PhaC_cen_dom
Relationship
Comment
(The family Pha_synthase was split in four families (PHA_synth_I, PHA_synth_II, PHA_synth_III, PhaC_cen_dom ) according to Interpro and Tigrpfam. PhaC_cen_dom groups enzyme with the central domain but not the class I,II,III domains)This entry represents the central domain of the bacterial poly-beta-hydroxybutyrate polymerase (PhaC). Polyhydroxyalkanoic acids (PHAs) are carbon and energy reserve polymers produced in some bacteria when carbon sources are plentiful and another nutrient, such as nitrogen, phosphate, oxygen, or sulphur, becomes limiting. PHAs composed of monomeric units ranging from 3 to 14 carbons exist in nature. When the carbon source is exhausted, PHA is utilised by the bacterium. PhaC links D-(-)-3-hydroxybutyrl-CoA to an existing PHA molecule by the formation of an ester bond. Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus. This entry represents the central domain of the bacterial poly-beta-hydroxybutyrate polymerase (PhaC). Polyhydroxyalkanoic acids (PHAs) are carbon and energy reserve polymers produced in some bacteria when carbon sources are plentiful and another nutrient, such as nitrogen, phosphate, oxygen, or sulphur, becomes limiting. PHAs composed of monomeric units ranging from 3 to 14 carbons exist in nature. When the carbon source is exhausted, PHA is utilised by the bacterium. PhaC links D-(-)-3-hydroxybutyrl-CoA to an existing PHA molecule by the formation of an ester bond PHA_synth_I TIGR01838 PHA_synth_II TIGR01839. The nucleophilic residue of the catalytic triad is a cysteine (with exceptions)
Database
Interpro : IPR010941 PhaC_cen_dom Poly-beta-hydroxybutyrate polymerase, central domain
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : PF07167 PhaC_N
Prints : No Print
EC Number : No EC Number
Sequences
| Peptide in | Fasta |
| Nucleotide in | Fasta |
| Alignment with Multalin | Text only |
| Seed alignment with MAFFT | No colour / coloured with Mview |
| Alignment with MAFFT | No colour / coloured with Mview |
| Dendrogram | The dnd file |
| Gene_locus | Name | Species |
|---|---|---|
| 9brad-q35fu4 | Bradyrhizobium sp. BTAi1 probable poly-beta-hydroxybutyrate polymerase | Bradyrhizobium sp. BTAi1 |
| 9brad-q355g0 | Bradyrhizobium sp. BTAi1 poly(3-hydroxyalkanoate) polymerase family protein | Bradyrhizobium sp. BTAi1 |
| 9burk-q3fd95 | Burkholderia ambifaria AMMD Alpha\/beta hydrolase fold:Poly-beta-hydroxybutyrate polymerase, N-terminal | Burkholderia ambifaria AMMD |
| 9burk-q4b3g8 | Polaromonas sp. JS666 terminal | Polaromonas sp. JS666 |
| 9gamm-q34zq5 | Alkalilimnicola ehrlichei MLHE-1 poly(3-hydroxyalkanoate) polymerase family protein | Alkalilimnicola ehrlichei MLHE-1 |
| 9gamm-q350p6 | Alkalilimnicola ehrlichei MLHE-1 poly-beta-hydroxybutyrate synthase | Alkalilimnicola ehrlichei MLHE-1 |
| acicj-a5g2y8 | Acidiphilium cryptum JF-5 putative poly-beta-hydroxyalkanoate synthase | Acidiphilium cryptum JF-5 |
| hydte-a0a2z6dwt1 | Hydrogenophilus thermoluteolus (Pseudomonas hydrogenothermophila) Poly-beta-hydroxybutyrate polymerase | Hydrogenophilus thermoluteolus |
| aroae-q5p0w7 | Aromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1)) poly-beta-hydroxybutyrate synthase | Aromatoleum aromaticum EbN1 |
| aroae-q5p115 | Aromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1)) putative poly-beta-hydroxyalkanoate synthase | Aromatoleum aromaticum EbN1 |
| braja-bll6073 | Bradyrhizobium japonicum phbc protein | Bradyrhizobium japonicum |
| brasb-a5esl7 | Bradyrhizobium sp. (strain BTAi1 \/ ATCC BAA-1182) poly-beta-hydroxybutyrate polymerase | Bradyrhizobium sp. BTAi1 |
| burma-q62eb8 | Burkholderia mallei (Pseudomonas mallei), Burkholderia pseudomallei (Pseudomonas pseudomallei), Burkholderia thailandensis poly-beta-hydroxybutyrate polymerase (EC 2.3.1.-) | Burkholderia mallei |
| burvg-a4jsh6 | Burkholderia vietnamiensis (strain G4 \/ LMG 22486) (Burkholderia cepacia (strain R1808)) Alpha\/beta hydrolase fold:Poly-beta-hydroxybutyrate polymerase, N-terminal | Burkholderia vietnamiensis G4 |
