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BACE1-inhibitor

General

The main neuropathological feature of Alzheimer's disease consist in extracellular amyloid-beta (A/beta) plaque deposition. The critical molecular event in the AD is the accumulation of Abet neurotoxic oligomers. The proteolytic processing of Amyloid Precursor Protein (APP) by beta-secretase (beta-site APP cleaving enzyme 1, BACE1) is the rate-limiting step in the production of Abeta. BACE1 is not an alpha beta hydrolase but multitarget compounds are studied that inhibit both BACE1 and cholinesterases for example
Inhibitor Main targeted enzyme families Type Structure
Indazol-methoxybenzyl-piperazin-acetamide-Cpd13f BCHE ACHE Derivative of Donepezil Piperazine Indazole Multitarget BACE1-inhibitor
CHEMBL2159662 ACHE BCHE Multitarget BACE1-inhibitor Quinoline Alkyl linked bis-ligand
Dimethoxyquinazolin-fluorobenzohydrazide-Cpd3 ACHE Quinazoline Multitarget Hydrazide BACE1-inhibitor
2E(CF3) ACHE Azabicyclo Trifluoro Triazol Carboxamide Multitarget BACE1-inhibitor
Aminoethyl-methyl-phenyl-triazole-carboxamide-cpd1D ACHE Triazol Carboxamide Multitarget BACE1-inhibitor
Arylidene-hydrazinyl-1,3-thiazole-cpd8 ACHE Thiazole Sulfur Compound Hydrazinylidene Hydrazide Multitarget BACE1-inhibitor Organochlorine
Arylidene-hydrazinyl-1,3-thiazole-cpd14 ACHE Thiazole Sulfur Compound Hydrazinylidene Hydrazide Multitarget BACE1-inhibitor Organochlorine
CHEMBL1613299 ACHE Carboxamide Multitarget Piperidine BACE1-inhibitor Dimethoxyphenyl
3-hydrazinyl-indole-phenacetamide-cpd5a ACHE Multitarget BACE1-inhibitor Indole Hydrazide
Dioxothiazolidin-benzothiazol-methoxyphenyl-acrylamide-Cpd49 ACHE Monoamine-oxidase-inhibitor Multitarget BACE1-inhibitor Carboxamide Acrylate Benzothiazol Thiazole Dioxothiazolidine Sulfur Compound
Benzylpiperazinephenyl-phenyl-pyrazol-cpd48 BCHE Multitarget BACE1-inhibitor anti-Abeta-aggregation Piperazine Pyrazole
SCHEMBL24050193 BCHE Fluoren Cyclopropyl Multitarget BACE1-inhibitor anti-Abeta-aggregation GABA-transporter-inhibitor
CHEMBL4240861 ACHE Inden Multitarget BACE1-inhibitor Quinoline
Benzylpiperidin-methylene-methoxy-dihydro-inden-one ACHE Inden BACE1-inhibitor Derivative of Donepezil Multitarget Piperidine Benzylpiperidine
JW8 ACHE Multitarget BACE1-inhibitor Benzamide
Biphenyl-oxo-triazine-S-12 ACHE Multitarget Triazine BACE1-inhibitor Dimethoxyphenyl
Indole-piperidine-amide-cpd23a ACHE Multitarget Indole Carboxamide Derivative of Donepezil BACE1-inhibitor Piperidine Benzylpiperidine
SB-1448 BCHE ACHE Multitarget Derivative of Donepezil BACE1-inhibitor Piperidine
Compound5d-Benzylpiperidine-Phenyl-oxadiazol-thiol ACHE anti-Abeta-aggregation Sulfur Compound BACE1-inhibitor Piperidine Multitarget Carboxamide Oxadiazol Derivative of Donepezil Cyanide Benzylpiperidine
