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BACE1-inhibitor

General

The main neuropathological feature of Alzhzimer's disease consist in extracellular amyloid-beta (A\/beta) plaque deposition. The critical molecular event in the AD is the accumulation of Abet neurotoxic oligomers. The proteolytic processing of Amyloid Precursor Protein (APP) by beta-secretase (beta-site APP cleaving enzyme 1, BACE1) is the rate-limiting step in the production of Abeta. BACE1 is not an alpha beta hydrolase but multitarget compounds are studied that inhibit both BACE1 and cholinesterases for example
Inhibitor Main targeted enzyme familyes Type Structure
Indole-piperidine-amide-cpd23a ACHE Multitarget Indole Carboxamide Derivative of Donepezil BACE1-inhibitor Piperidine
SB-1448 BCHE ACHE Multitarget Derivative of Donepezil BACE1-inhibitor Piperidine
Compound5d-Benzylpiperidine-Phenyl-oxadiazol-thiol ACHE anti-Abeta-aggregation Sulfur Compound BACE1-inhibitor Piperidine Multitarget Carboxamide Oxadiazol Derivative of Donepezil Cyanide
ZINC22029744 ACHE BCHE Multitarget Sulfur Compound Derivative of Donepezil BACE1-inhibitor Piperazine Oxadiazol
3,5-dihydroxybenzamido-huprine-hybrid-11 BCHE ACHE Multitarget Derivative of Huperzine BACE1-inhibitor Alkyl linked bis-ligand
MTDL-cpd51-diphenylacetamide BCHE Multitarget BACE1-inhibitor anti-Abeta-aggregation GABA-transporter-inhibitor Diphenylacetamide
MTDL-cpd36-diphenylacetamide BCHE Multitarget BACE1-inhibitor anti-Abeta-aggregation GABA-transporter-inhibitor Diphenylacetamide tert-Butyl
Ass-IN-10 BCHE Multitarget BACE1-inhibitor anti-Abeta-aggregation anti-tau-aggregation Alkyl linked bis-ligand tert-Butyl
Memoquin ACHE Multitarget BACE1-inhibitor Antioxidant Alkyl linked bis-ligand
QTC-4-MeOBnE ACHE Multitarget BACE1-inhibitor Triazol Derivative of Tacrine
Tacrine-Benzofuran ACHE Multitarget BACE1-inhibitor Derivative of Tacrine Acridine Alkyl linked bis-ligand Benzofuran