Arb2

Relationship

Family: Arb2

Block: X

Parent Family: No family

Comment

This domain is found at the C-terminal of Clr3 (Cryptic loci regulator 3) also known as histone deacetylase clr3 (EC:3.5.1.98). Structure analysis reveals that the Arb2 domain has clear homology to alpha/beta-hydrolases but that it is lacking the catalytic triad of these enzymes. Structural and histone binding ability characterization of the ARB2 domain of a histone deacetylase Hda1 from Saccharomyces cerevisiae was published (Shen et al.) and from Saccharomyces pombe (Job et al.) . FAM172A plays an important role in the regulation of cotranscriptional alternative splicing by interacting with Ago2 (Argonaute-2) and Chd7. The FAM172A mutant mice display a complex phenotype mimicking both the major and minor features of CHARGE syndrome (Belanger et al.)

Database

Interpro : IPR039929 Cotranscriptional regulator FAM172A , IPR019154 Arb2 domain

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : PF09757 Arb2

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

No structure scheme yet for this family

No Genes Proteins

No fragment of genes

No fragment of genes

No substrate

No Inhibitor

References (4)

Title : Dysregulation of cotranscriptional alternative splicing underlies CHARGE syndrome - Belanger_2018_Proc.Natl.Acad.Sci.U.S.A_115_E620
Author(s) : Belanger C , Berube-Simard FA , Leduc E , Bernas G , Campeau PM , Lalani SR , Martin DM , Bielas S , Moccia A , Srivastava A , Silversides DW , Pilon N
Ref : Proc Natl Acad Sci U S A , 115 :E620 , 2018
PubMedID: 29311329
Gene_locus related to this paper: mouse-f172a , human-f172a

Title : SHREC Silences Heterochromatin via Distinct Remodeling and Deacetylation Modules - Job_2016_Mol.Cell_62_207
Author(s) : Job G , Brugger C , Xu T , Lowe BR , Pfister Y , Qu C , Shanker S , Banos Sanz JI , Partridge JF , Schalch T
Ref : Mol Cell , 62 :207 , 2016
PubMedID: 27105116
Gene_locus related to this paper: schpo-clr3

Title : Structural and histone binding ability characterization of the ARB2 domain of a histone deacetylase Hda1 from Saccharomyces cerevisiae - Shen_2016_Sci.Rep_6_33905
Author(s) : Shen H , Zhu Y , Wang C , Yan H , Teng M , Li X
Ref : Sci Rep , 6 :33905 , 2016
PubMedID: 27665728
Gene_locus related to this paper: yeast-hda1

Title : Two different Argonaute complexes are required for siRNA generation and heterochromatin assembly in fission yeast - Buker_2007_Nat.Struct.Mol.Biol_14_200
Author(s) : Buker SM , Iida T , Buhler M , Villen J , Gygi SP , Nakayama J , Moazed D
Ref : Nat Struct Mol Biol , 14 :200 , 2007
PubMedID: 17310250