ESTHER : Measom_2017_ACS.Med.Chem.Lett_8_43 |
| PubMedSearch : Measom_2017_ACS.Med.Chem.Lett_8_43 |
| PubMedID: 28105273 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening - Woolford_2016_J.Med.Chem_59_5356 |
| Author(s) : Woolford AJ , Pero JE , Aravapalli S , Berdini V , Coyle JE , Day PJ , Dodson AM , Grondin P , Holding FP , Lee LY , Li P , Manas ES , Marino J, Jr. , Martin AC , McCleland BW , McMenamin RL , Murray CW , Neipp CE , Page LW , Patel VK , Potvain F , Rich S , Rivero RA , Smith K , Somers DO , Trottet L , Velagaleti R , Williams G , Xie R |
| Ref : Journal of Medicinal Chemistry , 59 :5356 , 2016 |
| Abstract : Woolford_2016_J.Med.Chem_59_5356 |
| ESTHER : Woolford_2016_J.Med.Chem_59_5356 |
| PubMedSearch : Woolford_2016_J.Med.Chem_59_5356 |
| PubMedID: 27167608 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) - Woolford_2016_J.Med.Chem_59_10738 |
| Author(s) : Woolford AJ , Day PJ , Beneton V , Berdini V , Coyle JE , Dudit Y , Grondin P , Huet P , Lee LY , Manas ES , McMenamin RL , Murray CW , Page LW , Patel VK , Potvain F , Rich SJ , Sang Y , Somers DO , Trottet L , Wan Z , Zhang X |
| Ref : Journal of Medicinal Chemistry , 59 :10738 , 2016 |
| Abstract : Woolford_2016_J.Med.Chem_59_10738 |
| ESTHER : Woolford_2016_J.Med.Chem_59_10738 |
| PubMedSearch : Woolford_2016_J.Med.Chem_59_10738 |
| PubMedID: 27933945 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Sequencing of Lp-PLA2-encoding PLA2G7 gene in 2000 Europeans reveals several rare loss-of-function mutations - Song_2012_Pharmacogenomics.J_12_425 |
| Author(s) : Song K , Nelson MR , Aponte J , Manas ES , Bacanu SA , Yuan X , Kong X , Cardon L , Mooser VE , Whittaker JC , Waterworth DM |
| Ref : Pharmacogenomics J , 12 :425 , 2012 |
| Abstract : Song_2012_Pharmacogenomics.J_12_425 |
| ESTHER : Song_2012_Pharmacogenomics.J_12_425 |
| PubMedSearch : Song_2012_Pharmacogenomics.J_12_425 |
| PubMedID: 21606947 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors - Goodman_2009_Bioorg.Med.Chem.Lett_19_27 |
| Author(s) : Goodman KB , Bury MJ , Cheung M , Cichy-Knight MA , Dowdell SE , Dunn AK , Lee D , Lieby JA , Moore ML , Scherzer DA , Sha D , Suarez DP , Murphy DJ , Harpel MR , Manas ES , McNulty DE , Annan RS , Matico RE , Schwartz BK , Trill JJ , Sweitzer TD , Wang DY , Keller PM , Krawiec JA , Jaye MC |
| Ref : Bioorganic & Medicinal Chemistry Lett , 19 :27 , 2009 |
| Abstract : Goodman_2009_Bioorg.Med.Chem.Lett_19_27 |
| ESTHER : Goodman_2009_Bioorg.Med.Chem.Lett_19_27 |
| PubMedSearch : Goodman_2009_Bioorg.Med.Chem.Lett_19_27 |
| PubMedID: 19058966 |
| Gene_locus related to this paper: human-LIPG |