Homo sapiens (Human).Cotranscriptional regulator Protein FAM172A ARB2A
Plays a role in the regulation of alternative splicing, by interacting with AGO2 and CHD7. Seems to be required for stabilizing protein-protein interactions at the chromatin-spliceosome interface. May have hydrolase activity.
Family : Arb2_FAM172A
Block : X
Position in NCBI Life Tree : Homo sapiens
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N EMSISLSSLIL LPIWINMAQI QQGGPDEKEK TTALKDLLSR IDLDELMKKD EPPLDFPDTL EGFEYAFNEK GQLRHIKTGE PFVFNYREDL HRWNQKRYEA LGEIITKYVY ELLEKDCNLK KVSIPVDATE SEPKSFIFMS EDALTNPQKL MVLIHGSGVV RAGQWARRLI INEDLDSGTQ IPFIKRAVAE GYGVIVLNPN ENYIEVEKPK IHVQSSSDSS DEPAEKRERK DKVSKETKKR RDFYEKYRNP QREKEMMQLY IRENGSPEEH AIYVWDHFIA QAAAENVFFV AHSYGGLAFV ELMIQREADV KNKVTAVALT DSVHNVWHQE AGKTIREWMR ENCCNWVSSS EPLDTSVESM LPDCPRVSAG TDRHELTSWK SFPSIFKFFT EASEAKTSSL KPAVTRRSHR IKHEEL
| Title : CHARGE syndrome-associated proteins FAM172A and CHD7 influence male sex determination and differentiation through transcriptional and alternative splicing mechanisms - Belanger_2022_FASEB.J_36_e22176 |
| Author(s) : Belanger C , Cardinal T , Leduc E , Viger RS , Pilon N |
| Ref : FASEB Journal , 36 :e22176 , 2022 |
| Abstract : |
| PubMedSearch : Belanger_2022_FASEB.J_36_e22176 |
| PubMedID: 35129866 |
| Gene_locus related to this paper: mouse-f172a , human-f172a |
| Title : FAM172A promotes follicular thyroid carcinogenesis and may be a marker of FTC - Xu_2020_Endocr.Relat.Cancer_27_657 |
| Author(s) : Xu PP , Zeng S , Xia XT , Ye ZH , Li MF , Chen MY , Xia T , Xu JJ , Jiao Q , Liu L , Li LX , Guo MG |
| Ref : Endocr Relat Cancer , 27 :657 , 2020 |
| Abstract : |
| PubMedSearch : Xu_2020_Endocr.Relat.Cancer_27_657 |
| PubMedID: 33095186 |
| Gene_locus related to this paper: mouse-f172a , human-f172a |
| Title : FAM172A inhibits EMT in pancreatic cancer via ERK-MAPK signaling - Chen_2020_Biol.Open_9_bio048462 |
| Author(s) : Chen Y , Liu P , Shen D , Liu H , Xu L , Wang J , Sun H , Wu H |
| Ref : Biol Open , 9 : , 2020 |
| Abstract : |
| PubMedSearch : Chen_2020_Biol.Open_9_bio048462 |
| PubMedID: 31988090 |
| Gene_locus related to this paper: human-f172a |
| Title : The Effect of Protein FAM172A on Proliferation in HepG2 Cells and Investigation of the Possible Molecular Mechanism - Zhao_2019_Anal.Cell.Pathol.(Amst)_2019_5901083 |
| Author(s) : Zhao H , Wang Y , Liu Y , Hao X , Wei H , Xie W |
| Ref : Anal Cell Pathol (Amst) , 2019 :5901083 , 2019 |
| Abstract : |
| PubMedSearch : Zhao_2019_Anal.Cell.Pathol.(Amst)_2019_5901083 |
| PubMedID: 31915594 |
| Gene_locus related to this paper: human-f172a |
| Title : Dysregulation of cotranscriptional alternative splicing underlies CHARGE syndrome - Belanger_2018_Proc.Natl.Acad.Sci.U.S.A_115_E620 |
| Author(s) : Belanger C , Berube-Simard FA , Leduc E , Bernas G , Campeau PM , Lalani SR , Martin DM , Bielas S , Moccia A , Srivastava A , Silversides DW , Pilon N |
| Ref : Proc Natl Acad Sci U S A , 115 :E620 , 2018 |
| Abstract : |
| PubMedSearch : Belanger_2018_Proc.Natl.Acad.Sci.U.S.A_115_E620 |
| PubMedID: 29311329 |
| Gene_locus related to this paper: mouse-f172a , human-f172a |
| Title : Detection of FAM172A expressed in circulating tumor cells is a feasible method to predict high-risk subgroups of colorectal cancer - Cui_2017_Tumour.Biol_39_1010428317699126 |
