Full name : Nepovimova Eugenie
First name : Eugenie
Mail : Charles University in Prague\; Faculty of Pharmacy in Hradec Kralove\; Department of Toxicology and Military Pharmacy\; Trebesska 1575\; 500 05 Hradec Kralove
Zip Code :
City :
Country : Czech Republic
Email : Evzenie.N@seznam.cz
Phone : +420608324886
Fax :
Website :
Directory :
Comment
| Title : Quantification of oxidative stress markers in the blood sera following subacute administration of different oximes in rats - Jacevic_2024_Chem.Biol.Interact_399_111138 |
| Author(s) : Jacevic V , Grujic-Milanovic J , Milovanovic Z , Nezic L , Amidzic L , Vojinovic N , Markovic B , Dobricic V , Milosavljevic P , Nepovimova E , Kuca K |
| Ref : Chemico-Biological Interactions , 399 :111138 , 2024 |
| Abstract : |
| PubMedSearch : Jacevic_2024_Chem.Biol.Interact_399_111138 |
| PubMedID: 38992768 |
| Title : Oxidative stress status assessment of rats' brains injury following subacute exposure to K-oximes - Jacevic_2023_Chem.Biol.Interact_14ChEPon_110658 |
| Author(s) : Jacevic V , Dumanovic J , Grujic-Milanovic J , Milovanovic Z , Amidzic L , Vojinovic N , Nezic L , Markovic B , Dobricic V , Milosavljevic P , Nepovimova E , Kuca K |
| Ref : Chemico-Biological Interactions , :110658 , 2023 |
| Abstract : |
| PubMedSearch : Jacevic_2023_Chem.Biol.Interact_14ChEPon_110658 |
| PubMedID: 37572873 |
| Title : Pralidoxime-like reactivator with increased lipophilicity - Molecular modeling and in vitro study - Kuca_2023_Chem.Biol.Interact_14ChEPon_110734 |
| Author(s) : Kuca K , Valle da Silva JA , Nepovimova E , Pham NL , Wu W , Valis M , Wu Q , Franca TCC |
| Ref : Chemico-Biological Interactions , :110734 , 2023 |
| Abstract : |
| PubMedSearch : Kuca_2023_Chem.Biol.Interact_14ChEPon_110734 |
| PubMedID: 37788753 |
| Title : Influence of the chronic groundwater fluoride consumption on cholinergic enzymes, ACHE and BCHE gene SNPs and pro-inflammatory cytokines: A study with Pakistani population groups - Bibi_2023_Sci.Total.Environ__163359 |
| Author(s) : Bibi S , Habib R , Shafiq S , Abbas SS , Khan S , Eqani S , Nepovimova E , Khan MS , Kuca K , Nurulain SM |
| Ref : Sci Total Environ , :163359 , 2023 |
| Abstract : |
| PubMedSearch : Bibi_2023_Sci.Total.Environ__163359 |
| PubMedID: 37030382 |
| Title : Are the current commercially available oximes capable of reactivating acetylcholinesterase inhibited by the nerve agents of the A-series? - Santos_2022_Arch.Toxicol__ |
| Author(s) : Santos MC , Botelho FD , Goncalves AS , Kitagawa DAS , Borges CVN , Carvalho-Silva T , Bernardo LB , Ferreira CN , Rodrigues RB , Ferreira Neto DC , Nepovimova E , Kuca K , LaPlante SR , Lima ALS , Franca TCC , Cavalcante SFA |
| Ref : Archives of Toxicology , : , 2022 |
| Abstract : |
| PubMedSearch : Santos_2022_Arch.Toxicol__ |
| PubMedID: 35666269 |
| Title : Theoretical assessment of the performances of commercial oximes on the reactivation of acetylcholinesterase inhibited by the nerve agent A-242 (novichok) - Santos_2022_Food.Chem.Toxicol__113084 |
| Author(s) : Santos MC , Botelho FD , Goncalves AS , Kuca K , Nepovimova E , Cavalcante SFA , Lima ALS , Franca TCC |
| Ref : Food & Chemical Toxicology , :113084 , 2022 |
| Abstract : |
| PubMedSearch : Santos_2022_Food.Chem.Toxicol__113084 |
| PubMedID: 35489467 |
| Title : Privileged multi-target directed propargyl-tacrines combining cholinesterase and monoamine oxidase inhibition activities - Chrienova_2022_J.Enzyme.Inhib.Med.Chem_37_2605 |
| Author(s) : Chrienova Z , Nepovimova E , Andrys R , Dolezal R , Janockova J , Muckova L , Fabova L , Soukup O , Oleksak P , Valis M , Korabecny J , Marco-Contelles J , Kuca K |
| Ref : J Enzyme Inhib Med Chem , 37 :2605 , 2022 |
