OphMA-core-peptide-15mer
GFPWVIVVGVIGVIG || Backbone N-methylated, macrocyclic dodecapeptides produced by the mushroom Omphalotus olearius. Omphalotins display a strong and selective toxicity toward the plant parasitic nematode Meloidogyne incognita. N-methylated peptide macrocycle omphalotin A (nematicidal cyclododecapeptide). A methyltransferase OphMA that catalyzes the automethylation of its C-terminus, which is then released and cyclized by the protease OphP
General
Type : Peptide, Macrocycle
Chemical_Nomenclature :
Canonical SMILES :
InChI :
InChIKey :
Other name(s) :
MW :
Formula :
CAS_number :
PubChem :
UniChem :
Target
Structures : 7ZB0
Families : S9N_PPCE_Peptidase_S9
References (4)
| Title : Molecular insight into the enzymatic macrocyclization of multiply backbone N-methylated peptides - Matabaro_2022_bioRxiv__ |
| Author(s) : Matabaro E , Song H , Sonderegger L , Gherlone F , Giltrap A , Liver S , Gossert A , Kunzler M , Naismith JH |
| Ref : Biorxiv , : , 2022 |
| Abstract : |
| PubMedSearch : Matabaro_2022_bioRxiv__ |
| PubMedID: |
| Gene_locus related to this paper: ompol-OphP |
| Title : Enzyme-mediated backbone N-methylation in ribosomally encoded peptides - Matabaro_2021_Methods.Enzymol_656_429 |
| Author(s) : Matabaro E , Song H , Chepkirui C , Kaspar H , Witte L , Naismith JH , Freeman MF , Kunzler M |
| Ref : Methods Enzymol , 656 :429 , 2021 |
| Abstract : |
| PubMedSearch : Matabaro_2021_Methods.Enzymol_656_429 |
| PubMedID: 34325794 |
| Gene_locus related to this paper: ompol-OphP |
| Title : Identification, heterologous production and bioactivity of lentinulin A and dendrothelin A, two natural variants of backbone N-methylated peptide macrocycle omphalotin A - Matabaro_2021_Sci.Rep_11_3541 |
| Author(s) : Matabaro E , Kaspar H , Dahlin P , Bader DLV , Murar CE , Staubli F , Field CM , Bode JW , Kunzler M |
| Ref : Sci Rep , 11 :3541 , 2021 |
| Abstract : |
| PubMedSearch : Matabaro_2021_Sci.Rep_11_3541 |
| PubMedID: 33574430 |
| Gene_locus related to this paper: ompol-OphP |
| Title : A Self-Sacrificing N-Methyltransferase Is the Precursor of the Fungal Natural Product Omphalotin - Ramm_2017_Angew.Chem.Int.Ed.Engl_56_9994 |
| Author(s) : Ramm S , Krawczyk B , Muhlenweg A , Poch A , Mosker E , Sussmuth RD |
| Ref : Angew Chem Int Ed Engl , 56 :9994 , 2017 |
| Abstract : |
| PubMedSearch : Ramm_2017_Angew.Chem.Int.Ed.Engl_56_9994 |
| PubMedID: 28715095 |
| Gene_locus related to this paper: ompol-OphP |