mouse-acot3

Mus musculus (Mouse) (peroxisomal long-chain Acyl-CoA thioesterase 2) (pte-IA) (EC 3.1.2.2)

Comment

The mouse ACOT gene cluster comprises six genes with localizations in cytosol (ACOT1), mitochondria (ACOT2), and peroxisomes (ACOT3-6). The corresponding human gene cluster contains only three genes (ACOT1, ACOT2, and ACOT4) coding for full-length thioesterase proteins only ACOT4 is peroxisomal

Relationship

Family : Acyl-CoA_Thioesterase

Block : X

Position in NCBI Life Tree : Mus musculus

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Glires N E > Rodentia N E > Myomorpha N E > Muroidea N E > Muridae N E > Murinae N E > Mus [genus] N E > Mus [subgenus] N E > Mus musculus N E

Molecular evidence

No mutation

No structure

No kinetic

No disease

No substrate

No inhibitor

Database

Sequence

Peptide

MHAFTTQNPN RMAPTVILEP AGGCLCDQPV HIAVRGLAPE QPVTLRSVLR DEKGALFRAH ARYRADSHGE LDLARTPALG GSFSGLEPMG LLWAMEPDRP FWRLIKRDVQ TPFVVELEVL DGHEPDGGQR LARAVHERHF MAPGVRRVPV REGRVRATLF LPPGTGPFPG IIDLFGIGSG LLEYRASLLA GKGFAVMALA YNNYEDLPKD MDIIHLEYFE EAVTYLLSHP QVTGSGVGVL GISKGGELGF AMASFLKNIT AAVIINGSIS NIGGNLQYKD ETVPSVGINT KRVKRTKDGL KDIVDLLNNP LEGPDQKSLI PVERSDTAFL FLVGQDDHNW KSEFYAREAS KRLQAHGKEK PQIICYPETG HHIEPPYFPL CKASLNSLVG GPVIWGGEPR AHAMAQVDAW QQLQTFFHNH LDGKKKTIPA KL

References (3)

Title : Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs - Hunt_2006_FASEB.J_20_1855
Author(s) : Hunt MC , Rautanen A , Westin MA , Svensson LT , Alexson SE
Ref : FASEB Journal , 20 :1855 , 2006
PubMedID: 16940157
Gene_locus related to this paper: human-ACOT1 , human-ACOT2 , human-ACOT4 , human-ACOT6 , mouse-acot1 , mouse-acot2 , mouse-acot3 , mouse-acot4 , mouse-acot5 , mouse-ACOT6

Title : Molecular cloning and characterization of two mouse peroxisome proliferator-activated receptor alpha (PPARalpha)-regulated peroxisomal acyl-CoA thioesterases - Westin_2004_J.Biol.Chem_279_21841
Author(s) : Westin MA , Alexson SE , Hunt MC
Ref : Journal of Biological Chemistry , 279 :21841 , 2004
PubMedID: 15007068
Gene_locus related to this paper: mouse-acot3 , mouse-acot5

Title : Peroxisome proliferator-induced long chain acyl-CoA thioesterases comprise a highly conserved novel multi-gene family involved in lipid metabolism - Hunt_1999_J.Biol.Chem_274_34317
Author(s) : Hunt MC , Nousiainen SE , Huttunen MK , Orii KE , Svensson LT , Alexson SE
Ref : Journal of Biological Chemistry , 274 :34317 , 1999
PubMedID: 10567408
Gene_locus related to this paper: mouse-acot1 , mouse-acot2 , mouse-acot3 , mouse-acot4