| Abstract : |
| PubMedSearch : Chrienova_2022_J.Enzyme.Inhib.Med.Chem_37_2605 |
| PubMedID: 36131624 |
| Title : Dysregulation of butyrylcholinesterase, BCHE gene SNP rs1803274, and pro-inflammatory cytokines in occupational workers - Khan_2022_Environ.Res__115195 |
| Author(s) : Khan SA , Ntepe LJM , Abbas Shah ST , Bibi N , Muneer Z , Hussain S , Nepovimova E , Kuca K , Nurulain SM |
| Ref : Environ Research , :115195 , 2022 |
| Abstract : |
| PubMedSearch : Khan_2022_Environ.Res__115195 |
| PubMedID: 36592809 |
| Title : Design, synthesis, in silico studies and in vitro evaluation of isatin-pyridine oximes hybrids as novel acetylcholinesterase reactivators - Kitagawa_2021_J.Enzyme.Inhib.Med.Chem_36_1370 |
| Author(s) : Kitagawa DAS , Rodrigues RB , Silva TN , Dos Santos WV , da Rocha VCV , de Almeida JSFD , Bernardo LB , Carvalho-Silva T , Ferreira CN , da Silva AAT , Simas ABC , Nepovimova E , Kuca K , Franca TCC , Cavalcante SFA |
| Ref : J Enzyme Inhib Med Chem , 36 :1370 , 2021 |
| Abstract : |
| PubMedSearch : Kitagawa_2021_J.Enzyme.Inhib.Med.Chem_36_1370 |
| PubMedID: 34148470 |
| Title : Cannabis Constituents and Acetylcholinesterase Interaction: Molecular Docking, In Vitro Studies and Association with CNR1 rs806368 and ACHE rs17228602 - Furqan_2020_Biomolecules_10_ |
| Author(s) : Furqan T , Batool S , Habib R , Shah M , Kalasz H , Darvas F , Kuca K , Nepovimova E , Nurulain SM |
| Ref : Biomolecules , 10 : , 2020 |
| Abstract : |
| PubMedSearch : Furqan_2020_Biomolecules_10_ |
| PubMedID: 32414087 |
| Title : Oxidative Stress and Analysis of Selected SNPs of ACHE (rs 2571598), BCHE (rs 3495), CAT (rs 7943316), SIRT1 (rs 10823108), GSTP1 (rs 1695), and Gene GSTM1, GSTT1 in Chronic Organophosphates Exposed Groups from Cameroon and Pakistan - Ntepe_2020_Int.J.Mol.Sci_21_ |
| Author(s) : Ntepe LJM , Habib R , Ngondi JL , Raza S , Nepovimova E , Kuca K , Batool S , Nurulain SM |
| Ref : Int J Mol Sci , 21 : , 2020 |
| Abstract : |
| PubMedSearch : Ntepe_2020_Int.J.Mol.Sci_21_ |
| PubMedID: 32899431 |
| Title : Analysis of PON1 gene polymorphisms (rs662 and rs854560) and inflammatory markers in organophosphate pesticides exposed cohorts from two distinct populations - Leonel_2020_Environ.Res__110210 |
| Author(s) : Leonel Javeres MN , Habib R , Judith N , Iqbal M , Nepovimova E , Kuca K , Batool S , Nurulain SM |
| Ref : Environ Research , :110210 , 2020 |
| Abstract : |
| PubMedSearch : Leonel_2020_Environ.Res__110210 |
| PubMedID: 32949615 |
| Title : An update on T-2 toxin and its modified forms: metabolism, immunotoxicity mechanism, and human exposure assessment - Wu_2020_Arch.Toxicol_94_3645 |
| Author(s) : Wu Q , Qin Z , Kuca K , You L , Zhao Y , Liu A , Musilek K , Chrienova Z , Nepovimova E , Oleksak P , Wu W , Wang X |
| Ref : Archives of Toxicology , 94 :3645 , 2020 |
| Abstract : |
| PubMedSearch : Wu_2020_Arch.Toxicol_94_3645 |
| PubMedID: 32910237 |
| Title : Understanding the Interaction Modes and Reactivity of Trimedoxime toward MmAChE Inhibited by Nerve Agents: Theoretical and Experimental Aspects - de Castro_2020_Int.J.Mol.Sci_21_ |
| Author(s) : de Castro AA , Polisel DA , Pereira BTL , da Cunha EFF , Kuca K , Nepovimova E , Ramalho TC |
| Ref : Int J Mol Sci , 21 : , 2020 |
| Abstract : |
| PubMedSearch : de Castro_2020_Int.J.Mol.Sci_21_ |
| PubMedID: 32899591 |
| Title : Tacrine - Benzothiazoles: Novel class of potential multitarget anti-Alzheimes drugs dealing with cholinergic, amyloid and mitochondrial systems - Nepovimova_2020_Bioorg.Chem_107_104596 |
