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Family Report for: S9N_PPCE_Peptidase_S9

S9N_PPCE_Peptidase_S9



Relationship
Block X
Parent Family : Peptidase_S9

Comment
prolyl oligopeptidase (EC 3.4.21.26) (also called post-proline cleaving enzyme PPCE, Prolyl endopeptidase PE, prolyl oligopeptidase POP). Prolyl oligopeptidases are either located in the cytosol or they are membrane bound, where they cleave peptide bonds with prolyl P1 specificities (but cleavage of alanyl bonds has been detected). The proline must adopt a trans con- figuration within the chain. Peptides of up to 30 residues are cleaved. N-terminal domain is a 7-bladed beta-propeller

Database
Sequences
Interpro
|
IPR004106 (Peptidase S9A/B/C, oligopeptidase, N-terminal beta-propeller), IPR001375 (Peptidase_S9)
PIRSF
|
Pdoc
|
PFam
|
PF00326 (Peptidase_S9), PF02897 (Peptidase_S9_N)
Prints
|
Prosite
|
no EC number



Peptide in
|Fasta
Nucleotide in
|Fasta
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
Dendrogram
|Graphical display, obtained with the dnd file produced by Clustalw

References
3 more
    Title: The prolyl oligopeptidase family
    Polgar L
    Ref: Cell Mol Life Sciences, 59:349, 2002 : PubMed

            

    Title: Catalysis of serine oligopeptidases is controlled by a gating filter mechanism
    Fulop V, Szeltner Z, Polgar L
    Ref: EMBO Rep, 1:277, 2000 : PubMed

            

    Title: Prolyl oligopeptidase: an unusual beta-propeller domain regulates proteolysis
    Fulop V, Bocskei Z, Polgar L
    Ref: Cell, 94:161, 1998 : PubMed

            

Other Papers


No structure scheme yet for this family

Structures in S9N_PPCE_Peptidase_S9 family (66)

Genes Proteins in S9N_PPCE_Peptidase_S9 family (143)

Fragments of genes in S9N_PPCE_Peptidase_S9 family (3)

Substrates of some enzymes in the S9N_PPCE_Peptidase_S9 family (10)

Inhibitors of some enzymes in the S9N_PPCE_Peptidase_S9 family (30)



Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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