Report for Nepovimova E

General

Full name : Nepovimova Eugenie

First name : Eugenie

Mail : Charles University in Prague\; Faculty of Pharmacy in Hradec Kralove\; Department of Toxicology and Military Pharmacy\; Trebesska 1575\; 500 05 Hradec Kralove

Zip Code :

City :

Country : Czech Republic

Email : Evzenie.N@seznam.cz

Phone : +420608324886

Fax :

Website :

Directory :

References (62)

Title : Influence of the chronic groundwater fluoride consumption on cholinergic enzymes, ACHE and BCHE gene SNPs and pro-inflammatory cytokines: A study with Pakistani population groups - Bibi_2023_Sci.Total.Environ__163359
Author(s) : Bibi S , Habib R , Shafiq S , Abbas SS , Khan S , Eqani S , Nepovimova E , Khan MS , Kuca K , Nurulain SM
Ref : Sci Total Environ , :163359 , 2023
Abstract : Bibi_2023_Sci.Total.Environ__163359
ESTHER : Bibi_2023_Sci.Total.Environ__163359
PubMedSearch : Bibi_2023_Sci.Total.Environ__163359
PubMedID: 37030382

Title : Pralidoxime-like reactivator with increased lipophilicity - Molecular modeling and in vitro study - Kuca_2023_Chem.Biol.Interact_14ChEPon_110734
Author(s) : Kuca K , Valle da Silva JA , Nepovimova E , Pham NL , Wu W , Valis M , Wu Q , Franca TCC
Ref : Chemico-Biological Interactions , :110734 , 2023
Abstract : Kuca_2023_Chem.Biol.Interact_14ChEPon_110734
ESTHER : Kuca_2023_Chem.Biol.Interact_14ChEPon_110734
PubMedSearch : Kuca_2023_Chem.Biol.Interact_14ChEPon_110734
PubMedID: 37788753

Title : Oxidative stress status assessment of rats' brains injury following subacute exposure to K-oximes - Jacevic_2023_Chem.Biol.Interact_14ChEPon_110658
Author(s) : Jacevic V , Dumanovic J , Grujic-Milanovic J , Milovanovic Z , Amidzic L , Vojinovic N , Nezic L , Markovic B , Dobricic V , Milosavljevic P , Nepovimova E , Kuca K
Ref : Chemico-Biological Interactions , :110658 , 2023
Abstract : Jacevic_2023_Chem.Biol.Interact_14ChEPon_110658
ESTHER : Jacevic_2023_Chem.Biol.Interact_14ChEPon_110658
PubMedSearch : Jacevic_2023_Chem.Biol.Interact_14ChEPon_110658
PubMedID: 37572873

Title : Theoretical assessment of the performances of commercial oximes on the reactivation of acetylcholinesterase inhibited by the nerve agent A-242 (novichok) - Santos_2022_Food.Chem.Toxicol__113084
Author(s) : Santos MC , Botelho FD , Goncalves AS , Kuca K , Nepovimova E , Cavalcante SFA , Lima ALS , Franca TCC
Ref : Food & Chemical Toxicology , :113084 , 2022
Abstract : Santos_2022_Food.Chem.Toxicol__113084
ESTHER : Santos_2022_Food.Chem.Toxicol__113084
PubMedSearch : Santos_2022_Food.Chem.Toxicol__113084
PubMedID: 35489467

Title : Privileged multi-target directed propargyl-tacrines combining cholinesterase and monoamine oxidase inhibition activities - Chrienova_2022_J.Enzyme.Inhib.Med.Chem_37_2605
Author(s) : Chrienova Z , Nepovimova E , Andrys R , Dolezal R , Janockova J , Muckova L , Fabova L , Soukup O , Oleksak P , Valis M , Korabecny J , Marco-Contelles J , Kuca K
Ref : J Enzyme Inhib Med Chem , 37 :2605 , 2022
Abstract : Chrienova_2022_J.Enzyme.Inhib.Med.Chem_37_2605
ESTHER : Chrienova_2022_J.Enzyme.Inhib.Med.Chem_37_2605
PubMedSearch : Chrienova_2022_J.Enzyme.Inhib.Med.Chem_37_2605
PubMedID: 36131624

Title : Dysregulation of butyrylcholinesterase, BCHE gene SNP rs1803274, and pro-inflammatory cytokines in occupational workers - Khan_2022_Environ.Res__115195
Author(s) : Khan SA , Leonel Javeres MN , Abbas Shah ST , Bibi N , Muneer Z , Hussain S , Nepovimova E , Kuca K , Nurulain SM
Ref : Environ Research , :115195 , 2022
Abstract : Khan_2022_Environ.Res__115195
ESTHER : Khan_2022_Environ.Res__115195
PubMedSearch : Khan_2022_Environ.Res__115195
PubMedID: 36592809

Title : Are the current commercially available oximes capable of reactivating acetylcholinesterase inhibited by the nerve agents of the A-series? - Santos_2022_Arch.Toxicol__
Author(s) : Santos MC , Botelho FD , Goncalves AS , Kitagawa DAS , Borges CVN , Carvalho-Silva T , Bernardo LB , Ferreira CN , Rodrigues RB , Ferreira Neto DC , Nepovimova E , Kuca K , LaPlante SR , Lima ALS , Franca TCC , Cavalcante SFA
Ref : Archives of Toxicology , : , 2022
Abstract : Santos_2022_Arch.Toxicol__
ESTHER : Santos_2022_Arch.Toxicol__
PubMedSearch : Santos_2022_Arch.Toxicol__
PubMedID: 35666269