| Author(s) : Nepovimova E , Svobodova L , Dolezal R , Hepnarova V , Junova L , Jun D , Korabecny J , Kucera T , Gazova Z , Motykova K , Kubackova J , Bednarikova Z , Janockova J , Jesus C , Cortes L , Pina J , Rostohar D , Serpa C , Soukup O , Aitken L , Hughes RE , Musilek K , Muckova L , Jost P , Chvojkova M , Vales K , Valis M , Chrienova Z , Chalupova K , Kuca K |
| Ref : Bioorg Chem , 107 :104596 , 2020 |
| Abstract : |
| PubMedSearch : Nepovimova_2020_Bioorg.Chem_107_104596 |
| PubMedID: 33421953 |
| Title : Interaction of Synthesized Nitrogen enriched Graphene Quantum Dots with Novel Anti-Alzheimer's Drugs: Spectroscopic Insights - Sharma_2020_J.Biomol.Struct.Dyn_38_1822 |
| Author(s) : Sharma S , Singh N , Nepovimova E , Korabecny J , Kuca K , Satnami ML , Ghosh KK |
| Ref : J Biomol Struct Dyn , 38 :1822 , 2020 |
| Abstract : |
| PubMedSearch : Sharma_2020_J.Biomol.Struct.Dyn_38_1822 |
| PubMedID: 31096863 |
| Title : Toxic Injury to Muscle Tissue of Rats Following Acute Oximes Exposure - Jacevic_2019_Sci.Rep_9_1457 |
| Author(s) : Jacevic V , Nepovimova E , Kuca K |
| Ref : Sci Rep , 9 :1457 , 2019 |
| Abstract : |
| PubMedSearch : Jacevic_2019_Sci.Rep_9_1457 |
| PubMedID: 30728420 |
| Title : Traditional Ayurvedic and herbal remedies for Alzheimer's disease: from bench to bedside - Sharma_2019_Expert.Rev.Neurother_19_359 |
| Author(s) : Sharma R , Kuca K , Nepovimova E , Kabra A , Rao MM , Prajapati PK |
| Ref : Expert Rev Neurother , 19 :359 , 2019 |
| Abstract : |
| PubMedSearch : Sharma_2019_Expert.Rev.Neurother_19_359 |
| PubMedID: 30884983 |
| Title : Molecular modeling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime, 4-PA, 2-PAM, and obidoxime with VX-inhibited human acetylcholinesterase: a near attack conformation approach - da Silva_2019_J.Enzyme.Inhib.Med.Chem_34_1018 |
| Author(s) : da Silva JAV , Nepovimova E , Ramalho TC , Kuca K , Franca TCC |
| Ref : J Enzyme Inhib Med Chem , 34 :1018 , 2019 |
| Abstract : |
| PubMedSearch : da Silva_2019_J.Enzyme.Inhib.Med.Chem_34_1018 |
| PubMedID: 31074292 |
| Title : Molecular modelling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime with VX-inhibited human acetylcholinesterase. A near attack approach to assess different spacer-lengths - da Silva_2019_Chem.Biol.Interact_13ChEPon_307_195 |
| Author(s) : da Silva JAV , Nepovimova E , Ramalho TC , Kuca K , Franca TCC |
| Ref : Chemico-Biological Interactions , 307 :195 , 2019 |
| Abstract : |
| PubMedSearch : da Silva_2019_Chem.Biol.Interact_13ChEPon_307_195 |
| PubMedID: 31121152 |
| Title : Orexin supplementation in narcolepsy treatment: A review - Nepovimova_2019_Med.Res.Rev_39_961 |
| Author(s) : Nepovimova E , Janockova J , Misik J , Kubik S , Stuchlik A , Vales K , Korabecny J , Mezeiova E , Dolezal R , Soukup O , Kobrlova T , Pham NL , Nguyen TD , Konecny J , Kuca K |
| Ref : Med Res Rev , 39 :961 , 2019 |
| Abstract : |
| PubMedSearch : Nepovimova_2019_Med.Res.Rev_39_961 |
| PubMedID: 30426515 |
| Title : Donepezil Derivatives Targeting Amyloid-beta Cascade in Alzheimer's Disease - Mezeiova_2019_Curr.Alzheimer.Res_16_772 |
| Author(s) : Mezeiova E , Chalupova K , Nepovimova E , Gorecki L , Prchal L , Malinak D , Kuca K , Soukup O , Korabecny J |
| Ref : Curr Alzheimer Res , 16 :772 , 2019 |
| Abstract : |
| PubMedSearch : Mezeiova_2019_Curr.Alzheimer.Res_16_772 |
| PubMedID: 30819078 |
| Title : N-alkylated Tacrine Derivatives as Potential Agents in Alzheimer's Disease Therapy - Nepovimova_2019_Curr.Alzheimer.Res_16_333 |
| Author(s) : Nepovimova E , Korabecny J , Hepnarova V , Jun D , Dolezal R , Muckova L , Jost P , Soukup O , Janockova J , Pham NL , Nguyen TD , Valis M , Kuca K |
| Ref : Curr Alzheimer Res , 16 :333 , 2019 |
| Abstract : |
| PubMedSearch : Nepovimova_2019_Curr.Alzheimer.Res_16_333 |
| PubMedID: 30873921 |