| decar-q47hd2 | Dechloromonas aromatica (strain RCB) terminal | Dechloromonas aromatica |
| 9gamm-a0a265du41 | Halomonas boliviensis LC1 Poly-beta-hydroxybutyrate polymerase | Halomonas boliviensis LC1 |
| 9gamm-a0a265dzk1 | Halomonas boliviensis LC1 Poly-beta-hydroxybutyrate polymerase | Halomonas boliviensis LC1 |
| ectha-q2cqy0 | Halorhodospira halophila SL1 poly(3-hydroxyalkanoate) polymerase family protein | Halorhodospira halophila SL1 |
| hahch-q2spi5 | Hahella chejuensis (strain KCTC 2396) poly(3-hydroxyalkanoate) synthetase | Hahella chejuensis |
| legpa-q5x2r4 | Legionella pneumophila, Polyhydroxyalkanoic synthase phbC | Legionella pneumophila |
| legpa-q5x3j6 | Legionella pneumophila (strain Paris) hypothetical protein | Legionella pneumophila |
| legpa-q5x322 | Legionella pneumophila PHA synthase | Legionella pneumophila |
| legph-q5zwi8 | Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 polyhydroxyalkanoic synthase (EC 2.3.1.-) | Legionella pneumophila subsp. pneumophila |
| pardp-a1b9s7 | Paracoccus denitrificans (strain Pd 1222) Poly-beta-hydroxybutyrate polymerase domain protein | Paracoccus denitrificans |
| pardp-a1bcb9 | Paracoccus denitrificans (strain Pd 1222) Poly-beta-hydroxybutyrate polymerase domain protein | Paracoccus denitrificans |
| ralme-q1lcz5 | Ralstonia metallidurans (strain CH34 \/ ATCC 43123 \/ DSM 2839) poly-beta-hydroxybutyrate polymerase-like protein | Ralstonia metallidurans |
| rhofd-q21u70 | Rhodoferax ferrireducens (strain DSM 15236 \/ ATCC BAA-621 \/ T118) poly-beta-hydroxybutyrate polymerase-like | Rhodoferax ferrireducens |
| rhop2-q2j0d2 | Rhodopseudomonas palustris (strain HaA2) poly-beta-hydroxybutyrate synthase | Rhodopseudomonas palustris |
| rhopa-q6n209 | Rhodopseudomonas palustris putative poly-beta-hydroxyalkanoate synthase | Rhodopseudomonas palustris |
| rhopa-q37lc6 | Rhodopseudomonas palustris BisB5 terminal | Rhodopseudomonas palustris BisB5 |
| rhopa-q374l7 | Rhodopseudomonas palustris BisA53 hydroxybutyrate polymerase, n-terminal | Rhodopseudomonas palustris BisA53 |
| rhopb-q20z62 | Rhodopseudomonas palustris (strain BisB18) poly-beta-hydroxybutyrate polymerase-like | Rhodopseudomonas palustris |
| rhos4-q3iye8 | Rhodobacter sphaeroides, putative polyhydroxyalkanoic synthase, pha synthase | Rhodobacter sphaeroides |
| silpo-q5lws0 | Silicibacter pomeroyi poly(3-hydroxyalkanoate) polymerase family protein | Silicibacter pomeroyi |
| xanp2-a7igw0 | Xanthobacter autotrophicus (strain ATCC BAA-1158 \/ Py2) putative polymerase | Xanthobacter sp. |
| Gene_locus_frgt | Name | Species |
|---|---|---|
| 9bact-q4h1y5 | uncultured bacterium pha synthase (fragment) | uncultured bacterium |
| 9prot-q7x588 | Rhodocista pekingensis polyhydroxyalkanoates synthase (fragment) | Rhodocista pekingensis |
| 9psed-q4jhn4 | Pseudomonas sp. PC17 phac2 (fragment) | Pseudomonas sp. PC17 |
References (3)
| Title : Polyhydroxyalkanoate synthase (PhaC): The key enzyme for biopolyester synthesis - Neoh_2022_Curr.Res.Biotechnol_4_87 |
| Author(s) : Neoh SZ , Chek MF , Tan HT , Linares-Pasten JA , Nandakumar A , Hakoshima T , Sudesh K |
| Ref : Current Research in Biotechnology , 4 :87 , 2022 |
| Abstract : |
| PubMedSearch : Neoh_2022_Curr.Res.Biotechnol_4_87 |
| PubMedID: |
| Title : Polyester synthases: natural catalysts for plastics - Rehm_2003_Biochem.J_376_15 |
| Author(s) : Rehm BH |
| Ref : Biochemical Journal , 376 :15 , 2003 |
| Abstract : |
| PubMedSearch : Rehm_2003_Biochem.J_376_15 |
| PubMedID: 12954080 |
| Title : Cloning, molecular analysis, and expression of the polyhydroxyalkanoic acid synthase (phaC) gene from Chromobacterium violaceum - Kolibachuk_1999_Appl.Environ.Microbiol_65_3561 |
| Author(s) : Kolibachuk D , Miller A , Dennis D |
| Ref : Applied Environmental Microbiology , 65 :3561 , 1999 |
| Abstract : |
| PubMedSearch : Kolibachuk_1999_Appl.Environ.Microbiol_65_3561 |
| PubMedID: 10427049 |
| Gene_locus related to this paper: chrvi-PHAC , vibpa-PHAC |