Title : Design, synthesis, in silico studies and in vitro evaluation of isatin-pyridine oximes hybrids as novel acetylcholinesterase reactivators - Kitagawa_2021_J.Enzyme.Inhib.Med.Chem_36_1370
Author(s) : Kitagawa DAS , Rodrigues RB , Silva TN , Dos Santos WV , da Rocha VCV , de Almeida JSFD , Bernardo LB , Carvalho-Silva T , Ferreira CN , da Silva AAT , Simas ABC , Nepovimova E , Kuca K , Franca TCC , Cavalcante SFA
Ref : J Enzyme Inhib Med Chem , 36 :1370 , 2021
Abstract : Kitagawa_2021_J.Enzyme.Inhib.Med.Chem_36_1370
ESTHER : Kitagawa_2021_J.Enzyme.Inhib.Med.Chem_36_1370
PubMedSearch : Kitagawa_2021_J.Enzyme.Inhib.Med.Chem_36_1370
PubMedID: 34148470

Title : Tacrine - Benzothiazoles: Novel class of potential multitarget anti-Alzheimes drugs dealing with cholinergic, amyloid and mitochondrial systems - Nepovimova_2020_Bioorg.Chem_107_104596
Author(s) : Nepovimova E , Svobodova L , Dolezal R , Hepnarova V , Junova L , Jun D , Korabecny J , Kucera T , Gazova Z , Motykova K , Kubackova J , Bednarikova Z , Janockova J , Jesus C , Cortes L , Pina J , Rostohar D , Serpa C , Soukup O , Aitken L , Hughes RE , Musilek K , Muckova L , Jost P , Chvojkova M , Vales K , Valis M , Chrienova Z , Chalupova K , Kuca K
Ref : Bioorg Chem , 107 :104596 , 2020
Abstract : Nepovimova_2020_Bioorg.Chem_107_104596
ESTHER : Nepovimova_2020_Bioorg.Chem_107_104596
PubMedSearch : Nepovimova_2020_Bioorg.Chem_107_104596
PubMedID: 33421953

Title : Cannabis Constituents and Acetylcholinesterase Interaction: Molecular Docking, In Vitro Studies and Association with CNR1 rs806368 and ACHE rs17228602 - Furqan_2020_Biomolecules_10_
Author(s) : Furqan T , Batool S , Habib R , Shah M , Kalasz H , Darvas F , Kuca K , Nepovimova E , Nurulain SM
Ref : Biomolecules , 10 : , 2020
Abstract : Furqan_2020_Biomolecules_10_
ESTHER : Furqan_2020_Biomolecules_10_
PubMedSearch : Furqan_2020_Biomolecules_10_
PubMedID: 32414087

Title : Oxidative Stress and Analysis of Selected SNPs of ACHE (rs 2571598), BCHE (rs 3495), CAT (rs 7943316), SIRT1 (rs 10823108), GSTP1 (rs 1695), and Gene GSTM1, GSTT1 in Chronic Organophosphates Exposed Groups from Cameroon and Pakistan - Mbah Ntepe_2020_Int.J.Mol.Sci_21_
Author(s) : Mbah Ntepe LJ , Habib R , Judith Laure N , Raza S , Nepovimova E , Kuca K , Batool S , Muhammad Nurulain S
Ref : Int J Mol Sci , 21 : , 2020
Abstract : Mbah Ntepe_2020_Int.J.Mol.Sci_21_
ESTHER : Mbah Ntepe_2020_Int.J.Mol.Sci_21_
PubMedSearch : Mbah Ntepe_2020_Int.J.Mol.Sci_21_
PubMedID: 32899431

Title : Analysis of PON1 gene polymorphisms (rs662 and rs854560) and inflammatory markers in organophosphate pesticides exposed cohorts from two distinct populations - Leonel_2020_Environ.Res__110210
Author(s) : Leonel Javeres MN , Habib R , Judith N , Iqbal M , Nepovimova E , Kuca K , Batool S , Nurulain SM
Ref : Environ Research , :110210 , 2020
Abstract : Leonel_2020_Environ.Res__110210
ESTHER : Leonel_2020_Environ.Res__110210
PubMedSearch : Leonel_2020_Environ.Res__110210
PubMedID: 32949615

Title : An update on T-2 toxin and its modified forms: metabolism, immunotoxicity mechanism, and human exposure assessment - Wu_2020_Arch.Toxicol_94_3645
Author(s) : Wu Q , Qin Z , Kuca K , You L , Zhao Y , Liu A , Musilek K , Chrienova Z , Nepovimova E , Oleksak P , Wu W , Wang X
Ref : Archives of Toxicology , 94 :3645 , 2020
Abstract : Wu_2020_Arch.Toxicol_94_3645
ESTHER : Wu_2020_Arch.Toxicol_94_3645
PubMedSearch : Wu_2020_Arch.Toxicol_94_3645
PubMedID: 32910237

Title : Understanding the Interaction Modes and Reactivity of Trimedoxime toward MmAChE Inhibited by Nerve Agents: Theoretical and Experimental Aspects - de Castro_2020_Int.J.Mol.Sci_21_
Author(s) : de Castro AA , Polisel DA , Pereira BTL , da Cunha EFF , Kuca K , Nepovimova E , Ramalho TC
Ref : Int J Mol Sci , 21 : , 2020
Abstract : de Castro_2020_Int.J.Mol.Sci_21_
ESTHER : de Castro_2020_Int.J.Mol.Sci_21_
PubMedSearch : de Castro_2020_Int.J.Mol.Sci_21_
PubMedID: 32899591

