ATG15-related-lipase
Relationship
Comment
Autophagy-related protein 15. PTHR47175 panther LIPASE ATG15-RELATED (ATG15, AUT5, CVT17), phospholipase activity, macroautophagy, cellular component disassembly. Atg15 is a lipase essential for disintegration of autophagic body membranes and has a transmembrane domain at the N-terminus and a lipase domain at the C-terminus. The N-terminal domain alone can travel to the vacuole. Targeting of the C-terminal lipase domain to the vacuole is required for degradation of autophagic bodies. H435 belongs to the catalytic triad. W466 is important for degradation of autophagic bodies.
Database
Interpro : IPR050805 ATG15 Lipase
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : No Pfam
Prints : No Print
EC Number : No EC Number
Sequences
| Peptide in | Fasta |
| Nucleotide in | Fasta |
| Alignment with Multalin | Text only |
| Seed alignment with MAFFT | No colour / coloured with Mview |
| Alignment with MAFFT | No colour / coloured with Mview |
| Dendrogram | The dnd file |
| Gene_locus | Name | Species |
|---|---|---|
| 9basi-a0a3g2sas0 | Malassezia restricta CBS 7877. Lipase ATG15 | Malassezia restricta CBS 7877 |
| 9euro-w2s4w2 | Cyphellophora europaea CBS 101466. Fungal lipase-like domain-containing protein | Cyphellophora europaea CBS 101466 |
| ajecn-atg15 | Ajellomyces capsulata (strain NAm1 \/ WU24) (Darling's disease fungus) (Histoplasma capsulatum) Autophagy-related protein 15 | Ajellomyces capsulata |
| ashgo-q75en3 | Ashbya gossypii (Yeast) (Eremothecium gossypii) aar046cp putative lipase atg15 (EC 3.1.1.3) (autophagy-related protein 15) | Ashbya gossypii |
| aspcl-atg15 | Aspergillus clavatus Autophagy-related protein 15 | Aspergillus clavatus |
| aspfu-atg15 | Aspergillus fumigatus (Sartorya fumigata) putative lipase atg15 (EC 3.1.1.3) (autophagy-related protein 15) | Aspergillus fumigatus |
| aspnc-atg15 | Aspergillus niger (strain CBS 513.88 \/ FGSC A1513) Autophagy-related protein 15 | Aspergillus niger |
| aspoz-e9rh17 | Aspergillus oryzae (Yellow koji mold). Lipase class 3 | Aspergillus oryzae |
| asptn-atg15 | Aspergillus terreus (strain NIH 2624 \/ FGSC A1156) Autophagy-related protein 15 | Aspergillus terreus |
| botpv-r1exw1 | Botryosphaeria parva (strain UCR-NP2) (Grapevine canker fungus) (Neofusicoccum parvum). Putative autophagy related lipase protein | Botryosphaeria parva |
| canal-ATG15 | Candida albicans (Yeast), Candida tropicalis, Candida dubliniensis, putative lipase atg15 (EC 3.1.1.3) (autophagy-related protein 15) | Candida albicans |
| canga-q6fpi6 | Candida glabrata (Yeast) (Torulopsis glabrata) putative lipase atg15 (EC 3.1.1.3) (autophagy-related protein 15) | Candida glabrata |
| chagb-atg15 | Chaetomium globosum (Soil fungus) Autophagy-related protein 15 | Chaetomium globosum |
| chatd-g0sfg7 | Chaetomium thermophilum (strain DSM 1495 \/ CBS 144.50 \/ IMI 039719) (Thermochaetoides thermophila). Putative lysis of subvacuolar cytoplasm to vacuole targeted bodies protein | Chaetomium thermophilum |
| clafu-PSI7 | Cladosporium fulvum (Fulvia fulva) psi-7 protein | Cladosporium fulvum |
| clap2-m1w670 | Claviceps purpurea (strain 20.1) (Ergot fungus) (Sphacelia segetum). Related to starvation induced protein PSI-7 | Claviceps purpurea |
| cocim-atg15 | Coccidioides immitis (Valley fever fungus) Autophagy-related protein 15 | Coccidioides immitis |
| colgm-e3q8b3 | Colletotrichum graminicola (strain M1.001 \/ M2 \/ FGSC 10212) (Maize anthracnose fungus) (Glomerella graminicola). Fungal lipase-like domain-containing protein | Colletotrichum graminicola |