| Author(s) : Cui CH , Chen RH , Zhai DY , Xie L , Qi J , Yu JL |
| Ref : Tumour Biol , 39 :1010428317699126 , 2017 |
| Abstract : |
| PubMedSearch : Cui_2017_Tumour.Biol_39_1010428317699126 |
| PubMedID: 28618931 |
| Gene_locus related to this paper: human-f172a |
| Title : miR27a promotes proliferation, migration, and invasion of colorectal cancer by targeting FAM172A and acts as a diagnostic and prognostic biomarker - Liu_2017_Oncol.Rep_37_3554 |
| Author(s) : Liu W , Qian K , Wei X , Deng H , Zhao B , Chen Q , Zhang J , Liu H |
| Ref : Oncol Rep , 37 :3554 , 2017 |
| Abstract : |
| PubMedSearch : Liu_2017_Oncol.Rep_37_3554 |
| PubMedID: 28440497 |
| Gene_locus related to this paper: human-f172a |
| Title : FAM172A modulates apoptosis and proliferation of colon cancer cells via STAT1 binding to its promoter - Qian_2016_Oncol.Rep_35_1273 |
| Author(s) : Qian K , Zhang J , Lu J , Liu W , Yao X , Chen Q , Lu S , Xiang G , Liu H |
| Ref : Oncol Rep , 35 :1273 , 2016 |
| Abstract : |
| PubMedSearch : Qian_2016_Oncol.Rep_35_1273 |
| PubMedID: 26676844 |
| Gene_locus related to this paper: human-f172a |
| Title : FAM172A is a tumor suppressor in colorectal carcinoma - Cui_2016_Tumour.Biol_37_6501 |
| Author(s) : Cui C , Ye L , Huang Z , Huang S , Liu H , Yu J |
| Ref : Tumour Biol , 37 :6501 , 2016 |
| Abstract : |
| PubMedSearch : Cui_2016_Tumour.Biol_37_6501 |
| PubMedID: 26637224 |
| Gene_locus related to this paper: human-f172a |
| Title : FAM172A protein promotes the proliferation of human papillary thyroid carcinoma cells via the p38 mitogen-activated protein kinase pathway - Li_2016_Mol.Med.Rep_13_353 |
| Author(s) : Li MF , Zhang R , Guo MG , Li LX , Lu HK , Lu JX , Jia WP |
| Ref : Mol Med Rep , 13 :353 , 2016 |
| Abstract : |
| PubMedSearch : Li_2016_Mol.Med.Rep_13_353 |
| PubMedID: 26573560 |
| Gene_locus related to this paper: human-f172a |
| Title : [Effect of FAM172A protein on apoptosis and proliferation in HEK293 cells] - Li_2010_Zhonghua.Yi.Xue.Za.Zhi_90_2424 |
| Author(s) : Li LX , Zhou WB , Tao Z , Deng WJ , Liang WC , Yang ZH , Ye WW , Bao YQ , Jia WP , Hu RM |
| Ref : Zhonghua Yi Xue Za Zhi , 90 :2424 , 2010 |
| Abstract : |
| PubMedSearch : Li_2010_Zhonghua.Yi.Xue.Za.Zhi_90_2424 |
| PubMedID: 21092515 |
| Gene_locus related to this paper: human-f172a |
| Title : Identification of the novel protein FAM172A, and its up-regulation by high glucose in human aortic smooth muscle cells - Li_2010_Int.J.Mol.Med_26_483 |
| Author(s) : Li L , Dong X , Leong MC , Zhou W , Yang Z , Chen F , Bao Y , Jia W , Hu R |
| Ref : Int J Mol Med , 26 :483 , 2010 |
| Abstract : |
| PubMedSearch : Li_2010_Int.J.Mol.Med_26_483 |
| PubMedID: 20818486 |
| Gene_locus related to this paper: human-f172a |
| Title : [Molecular cloning of a novel gene, C5orf21 gene and its roles in diabetic macroangiopathy] - Li_2009_Zhonghua.Yi.Xue.Za.Zhi_89_2574 |
| Author(s) : Li LX , Tao Z , Dong XH , Liang WC , Yang ZH , Mou B , Bao YQ , Wang C , Jia WP , Hu RM |
| Ref : Zhonghua Yi Xue Za Zhi , 89 :2574 , 2009 |
| Abstract : |
| PubMedSearch : Li_2009_Zhonghua.Yi.Xue.Za.Zhi_89_2574 |
| PubMedID: 20137623 |
| Gene_locus related to this paper: human-f172a |