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yeast-ATG15

CDS from: Saccharomyces cerevisiae (and strain YJM789) lipase involved in lipid vesicles degradation YCR068W Cytoplasm to vacuole targeting protein 17 ATG15

Comment

Atg15 is a phospholipase B of broad substrate specificity that is likely implicated in the disruption of a range of membrane

Relationship

Family : ATG15-related-lipase

Block : L

Position in NCBI Life Tree : Saccharomyces cerevisiae

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Fungi N E > Dikarya N E > Ascomycota N E > saccharomyceta N E > Saccharomycotina N E > Saccharomycetes N E > Saccharomycetales N E > Saccharomycetaceae N E > Saccharomyces N E > Saccharomyces cerevisiae N E

Molecular evidence

No mutation

No structure

No kinetic

No disease

No substrate

No inhibitor

Database

Sequence

Peptide

MLHKSPSRKR FASPLHLGCI LTLTVLCLIA YYFALPDYLS VGKSSSRGAM DQKSDGTFRL KSIYRHGVGA NHRLHQRLEV TPEVISAAGM LYQETTTQGQ DFEDQEPLWT TNAEYATTNP FDFEFELRRM PLLMKRMKER DPEFIESYIY GETYMTEEEE HAMWIDDDIV APNITDRGTV VSLALMSSNA YVRIPQTGDW RNVTEPWNET EPEDFGWDGD GIRGHVFYNE VENIVVLSIK GTSAQGLPGS GEDETTGNDK INDNLLFSCC CARVSYLWTT VCDCYVKSYI CDESCLEKEL RRKDRFYSAV VDIYKGVLKE YPDAAIWVTG HSLGGALASL LGRTFGLPAV AFESPGELLP SKRLHLPFPP GLPSYMEGIW HFGHNADPIF MGTCNGASSS CSLVGYAMET ACHTGRVCVY DVVNDKGWSV NMFNHRIHKV IDEVLLGYEQ AAKCVEPEPC VDCYNWKFIP SRDWESSSRL ITKTKSHAAP TTTTRTTATT TSSSTCVGRN WLGFCTKYEL

References (10)

Title : The mechanism of Atg15-mediated membrane disruption in autophagy - Kagohashi_2023_J.Cell.Biol_222_e202306120
Author(s) : Kagohashi Y , Sasaki M , May AI , Kawamata T , Ohsumi Y
Ref : Journal of Cell Biology , 222 : , 2023
Abstract :
PubMedSearch : Kagohashi_2023_J.Cell.Biol_222_e202306120
PubMedID: 37917025
Gene_locus related to this paper: yeast-ATG15

Title : Atg15 in Saccharomyces cerevisiae consists of two functionally distinct domains - Hirata_2021_Mol.Biol.Cell__mbcE20070500
Author(s) : Hirata E , Shirai K , Kawaoka T , Sato K , Kodama F , Suzuki K
Ref : Mol Biology of the cell , :mbcE20070500 , 2021
Abstract :
PubMedSearch : Hirata_2021_Mol.Biol.Cell__mbcE20070500
PubMedID: 33625870
Gene_locus related to this paper: yeast-ATG15

Title : ATG15 encodes a phospholipase and is transcriptionally regulated by YAP1 in Saccharomyces cerevisiae - Ramya_2016_FEBS.Lett_590_3155
Author(s) : Ramya V , Rajasekharan R
Ref : FEBS Letters , 590 :3155 , 2016
Abstract :
PubMedSearch : Ramya_2016_FEBS.Lett_590_3155
PubMedID: 27543826
Gene_locus related to this paper: yeast-ATG15

Title : A defect of the vacuolar putative lipase Atg15 accelerates degradation of lipid droplets through lipolysis - Maeda_2015_Autophagy_11_1247
Author(s) : Maeda Y , Oku M , Sakai Y
Ref : Autophagy , 11 :1247 , 2015
Abstract :
PubMedSearch : Maeda_2015_Autophagy_11_1247
PubMedID: 26061644
Gene_locus related to this paper: yeast-ATG15

