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Family Report for: GTSAGmotif


Family GTSAGmotif
Block H
Sequences of lipases from metagenomic library were grouped in a new subset of Alphabeta hydrolase fold-3 (Arpigny_Jaeger Family_IV). Most sequences have a G(TDC)SA(G)G motif encompassing the active site serine.

IPR013094 (Alpha/beta hydrolase fold-3)
PF07859 (Abhydrolase_3)
no EC number

Peptide in
Nucleotide in
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
|Graphical display, obtained with the dnd file produced by Clustalw

2 more
    Title: Crystal structure of PMGL2 esterase from the hormone-sensitive lipase family with GCSAG motif around the catalytic serine
    Boyko KM, Kryukova MV, Petrovskaya LE, Nikolaeva AY, Korzhenevsky DA, Novototskaya-Vlasova KA, Rivkina EM, Dolgikh DA, Kirpichnikov MP, Popov VO
    Ref: PLoS ONE, 15:e0226838, 2020 : PubMed


    Title: Expression and characterization of a new esterase with GCSAG motif from a permafrost metagenomic library
    Petrovskaya LE, Novototskaya-Vlasova KA, Spirina EV, Durdenko EV, Lomakina GY, Zavialova MG, Nikolaev EN, Rivkina EM
    Ref: FEMS Microbiol Ecol, 92:, 2016 : PubMed


    Title: Structural Basis for Dimerization and Catalysis of a Novel Esterase from the GTSAG Motif Subfamily of the Bacterial Hormone-sensitive Lipase Family
    Li PY, Ji P, Li CY, Zhang Y, Wang GL, Zhang XY, Xie BB, Qin QL, Chen XL and Zhang YZ <1 more author(s)>
    Ref: Journal of Biological Chemistry, 289:19031, 2014 : PubMed


Other Papers

Structure scheme for GTSAGmotif

Structures in GTSAGmotif family (5)

Genes Proteins in GTSAGmotif family (112)

Fragments of genes in GTSAGmotif family (9)

Substrates of some enzymes in the GTSAGmotif family (6)

Inhibitors of some enzymes in the GTSAGmotif family (1)

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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