Title : Interaction of Synthesized Nitrogen enriched Graphene Quantum Dots with Novel Anti-Alzheimer's Drugs: Spectroscopic Insights - Sharma_2020_J.Biomol.Struct.Dyn_38_1822
Author(s) : Sharma S , Singh N , Nepovimova E , Korabecny J , Kuca K , Satnami ML , Ghosh KK
Ref : J Biomol Struct Dyn , 38 :1822 , 2020
Abstract : Sharma_2020_J.Biomol.Struct.Dyn_38_1822
ESTHER : Sharma_2020_J.Biomol.Struct.Dyn_38_1822
PubMedSearch : Sharma_2020_J.Biomol.Struct.Dyn_38_1822
PubMedID: 31096863

Title : Donepezil Derivatives Targeting Amyloid-beta Cascade in Alzheimer's Disease - Mezeiova_2019_Curr.Alzheimer.Res_16_772
Author(s) : Mezeiova E , Chalupova K , Nepovimova E , Gorecki L , Prchal L , Malinak D , Kuca K , Soukup O , Korabecny J
Ref : Curr Alzheimer Res , 16 :772 , 2019
Abstract : Mezeiova_2019_Curr.Alzheimer.Res_16_772
ESTHER : Mezeiova_2019_Curr.Alzheimer.Res_16_772
PubMedSearch : Mezeiova_2019_Curr.Alzheimer.Res_16_772
PubMedID: 30819078

Title : Non-conventional compounds with potential therapeutic effects against Alzheimer's disease - de Castro_2019_Expert.Rev.Neurother_19_375
Author(s) : de Castro AA , Soares FV , Pereira AF , Polisel DA , Caetano MS , Leal DHS , da Cunha EFF , Nepovimova E , Kuca K , Ramalho TC
Ref : Expert Rev Neurother , 19 :375 , 2019
Abstract : de Castro_2019_Expert.Rev.Neurother_19_375
ESTHER : de Castro_2019_Expert.Rev.Neurother_19_375
PubMedSearch : de Castro_2019_Expert.Rev.Neurother_19_375
PubMedID: 30999771

Title : Molecular modeling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime, 4-PA, 2-PAM, and obidoxime with VX-inhibited human acetylcholinesterase: a near attack conformation approach - da Silva_2019_J.Enzyme.Inhib.Med.Chem_34_1018
Author(s) : da Silva JAV , Nepovimova E , Ramalho TC , Kuca K , Franca TCC
Ref : J Enzyme Inhib Med Chem , 34 :1018 , 2019
Abstract : da Silva_2019_J.Enzyme.Inhib.Med.Chem_34_1018
ESTHER : da Silva_2019_J.Enzyme.Inhib.Med.Chem_34_1018
PubMedSearch : da Silva_2019_J.Enzyme.Inhib.Med.Chem_34_1018
PubMedID: 31074292

Title : Molecular modelling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime with VX-inhibited human acetylcholinesterase. A near attack approach to assess different spacer-lengths - da Silva_2019_Chem.Biol.Interact_13ChEPon_307_195
Author(s) : da Silva JAV , Nepovimova E , Ramalho TC , Kuca K , Franca TCC
Ref : Chemico-Biological Interactions , 307 :195 , 2019
Abstract : da Silva_2019_Chem.Biol.Interact_13ChEPon_307_195
ESTHER : da Silva_2019_Chem.Biol.Interact_13ChEPon_307_195
PubMedSearch : da Silva_2019_Chem.Biol.Interact_13ChEPon_307_195
PubMedID: 31121152

Title : Toxic Injury to Muscle Tissue of Rats Following Acute Oximes Exposure - Jacevic_2019_Sci.Rep_9_1457
Author(s) : Jacevic V , Nepovimova E , Kuca K
Ref : Sci Rep , 9 :1457 , 2019
Abstract : Jacevic_2019_Sci.Rep_9_1457
ESTHER : Jacevic_2019_Sci.Rep_9_1457
PubMedSearch : Jacevic_2019_Sci.Rep_9_1457
PubMedID: 30728420

Title : Combination of Memantine and 6-Chlorotacrine as Novel Multi-Target Compound against Alzheimer's Disease - Kaniakova_2019_Curr.Alzheimer.Res_16_821
Author(s) : Kaniakova M , Nepovimova E , Kleteckova L , Skrenkova K , Holubova K , Chrienova Z , Hepnarova V , Kucera T , Kobrlova T , Vales K , Korabecny J , Soukup O , Horak M
Ref : Curr Alzheimer Res , 16 :821 , 2019
Abstract : Kaniakova_2019_Curr.Alzheimer.Res_16_821
ESTHER : Kaniakova_2019_Curr.Alzheimer.Res_16_821
PubMedSearch : Kaniakova_2019_Curr.Alzheimer.Res_16_821
PubMedID: 30819076

Title : Traditional Ayurvedic and herbal remedies for Alzheimer's disease: from bench to bedside - Sharma_2019_Expert.Rev.Neurother_19_359
Author(s) : Sharma R , Kuca K , Nepovimova E , Kabra A , Rao MM , Prajapati PK
Ref : Expert Rev Neurother , 19 :359 , 2019
Abstract : Sharma_2019_Expert.Rev.Neurother_19_359
ESTHER : Sharma_2019_Expert.Rev.Neurother_19_359
PubMedSearch : Sharma_2019_Expert.Rev.Neurother_19_359
PubMedID: 30884983

Title : Novichoks: The Dangerous Fourth Generation of Chemical Weapons - Franca_2019_Int.J.Mol.Sci_20_
Author(s) : Franca TCC , Kitagawa DAS , Cavalcante SFA , da Silva JAV , Nepovimova E , Kuca K
Ref : Int J Mol Sci , 20 : , 2019
Abstract : Franca_2019_Int.J.Mol.Sci_20_
ESTHER : Franca_2019_Int.J.Mol.Sci_20_
PubMedSearch : Franca_2019_Int.J.Mol.Sci_20_
PubMedID: 30862059

