human-f172a

Homo sapiens (Human).Cotranscriptional regulator Protein FAM172A ARB2A

Comment

Plays a role in the regulation of alternative splicing, by interacting with AGO2 and CHD7. Seems to be required for stabilizing protein-protein interactions at the chromatin-spliceosome interface. May have hydrolase activity.

Relationship

Family : Arb2_FAM172A

Block : X

Position in NCBI Life Tree : Homo sapiens

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N E

Molecular evidence

No mutation

No structure

No kinetic

No disease

No substrate

No inhibitor

Sequence

Peptide

MSISLSSLIL LPIWINMAQI QQGGPDEKEK TTALKDLLSR IDLDELMKKD EPPLDFPDTL EGFEYAFNEK GQLRHIKTGE PFVFNYREDL HRWNQKRYEA LGEIITKYVY ELLEKDCNLK KVSIPVDATE SEPKSFIFMS EDALTNPQKL MVLIHGSGVV RAGQWARRLI INEDLDSGTQ IPFIKRAVAE GYGVIVLNPN ENYIEVEKPK IHVQSSSDSS DEPAEKRERK DKVSKETKKR RDFYEKYRNP QREKEMMQLY IRENGSPEEH AIYVWDHFIA QAAAENVFFV AHSYGGLAFV ELMIQREADV KNKVTAVALT DSVHNVWHQE AGKTIREWMR ENCCNWVSSS EPLDTSVESM LPDCPRVSAG TDRHELTSWK SFPSIFKFFT EASEAKTSSL KPAVTRRSHR IKHEEL

References (13)

Title : CHARGE syndrome-associated proteins FAM172A and CHD7 influence male sex determination and differentiation through transcriptional and alternative splicing mechanisms - Belanger_2022_FASEB.J_36_e22176
Author(s) : Belanger C , Cardinal T , Leduc E , Viger RS , Pilon N
Ref : FASEB Journal , 36 :e22176 , 2022
Abstract :
PubMedSearch : Belanger_2022_FASEB.J_36_e22176
PubMedID: 35129866
Gene_locus related to this paper: mouse-f172a , human-f172a

Title : FAM172A promotes follicular thyroid carcinogenesis and may be a marker of FTC - Xu_2020_Endocr.Relat.Cancer_27_657
Author(s) : Xu PP , Zeng S , Xia XT , Ye ZH , Li MF , Chen MY , Xia T , Xu JJ , Jiao Q , Liu L , Li LX , Guo MG
Ref : Endocr Relat Cancer , 27 :657 , 2020
Abstract :
PubMedSearch : Xu_2020_Endocr.Relat.Cancer_27_657
PubMedID: 33095186
Gene_locus related to this paper: mouse-f172a , human-f172a

Title : FAM172A inhibits EMT in pancreatic cancer via ERK-MAPK signaling - Chen_2020_Biol.Open_9_bio048462
Author(s) : Chen Y , Liu P , Shen D , Liu H , Xu L , Wang J , Sun H , Wu H
Ref : Biol Open , 9 : , 2020
Abstract :
PubMedSearch : Chen_2020_Biol.Open_9_bio048462
PubMedID: 31988090
Gene_locus related to this paper: human-f172a

Title : The Effect of Protein FAM172A on Proliferation in HepG2 Cells and Investigation of the Possible Molecular Mechanism - Zhao_2019_Anal.Cell.Pathol.(Amst)_2019_5901083
Author(s) : Zhao H , Wang Y , Liu Y , Hao X , Wei H , Xie W
Ref : Anal Cell Pathol (Amst) , 2019 :5901083 , 2019
Abstract :
PubMedSearch : Zhao_2019_Anal.Cell.Pathol.(Amst)_2019_5901083
PubMedID: 31915594
Gene_locus related to this paper: human-f172a

Title : Dysregulation of cotranscriptional alternative splicing underlies CHARGE syndrome - Belanger_2018_Proc.Natl.Acad.Sci.U.S.A_115_E620
Author(s) : Belanger C , Berube-Simard FA , Leduc E , Bernas G , Campeau PM , Lalani SR , Martin DM , Bielas S , Moccia A , Srivastava A , Silversides DW , Pilon N
Ref : Proc Natl Acad Sci U S A , 115 :E620 , 2018
Abstract :
PubMedSearch : Belanger_2018_Proc.Natl.Acad.Sci.U.S.A_115_E620
PubMedID: 29311329
Gene_locus related to this paper: mouse-f172a , human-f172a

