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Gene_locus Report for: metmf-pks2

Metarhizium majus; Metarhizium guizhouense. Polyketide synthase 2. Thioesterase domain

Comment
Other strains: Metarhizium majus (strain ARSEF 297); Metarhizium guizhouense (strain ARSEF 977)


Relationship
Family|Thioesterase
Block| X
Position in NCBI Life Tree|Metarhizium majus
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Fungi: N E > Dikarya: N E > Ascomycota: N E > saccharomyceta: N E > Pezizomycotina: N E > leotiomyceta: N E > sordariomyceta: N E > Sordariomycetes: N E > Hypocreomycetidae: N E > Hypocreales: N E > Clavicipitaceae: N E > Metarhizium: N E > Metarhizium majus: N E
Warning: This entry is a compilation of different species or line or strain with more than 90% amino acid identity. You can retrieve all strain data


Molecular evidence
Database
No mutation
No structure
No kinetic





No Substrate
No inhibitor
Sequence
Graphical view for this peptide sequence: metmf-pks2
Colored MSA for Thioesterase (raw)
GVDSLLSLTITGRIREELGLDMDSSIFTHYSTLGELKAFLGADQHPDDAV
ACESSNGQHTPQTSDKGSGTLAASKPDDDTGSDTTLHRVCAIIAEEVGIS
VQELSSSQDFQELGIDSLSSLTILSRVREELQLDLESDFFDTHPSFCSLQ
KALCGTEAASNGAPEANETTPSSHRLESDLRTITWQSGQNIVASPPHATS
ILVSGSPSTARMILVLFPDGSGSAASYGALAPKIRRDTAVYALNCPWRTN
GEEILRLGVSLDQMVAKHLVEVGRILDSHQHGRPGSGNASVGLALGGWSA
GGILALEAVRQLREAGVAVQKMVLLDAPNPIGLQNPPPRMFHFLDELGIL
GAGKGKAPAWVLRHFDAMVTLLKSYRPRRLGAEYAPKCLIVYARDGICKD
PDGPRMDTKPDDAREMLWLLYNRVDFSAEGWKSLVGQQNLAVGVVEDVNH
FSMMNPGPRMAEMGDLIGEFLLGPS
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

GVDSLLSLTITGRIREELGLDMDSSIFTHYSTLGELKAFLGADQHPDDAV
ACESSNGQHTPQTSDKGSGTLAASKPDDDTGSDTTLHRVCAIIAEEVGIS
VQELSSSQDFQELGIDSLSSLTILSRVREELQLDLESDFFDTHPSFCSLQ
KALCGTEAASNGAPEANETTPSSHRLESDLRTITWQSGQNIVASPPHATS
ILVSGSPSTARMILVLFPDGSGSAASYGALAPKIRRDTAVYALNCPWRTN
GEEILRLGVSLDQMVAKHLVEVGRILDSHQHGRPGSGNASVGLALGGWSA
GGILALEAVRQLREAGVAVQKMVLLDAPNPIGLQNPPPRMFHFLDELGIL
GAGKGKAPAWVLRHFDAMVTLLKSYRPRRLGAEYAPKCLIVYARDGICKD
PDGPRMDTKPDDAREMLWLLYNRVDFSAEGWKSLVGQQNLAVGVVEDVNH
FSMMNPGPRMAEMGDLIGEFLLGPS


References
    Title: Duplication of a Pks gene cluster and subsequent functional diversification facilitate environmental adaptation in Metarhizium species
    Zeng G, Zhang P, Zhang Q, Zhao H, Li Z, Zhang X, Wang C, Yin WB, Fang W
    Ref: PLoS Genet, 14:e1007472, 2018 : PubMed

            

    Title: Trajectory and genomic determinants of fungal-pathogen speciation and host adaptation
    Hu X, Xiao G, Zheng P, Shang Y, Su Y, Zhang X, Liu X, Zhan S, St Leger RJ, Wang C
    Ref: Proc Natl Acad Sci U S A, 111:16796, 2014 : PubMed

            


Other Papers


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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