Title : Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease - Chalupova_2019_Eur.J.Med.Chem_168_491
Author(s) : Chalupova K , Korabecny J , Bartolini M , Monti B , Lamba D , Caliandro R , Pesaresi A , Brazzolotto X , Gastellier AJ , Nachon F , Pejchal J , Jarosova M , Hepnarova V , Jun D , Hrabinova M , Dolezal R , Karasova JZ , Mzik M , Kristofikova Z , Misik J , Muckova L , Jost P , Soukup O , Benkova M , Setnicka V , Habartova L , Chvojkova M , Kleteckova L , Vales K , Mezeiova E , Uliassi E , Valis M , Nepovimova E , Bolognesi ML , Kuca K
Ref : Eur Journal of Medicinal Chemistry , 168 :491 , 2019
Abstract : Chalupova_2019_Eur.J.Med.Chem_168_491
ESTHER : Chalupova_2019_Eur.J.Med.Chem_168_491
PubMedSearch : Chalupova_2019_Eur.J.Med.Chem_168_491
PubMedID: 30851693
Gene_locus related to this paper: torca-ACHE

Title : N-alkylated Tacrine Derivatives as Potential Agents in Alzheimer's Disease Therapy - Nepovimova_2019_Curr.Alzheimer.Res_16_333
Author(s) : Nepovimova E , Korabecny J , Hepnarova V , Jun D , Dolezal R , Muckova L , Jost P , Soukup O , Janockova J , Pham NL , Nguyen TD , Valis M , Kuca K
Ref : Curr Alzheimer Res , 16 :333 , 2019
Abstract : Nepovimova_2019_Curr.Alzheimer.Res_16_333
ESTHER : Nepovimova_2019_Curr.Alzheimer.Res_16_333
PubMedSearch : Nepovimova_2019_Curr.Alzheimer.Res_16_333
PubMedID: 30873921

Title : Orexin supplementation in narcolepsy treatment: A review - Nepovimova_2019_Med.Res.Rev_39_961
Author(s) : Nepovimova E , Janockova J , Misik J , Kubik S , Stuchlik A , Vales K , Korabecny J , Mezeiova E , Dolezal R , Soukup O , Kobrlova T , Pham NL , Nguyen TD , Konecny J , Kuca K
Ref : Med Res Rev , 39 :961 , 2019
Abstract : Nepovimova_2019_Med.Res.Rev_39_961
ESTHER : Nepovimova_2019_Med.Res.Rev_39_961
PubMedSearch : Nepovimova_2019_Med.Res.Rev_39_961
PubMedID: 30426515

Title : Interspecies and intergender differences in acute toxicity of K-oximes drug candidates - Jacevic_2019_Chem.Biol.Interact_13ChEPon_308_312
Author(s) : Jacevic V , Nepovimova E , Kuca K
Ref : Chemico-Biological Interactions , 308 :312 , 2019
Abstract : Jacevic_2019_Chem.Biol.Interact_13ChEPon_308_312
ESTHER : Jacevic_2019_Chem.Biol.Interact_13ChEPon_308_312
PubMedSearch : Jacevic_2019_Chem.Biol.Interact_13ChEPon_308_312
PubMedID: 31153983

Title : Molecular Modeling and In Vitro Studies of a Neutral Oxime as a Potential Reactivator for Acetylcholinesterase Inhibited by Paraoxon - de Paula_2018_Molecules_23_
Author(s) : de Paula RL , de Almeida JSFD , Cavalcante SFA , Goncalves AS , Simas ABC , Franca TCC , Valis M , Kuca K , Nepovimova E , Granjeiro JM
Ref : Molecules , 23 : , 2018
Abstract : de Paula_2018_Molecules_23_
ESTHER : de Paula_2018_Molecules_23_
PubMedSearch : de Paula_2018_Molecules_23_
PubMedID: 30424582

Title : Quantification through TLC-densitometric analysis, repellency and anticholinesterase activity of the homemade extract of Indian cloves - Affonso_2018_Biomed.Chromatogr_32_
Author(s) : Affonso RS , Lima JA , Lessa BM , Caetano JVO , Obara MT , Nobrega AB , Nepovimova E , Musilek K , Kuca K , Slana G , Franca TCC
Ref : Biomedical Chromatography , 32 : , 2018
Abstract : Affonso_2018_Biomed.Chromatogr_32_
ESTHER : Affonso_2018_Biomed.Chromatogr_32_
PubMedSearch : Affonso_2018_Biomed.Chromatogr_32_
PubMedID: 28913959

Title : Newly Developed Drugs for Alzheimer's Disease in Relation to Energy Metabolism, Cholinergic and Monoaminergic Neurotransmission - Korabecny_2018_Neurosci_370_191
Author(s) : Korabecny J , Nepovimova E , Cikankova T , Spilovska K , Vaskova L , Mezeiova E , Kuca K , Hroudova J
Ref : Neuroscience , 370 :191 , 2018
Abstract : Korabecny_2018_Neurosci_370_191
ESTHER : Korabecny_2018_Neurosci_370_191
PubMedSearch : Korabecny_2018_Neurosci_370_191
PubMedID: 28673719

Title : Cholinesterase inhibitor 6-chlorotacrine - in vivo toxicological profile and behavioural effects - Misik_2018_Curr.Alzheimer.Res_15_552
Author(s) : Misik J , Nepovimova E , Pejchal J , Kassa J , Korabecny J , Soukup O
Ref : Curr Alzheimer Res , 15 :552 , 2018
Abstract : Misik_2018_Curr.Alzheimer.Res_15_552
ESTHER : Misik_2018_Curr.Alzheimer.Res_15_552
PubMedSearch : Misik_2018_Curr.Alzheimer.Res_15_552
PubMedID: 29231138