ZINC22029744 ACHE BCHE Multitarget Sulfur Compound Derivative of Donepezil BACE1-inhibitor Piperazine Oxadiazol
3,5-dihydroxybenzamido-huprine-hybrid-11 BCHE ACHE Multitarget Derivative of Huperzine BACE1-inhibitor Alkyl linked bis-ligand Organochlorine
Difluorophenyl-pyridin-piperazin-1,3,4-oxadiazole-49 ACHE BCHE Oxadiazol Pyridine Piperazine BACE1-inhibitor
MTDL-cpd51-diphenylacetamide BCHE Multitarget BACE1-inhibitor anti-Abeta-aggregation GABA-transporter-inhibitor Diphenylacetamide
MTDL-cpd36-diphenylacetamide BCHE Multitarget BACE1-inhibitor anti-Abeta-aggregation GABA-transporter-inhibitor Diphenylacetamide tert-Butyl
Ass-IN-10 BCHE Multitarget BACE1-inhibitor anti-Abeta-aggregation anti-tau-aggregation Alkyl linked bis-ligand tert-Butyl
SCHEMBL8072716 ACHE Multitarget BACE1-inhibitor Derivative of Memoquin Antioxidant Alkyl linked bis-ligand Sulfur Compound Dithiolane
Memoquin ACHE Multitarget BACE1-inhibitor Derivative of Memoquin Antioxidant Alkyl linked bis-ligand
QTC-4-MeOBnE ACHE Multitarget BACE1-inhibitor Triazol Derivative of Tacrine Organochlorine
Tacrine-Benzofuran ACHE BCHE Multitarget BACE1-inhibitor Derivative of Tacrine Acridine Alkyl linked bis-ligand Benzofuran
CHEMBL4793341 ACHE BCHE Trifluoro Pyrrolidine Multitarget BACE1-inhibitor
Indazol-methoxybenzyl-piperazin-acetamide-Cpd13f BCHE ACHE Derivative of Donepezil Piperazine Indazole Multitarget BACE1-inhibitor
CHEMBL2159662 ACHE BCHE Multitarget BACE1-inhibitor Quinoline Alkyl linked bis-ligand
Dimethoxyquinazolin-fluorobenzohydrazide-Cpd3 ACHE Quinazoline Multitarget Hydrazide BACE1-inhibitor
2E(CF3) ACHE Azabicyclo Trifluoro Triazol Carboxamide Multitarget BACE1-inhibitor
Aminoethyl-methyl-phenyl-triazole-carboxamide-cpd1D ACHE Triazol Carboxamide Multitarget BACE1-inhibitor
Arylidene-hydrazinyl-1,3-thiazole-cpd8 ACHE Thiazole Sulfur Compound Hydrazinylidene Hydrazide Multitarget BACE1-inhibitor Organochlorine
Arylidene-hydrazinyl-1,3-thiazole-cpd14 ACHE Thiazole Sulfur Compound Hydrazinylidene Hydrazide Multitarget BACE1-inhibitor Organochlorine
CHEMBL1613299 ACHE Carboxamide Multitarget Piperidine BACE1-inhibitor Dimethoxyphenyl
3-hydrazinyl-indole-phenacetamide-cpd5a ACHE Multitarget BACE1-inhibitor Indole Hydrazide
Dioxothiazolidin-benzothiazol-methoxyphenyl-acrylamide-Cpd49 ACHE Monoamine-oxidase-inhibitor Multitarget BACE1-inhibitor Carboxamide Acrylate Benzothiazol Thiazole Dioxothiazolidine Sulfur Compound
Benzylpiperazinephenyl-phenyl-pyrazol-cpd48 BCHE Multitarget BACE1-inhibitor anti-Abeta-aggregation Piperazine Pyrazole
SCHEMBL24050193 BCHE Fluoren Cyclopropyl Multitarget BACE1-inhibitor anti-Abeta-aggregation GABA-transporter-inhibitor
