ompol-OphP

Omphalotus olearius (Jack o'lantern) macrocyclase OphP prolyl oligopeptidase

Comment

N-methylated peptide macrocycle omphalotin A (nematicidal cyclododecapeptide). A methyltransferase OphMA that catalyzes the automethylation of its C-terminus, which is then released and cyclized by the protease OphP

Relationship

Family : S9N_PPCE_Peptidase_S9

Block : X

Position in NCBI Life Tree : Omphalotus olearius

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Fungi N E > Dikarya N E > Basidiomycota N E > Agaricomycotina N E > Agaricomycetes N E > Agaricomycetidae N E > Agaricales N E > Omphalotaceae N E > Marasmiineae N E > Omphalotus N E > Omphalotus olearius N E

Database

No Genbank

Sequence

Peptide

MSFPGWGPYP PVERDETSAI TYSSKLHGSV TVRDPYSQLE VPFEDSEETK AFVHSQRKFA RTYLDENPDR EAWLETLKKS WNYRRFSALK PESDGHYYFE YNDGLQSQLS LYRVRMGEED TVLTESGPGG ELFFNPNLLS LDGNAALTGF VMSPCGNYWA YGVSEHGSDW MSIYVRKTSS PHLPSQERGK DPGRMNDKIR HVRFFIVSWT SDSKGFFYSR YPPEDDEGKG NAPAMNCMVY YHRIGEDQES DVLVHEDPEH PFWISSVQLT PSGRYILFAA SRDASHTQLV KIADLHENDI GTNMKWKNLH DPWEARFTIV GDEGSKIYFM TNLKAKNYKV ATFDANHPDE GLTTLIAEDP NAFLVSASIH AQDKLLLVYL RNASHEIHIR DLTTGKPLGR IFEDLLGQFM VSGRRQDNDI FVLFSSFLSP GTVYRYTFGE EKGYRSLFRA ISIPGLNLDD FMTESVFYPS KDGTSVHMFI TRPKDVLLDG TSPVLQYGYG GFSLAMLPTF SLSTLLFCKI YRAIYAIPNI RGGSEYGESW HREGMLDKKQ NVFDDFNAAT EWLIANKYAS KDRIAIRGGS NGGVLTTACA NQAPGLYRCV ITIEGIIDML RFPKFTFGAS WRSEYGDPED PEDFDFIFKY SPYHNIPPPG DTVMPAMLFF TAAYDDRVSP LHTFKHVAAL QHNFPKGPNP CLMRIDLNSG HFAGKSTQEM LEETADEYSF IGKSMGLTMQ TQGSVDSSRW SCVTV

References (4)

Title : Molecular insight into the enzymatic macrocyclization of multiply backbone N-methylated peptides - Matabaro_2022_bioRxiv__
Author(s) : Matabaro E , Song H , Sonderegger L , Gherlone F , Giltrap A , Liver S , Gossert A , Kunzler M , Naismith JH
Ref : Biorxiv , : , 2022
PubMedID:
Gene_locus related to this paper: ompol-OphP

Title : Enzyme-mediated backbone N-methylation in ribosomally encoded peptides - Matabaro_2021_Methods.Enzymol_656_429
Author(s) : Matabaro E , Song H , Chepkirui C , Kaspar H , Witte L , Naismith JH , Freeman MF , Kunzler M
Ref : Methods Enzymol , 656 :429 , 2021
PubMedID: 34325794
Gene_locus related to this paper: ompol-OphP

Title : Identification, heterologous production and bioactivity of lentinulin A and dendrothelin A, two natural variants of backbone N-methylated peptide macrocycle omphalotin A - Matabaro_2021_Sci.Rep_11_3541
Author(s) : Matabaro E , Kaspar H , Dahlin P , Bader DLV , Murar CE , Staubli F , Field CM , Bode JW , Kunzler M
Ref : Sci Rep , 11 :3541 , 2021
PubMedID: 33574430
Gene_locus related to this paper: ompol-OphP

Title : A Self-Sacrificing N-Methyltransferase Is the Precursor of the Fungal Natural Product Omphalotin - Ramm_2017_Angew.Chem.Int.Ed.Engl_56_9994
Author(s) : Ramm S , Krawczyk B , Muhlenweg A , Poch A , Mosker E , Sussmuth RD
Ref : Angew Chem Int Ed Engl , 56 :9994 , 2017
PubMedID: 28715095
Gene_locus related to this paper: ompol-OphP