Title : A Review of the Synthesis of Quaternary Acetylcholinesterase Reactivators - Tsai_2021_J.Food.Drug.Anal_29_153
Author(s) : Malinak D , Korabecny J , Soukup O , Gorecki L , Nepovimova E , Psotka M , Dolezal R , Nguyen TD , Mezeiova E , Musilek K , Kuca K
Ref : Current Organic Chemistry , 22\ :1619 , 2018
Abstract : Tsai_2021_J.Food.Drug.Anal_29_153
ESTHER : Tsai_2021_J.Food.Drug.Anal_29_153
PubMedSearch : Tsai_2021_J.Food.Drug.Anal_29_153
PubMedID:

Title : The New Acetylcholinesterase Inhibitors PC-37 and PC-48 (7-Methoxytacrine-Donepezil-Like Compounds): Characterization of Their Metabolites in Human Liver Microsomes, Pharmacokinetics and In Vivo Formation of the Major Metabolites in Rats - Zdarova Karasova_2018_Basic.Clin.Pharmacol.Toxicol_122_373
Author(s) : Karasova JZ , Mzik M , Hroch M , Korabecny J , Nepovimova E , Vorisek V , Palicka V , Kuca K
Ref : Basic Clin Pharmacol Toxicol , 122 :373 , 2018
Abstract : Zdarova Karasova_2018_Basic.Clin.Pharmacol.Toxicol_122_373
ESTHER : Zdarova Karasova_2018_Basic.Clin.Pharmacol.Toxicol_122_373
PubMedSearch : Zdarova Karasova_2018_Basic.Clin.Pharmacol.Toxicol_122_373
PubMedID: 29067789

Title : The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease - Hepnarova_2018_Eur.J.Med.Chem_150_292
Author(s) : Hepnarova V , Korabecny J , Matouskova L , Jost P , Muckova L , Hrabinova M , Vykoukalova N , Kerhartova M , Kucera T , Dolezal R , Nepovimova E , Spilovska K , Mezeiova E , Pham NL , Jun D , Staud F , Kaping D , Kuca K , Soukup O
Ref : Eur Journal of Medicinal Chemistry , 150 :292 , 2018
Abstract : Hepnarova_2018_Eur.J.Med.Chem_150_292
ESTHER : Hepnarova_2018_Eur.J.Med.Chem_150_292
PubMedSearch : Hepnarova_2018_Eur.J.Med.Chem_150_292
PubMedID: 29533874

Title : In vitro and in silico Evaluation of Non-Quaternary Reactivators of AChE as Antidotes of Organophosphorus Poisoning - a New Hope or a Blind Alley? - Soukup_2018_Med.Chem_14_281
Author(s) : Soukup O , Korabecny J , Malinak D , Nepovimova E , Pham NL , Musilek K , Hrabinova M , Hepnarova V , Dolezal R , Pavek P , Jost P , Kobrlova T , Jankockova J , Gorecki L , Psotka M , Nguyen TD , Box K , Outhwaite B , Ceckova M , Sorf A , Jun D , Kuca K
Ref : Med Chem , 14 :281 , 2018
Abstract : Soukup_2018_Med.Chem_14_281
ESTHER : Soukup_2018_Med.Chem_14_281
PubMedSearch : Soukup_2018_Med.Chem_14_281
PubMedID: 29332594

Title : Profiling donepezil template into multipotent hybrids with antioxidant properties - Mezeiova_2018_J.Enzyme.Inhib.Med.Chem_33_583
Author(s) : Mezeiova E , Spilovska K , Nepovimova E , Gorecki L , Soukup O , Dolezal R , Malinak D , Janockova J , Jun D , Kuca K , Korabecny J
Ref : J Enzyme Inhib Med Chem , 33 :583 , 2018
Abstract : Mezeiova_2018_J.Enzyme.Inhib.Med.Chem_33_583
ESTHER : Mezeiova_2018_J.Enzyme.Inhib.Med.Chem_33_583
PubMedSearch : Mezeiova_2018_J.Enzyme.Inhib.Med.Chem_33_583
PubMedID: 29529892

Title : A newly developed oxime K203 is the most effective reactivator of tabun-inhibited acetylcholinesterase - Kuca_2018_BMC.Pharmacol.Toxicol_19_8
Author(s) : Kuca K , Musilek K , Jun D , Karasova JZ , Nepovimova E , Soukup O , Hrabinova M , Mikler J , Franca TCC , da Cunha EFF , de Castro AA , Valis M , Ramalho TC
Ref : BMC Pharmacol Toxicol , 19 :8 , 2018
Abstract : Kuca_2018_BMC.Pharmacol.Toxicol_19_8
ESTHER : Kuca_2018_BMC.Pharmacol.Toxicol_19_8
PubMedSearch : Kuca_2018_BMC.Pharmacol.Toxicol_19_8
PubMedID: 29467029

Title : Chemical warfare agent NOVICHOK - mini-review of available data - Nepovimova_2018_Food.Chem.Toxicol_121_343
Author(s) : Nepovimova E , Kuca K
Ref : Food & Chemical Toxicology , 121 :343 , 2018
Abstract : Nepovimova_2018_Food.Chem.Toxicol_121_343
ESTHER : Nepovimova_2018_Food.Chem.Toxicol_121_343
PubMedSearch : Nepovimova_2018_Food.Chem.Toxicol_121_343
PubMedID: 30213549