| cryne-q5kl13 | Cryptococcus neoformans var. neoformans JEC21 (and B-3501A) lipase, putative | Cryptococcus neoformans |
| debha-atg15 | Debaryomyces hansenii (Yeast) (Torulaspora hansenii) Autophagy-related protein 15 | Debaryomyces hansenii |
| emeni-atg15 | Emericella nidulans (Aspergillus nidulans) putative lipase atg15 (EC 3.1.1.3) (autophagy-related protein 15) | Emericella nidulans |
| gibze-I1RFN8 | Gibberella zeae (Fusarium graminearum) Putative lipase ATG15 | Gibberella zeae |
| glal2-s3de12 | Glarea lozoyensis (strain ATCC 20868 \/ MF5171). Alpha\/beta-Hydrolase | Glarea lozoyensis |
| hypai-g9nkx5 | Hypocrea atroviridis (strain ATCC 20476 \/ IMI 206040) (Trichoderma atroviride). Fungal lipase-like domain-containing protein | Hypocrea atroviridis |
| klula-q6cu02 | Kluyveromyces lactis (Yeast) putative lipase atg15 (EC 3.1.1.3) (autophagy-related protein 15) | Kluyveromyces lactis |
| lodel-atg15 | Lodderomyces elongisporus (Yeast) (Saccharomyces elongisporus) Autophagy-related protein 15 | Lodderomyces elongisporus |
| macph-k2s6r2 | Macrophomina phaseolina (strain MS6) (Charcoal rot fungus). Lipase class 3 | Macrophomina phaseolina |
| mago7-g4n703 | Magnaporthe oryzae (strain 70-15 \/ ATCC MYA-4617 \/ FGSC 8958) (Rice blast fungus) (Pyricularia oryzae). Fungal lipase-like domain-containing protein | Magnaporthe oryzae |
| marbu-k1wxv8 | Marssonina brunnea f. sp. multigermtubi (strain MB_m1) (Marssonina leaf spot fungus). Autophagy related lipase | Marssonina brunnea f. sp. multigermtubi |
| metaq-e9e9z0 | Metarhizium acridum (strain CQMa 102). Autophagy related lipase | Metarhizium acridum |
| muccl-a0a168jlm0 | Mucor circinelloides f. lusitanicus CBS 277.49. Lipase_3 domain-containing protein | Mucor circinelloides f. lusitanicus CBS 277.49 |
| muccl-a0a168jxt4 | Mucor circinelloides f. lusitanicus CBS 277.49. Lipase_3 domain-containing protein | Mucor circinelloides f. lusitanicus CBS 277.49 |
| neofi-atg15 | Neosartorya fischeri (strain ATCC 1020 \/ DSM 3700 \/ FGSC A1164 \/ NRR181) (Aspergillus fischerianus)) Autophagy-related protein 15 | Neosartorya fischeri |
| neucr-ATG15 | Neurospora crassa Putative lipase atg-15 | Neurospora crassa |
| ophp1-s3cys3 | Ophiostoma piceae (strain UAMH 11346) (Sap stain fungus). Autophagy protein atg15 | Ophiostoma piceae |
| pencw-atg15 | Penicillium chrysogenum (strain ATCC 28089 \/ DSM 1075 \/ Wisconsin 54-1255) (Penicillium notatum) Autophagy-related protein 15 | Penicillium chrysogenum |
| penen-a0a0a2kjd4 | Penicillium expansum (Blue mold rot fungus). Lipase, class 3 | Penicillium expansum |
| phano-at151 | Phaeosphaeria nodorum (Glume blotch fungus) (Septoria nodorum) Autophagy-related protein 15 | Phaeosphaeria nodorum |
| pican-atg15 | Pichia angusta (Yeast) (Hansenula polymorpha) Autophagy-related protein 15 | Pichia angusta |
| picgu-atg15 | Pichia guilliermondii (Yeast) (Candida guilliermondii) Autophagy-related protein 15 | Pichia guilliermondii |
| picst-atg15 | Pichia stipitis (Yeast) Autophagy-related protein 15 | Pichia stipitis |
| pnemu-m7nsb0 | Pneumocystis murina (strain B123) (Mouse pneumocystis pneumonia agent) (Pneumocystis carinii f. sp. muris). Fungal lipase-like domain-containing protein | Pneumocystis murina |
| schpo-C23C4.16C | Schizosaccharomyces pombe (Fission yeast) hypothetical 47.9 kda protein c23c4.16c in chromosome I (autophagy-related protein 15) | Schizosaccharomyces pombe |
