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sacer-ery3

Saccharopolyspora erythraea (Streptomyces erythraeus) deoxyerythronolide b synthase III (debs 3) Thioesterase domain DEBS TE

Comment

Relationship

Family : Thioesterase

Block : X

Position in NCBI Life Tree : Saccharopolyspora erythraea

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Bacteria N E > Terrabacteria group N E > Actinobacteria [phylum] N E > Actinobacteria [class] N E > Pseudonocardiales N E > Pseudonocardiaceae N E > Saccharopolyspora N E > Saccharopolyspora erythraea N E

Molecular evidence

Database

Sequence

Peptide

SSALRDGYRQ AGVSGRVRSY LDLLAGLSDF REHFDGSDGF SLDLVDMADG PGEVTVICCA GTAAISGPHE FTRLAGALRG IAPVRAVPQP GYEEGEPLPS SMAAVAAVQA DAVIRTQGDK PFVVAGHSAG ALMAYALATE LLDRGHPPRG VVLIDVYPPG HQDAMNAWLE ELTATLFDRE TVRMDDTRLT ALGAYDRLTG QWRPRETGLP TLLVSAGEPM GPWPDDSWKP TWPFEHDTVA VPGDHFTMVQ EHADAIARHI DAWLGGGNS

References (11)

Title : Mapping the catalytic conformations of an assembly-line polyketide synthase module - Cogan_2021_Science_374_729
Author(s) : Cogan DP , Zhang K , Li X , Li S , Pintilie GD , Roh SH , Craik CS , Chiu W , Khosla C
Ref : Science , 374 :729 , 2021
Abstract :
PubMedSearch : Cogan_2021_Science_374_729
PubMedID: 34735239
Gene_locus related to this paper: sacer-ery3

Title : Discovery and Characterization of a Thioesterase-Specific Monoclonal Antibody That Recognizes the 6-Deoxyerythronolide B Synthase - Li_2018_Biochemistry_57_6201
Author(s) : Li X , Sevillano N , La Greca F , Hsu J , Mathews, II , Matsui T , Craik CS , Khosla C
Ref : Biochemistry , 57 :6201 , 2018
Abstract :
PubMedSearch : Li_2018_Biochemistry_57_6201
PubMedID: 30289692
Gene_locus related to this paper: sacer-ery3

Title : Towards a characterization of the structural determinants of specificity in the macrocyclizing thioesterase for deoxyerythronolide B biosynthesis - Argyropoulos_2016_Biochim.Biophys.Acta_1860_486
Author(s) : Argyropoulos P , Bergeret F , Pardin C , Reimer JM , Pinto A , Boddy CN , Schmeing TM
Ref : Biochimica & Biophysica Acta , 1860 :486 , 2016
Abstract :
PubMedSearch : Argyropoulos_2016_Biochim.Biophys.Acta_1860_486
PubMedID: 26592346
Gene_locus related to this paper: sacer-ery3

Title : Identification of NanE as the thioesterase for polyether chain release in nanchangmycin biosynthesis - Liu_2006_Chem.Biol_13_945
Author(s) : Liu T , You D , Valenzano C , Sun Y , Li J , Yu Q , Zhou X , Cane DE , Deng Z
Ref : Chemical Biology , 13 :945 , 2006
Abstract :
PubMedSearch : Liu_2006_Chem.Biol_13_945
PubMedID: 16984884
Gene_locus related to this paper: sacer-ery3 , strci-MONAX , strna-NANE

Title : Total synthesis of long DNA sequences: synthesis of a contiguous 32-kb polyketide synthase gene cluster - Kodumal_2004_Proc.Natl.Acad.Sci.U.S.A_101_15573
Author(s) : Kodumal SJ , Patel KG , Reid R , Menzella HG , Welch M , Santi DV
Ref : Proc Natl Acad Sci U S A , 101 :15573 , 2004
Abstract :
PubMedSearch : Kodumal_2004_Proc.Natl.Acad.Sci.U.S.A_101_15573
PubMedID: 15496466
Gene_locus related to this paper: sacer-ery3

Title : Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases - Tsai_2002_Biochemistry_41_12598
Author(s) : Tsai SC , Lu H , Cane DE , Khosla C , Stroud RM
Ref : Biochemistry , 41 :12598 , 2002
Abstract :
PubMedSearch : Tsai_2002_Biochemistry_41_12598
PubMedID: 12379102
Gene_locus related to this paper: sacer-ery3 , strve-PIKAIV

Title : Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: versatility from a unique substrate channel - Tsai_2001_Proc.Natl.Acad.Sci.U.S.A_98_14808
Author(s) : Tsai SC , Miercke LJ , Krucinski J , Gokhale R , Chen JC , Foster PG , Cane DE , Khosla C , Stroud RM
Ref : Proc Natl Acad Sci U S A , 98 :14808 , 2001
Abstract :
PubMedSearch : Tsai_2001_Proc.Natl.Acad.Sci.U.S.A_98_14808
PubMedID: 11752428
Gene_locus related to this paper: sacer-ery3

Title : 6-Deoxyerythronolide-B synthase 2 from Saccharopolyspora erythraea. Cloning of the structural gene, sequence analysis and inferred domain structure of the multifunctional enzyme - Bevitt_1992_Eur.J.Biochem_204_39
Author(s) : Bevitt DJ , Cortes J , Haydock SF , Leadlay PF
Ref : European Journal of Biochemistry , 204 :39 , 1992
Abstract :
PubMedSearch : Bevitt_1992_Eur.J.Biochem_204_39
PubMedID: 1740151
Gene_locus related to this paper: sacer-ery3

Title : Identification of DEBS 1, DEBS 2 and DEBS 3, the multienzyme polypeptides of the erythromycin-producing polyketide synthase from Saccharopolyspora erythraea - Caffrey_1992_FEBS.Lett_304_225
Author(s) : Caffrey P , Bevitt DJ , Staunton J , Leadlay PF
Ref : FEBS Letters , 304 :225 , 1992
Abstract :
PubMedSearch : Caffrey_1992_FEBS.Lett_304_225
PubMedID: 1618327
Gene_locus related to this paper: sacer-ery3

Title : Modular organization of genes required for complex polyketide biosynthesis - Donadio_1991_Science_252_675
Author(s) : Donadio S , Staver MJ , McAlpine JB , Swanson SJ , Katz L
Ref : Science , 252 :675 , 1991
Abstract :
PubMedSearch : Donadio_1991_Science_252_675
PubMedID: 2024119
Gene_locus related to this paper: sacer-ery3

Title : An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea - Cortes_1990_Nature_348_176
Author(s) : Cortes J , Haydock SF , Roberts GA , Bevitt DJ , Leadlay PF
Ref : Nature , 348 :176 , 1990
Abstract :
PubMedSearch : Cortes_1990_Nature_348_176
PubMedID: 2234082
Gene_locus related to this paper: sacer-ery3