Title : Development of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings - Kuca_2018_Drug.Des.Devel.Ther_12_505
Author(s) : Kuca K , Karasova JZ , Soukup O , Kassa J , Novotna E , Sepsova V , Horova A , Pejchal J , Hrabinova M , Vodakova E , Jun D , Nepovimova E , Valis M , Musilek K
Ref : Drug Des Devel Ther , 12 :505 , 2018
Abstract : Kuca_2018_Drug.Des.Devel.Ther_12_505
ESTHER : Kuca_2018_Drug.Des.Devel.Ther_12_505
PubMedSearch : Kuca_2018_Drug.Des.Devel.Ther_12_505
PubMedID: 29563775

Title : Synthesis, Biological Evaluation, and Docking Studies of Novel Bisquaternary Aldoxime Reactivators on Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon - Kuca_2018_Molecules_23_
Author(s) : Kuca K , Jun D , Junova L , Musilek K , Hrabinova M , da Silva JAV , Ramalho TC , Valko M , Wu Q , Nepovimova E , Franca TCC
Ref : Molecules , 23 : , 2018
Abstract : Kuca_2018_Molecules_23_
ESTHER : Kuca_2018_Molecules_23_
PubMedSearch : Kuca_2018_Molecules_23_
PubMedID: 29735900

Title : Novel Group of AChE Reactivators-Synthesis, In Vitro Reactivation and Molecular Docking Study - Malinak_2018_Molecules_23_
Author(s) : Malinak D , Nepovimova E , Jun D , Musilek K , Kuca K
Ref : Molecules , 23 : , 2018
Abstract : Malinak_2018_Molecules_23_
ESTHER : Malinak_2018_Molecules_23_
PubMedSearch : Malinak_2018_Molecules_23_
PubMedID: 30205495

Title : Investigation of New Orexin 2 Receptor Modulators Using In Silico and In Vitro Methods - Janockova_2018_Molecules_23_
Author(s) : Janockova J , Dolezal R , Nepovimova E , Kobrlova T , Benkova M , Kuca K , Konecny J , Mezeiova E , Melikova M , Hepnarova V , Ring A , Soukup O , Korabecny J
Ref : Molecules , 23 : , 2018
Abstract : Janockova_2018_Molecules_23_
ESTHER : Janockova_2018_Molecules_23_
PubMedSearch : Janockova_2018_Molecules_23_
PubMedID: 30423961

Title : Multitarget Tacrine Hybrids with Neuroprotective Properties to Confront Alzheimer's Disease - Spilovska_2017_Curr.Top.Med.Chem_17_1006
Author(s) : Spilovska K , Korabecny J , Nepovimova E , Dolezal R , Mezeiova E , Soukup O , Kuca K
Ref : Curr Top Med Chem , 17 :1006 , 2017
Abstract : Spilovska_2017_Curr.Top.Med.Chem_17_1006
ESTHER : Spilovska_2017_Curr.Top.Med.Chem_17_1006
PubMedSearch : Spilovska_2017_Curr.Top.Med.Chem_17_1006
PubMedID: 27697055

Title : The Evaluation of Benefit of Newly Prepared Reversible Inhibitors of Acetylcholinesterase and Commonly Used Pyridostigmine as Pharmacological Pretreatment of Soman-Poisoned Mice - Kassa_2017_Acta.Medica.(Hradec.Kralove)_60_37
Author(s) : Kassa J , Korabecny J , Nepovimova E
Ref : Acta Medica (Hradec Kralove) , 60 :37 , 2017
Abstract : Kassa_2017_Acta.Medica.(Hradec.Kralove)_60_37
ESTHER : Kassa_2017_Acta.Medica.(Hradec.Kralove)_60_37
PubMedSearch : Kassa_2017_Acta.Medica.(Hradec.Kralove)_60_37
PubMedID: 28418831

Title : The pharmacology of tacrine at N-methyl-d-aspartate receptors - Horak_2017_Prog.Neuropsychopharmacol.Biol.Psychiatry_75_54
Author(s) : Horak M , Holubova K , Nepovimova E , Krusek J , Kaniakova M , Korabecny J , Vyklicky L , Kuca K , Stuchlik A , Ricny J , Vales K , Soukup O
Ref : Prog Neuropsychopharmacol Biological Psychiatry , 75 :54 , 2017
Abstract : Horak_2017_Prog.Neuropsychopharmacol.Biol.Psychiatry_75_54
ESTHER : Horak_2017_Prog.Neuropsychopharmacol.Biol.Psychiatry_75_54
PubMedSearch : Horak_2017_Prog.Neuropsychopharmacol.Biol.Psychiatry_75_54
PubMedID: 28089695

Title : Prolyl oligopeptidase and its role in the organism: attention to the most promising and clinically relevant inhibitors - Babkova_2017_Future.Med.Chem_9_1015
Author(s) : Babkova K , Korabecny J , Soukup O , Nepovimova E , Jun D , Kuca K
Ref : Future Med Chem , 9 :1015 , 2017
Abstract : Babkova_2017_Future.Med.Chem_9_1015
ESTHER : Babkova_2017_Future.Med.Chem_9_1015
PubMedSearch : Babkova_2017_Future.Med.Chem_9_1015
PubMedID: 28632451

Title : Progress in acetylcholinesterase reactivators and in the treatment of organophosphorus intoxication: a patent review (2006-2016) - Gorecki_2017_Expert.Opin.Ther.Pat_27_971
Author(s) : Gorecki L , Korabecny J , Musilek K , Nepovimova E , Malinak D , Kucera T , Dolezal R , Jun D , Soukup O , Kuca K
Ref : Expert Opin Ther Pat , 27 :971 , 2017
Abstract : Gorecki_2017_Expert.Opin.Ther.Pat_27_971
ESTHER : Gorecki_2017_Expert.Opin.Ther.Pat_27_971
PubMedSearch : Gorecki_2017_Expert.Opin.Ther.Pat_27_971
PubMedID: 28569609