| scls1-a7ecx1 | Sclerotinia sclerotiorum (strain ATCC 18683 \/ 1980 \/ Ss-1) (White mold) (Whetzelinia sclerotiorum). Fungal lipase-like domain-containing protein | Sclerotinia sclerotiorum |
| talmq-b6qp22 | Talaromyces marneffei (strain ATCC 18224 \/ CBS 334.59 \/ QM 7333) (Penicillium marneffei). Fungal lipase-like domain-containing protein | Talaromyces marneffei |
| ustma-q4phz2 | Ustilago maydis (strain 521 \/ FGSC 9021) (Corn smut fungus) hypothetical protein | Ustilago maydis 521 |
| vanpo-atg15 | Vanderwaltozyma polyspora (strain ATCC 22028 \/ DSM 70294) (Kluyveromyces polysporus) Autophagy-related protein 15 | Vanderwaltozyma polyspora |
| yarli-atg15 | Yarrowia lipolytica (Candida lipolytica) putative lipase atg15 (EC 3.1.1.3) (autophagy-related protein 15) | Yarrowia lipolytica |
| yeast-ATG15 | CDS from: Saccharomyces cerevisiae (and strain YJM789) lipase involved in lipid vesicles degradation YCR068W Cytoplasm to vacuole targeting protein 17 ATG15 | Saccharomyces cerevisiae |
| Gene_locus_frgt | Name | Species |
|---|---|---|
| enccu-Q8SVV1 | Encephalitozoon cuniculi hypothetical protein ecu04_0660 | Encephalitozoon cuniculi |
References (6)
| Title : The activation mechanism of Atg15, a vacuolar phospholipase required for the disintegration of organelle membranes - Watanabe_2024_Autophagy__1 |
| Author(s) : Watanabe Y , Suzuki K |
| Ref : Autophagy , :1 , 2024 |
| Abstract : |
| PubMedSearch : Watanabe_2024_Autophagy__1 |
| PubMedID: 38513722 |
| Gene_locus related to this paper: chatd-g0sfg7 |
| Title : The mechanism of Atg15-mediated membrane disruption in autophagy - Kagohashi_2023_J.Cell.Biol_222_e202306120 |
| Author(s) : Kagohashi Y , Sasaki M , May AI , Kawamata T , Ohsumi Y |
| Ref : Journal of Cell Biology , 222 : , 2023 |
| Abstract : |
| PubMedSearch : Kagohashi_2023_J.Cell.Biol_222_e202306120 |
| PubMedID: 37917025 |
| Gene_locus related to this paper: yeast-ATG15 |
| Title : Atg15 in Saccharomyces cerevisiae consists of two functionally distinct domains - Hirata_2021_Mol.Biol.Cell__mbcE20070500 |
| Author(s) : Hirata E , Shirai K , Kawaoka T , Sato K , Kodama F , Suzuki K |
| Ref : Mol Biology of the cell , :mbcE20070500 , 2021 |
| Abstract : |
| PubMedSearch : Hirata_2021_Mol.Biol.Cell__mbcE20070500 |
| PubMedID: 33625870 |
| Gene_locus related to this paper: yeast-ATG15 |
| Title : ATG15 encodes a phospholipase and is transcriptionally regulated by YAP1 in Saccharomyces cerevisiae - Ramya_2016_FEBS.Lett_590_3155 |
| Author(s) : Ramya V , Rajasekharan R |
| Ref : FEBS Letters , 590 :3155 , 2016 |
| Abstract : |
| PubMedSearch : Ramya_2016_FEBS.Lett_590_3155 |
| PubMedID: 27543826 |
| Gene_locus related to this paper: yeast-ATG15 |
| Title : Degradation of lipid vesicles in the yeast vacuole requires function of Cvt17, a putative lipase - Teter_2001_J.Biol.Chem_276_2083 |
| Author(s) : Teter SA , Eggerton KP , Scott SV , Kim J , Fischer AM , Klionsky DJ |
| Ref : Journal of Biological Chemistry , 276 :2083 , 2001 |
| Abstract : |
| PubMedSearch : Teter_2001_J.Biol.Chem_276_2083 |
| PubMedID: 11085977 |
| Gene_locus related to this paper: yeast-ATG15 |
| Title : Aut5\/Cvt17p, a putative lipase essential for disintegration of autophagic bodies inside the vacuole - Epple_2001_J.Bacteriol_183_5942 |
| Author(s) : Epple UD , Suriapranata I , Eskelinen EL , Thumm M |
| Ref : Journal of Bacteriology , 183 :5942 , 2001 |
| Abstract : |
| PubMedSearch : Epple_2001_J.Bacteriol_183_5942 |
| PubMedID: 11566994 |
| Gene_locus related to this paper: yeast-ATG15 |