Title : Detection of FAM172A expressed in circulating tumor cells is a feasible method to predict high-risk subgroups of colorectal cancer - Cui_2017_Tumour.Biol_39_1010428317699126
Author(s) : Cui CH , Chen RH , Zhai DY , Xie L , Qi J , Yu JL
Ref : Tumour Biol , 39 :1010428317699126 , 2017
Abstract :
PubMedSearch : Cui_2017_Tumour.Biol_39_1010428317699126
PubMedID: 28618931
Gene_locus related to this paper: human-f172a

Title : miR27a promotes proliferation, migration, and invasion of colorectal cancer by targeting FAM172A and acts as a diagnostic and prognostic biomarker - Liu_2017_Oncol.Rep_37_3554
Author(s) : Liu W , Qian K , Wei X , Deng H , Zhao B , Chen Q , Zhang J , Liu H
Ref : Oncol Rep , 37 :3554 , 2017
Abstract :
PubMedSearch : Liu_2017_Oncol.Rep_37_3554
PubMedID: 28440497
Gene_locus related to this paper: human-f172a

Title : FAM172A modulates apoptosis and proliferation of colon cancer cells via STAT1 binding to its promoter - Qian_2016_Oncol.Rep_35_1273
Author(s) : Qian K , Zhang J , Lu J , Liu W , Yao X , Chen Q , Lu S , Xiang G , Liu H
Ref : Oncol Rep , 35 :1273 , 2016
Abstract :
PubMedSearch : Qian_2016_Oncol.Rep_35_1273
PubMedID: 26676844
Gene_locus related to this paper: human-f172a

Title : FAM172A is a tumor suppressor in colorectal carcinoma - Cui_2016_Tumour.Biol_37_6501
Author(s) : Cui C , Ye L , Huang Z , Huang S , Liu H , Yu J
Ref : Tumour Biol , 37 :6501 , 2016
Abstract :
PubMedSearch : Cui_2016_Tumour.Biol_37_6501
PubMedID: 26637224
Gene_locus related to this paper: human-f172a

Title : FAM172A protein promotes the proliferation of human papillary thyroid carcinoma cells via the p38 mitogen-activated protein kinase pathway - Li_2016_Mol.Med.Rep_13_353
Author(s) : Li MF , Zhang R , Guo MG , Li LX , Lu HK , Lu JX , Jia WP
Ref : Mol Med Rep , 13 :353 , 2016
Abstract :
PubMedSearch : Li_2016_Mol.Med.Rep_13_353
PubMedID: 26573560
Gene_locus related to this paper: human-f172a

Title : [Effect of FAM172A protein on apoptosis and proliferation in HEK293 cells] - Li_2010_Zhonghua.Yi.Xue.Za.Zhi_90_2424
Author(s) : Li LX , Zhou WB , Tao Z , Deng WJ , Liang WC , Yang ZH , Ye WW , Bao YQ , Jia WP , Hu RM
Ref : Zhonghua Yi Xue Za Zhi , 90 :2424 , 2010
Abstract :
PubMedSearch : Li_2010_Zhonghua.Yi.Xue.Za.Zhi_90_2424
PubMedID: 21092515
Gene_locus related to this paper: human-f172a

Title : Identification of the novel protein FAM172A, and its up-regulation by high glucose in human aortic smooth muscle cells - Li_2010_Int.J.Mol.Med_26_483
Author(s) : Li L , Dong X , Leong MC , Zhou W , Yang Z , Chen F , Bao Y , Jia W , Hu R
Ref : Int J Mol Med , 26 :483 , 2010
Abstract :
PubMedSearch : Li_2010_Int.J.Mol.Med_26_483
PubMedID: 20818486
Gene_locus related to this paper: human-f172a

Title : [Molecular cloning of a novel gene, C5orf21 gene and its roles in diabetic macroangiopathy] - Li_2009_Zhonghua.Yi.Xue.Za.Zhi_89_2574
Author(s) : Li LX , Tao Z , Dong XH , Liang WC , Yang ZH , Mou B , Bao YQ , Wang C , Jia WP , Hu RM
Ref : Zhonghua Yi Xue Za Zhi , 89 :2574 , 2009
Abstract :
PubMedSearch : Li_2009_Zhonghua.Yi.Xue.Za.Zhi_89_2574
PubMedID: 20137623
Gene_locus related to this paper: human-f172a