| Title : Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease - Chalupova_2019_Eur.J.Med.Chem_168_491 |
| Author(s) : Chalupova K , Korabecny J , Bartolini M , Monti B , Lamba D , Caliandro R , Pesaresi A , Brazzolotto X , Gastellier AJ , Nachon F , Pejchal J , Jarosova M , Hepnarova V , Jun D , Hrabinova M , Dolezal R , Karasova JZ , Mzik M , Kristofikova Z , Misik J , Muckova L , Jost P , Soukup O , Benkova M , Setnicka V , Habartova L , Chvojkova M , Kleteckova L , Vales K , Mezeiova E , Uliassi E , Valis M , Nepovimova E , Bolognesi ML , Kuca K |
| Ref : Eur Journal of Medicinal Chemistry , 168 :491 , 2019 |
| Abstract : |
| PubMedSearch : Chalupova_2019_Eur.J.Med.Chem_168_491 |
| PubMedID: 30851693 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Interspecies and intergender differences in acute toxicity of K-oximes drug candidates - Jacevic_2019_Chem.Biol.Interact_13ChEPon_308_312 |
| Author(s) : Jacevic V , Nepovimova E , Kuca K |
| Ref : Chemico-Biological Interactions , 308 :312 , 2019 |
| Abstract : |
| PubMedSearch : Jacevic_2019_Chem.Biol.Interact_13ChEPon_308_312 |
| PubMedID: 31153983 |
| Title : Non-conventional compounds with potential therapeutic effects against Alzheimer's disease - de Castro_2019_Expert.Rev.Neurother_19_375 |
| Author(s) : de Castro AA , Soares FV , Pereira AF , Polisel DA , Caetano MS , Leal DHS , da Cunha EFF , Nepovimova E , Kuca K , Ramalho TC |
| Ref : Expert Rev Neurother , 19 :375 , 2019 |
| Abstract : |
| PubMedSearch : de Castro_2019_Expert.Rev.Neurother_19_375 |
| PubMedID: 30999771 |
| Title : Combination of Memantine and 6-Chlorotacrine as Novel Multi-Target Compound against Alzheimer's Disease - Kaniakova_2019_Curr.Alzheimer.Res_16_821 |
| Author(s) : Kaniakova M , Nepovimova E , Kleteckova L , Skrenkova K , Holubova K , Chrienova Z , Hepnarova V , Kucera T , Kobrlova T , Vales K , Korabecny J , Soukup O , Horak M |
| Ref : Curr Alzheimer Res , 16 :821 , 2019 |
| Abstract : |
| PubMedSearch : Kaniakova_2019_Curr.Alzheimer.Res_16_821 |
| PubMedID: 30819076 |
| Title : Novichoks: The Dangerous Fourth Generation of Chemical Weapons - Franca_2019_Int.J.Mol.Sci_20_ |
| Author(s) : Franca TCC , Kitagawa DAS , Cavalcante SFA , da Silva JAV , Nepovimova E , Kuca K |
| Ref : Int J Mol Sci , 20 : , 2019 |
| Abstract : |
| PubMedSearch : Franca_2019_Int.J.Mol.Sci_20_ |
| PubMedID: 30862059 |
| Title : Molecular Modeling and In Vitro Studies of a Neutral Oxime as a Potential Reactivator for Acetylcholinesterase Inhibited by Paraoxon - de Paula_2018_Molecules_23_ |
| Author(s) : de Paula RL , de Almeida JSFD , Cavalcante SFA , Goncalves AS , Simas ABC , Franca TCC , Valis M , Kuca K , Nepovimova E , Granjeiro JM |
| Ref : Molecules , 23 : , 2018 |
| Abstract : |
| PubMedSearch : de Paula_2018_Molecules_23_ |
| PubMedID: 30424582 |
| Title : Quantification through TLC-densitometric analysis, repellency and anticholinesterase activity of the homemade extract of Indian cloves - Affonso_2018_Biomed.Chromatogr_32_ |
| Author(s) : Affonso RS , Lima JA , Lessa BM , Caetano JVO , Obara MT , Nobrega AB , Nepovimova E , Musilek K , Kuca K , Slana G , Franca TCC |
| Ref : Biomedical Chromatography , 32 : , 2018 |
| Abstract : |
| PubMedSearch : Affonso_2018_Biomed.Chromatogr_32_ |
| PubMedID: 28913959 |
| Title : Newly Developed Drugs for Alzheimer's Disease in Relation to Energy Metabolism, Cholinergic and Monoaminergic Neurotransmission - Korabecny_2018_Neurosci_370_191 |
| Author(s) : Korabecny J , Nepovimova E , Cikankova T , Spilovska K , Vaskova L , Mezeiova E , Kuca K , Hroudova J |
| Ref : Neuroscience , 370 :191 , 2018 |
| Abstract : |
| PubMedSearch : Korabecny_2018_Neurosci_370_191 |
| PubMedID: 28673719 |
