pea-RMS3

Pisum sativum (Garden pea) Strigolactone esterase, PsD14, RAMOSUS 3, RMS3

Comment

Involved in strigolactone signaling pathway. Functions downstream of strigolactone synthesis, as a component of hormone signaling and as an enzyme that participates in the conversion of strigolactones to the bioactive form. Binds and hydrolyzes the synthetic strigolactone analog GR24 and its enantiomers in vitro. Forms a stable covalent complex with the D-ring of strigolactone, which is essential for hormone bioactivity. The D-ring is attached to His-247 of the catalytic triad. The hydrolysis of strigolactone into a covalently linked intermediate molecule is required to trigger strigolactone signaling. This mechanism defines RMS3 as a non-canonical hormone receptor with dual functions to generate and sense the active form of strigolactone

Relationship

Family : RsbQ-like

Block : X

Position in NCBI Life Tree : Pisum sativum

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Viridiplantae N E > Streptophyta N E > Streptophytina N E > Embryophyta N E > Tracheophyta N E > Euphyllophyta N E > Spermatophyta N E > Magnoliophyta N E > Mesangiospermae N E > eudicotyledons N E > Gunneridae N E > Pentapetalae N E > rosids N E > fabids N E > Fabales N E > Fabaceae N E > Papilionoideae N E > Fabeae N E > Pisum N E > Pisum sativum N E

Molecular evidence

No mutation

No structure

No kinetic

No disease

No inhibitor

Database

Sequence

Peptide

MGTPILDAFN VRVEGSGDKY LVFAHGFGTD QSAWQRVLPY FTRSYKVILY DLVCAGSVNP DHFDFRRYTT LDAYVDDLLN ILDSLHVTRC AYVGHSISAM TGMLASIRRP ELFSKLILIG ASPRFLNDGE NYHGGFEQGE IEHVFSAMEA NYEAWVNGFA PLAVGADVPT AVREFSRTLF NMRPDISLFV SRTVFNSDLR GILGLVNVPC CIMQTARDMS VPASVATYMK EHIGGKSTVQ WLDTEGHLPH LSAPSYLAHQ LEIALSQ

References (1)

Title : An histidine covalent receptor and butenolide complex mediates strigolactone perception - de Saint Germain_2016_Nat.Chem.Biol_12_787
Author(s) : de Saint Germain A , Clave G , Badet-Denisot MA , Pillot JP , Cornu D , Le Caer JP , Burger M , Pelissier F , Retailleau P , Turnbull C , Bonhomme S , Chory J , Rameau C , Boyer FD
Ref : Nat Chemical Biology , 12 :787 , 2016
PubMedID: 27479744
Gene_locus related to this paper: pea-RMS3