3-hydrazinyl-indole-phenacetamide-cpd5a
IC50 AChE 0.268 +/- 0.01 BChE 2.777 +/- 0.45 microM BACE1 11.638 microM
General
Type : Multitarget, BACE1-inhibitor, Indole, Hydrazide
Chemical_Nomenclature : N-Phenyl-2-(3-((2-phenylhydrazineylidene)methyl)-1H-indol-1-yl)acetamide
Canonical SMILES : C1=CC=CC(=C1)NC(C[N]2C=C(C3=CC=CC=C23)C=NNC4=CC=CC=C4)=O
InChI : InChI=1S\/C23H20N4O\/c28-23(25-19-9-3-1-4-10-19)17-27-16-18(21-13-7-8-14-22(21)27)15-24-26-20-11-5-2-6-12-20\/h1-16,26H,17H2,(H,25,28)
InChIKey : PXSZIMLWEVFSEV-UHFFFAOYSA-N
Other name(s) : Compound 5a
Target
Families : 3-hydrazinyl-indole-phenacetamide-cpd5a ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Probing new 3-hydrazinyl indole phenacetamide derivatives as multitarget anti-Alzheimer: Synthesis, in vivo, in vitro, and in silico studies - Said_2025_Eur.J.Med.Chem_295_117720 |
| Author(s) : Said MF , Wadie W , Abd El-Haleim EA , El Shiekh RA , El-Zoheiry HH |
| Ref : Eur Journal of Medicinal Chemistry , 295 :117720 , 2025 |
| Abstract : |
| PubMedSearch : Said_2025_Eur.J.Med.Chem_295_117720 |
| PubMedID: 40449120 |