| Title : Investigation of New Orexin 2 Receptor Modulators Using In Silico and In Vitro Methods - Janockova_2018_Molecules_23_ |
| Author(s) : Janockova J , Dolezal R , Nepovimova E , Kobrlova T , Benkova M , Kuca K , Konecny J , Mezeiova E , Melikova M , Hepnarova V , Ring A , Soukup O , Korabecny J |
| Ref : Molecules , 23 : , 2018 |
| Abstract : |
| PubMedSearch : Janockova_2018_Molecules_23_ |
| PubMedID: 30423961 |
| Title : The New Acetylcholinesterase Inhibitors PC-37 and PC-48 (7-Methoxytacrine-Donepezil-Like Compounds): Characterization of Their Metabolites in Human Liver Microsomes, Pharmacokinetics and In Vivo Formation of the Major Metabolites in Rats - Zdarova Karasova_2018_Basic.Clin.Pharmacol.Toxicol_122_373 |
| Author(s) : Karasova JZ , Mzik M , Hroch M , Korabecny J , Nepovimova E , Vorisek V , Palicka V , Kuca K |
| Ref : Basic Clin Pharmacol Toxicol , 122 :373 , 2018 |
| Abstract : |
| PubMedSearch : Zdarova Karasova_2018_Basic.Clin.Pharmacol.Toxicol_122_373 |
| PubMedID: 29067789 |
| Title : A newly developed oxime K203 is the most effective reactivator of tabun-inhibited acetylcholinesterase - Kuca_2018_BMC.Pharmacol.Toxicol_19_8 |
| Author(s) : Kuca K , Musilek K , Jun D , Karasova JZ , Nepovimova E , Soukup O , Hrabinova M , Mikler J , Franca TCC , da Cunha EFF , de Castro AA , Valis M , Ramalho TC |
| Ref : BMC Pharmacol Toxicol , 19 :8 , 2018 |
| Abstract : |
| PubMedSearch : Kuca_2018_BMC.Pharmacol.Toxicol_19_8 |
| PubMedID: 29467029 |
| Title : The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease - Hepnarova_2018_Eur.J.Med.Chem_150_292 |
| Author(s) : Hepnarova V , Korabecny J , Matouskova L , Jost P , Muckova L , Hrabinova M , Vykoukalova N , Kerhartova M , Kucera T , Dolezal R , Nepovimova E , Spilovska K , Mezeiova E , Pham NL , Jun D , Staud F , Kaping D , Kuca K , Soukup O |
| Ref : Eur Journal of Medicinal Chemistry , 150 :292 , 2018 |
| Abstract : |
| PubMedSearch : Hepnarova_2018_Eur.J.Med.Chem_150_292 |
| PubMedID: 29533874 |
| Title : Development of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings - Kuca_2018_Drug.Des.Devel.Ther_12_505 |
| Author(s) : Kuca K , Karasova JZ , Soukup O , Kassa J , Novotna E , Sepsova V , Horova A , Pejchal J , Hrabinova M , Vodakova E , Jun D , Nepovimova E , Valis M , Musilek K |
| Ref : Drug Des Devel Ther , 12 :505 , 2018 |
| Abstract : |
| PubMedSearch : Kuca_2018_Drug.Des.Devel.Ther_12_505 |
| PubMedID: 29563775 |
| Title : Synthesis, Biological Evaluation, and Docking Studies of Novel Bisquaternary Aldoxime Reactivators on Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon - Kuca_2018_Molecules_23_ |
| Author(s) : Kuca K , Jun D , Junova L , Musilek K , Hrabinova M , da Silva JAV , Ramalho TC , Valko M , Wu Q , Nepovimova E , Franca TCC |
| Ref : Molecules , 23 : , 2018 |
| Abstract : |
| PubMedSearch : Kuca_2018_Molecules_23_ |
| PubMedID: 29735900 |
| Title : In vitro and in silico Evaluation of Non-Quaternary Reactivators of AChE as Antidotes of Organophosphorus Poisoning - a New Hope or a Blind Alley? - Soukup_2018_Med.Chem_14_281 |
| Author(s) : Soukup O , Korabecny J , Malinak D , Nepovimova E , Pham NL , Musilek K , Hrabinova M , Hepnarova V , Dolezal R , Pavek P , Jost P , Kobrlova T , Jankockova J , Gorecki L , Psotka M , Nguyen TD , Box K , Outhwaite B , Ceckova M , Sorf A , Jun D , Kuca K |
| Ref : Med Chem , 14 :281 , 2018 |
| Abstract : |
| PubMedSearch : Soukup_2018_Med.Chem_14_281 |
| PubMedID: 29332594 |
| Title : Profiling donepezil template into multipotent hybrids with antioxidant properties - Mezeiova_2018_J.Enzyme.Inhib.Med.Chem_33_583 |
| Author(s) : Mezeiova E , Spilovska K , Nepovimova E , Gorecki L , Soukup O , Dolezal R , Malinak D , Janockova J , Jun D , Kuca K , Korabecny J |