CHEMBL4240861 ACHE Inden Multitarget BACE1-inhibitor Quinoline
Benzylpiperidin-methylene-methoxy-dihydro-inden-one ACHE Inden BACE1-inhibitor Derivative of Donepezil Multitarget Piperidine Benzylpiperidine
JW8 ACHE Multitarget BACE1-inhibitor Benzamide
Biphenyl-oxo-triazine-S-12 ACHE Multitarget Triazine BACE1-inhibitor Dimethoxyphenyl
Indole-piperidine-amide-cpd23a ACHE Multitarget Indole Carboxamide Derivative of Donepezil BACE1-inhibitor Piperidine Benzylpiperidine
SB-1448 BCHE ACHE Multitarget Derivative of Donepezil BACE1-inhibitor Piperidine
Compound5d-Benzylpiperidine-Phenyl-oxadiazol-thiol ACHE anti-Abeta-aggregation Sulfur Compound BACE1-inhibitor Piperidine Multitarget Carboxamide Oxadiazol Derivative of Donepezil Cyanide Benzylpiperidine
ZINC22029744 ACHE BCHE Multitarget Sulfur Compound Derivative of Donepezil BACE1-inhibitor Piperazine Oxadiazol
3,5-dihydroxybenzamido-huprine-hybrid-11 BCHE ACHE Multitarget Derivative of Huperzine BACE1-inhibitor Alkyl linked bis-ligand Organochlorine
Difluorophenyl-pyridin-piperazin-1,3,4-oxadiazole-49 ACHE BCHE Oxadiazol Pyridine Piperazine BACE1-inhibitor
MTDL-cpd51-diphenylacetamide BCHE Multitarget BACE1-inhibitor anti-Abeta-aggregation GABA-transporter-inhibitor Diphenylacetamide
MTDL-cpd36-diphenylacetamide BCHE Multitarget BACE1-inhibitor anti-Abeta-aggregation GABA-transporter-inhibitor Diphenylacetamide tert-Butyl
Ass-IN-10 BCHE Multitarget BACE1-inhibitor anti-Abeta-aggregation anti-tau-aggregation Alkyl linked bis-ligand tert-Butyl
SCHEMBL8072716 ACHE Multitarget BACE1-inhibitor Derivative of Memoquin Antioxidant Alkyl linked bis-ligand Sulfur Compound Dithiolane
Memoquin ACHE Multitarget BACE1-inhibitor Derivative of Memoquin Antioxidant Alkyl linked bis-ligand
QTC-4-MeOBnE ACHE Multitarget BACE1-inhibitor Triazol Derivative of Tacrine Organochlorine
Tacrine-Benzofuran ACHE BCHE Multitarget BACE1-inhibitor Derivative of Tacrine Acridine Alkyl linked bis-ligand Benzofuran
CHEMBL4793341 ACHE BCHE Trifluoro Pyrrolidine Multitarget BACE1-inhibitor
Indazol-methoxybenzyl-piperazin-acetamide-Cpd13f BCHE ACHE Derivative of Donepezil Piperazine Indazole Multitarget BACE1-inhibitor
CHEMBL2159662 ACHE BCHE Multitarget BACE1-inhibitor Quinoline Alkyl linked bis-ligand
Dimethoxyquinazolin-fluorobenzohydrazide-Cpd3 ACHE Quinazoline Multitarget Hydrazide BACE1-inhibitor
2E(CF3) ACHE Azabicyclo Trifluoro Triazol Carboxamide Multitarget BACE1-inhibitor
Aminoethyl-methyl-phenyl-triazole-carboxamide-cpd1D ACHE Triazol Carboxamide Multitarget BACE1-inhibitor
Arylidene-hydrazinyl-1,3-thiazole-cpd8 ACHE Thiazole Sulfur Compound Hydrazinylidene Hydrazide Multitarget BACE1-inhibitor Organochlorine