Title : Multi-target-directed therapeutic potential of 7-methoxytacrine-adamantylamine heterodimers in the Alzheimer's disease treatment - Gazova_2017_Biochim.Biophys.Acta.Mol.Basis.Dis_1863_607
Author(s) : Gazova Z , Soukup O , Sepsova V , Siposova K , Drtinova L , Jost P , Spilovska K , Korabecny J , Nepovimova E , Fedunova D , Horak M , Kaniakova M , Wang ZJ , Hamouda AK , Kuca K
Ref : Biochimica & Biophysica Acta Mol Basis Dis , 1863 :607 , 2017
Abstract : Gazova_2017_Biochim.Biophys.Acta.Mol.Basis.Dis_1863_607
ESTHER : Gazova_2017_Biochim.Biophys.Acta.Mol.Basis.Dis_1863_607
PubMedSearch : Gazova_2017_Biochim.Biophys.Acta.Mol.Basis.Dis_1863_607
PubMedID: 27865910

Title : A 7-methoxytacrine-4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication - Nepovimova_2016_Toxicol.Res.(Camb)_5_1012
Author(s) : Nepovimova E , Korabecny J , Dolezal R , Nguyen TD , Jun D , Soukup O , Pasdiorova M , Jost P , Muckova L , Malinak D , Gorecki L , Musilek K , Kuca K
Ref : Toxicol Res (Camb) , 5 :1012 , 2016
Abstract : Nepovimova_2016_Toxicol.Res.(Camb)_5_1012
ESTHER : Nepovimova_2016_Toxicol.Res.(Camb)_5_1012
PubMedSearch : Nepovimova_2016_Toxicol.Res.(Camb)_5_1012
PubMedID: 30090408

Title : An HPLC-MS method for the quantification of new acetylcholinesterase inhibitor PC 48 (7-MEOTA-donepezil like compound) in rat plasma: Application to a pharmacokinetic study - Mzik_2016_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_1020_85
Author(s) : Mzik M , Korabecny J , Nepovimova E , Vorisek V , Palicka V , Kuca K , Karasova JZ
Ref : Journal of Chromatography B Analyt Technol Biomed Life Sciences , 1020 :85 , 2016
Abstract : Mzik_2016_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_1020_85
ESTHER : Mzik_2016_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_1020_85
PubMedSearch : Mzik_2016_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_1020_85
PubMedID: 27030895

Title : Effects of novel tacrine-related cholinesterase inhibitors in the reversal of 3-quinuclidinyl benzilate-induced cognitive deficit in rats-Is there a potential for Alzheimer's disease treatment? - Misik_2016_Neurosci.Lett_612_261
Author(s) : Misik J , Korabecny J , Nepovimova E , Kracmarova A , Kassa J
Ref : Neuroscience Letters , 612 :261 , 2016
Abstract : Misik_2016_Neurosci.Lett_612_261
ESTHER : Misik_2016_Neurosci.Lett_612_261
PubMedSearch : Misik_2016_Neurosci.Lett_612_261
PubMedID: 26708634

Title : SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides - Gorecki_2016_Arch.Toxicol_90_2831
Author(s) : Gorecki L , Korabecny J , Musilek K , Malinak D , Nepovimova E , Dolezal R , Jun D , Soukup O , Kuca K
Ref : Archives of Toxicology , 90 :2831 , 2016
Abstract : Gorecki_2016_Arch.Toxicol_90_2831
ESTHER : Gorecki_2016_Arch.Toxicol_90_2831
PubMedSearch : Gorecki_2016_Arch.Toxicol_90_2831
PubMedID: 27582056

Title : Inhibitors of Acetylcholinesterase Derived from 7-Methoxytacrine and Their Effects on the Choline Transporter CHT1 - Kristofikova_2016_Dement.Geriatr.Cogn.Disord_43_45
Author(s) : Kristofikova Z , Ricny J , Soukup O , Korabecny J , Nepovimova E , Kuca K , Ripova D
Ref : Dementia & Geriatric Cognitive Disorders , 43 :45 , 2016
Abstract : Kristofikova_2016_Dement.Geriatr.Cogn.Disord_43_45
ESTHER : Kristofikova_2016_Dement.Geriatr.Cogn.Disord_43_45
PubMedSearch : Kristofikova_2016_Dement.Geriatr.Cogn.Disord_43_45
PubMedID: 27988521

Title : The effects of novel 7-MEOTA-donepezil like hybrids and N-alkylated tacrine analogues in the treatment of quinuclidinyl benzilate-induced behavioural deficits in rats performing the multiple T-maze test - Misik_2015_Biomed.Pap.Med.Fac.Univ.Palacky.Olomouc.Czech.Repub_159_547
Author(s) : Misik J , Korabecny J , Nepovimova E , Cabelova P , Kassa J
Ref : Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub , 159 :547 , 2015
Abstract : Misik_2015_Biomed.Pap.Med.Fac.Univ.Palacky.Olomouc.Czech.Repub_159_547
ESTHER : Misik_2015_Biomed.Pap.Med.Fac.Univ.Palacky.Olomouc.Czech.Repub_159_547
PubMedSearch : Misik_2015_Biomed.Pap.Med.Fac.Univ.Palacky.Olomouc.Czech.Repub_159_547
PubMedID: 25690521

Title : 7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment - Korabecny_2015_Molecules_20_22084
Author(s) : Korabecny J , Andrs M , Nepovimova E , Dolezal R , Babkova K , Horova A , Malinak D , Mezeiova E , Gorecki L , Sepsova V , Hrabinova M , Soukup O , Jun D , Kuca K
Ref : Molecules , 20 :22084 , 2015
Abstract : Korabecny_2015_Molecules_20_22084
ESTHER : Korabecny_2015_Molecules_20_22084
PubMedSearch : Korabecny_2015_Molecules_20_22084
PubMedID: 26690394