| Ref : J Enzyme Inhib Med Chem , 33 :583 , 2018 |
| Abstract : |
| PubMedSearch : Mezeiova_2018_J.Enzyme.Inhib.Med.Chem_33_583 |
| PubMedID: 29529892 |
| Title : Novel Group of AChE Reactivators-Synthesis, In Vitro Reactivation and Molecular Docking Study - Malinak_2018_Molecules_23_ |
| Author(s) : Malinak D , Nepovimova E , Jun D , Musilek K , Kuca K |
| Ref : Molecules , 23 : , 2018 |
| Abstract : |
| PubMedSearch : Malinak_2018_Molecules_23_ |
| PubMedID: 30205495 |
| Title : Cholinesterase inhibitor 6-chlorotacrine - in vivo toxicological profile and behavioural effects - Misik_2018_Curr.Alzheimer.Res_15_552 |
| Author(s) : Misik J , Nepovimova E , Pejchal J , Kassa J , Korabecny J , Soukup O |
| Ref : Curr Alzheimer Res , 15 :552 , 2018 |
| Abstract : |
| PubMedSearch : Misik_2018_Curr.Alzheimer.Res_15_552 |
| PubMedID: 29231138 |
| Title : A Review of the Synthesis of Quaternary Acetylcholinesterase Reactivators - Tsai_2021_J.Food.Drug.Anal_29_153 |
| Author(s) : Malinak D , Korabecny J , Soukup O , Gorecki L , Nepovimova E , Psotka M , Dolezal R , Nguyen TD , Mezeiova E , Musilek K , Kuca K |
| Ref : Current Organic Chemistry , 22\ :1619 , 2018 |
| Abstract : |
| PubMedSearch : Tsai_2021_J.Food.Drug.Anal_29_153 |
| PubMedID: |
| Title : Chemical warfare agent NOVICHOK - mini-review of available data - Nepovimova_2018_Food.Chem.Toxicol_121_343 |
| Author(s) : Nepovimova E , Kuca K |
| Ref : Food & Chemical Toxicology , 121 :343 , 2018 |
| Abstract : |
| PubMedSearch : Nepovimova_2018_Food.Chem.Toxicol_121_343 |
| PubMedID: 30213549 |
| Title : The pharmacology of tacrine at N-methyl-d-aspartate receptors - Horak_2017_Prog.Neuropsychopharmacol.Biol.Psychiatry_75_54 |
| Author(s) : Horak M , Holubova K , Nepovimova E , Krusek J , Kaniakova M , Korabecny J , Vyklicky L , Kuca K , Stuchlik A , Ricny J , Vales K , Soukup O |
| Ref : Prog Neuropsychopharmacol Biological Psychiatry , 75 :54 , 2017 |
| Abstract : |
| PubMedSearch : Horak_2017_Prog.Neuropsychopharmacol.Biol.Psychiatry_75_54 |
| PubMedID: 28089695 |
| Title : Multi-target-directed therapeutic potential of 7-methoxytacrine-adamantylamine heterodimers in the Alzheimer's disease treatment - Gazova_2017_Biochim.Biophys.Acta.Mol.Basis.Dis_1863_607 |
| Author(s) : Gazova Z , Soukup O , Sepsova V , Siposova K , Drtinova L , Jost P , Spilovska K , Korabecny J , Nepovimova E , Fedunova D , Horak M , Kaniakova M , Wang ZJ , Hamouda AK , Kuca K |
| Ref : Biochimica & Biophysica Acta Mol Basis Dis , 1863 :607 , 2017 |
| Abstract : |
| PubMedSearch : Gazova_2017_Biochim.Biophys.Acta.Mol.Basis.Dis_1863_607 |
| PubMedID: 27865910 |
| Title : Prolyl oligopeptidase and its role in the organism: attention to the most promising and clinically relevant inhibitors - Babkova_2017_Future.Med.Chem_9_1015 |
| Author(s) : Babkova K , Korabecny J , Soukup O , Nepovimova E , Jun D , Kuca K |
| Ref : Future Med Chem , 9 :1015 , 2017 |
| Abstract : |
| PubMedSearch : Babkova_2017_Future.Med.Chem_9_1015 |
| PubMedID: 28632451 |
| Title : The Evaluation of Benefit of Newly Prepared Reversible Inhibitors of Acetylcholinesterase and Commonly Used Pyridostigmine as Pharmacological Pretreatment of Soman-Poisoned Mice - Kassa_2017_Acta.Medica.(Hradec.Kralove)_60_37 |
| Author(s) : Kassa J , Korabecny J , Nepovimova E |
| Ref : Acta Medica (Hradec Kralove) , 60 :37 , 2017 |
| Abstract : |
| PubMedSearch : Kassa_2017_Acta.Medica.(Hradec.Kralove)_60_37 |
| PubMedID: 28418831 |
| Title : Multitarget Tacrine Hybrids with Neuroprotective Properties to Confront Alzheimer's Disease - Spilovska_2017_Curr.Top.Med.Chem_17_1006 |
| Author(s) : Spilovska K , Korabecny J , Nepovimova E , Dolezal R , Mezeiova E , Soukup O , Kuca K |