Title : Genome sequencing and comparative analysis of Saccharomyces cerevisiae strain YJM789 - Wei_2007_Proc.Natl.Acad.Sci.U.S.A_104_12825
Author(s) : Wei W , McCusker JH , Hyman RW , Jones T , Ning Y , Cao Z , Gu Z , Bruno D , Miranda M , Nguyen M , Wilhelmy J , Komp C , Tamse R , Wang X , Jia P , Luedi P , Oefner PJ , David L , Dietrich FS , Li Y , Davis RW , Steinmetz LM
Ref : Proc Natl Acad Sci U S A , 104 :12825 , 2007
Abstract :
PubMedSearch : Wei_2007_Proc.Natl.Acad.Sci.U.S.A_104_12825
PubMedID: 17652520
Gene_locus related to this paper: yeast-AIM2 , yeast-BST1 , yeast-cbpy1 , yeast-cld1 , yeast-ATG15 , yeast-dap1 , yeast-dap2 , yeast-dlhh , yeast-ECM18 , yeast-FSH1 , yeast-FSH3 , yeast-ict1 , yeast-kex01 , yeast-LDH1 , yeast-MCFS1 , yeast-MCFS2 , yeast-met2 , yeast-mgll , yeast-pdat , yeast-ppme1 , yeast-ROG1 , yeast-SAY1 , yeast-tgl1 , yeast-tgl2 , yeast-yby9 , yeast-YDL109C , yeast-YDR428C , yeast-YDR444W , yeast-yfd4 , yeast-yg19 , yeast-yj77 , yeast-yjg8 , yeast-YLL012W , yeast-YLR020C , yeast-YLR118c , yeast-ym60 , yeast-ynl5 , yeast-yo059 , yeast-YPR147C , yeast-hda1

Title : Intravacuolar membrane lysis in Saccharomyces cerevisiae. Does vacuolar targeting of Cvt17\/Aut5p affect its function? - Epple_2003_J.Biol.Chem_278_7810
Author(s) : Epple UD , Eskelinen EL , Thumm M
Ref : Journal of Biological Chemistry , 278 :7810 , 2003
Abstract :
PubMedSearch : Epple_2003_J.Biol.Chem_278_7810
PubMedID: 12499386
Gene_locus related to this paper: yeast-ATG15

Title : Degradation of lipid vesicles in the yeast vacuole requires function of Cvt17, a putative lipase - Teter_2001_J.Biol.Chem_276_2083
Author(s) : Teter SA , Eggerton KP , Scott SV , Kim J , Fischer AM , Klionsky DJ
Ref : Journal of Biological Chemistry , 276 :2083 , 2001
Abstract :
PubMedSearch : Teter_2001_J.Biol.Chem_276_2083
PubMedID: 11085977
Gene_locus related to this paper: yeast-ATG15

Title : Aut5\/Cvt17p, a putative lipase essential for disintegration of autophagic bodies inside the vacuole - Epple_2001_J.Bacteriol_183_5942
Author(s) : Epple UD , Suriapranata I , Eskelinen EL , Thumm M
Ref : Journal of Bacteriology , 183 :5942 , 2001
Abstract :
PubMedSearch : Epple_2001_J.Bacteriol_183_5942
PubMedID: 11566994
Gene_locus related to this paper: yeast-ATG15

Title : Life with 6000 genes - Goffeau_1996_Science_274_563
Author(s) : Goffeau A , Barrell BG , Bussey H , Davis RW , Dujon B , Feldmann H , Galibert F , Hoheisel JD , Jacq C , Johnston M , Louis EJ , Mewes HW , Murakami Y , Philippsen P , Tettelin H , Oliver SG
Ref : Science , 274 :546 , 1996
Abstract :
PubMedSearch : Goffeau_1996_Science_274_563
PubMedID: 8849441
Gene_locus related to this paper: yeast-ATG15 , yeast-SAY1

Title : The complete DNA sequence of yeast chromosome III - Oliver_1992_Nature_357_38
Author(s) : Oliver SG , van der Aart QJ , Agostoni-Carbone ML , Aigle M , Alberghina L , Alexandraki D , Antoine G , Anwar R , Ballesta JP , Benit P , et al.
Ref : Nature , 357 :38 , 1992
Abstract :
PubMedSearch : Oliver_1992_Nature_357_38
PubMedID: 1574125
Gene_locus related to this paper: yeast-ATG15