Arylidene-hydrazinyl-1,3-thiazole-cpd14 ACHE Thiazole Sulfur Compound Hydrazinylidene Hydrazide Multitarget BACE1-inhibitor Organochlorine
CHEMBL1613299 ACHE Carboxamide Multitarget Piperidine BACE1-inhibitor Dimethoxyphenyl
3-hydrazinyl-indole-phenacetamide-cpd5a ACHE Multitarget BACE1-inhibitor Indole Hydrazide
Dioxothiazolidin-benzothiazol-methoxyphenyl-acrylamide-Cpd49 ACHE Monoamine-oxidase-inhibitor Multitarget BACE1-inhibitor Carboxamide Acrylate Benzothiazol Thiazole Dioxothiazolidine Sulfur Compound
Benzylpiperazinephenyl-phenyl-pyrazol-cpd48 BCHE Multitarget BACE1-inhibitor anti-Abeta-aggregation Piperazine Pyrazole
SCHEMBL24050193 BCHE Fluoren Cyclopropyl Multitarget BACE1-inhibitor anti-Abeta-aggregation GABA-transporter-inhibitor
CHEMBL4240861 ACHE Inden Multitarget BACE1-inhibitor Quinoline
Benzylpiperidin-methylene-methoxy-dihydro-inden-one ACHE Inden BACE1-inhibitor Derivative of Donepezil Multitarget Piperidine Benzylpiperidine
JW8 ACHE Multitarget BACE1-inhibitor Benzamide
Biphenyl-oxo-triazine-S-12 ACHE Multitarget Triazine BACE1-inhibitor Dimethoxyphenyl
Indole-piperidine-amide-cpd23a ACHE Multitarget Indole Carboxamide Derivative of Donepezil BACE1-inhibitor Piperidine Benzylpiperidine
SB-1448 BCHE ACHE Multitarget Derivative of Donepezil BACE1-inhibitor Piperidine
Compound5d-Benzylpiperidine-Phenyl-oxadiazol-thiol ACHE anti-Abeta-aggregation Sulfur Compound BACE1-inhibitor Piperidine Multitarget Carboxamide Oxadiazol Derivative of Donepezil Cyanide Benzylpiperidine
ZINC22029744 ACHE BCHE Multitarget Sulfur Compound Derivative of Donepezil BACE1-inhibitor Piperazine Oxadiazol
3,5-dihydroxybenzamido-huprine-hybrid-11 BCHE ACHE Multitarget Derivative of Huperzine BACE1-inhibitor Alkyl linked bis-ligand Organochlorine
Difluorophenyl-pyridin-piperazin-1,3,4-oxadiazole-49 ACHE BCHE Oxadiazol Pyridine Piperazine BACE1-inhibitor
MTDL-cpd51-diphenylacetamide BCHE Multitarget BACE1-inhibitor anti-Abeta-aggregation GABA-transporter-inhibitor Diphenylacetamide
MTDL-cpd36-diphenylacetamide BCHE Multitarget BACE1-inhibitor anti-Abeta-aggregation GABA-transporter-inhibitor Diphenylacetamide tert-Butyl
Ass-IN-10 BCHE Multitarget BACE1-inhibitor anti-Abeta-aggregation anti-tau-aggregation Alkyl linked bis-ligand tert-Butyl
SCHEMBL8072716 ACHE Multitarget BACE1-inhibitor Derivative of Memoquin Antioxidant Alkyl linked bis-ligand Sulfur Compound Dithiolane
Memoquin ACHE Multitarget BACE1-inhibitor Derivative of Memoquin Antioxidant Alkyl linked bis-ligand
QTC-4-MeOBnE ACHE Multitarget BACE1-inhibitor Triazol Derivative of Tacrine Organochlorine
Tacrine-Benzofuran ACHE BCHE Multitarget BACE1-inhibitor Derivative of Tacrine Acridine Alkyl linked bis-ligand Benzofuran
CHEMBL4793341 ACHE BCHE Trifluoro Pyrrolidine Multitarget BACE1-inhibitor