| Ref : Curr Top Med Chem , 17 :1006 , 2017 |
| Abstract : |
| PubMedSearch : Spilovska_2017_Curr.Top.Med.Chem_17_1006 |
| PubMedID: 27697055 |
| Title : Progress in acetylcholinesterase reactivators and in the treatment of organophosphorus intoxication: a patent review (2006-2016) - Gorecki_2017_Expert.Opin.Ther.Pat_27_971 |
| Author(s) : Gorecki L , Korabecny J , Musilek K , Nepovimova E , Malinak D , Kucera T , Dolezal R , Jun D , Soukup O , Kuca K |
| Ref : Expert Opin Ther Pat , 27 :971 , 2017 |
| Abstract : |
| PubMedSearch : Gorecki_2017_Expert.Opin.Ther.Pat_27_971 |
| PubMedID: 28569609 |
| Title : An HPLC-MS method for the quantification of new acetylcholinesterase inhibitor PC 48 (7-MEOTA-donepezil like compound) in rat plasma: Application to a pharmacokinetic study - Mzik_2016_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_1020_85 |
| Author(s) : Mzik M , Korabecny J , Nepovimova E , Vorisek V , Palicka V , Kuca K , Karasova JZ |
| Ref : Journal of Chromatography B Analyt Technol Biomed Life Sciences , 1020 :85 , 2016 |
| Abstract : |
| PubMedSearch : Mzik_2016_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_1020_85 |
| PubMedID: 27030895 |
| Title : SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides - Gorecki_2016_Arch.Toxicol_90_2831 |
| Author(s) : Gorecki L , Korabecny J , Musilek K , Malinak D , Nepovimova E , Dolezal R , Jun D , Soukup O , Kuca K |
| Ref : Archives of Toxicology , 90 :2831 , 2016 |
| Abstract : |
| PubMedSearch : Gorecki_2016_Arch.Toxicol_90_2831 |
| PubMedID: 27582056 |
| Title : Inhibitors of Acetylcholinesterase Derived from 7-Methoxytacrine and Their Effects on the Choline Transporter CHT1 - Kristofikova_2016_Dement.Geriatr.Cogn.Disord_43_45 |
| Author(s) : Kristofikova Z , Ricny J , Soukup O , Korabecny J , Nepovimova E , Kuca K , Ripova D |
| Ref : Dementia & Geriatric Cognitive Disorders , 43 :45 , 2016 |
| Abstract : |
| PubMedSearch : Kristofikova_2016_Dement.Geriatr.Cogn.Disord_43_45 |
| PubMedID: 27988521 |
| Title : Effects of novel tacrine-related cholinesterase inhibitors in the reversal of 3-quinuclidinyl benzilate-induced cognitive deficit in rats-Is there a potential for Alzheimer's disease treatment? - Misik_2016_Neurosci.Lett_612_261 |
| Author(s) : Misik J , Korabecny J , Nepovimova E , Kracmarova A , Kassa J |
| Ref : Neuroscience Letters , 612 :261 , 2016 |
| Abstract : |
| PubMedSearch : Misik_2016_Neurosci.Lett_612_261 |
| PubMedID: 26708634 |
| Title : A 7-methoxytacrine-4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication - Nepovimova_2016_Toxicol.Res.(Camb)_5_1012 |
| Author(s) : Nepovimova E , Korabecny J , Dolezal R , Nguyen TD , Jun D , Soukup O , Pasdiorova M , Jost P , Muckova L , Malinak D , Gorecki L , Musilek K , Kuca K |
| Ref : Toxicol Res (Camb) , 5 :1012 , 2016 |
| Abstract : |
| PubMedSearch : Nepovimova_2016_Toxicol.Res.(Camb)_5_1012 |
| PubMedID: 30090408 |
| Title : The effects of novel 7-MEOTA-donepezil like hybrids and N-alkylated tacrine analogues in the treatment of quinuclidinyl benzilate-induced behavioural deficits in rats performing the multiple T-maze test - Misik_2015_Biomed.Pap.Med.Fac.Univ.Palacky.Olomouc.Czech.Repub_159_547 |
| Author(s) : Misik J , Korabecny J , Nepovimova E , Cabelova P , Kassa J |
| Ref : Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub , 159 :547 , 2015 |
| Abstract : |
| PubMedSearch : Misik_2015_Biomed.Pap.Med.Fac.Univ.Palacky.Olomouc.Czech.Repub_159_547 |
| PubMedID: 25690521 |
| Title : Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity - Nepovimova_2015_J.Med.Chem_58_8985 |
