9cary-r4p353

Gypsophila vaccaria Prolyl endopeptidase Pcy1

Comment

Relationship

Block : X

Position in NCBI Life Tree : Gypsophila vaccaria

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Viridiplantae N E > Streptophyta N E > Streptophytina N E > Embryophyta N E > Tracheophyta N E > Euphyllophyta N E > Spermatophyta N E > Magnoliophyta N E > Mesangiospermae N E > eudicotyledons N E > Gunneridae N E > Pentapetalae N E > Caryophyllales N E > Caryophyllaceae N E > Caryophylleae N E > Gypsophila N E > Gypsophila vaccaria N E

Molecular evidence

No mutation

5O3U - Structural characterization of the fast and promiscuous macrocyclase from plant - PCY1-S562A bound to Presegetalin F1 5O3V - Structural characterization of the fast and promiscuous macrocyclase from plant Gypsophila vaccaria (Cow soapwort) - PCY1-S562A bound to Presegetalin B1 5O3W - Structural characterization of the fast and promiscuous macrocyclase from plant Gypsophila vaccaria (Cow soapwort) - PCY1-S562A bound to Presegetalin A1 5O3X - Structural characterization of the fast and promiscuous macrocyclase from plant Gypsophila vaccaria (Cow soapwort) - apo PCY1 5UW3 - Gypsophila vaccaria (Cow soapwort) macrocyclase PCY1 involved in the biosynthesis of RiPP cyclic peptide in complex with follower peptide 5UW5 - Gypsophila vaccaria (Cow soapwort) macrocyclase PCY1 involved in the biosynthesis of RiPP cyclic peptide PCY1 H695A Variant in Complex with Follower Peptide 5UW6 - Gypsophila vaccaria (Cow soapwort) macrocyclase PCY1 involved in the biosynthesis of RiPP cyclic peptide in complex with follower peptide and covalent inhibitor ZPP 5UW7 - PCY1 Y481F Variant in Complex with Follower Peptidee 5UZW - PCY1 G696Insertion Variant in Complex with Follower Peptide and the Covalent Inhibitor ZPP Z-Pro-Prolinal

No kinetic

No disease

No substrate

Follower-Peptide-Presegetalin-A1 Presegetalin-A1 Presegetalin-B1 Presegetalin-F1

Database

AGL51088

R4P353

Sequence

Peptide

MATSGFSKPL HYPPVRRDET VVDDYFGVKV ADPYRWLEDP NSEETKEFVD NQEKLANSVL EECELIDKFK QKIIDFVNFP RCGVPFRRAN KYFHFYNSGL QAQNVFQMQD DLDGKPEVLY DPNLREGGRS GLSLYSVSED AKYFAFGIHS GLTEWVTIKI LKTEDRSYLP DTLEWVKFSP AIWTHDNKGF FYCPYPPLKE GEDHMTRSAV NQEARYHFLG TDQSEDILLW RDLENPAHHL KCQITDDGKY FLLYILDGCD DANKVYCLDL TKLPNGLESF RGREDSAPFM KLIDSFDASY TAIANDGSVF TFQTNKDAPR KKLVRVDLNN PSVWTDLVPE SKKDLLESAH AVNENQLILR YLSDVKHVLE IRDLESGALQ HRLPIDIGSV DGITARRRDS VVFFKFTSIL TPGIVYQCDL KNDPTQLKIF RESVVPDFDR SEFEVKQVFV PSKDGTKIPI FIAARKGISL DGSHPCEMHG YGGFGINMMP TFSASRIVFL KHLGGVFCLA NIRGGGEYGE EWHKAGFRDK KQNVFDDFIS AAEYLISSGY TKARRVAIEG GSNGGLLVAA CINQRPDLFG CAEANCGVMD MLRFHKFTLG YLWTGDYGCS DKEEEFKWLI KYSPIHNVRR PWEQPGNEET QYPATMILTA DHDDRVVPLH SFKLLATMQH VLCTSLEDSP QKNPIIARIQ RKAAHYGRAT MTQIAEVADR YGFMAKALEA PWID

References (3)

Title : Characterization of the Fast and Promiscuous Macrocyclase from Plant PCY1 Enables the Use of Simple Substrates - Ludewig_2018_ACS.Chem.Biol_13_801

Author(s) : Ludewig H , Czekster CM , Oueis E , Munday ES , Arshad M , Synowsky SA , Bent AF , Naismith JH

Ref : ACS Chemical Biology , 13 :801 , 2018

Abstract :

PubMedSearch : Ludewig_2018_ACS.Chem.Biol_13_801

PubMedID: 29377663

Gene_locus related to this paper: 9cary-r4p353

Title : Characterization of the macrocyclase involved in the biosynthesis of RiPP cyclic peptides in plants - Chekan_2017_Proc.Natl.Acad.Sci.U.S.A_114_6551

Author(s) : Chekan JR , Estrada P , Covello PS , Nair SK

Ref : Proc Natl Acad Sci U S A , 114 :6551 , 2017

Abstract :

PubMedSearch : Chekan_2017_Proc.Natl.Acad.Sci.U.S.A_114_6551

PubMedID: 28584123

Gene_locus related to this paper: 9cary-r4p353

Title : The two-step biosynthesis of cyclic peptides from linear precursors in a member of the plant family Caryophyllaceae involves cyclization by a serine protease-like enzyme - Barber_2013_J.Biol.Chem_288_12500

Author(s) : Barber CJ , Pujara PT , Reed DW , Chiwocha S , Zhang H , Covello PS

Ref : Journal of Biological Chemistry , 288 :12500 , 2013

Abstract :

PubMedSearch : Barber_2013_J.Biol.Chem_288_12500

PubMedID: 23486480

Gene_locus related to this paper: 9cary-r4p353

9cary-r4p353

Comment

Relationship

Molecular evidence

Mutation (0)

Structure (9)

Kinetic (0)

Disease (0)

Substrate (0)

Inhibitor (4)

Database

Genbank (1)

Interpro (1)

Pfam (1)

UniProt (1)

PIRSF (1)

SUPERFAM (1)

Sequence

Peptide

References (3)

1. Characterization of the Fast and Promiscuous Macrocyclase from Plant PCY1 Enables the Use of Simple Substrates - Ludewig_2018_ACS.Chem.Biol_13_801

2. Characterization of the macrocyclase involved in the biosynthesis of RiPP cyclic peptides in plants - Chekan_2017_Proc.Natl.Acad.Sci.U.S.A_114_6551

3. The two-step biosynthesis of cyclic peptides from linear precursors in a member of the plant family Caryophyllaceae involves cyclization by a serine protease-like enzyme - Barber_2013_J.Biol.Chem_288_12500