Title : Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity - Nepovimova_2015_J.Med.Chem_58_8985
Author(s) : Nepovimova E , Korabecny J , Dolezal R , Babkova K , Ondrejicek A , Jun D , Sepsova V , Horova A , Hrabinova M , Soukup O , Bukum N , Jost P , Muckova L , Kassa J , Malinak D , Andrs M , Kuca K
Ref : Journal of Medicinal Chemistry , 58 :8985 , 2015
Abstract : Nepovimova_2015_J.Med.Chem_58_8985
ESTHER : Nepovimova_2015_J.Med.Chem_58_8985
PubMedSearch : Nepovimova_2015_J.Med.Chem_58_8985
PubMedID: 26503905

Title : From Pyridinium-based to Centrally Active Acetylcholinesterase Reactivators - Korabecny_2014_Mini.Rev.Med.Chem_14_215
Author(s) : Korabecny J , Soukup O , Dolezal R , Spilovska K , Nepovimova E , Andrs M , Nguyen TD , Jun D , Musilek K , Kucerova-Chlupacova M , Kuca K
Ref : Mini Rev Med Chem , 14 :215 , 2014
Abstract : Korabecny_2014_Mini.Rev.Med.Chem_14_215
ESTHER : Korabecny_2014_Mini.Rev.Med.Chem_14_215
PubMedSearch : Korabecny_2014_Mini.Rev.Med.Chem_14_215
PubMedID: 24552265

Title : Outcomes of Alzheimer's disease therapy with acetylcholinesterase inhibitors and memantine - Zemek_2014_Expert.Opin.Drug.Saf_13_759
Author(s) : Zemek F , Drtinova L , Nepovimova E , Sepsova V , Korabecny J , Klimes J , Kuca K
Ref : Expert Opin Drug Safety , 13 :759 , 2014
Abstract : Zemek_2014_Expert.Opin.Drug.Saf_13_759
ESTHER : Zemek_2014_Expert.Opin.Drug.Saf_13_759
PubMedSearch : Zemek_2014_Expert.Opin.Drug.Saf_13_759
PubMedID: 24845946

Title : 7-MEOTA-donepezil like compounds as cholinesterase inhibitors: Synthesis, pharmacological evaluation, molecular modeling and QSAR studies - Korabecny_2014_Eur.J.Med.Chem_82C_426
Author(s) : Korabecny J , Dolezal R , Cabelova P , Horova A , Hruba E , Ricny J , Sedlacek L , Nepovimova E , Spilovska K , Andrs M , Musilek K , Opletalova V , Sepsova V , Ripova D , Kuca K
Ref : Eur Journal of Medicinal Chemistry , 82C :426 , 2014
Abstract : Korabecny_2014_Eur.J.Med.Chem_82C_426
ESTHER : Korabecny_2014_Eur.J.Med.Chem_82C_426
PubMedSearch : Korabecny_2014_Eur.J.Med.Chem_82C_426
PubMedID: 24929293

Title : Multitarget Drug Design Strategy: Quinone-Tacrine Hybrids Designed To Block Amyloid-beta Aggregation and To Exert Anticholinesterase and Antioxidant Effects - Nepovimova_2014_J.Med.Chem_57_8576
Author(s) : Nepovimova E , Uliassi E , Korabecny J , Pena-Altamira LE , Samez S , Pesaresi A , Garcia GE , Bartolini M , Andrisano V , Bergamini C , Fato R , Lamba D , Roberti M , Kuca K , Monti B , Bolognesi ML
Ref : Journal of Medicinal Chemistry , 57 :8576 , 2014
Abstract : Nepovimova_2014_J.Med.Chem_57_8576
ESTHER : Nepovimova_2014_J.Med.Chem_57_8576
PubMedSearch : Nepovimova_2014_J.Med.Chem_57_8576
PubMedID: 25259726
Gene_locus related to this paper: torca-ACHE

Title : Synthesis and in vitro evaluation of 7-methoxy-N-(pent-4-enyl)-1,2,3,4-tetrahydroacridin-9-amine-new tacrine derivate with cholinergic properties - Korabecny_2011_Bioorg.Med.Chem.Lett_21_6563
Author(s) : Korabecny J , Musilek K , Zemek F , Horova A , Holas O , Nepovimova E , Opletalova V , Hroudova J , Fisar Z , Jung YS , Kuca K
Ref : Bioorganic & Medicinal Chemistry Lett , 21 :6563 , 2011
Abstract : Korabecny_2011_Bioorg.Med.Chem.Lett_21_6563
ESTHER : Korabecny_2011_Bioorg.Med.Chem.Lett_21_6563
PubMedSearch : Korabecny_2011_Bioorg.Med.Chem.Lett_21_6563
PubMedID: 21920739

Title : Synthesis and in vitro evaluation of N-(Bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine as a cholinesterase inhibitor with regard to Alzheimer's disease treatment - Korabecny_2010_Molecules_15_8804
Author(s) : Korabecny J , Musilek K , Holas O , Nepovimova E , Jun D , Zemek F , Opletalova V , Patocka J , Dohnal V , Nachon F , Hroudova J , Fisar Z , Kuca K
Ref : Molecules , 15 :8804 , 2010
Abstract : Korabecny_2010_Molecules_15_8804
ESTHER : Korabecny_2010_Molecules_15_8804
PubMedSearch : Korabecny_2010_Molecules_15_8804
PubMedID: 21127466