| Author(s) : Nepovimova E , Korabecny J , Dolezal R , Babkova K , Ondrejicek A , Jun D , Sepsova V , Horova A , Hrabinova M , Soukup O , Bukum N , Jost P , Muckova L , Kassa J , Malinak D , Andrs M , Kuca K |
| Ref : Journal of Medicinal Chemistry , 58 :8985 , 2015 |
| Abstract : |
| PubMedSearch : Nepovimova_2015_J.Med.Chem_58_8985 |
| PubMedID: 26503905 |
| Title : 7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment - Korabecny_2015_Molecules_20_22084 |
| Author(s) : Korabecny J , Andrs M , Nepovimova E , Dolezal R , Babkova K , Horova A , Malinak D , Mezeiova E , Gorecki L , Sepsova V , Hrabinova M , Soukup O , Jun D , Kuca K |
| Ref : Molecules , 20 :22084 , 2015 |
| Abstract : |
| PubMedSearch : Korabecny_2015_Molecules_20_22084 |
| PubMedID: 26690394 |
| Title : From Pyridinium-based to Centrally Active Acetylcholinesterase Reactivators - Korabecny_2014_Mini.Rev.Med.Chem_14_215 |
| Author(s) : Korabecny J , Soukup O , Dolezal R , Spilovska K , Nepovimova E , Andrs M , Nguyen TD , Jun D , Musilek K , Kucerova-Chlupacova M , Kuca K |
| Ref : Mini Rev Med Chem , 14 :215 , 2014 |
| Abstract : |
| PubMedSearch : Korabecny_2014_Mini.Rev.Med.Chem_14_215 |
| PubMedID: 24552265 |
| Title : Multitarget Drug Design Strategy: Quinone-Tacrine Hybrids Designed To Block Amyloid-beta Aggregation and To Exert Anticholinesterase and Antioxidant Effects - Nepovimova_2014_J.Med.Chem_57_8576 |
| Author(s) : Nepovimova E , Uliassi E , Korabecny J , Pena-Altamira LE , Samez S , Pesaresi A , Garcia GE , Bartolini M , Andrisano V , Bergamini C , Fato R , Lamba D , Roberti M , Kuca K , Monti B , Bolognesi ML |
| Ref : Journal of Medicinal Chemistry , 57 :8576 , 2014 |
| Abstract : |
| PubMedSearch : Nepovimova_2014_J.Med.Chem_57_8576 |
| PubMedID: 25259726 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Outcomes of Alzheimer's disease therapy with acetylcholinesterase inhibitors and memantine - Zemek_2014_Expert.Opin.Drug.Saf_13_759 |
| Author(s) : Zemek F , Drtinova L , Nepovimova E , Sepsova V , Korabecny J , Klimes J , Kuca K |
| Ref : Expert Opin Drug Safety , 13 :759 , 2014 |
| Abstract : |
| PubMedSearch : Zemek_2014_Expert.Opin.Drug.Saf_13_759 |
| PubMedID: 24845946 |
| Title : 7-MEOTA-donepezil like compounds as cholinesterase inhibitors: Synthesis, pharmacological evaluation, molecular modeling and QSAR studies - Korabecny_2014_Eur.J.Med.Chem_82C_426 |
| Author(s) : Korabecny J , Dolezal R , Cabelova P , Horova A , Hruba E , Ricny J , Sedlacek L , Nepovimova E , Spilovska K , Andrs M , Musilek K , Opletalova V , Sepsova V , Ripova D , Kuca K |
| Ref : Eur Journal of Medicinal Chemistry , 82C :426 , 2014 |
| Abstract : |
| PubMedSearch : Korabecny_2014_Eur.J.Med.Chem_82C_426 |
| PubMedID: 24929293 |
| Title : Synthesis and in vitro evaluation of 7-methoxy-N-(pent-4-enyl)-1,2,3,4-tetrahydroacridin-9-amine-new tacrine derivate with cholinergic properties - Korabecny_2011_Bioorg.Med.Chem.Lett_21_6563 |
| Author(s) : Korabecny J , Musilek K , Zemek F , Horova A , Holas O , Nepovimova E , Opletalova V , Hroudova J , Fisar Z , Jung YS , Kuca K |
| Ref : Bioorganic & Medicinal Chemistry Lett , 21 :6563 , 2011 |
| Abstract : |
| PubMedSearch : Korabecny_2011_Bioorg.Med.Chem.Lett_21_6563 |
| PubMedID: 21920739 |
| Title : Synthesis and in vitro evaluation of N-(Bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine as a cholinesterase inhibitor with regard to Alzheimer's disease treatment - Korabecny_2010_Molecules_15_8804 |
| Author(s) : Korabecny J , Musilek K , Holas O , Nepovimova E , Jun D , Zemek F , Opletalova V , Patocka J , Dohnal V , Nachon F , Hroudova J , Fisar Z , Kuca K |
| Ref : Molecules , 15 :8804 , 2010 |
| Abstract : |
| PubMedSearch : Korabecny_2010_Molecules_15_8804 |
| PubMedID: 21127466 |