A-242-Nerve-agent
Novichok (newcomer/ newbie/ novice, beginner/) is a series of binary chemical weapons developed by the Soviet Union and Russia between 1971 and 1993. Mirzayanov provided the first description of these agents but are somewhat different from the structures identified later.
General
Type : Organophosphate, Chemical Warfare Agent, Novichok
Chemical_Nomenclature : 1,1,3,3-tetraethyl-2-[fluoro(methyl)phosphoryl]guanidine
Canonical SMILES : CCN(CC)C(=NP(=O)(C)F)N(CC)CC
InChI : InChI=1S\/C10H23FN3OP\/c1-6-13(7-2)10(12-16(5,11)15)14(8-3)9-4\/h6-9H2,1-5H3
InChIKey : WJDIQLITBJEMBA-UHFFFAOYSA-N
Other name(s) : A-242 nerve agent || A-242 || A242 || SCHEMBL21981139 || DTXSID401036886 || Methyl-(bis(diethylamino)methylene)phosphonamidic fluoride
MW : 251.28
Formula : C10H23FN3OP
CAS_number : 2387496-14-0
PubChem : 146586254
UniChem : WJDIQLITBJEMBA-UHFFFAOYSA-N
Wikipedia : Novichok_agent
Target
Families : A-242-Nerve-agent ligand of proteins in family
ACHE
Protein :
human-ACHE
References (4)
| Title : In vitro comparison of the acetylcholinesterase inhibition caused by V- and A-series nerve agents' surrogates - Kitagawa_2023_Chem.Biol.Interact_14ChEPon_110678 |
| Author(s) : Kitagawa DAS , Dos Santos MC , Kuca K , Franca TCC , Cavalcante SFA |
| Ref : Chemico-Biological Interactions , 383 :110678 , 2023 |
| Abstract : |
| PubMedSearch : Kitagawa_2023_Chem.Biol.Interact_14ChEPon_110678 |
| PubMedID: 37595776 |
| Title : Are the current commercially available oximes capable of reactivating acetylcholinesterase inhibited by the nerve agents of the A-series? - Santos_2022_Arch.Toxicol__ |
| Author(s) : Santos MC , Botelho FD , Goncalves AS , Kitagawa DAS , Borges CVN , Carvalho-Silva T , Bernardo LB , Ferreira CN , Rodrigues RB , Ferreira Neto DC , Nepovimova E , Kuca K , LaPlante SR , Lima ALS , Franca TCC , Cavalcante SFA |
| Ref : Archives of Toxicology , : , 2022 |
| Abstract : |
| PubMedSearch : Santos_2022_Arch.Toxicol__ |
| PubMedID: 35666269 |
| Title : Novichoks: The Dangerous Fourth Generation of Chemical Weapons - Franca_2019_Int.J.Mol.Sci_20_ |
| Author(s) : Franca TCC , Kitagawa DAS , Cavalcante SFA , da Silva JAV , Nepovimova E , Kuca K |
| Ref : Int J Mol Sci , 20 : , 2019 |
| Abstract : |
| PubMedSearch : Franca_2019_Int.J.Mol.Sci_20_ |
| PubMedID: 30862059 |
| Title : Novichok nerve agents banned by chemical-weapons treaty - |
| Author(s) : Castelvecchi D |
| Ref : Nature , : , 2019 |
| PubMedID: 33244185 |