ATG15-related-lipase
Relationship
Comment
Autophagy-related protein 15. PTHR47175 panther LIPASE ATG15-RELATED (ATG15, AUT5, CVT17), phospholipase activity, macroautophagy, cellular component disassembly. Atg15 is a lipase essential for disintegration of autophagic body membranes and has a transmembrane domain at the N-terminus and a lipase domain at the C-terminus. The N-terminal domain alone can travel to the vacuole. Targeting of the C-terminal lipase domain to the vacuole is required for degradation of autophagic bodies. H435 belongs to the catalytic triad. W466 is important for degradation of autophagic bodies.Database
Interpro : No interpro
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : No Pfam
Prints : No Print
EC Number : No EC Number
References (6)
| Title : The activation mechanism of Atg15, a vacuolar phospholipase required for the disintegration of organelle membranes - Watanabe_2024_Autophagy__1 |
| Author(s) : Watanabe Y , Suzuki K |
| Ref : Autophagy , :1 , 2024 |
| Abstract : Watanabe_2024_Autophagy__1 |
| ESTHER : Watanabe_2024_Autophagy__1 |
| PubMedSearch : Watanabe_2024_Autophagy__1 |
| PubMedID: 38513722 |
| Gene_locus related to this paper: chatd-g0sfg7 |
| Title : The mechanism of Atg15-mediated membrane disruption in autophagy - Kagohashi_2023_J.Cell.Biol_222_e202306120 |
| Author(s) : Kagohashi Y , Sasaki M , May AI , Kawamata T , Ohsumi Y |
| Ref : Journal of Cell Biology , 222 : , 2023 |
| Abstract : Kagohashi_2023_J.Cell.Biol_222_e202306120 |
| ESTHER : Kagohashi_2023_J.Cell.Biol_222_e202306120 |
| PubMedSearch : Kagohashi_2023_J.Cell.Biol_222_e202306120 |
| PubMedID: 37917025 |
| Gene_locus related to this paper: yeast-ATG15 |
| Title : Atg15 in Saccharomyces cerevisiae consists of two functionally distinct domains - Hirata_2021_Mol.Biol.Cell__mbcE20070500 |
| Author(s) : Hirata E , Shirai K , Kawaoka T , Sato K , Kodama F , Suzuki K |
| Ref : Mol Biology of the cell , :mbcE20070500 , 2021 |
| Abstract : Hirata_2021_Mol.Biol.Cell__mbcE20070500 |
| ESTHER : Hirata_2021_Mol.Biol.Cell__mbcE20070500 |
| PubMedSearch : Hirata_2021_Mol.Biol.Cell__mbcE20070500 |
| PubMedID: 33625870 |
| Gene_locus related to this paper: yeast-ATG15 |
| Title : ATG15 encodes a phospholipase and is transcriptionally regulated by YAP1 in Saccharomyces cerevisiae - Ramya_2016_FEBS.Lett_590_3155 |
| Author(s) : Ramya V , Rajasekharan R |
| Ref : FEBS Letters , 590 :3155 , 2016 |
| Abstract : Ramya_2016_FEBS.Lett_590_3155 |
| ESTHER : Ramya_2016_FEBS.Lett_590_3155 |
| PubMedSearch : Ramya_2016_FEBS.Lett_590_3155 |
| PubMedID: 27543826 |
| Gene_locus related to this paper: yeast-ATG15 |
| Title : Degradation of lipid vesicles in the yeast vacuole requires function of Cvt17, a putative lipase - Teter_2001_J.Biol.Chem_276_2083 |
| Author(s) : Teter SA , Eggerton KP , Scott SV , Kim J , Fischer AM , Klionsky DJ |
| Ref : Journal of Biological Chemistry , 276 :2083 , 2001 |
| Abstract : Teter_2001_J.Biol.Chem_276_2083 |
| ESTHER : Teter_2001_J.Biol.Chem_276_2083 |
| PubMedSearch : Teter_2001_J.Biol.Chem_276_2083 |
| PubMedID: 11085977 |
| Gene_locus related to this paper: yeast-ATG15 |
| Title : Aut5\/Cvt17p, a putative lipase essential for disintegration of autophagic bodies inside the vacuole - Epple_2001_J.Bacteriol_183_5942 |
| Author(s) : Epple UD , Suriapranata I , Eskelinen EL , Thumm M |
| Ref : Journal of Bacteriology , 183 :5942 , 2001 |
| Abstract : Epple_2001_J.Bacteriol_183_5942 |
| ESTHER : Epple_2001_J.Bacteriol_183_5942 |
| PubMedSearch : Epple_2001_J.Bacteriol_183_5942 |
| PubMedID: 11566994 |
| Gene_locus related to this paper: yeast-ATG15 |
No structure scheme yet for this family
Genes Proteins in ATG15-related-lipase family (49)
Fragments of genes in ATG15-related-lipase family (1)
No fragment of genesNo substrate
No Inhibitor