Peptidase_S9

Relationship

Family: Peptidase_S9

Block: X

Parent Family: No family

Comment

Previously called Prolyl_oligopeptidase_S9 (but are not only prolyl peptidase) Peptidase_S9 are serine protease of the clan S family S9 in MEROPS database. It contains: - prolyl oligopeptidase (EC 3.4.21.26) (also called post-proline cleaving enzyme);- Escherichia coli protease II (EC 3.4.21.83) (oligopeptidase B) (gene prtB);- dipeptidyl petidase IV related proteins(EC 3.4.14.5) (DPP IV) important for the activation or inactivation of extracellular endocrine paracrine and autocrine peptides. DPPIV is synonymous with CD26 (important in HIV infection). Some members lack active serine and are probably not enzymes. The prototype structure has a beta propeller which guide substrates to the active site;- Yeast vacuolar dipeptidyl aminopeptidase A;- Acylamino-acid-releasing enzyme (EC 3.4.19.1) (acyl-peptide hydrolase).

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

No structure scheme yet for this family

No Genes Proteins

No fragment of genes

No fragment of genes

No substrate

No Inhibitor

References (6)

Title : The dipeptidyl peptidase IV family in cancer and cell biology - Yu_2010_FEBS.J_277_1126
Author(s) : Yu DM , Yao TW , Chowdhury S , Nadvi NA , Osborne B , Church WB , McCaughan GW , Gorrell MD
Ref : Febs J , 277 :1126 , 2010
PubMedID: 20074209

Title : Cloning and characterization of dipeptidyl peptidase 10, a new member of an emerging subgroup of serine proteases - Qi_2003_Biochem.J_373_179
Author(s) : Qi SY , Riviere PJ , Trojnar J , Junien JL , Akinsanya KO
Ref : Biochemical Journal , 373 :179 , 2003
PubMedID: 12662155
Gene_locus related to this paper: human-DPP8 , human-DPP9 , human-DPP10 , mouse-dpp9 , mouse-dpp10

Title : The prolyl oligopeptidase family - Polgar_2002_Cell.Mol.Life.Sci_59_349
Author(s) : Polgar L
Ref : Cell Mol Life Sciences , 59 :349 , 2002
PubMedID: 11915948

Title : Catalysis of serine oligopeptidases is controlled by a gating filter mechanism - Fulop_2000_EMBO.Rep_1_277
Author(s) : Fulop V , Szeltner Z , Polgar L
Ref : EMBO Rep , 1 :277 , 2000
PubMedID: 11256612
Gene_locus related to this paper: pig-ppce

Title : Families of serine peptidases -
Author(s) : Rawlings ND , Barrett AJ
Ref : Methods Enzymol , 244 :19 , 1994
PubMedID: 7845208

Title : Structural relationship between lipases and peptidases of the prolyl oligopeptidase family - Polgar_1992_FEBS.Lett_311_281
Author(s) : Polgar L
Ref : FEBS Letters , 311 :281 , 1992
PubMedID: 1397329