Arb2
Comment
This domain is found at the C-terminal of Clr3 (Cryptic loci regulator 3) also known as histone deacetylase clr3 (EC:3.5.1.98). Structure analysis reveals that the Arb2 domain has clear homology to alpha/beta-hydrolases but that it is lacking the catalytic triad of these enzymes. Structural and histone binding ability characterization of the ARB2 domain of a histone deacetylase Hda1 from Saccharomyces cerevisiae was published (Shen et al.) and from Saccharomyces pombe (Job et al.) . FAM172A plays an important role in the regulation of cotranscriptional alternative splicing by interacting with Ago2 (Argonaute-2) and Chd7. The FAM172A mutant mice display a complex phenotype mimicking both the major and minor features of CHARGE syndrome (Belanger et al.)
Database
Interpro : IPR039929 Cotranscriptional regulator FAM172A , IPR019154 Arb2 domain
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : PF09757 Arb2
Prints : No Print
EC Number : No EC Number
Sequences
| Peptide in | Fasta |
| Nucleotide in | Fasta |
| Alignment with Multalin | Text only |
| Seed alignment with MAFFT | No colour / coloured with Mview |
| Alignment with MAFFT | No colour / coloured with Mview |
| Dendrogram | The dnd file |
References (4)
| Title : Dysregulation of cotranscriptional alternative splicing underlies CHARGE syndrome - Belanger_2018_Proc.Natl.Acad.Sci.U.S.A_115_E620 |
| Author(s) : Belanger C , Berube-Simard FA , Leduc E , Bernas G , Campeau PM , Lalani SR , Martin DM , Bielas S , Moccia A , Srivastava A , Silversides DW , Pilon N |
| Ref : Proc Natl Acad Sci U S A , 115 :E620 , 2018 |
| Abstract : |
| PubMedSearch : Belanger_2018_Proc.Natl.Acad.Sci.U.S.A_115_E620 |
| PubMedID: 29311329 |
| Gene_locus related to this paper: mouse-f172a , human-f172a |
| Title : SHREC Silences Heterochromatin via Distinct Remodeling and Deacetylation Modules - Job_2016_Mol.Cell_62_207 |
| Author(s) : Job G , Brugger C , Xu T , Lowe BR , Pfister Y , Qu C , Shanker S , Banos Sanz JI , Partridge JF , Schalch T |
| Ref : Mol Cell , 62 :207 , 2016 |
| Abstract : |
| PubMedSearch : Job_2016_Mol.Cell_62_207 |
| PubMedID: 27105116 |
| Gene_locus related to this paper: schpo-clr3 |
| Title : Structural and histone binding ability characterization of the ARB2 domain of a histone deacetylase Hda1 from Saccharomyces cerevisiae - Shen_2016_Sci.Rep_6_33905 |
| Author(s) : Shen H , Zhu Y , Wang C , Yan H , Teng M , Li X |
| Ref : Sci Rep , 6 :33905 , 2016 |
| Abstract : |
| PubMedSearch : Shen_2016_Sci.Rep_6_33905 |
| PubMedID: 27665728 |
| Gene_locus related to this paper: yeast-hda1 |
| Title : Two different Argonaute complexes are required for siRNA generation and heterochromatin assembly in fission yeast - Buker_2007_Nat.Struct.Mol.Biol_14_200 |
| Author(s) : Buker SM , Iida T , Buhler M , Villen J , Gygi SP , Nakayama J , Moazed D |
| Ref : Nat Struct Mol Biol , 14 :200 , 2007 |
| Abstract : |
| PubMedSearch : Buker_2007_Nat.Struct.Mol.Biol_14_200 |
| PubMedID: 17310250 |