AChE-Nrf2modulator-Cpd32
Compound 32 stabilizes Nrf2 via Keap1 binding. AChE (IC50 = 14.79 microM)
General
Type : Chromen, Nrf2 modulator, Derivative of Donepezil, Multitarget, Flavonoid
Chemical_Nomenclature : 3-(4-bromophenyl)-7,8-dihydroxy-4H-chromen-4-one
Canonical SMILES : C1(=CC=C2C(=C1O)OC=C(C2=O)C3=CC=C(C=C3)Br)O
InChI : InChI=1S\/C15H9BrO4\/c16-9-3-1-8(2-4-9)11-7-20-15-10(13(11)18)5-6-12(17)14(15)19\/h1-7,17,19H
InChIKey : DGBMWYBHPCHGDQ-UHFFFAOYSA-N
Other name(s) : Compound 32
Target
References (1)
| Title : Emerging of a new neuroprotective isoflavonoid with potent Keap1\/Nrf2\/ARE pathway activation and AChE inhibition - Song_2025_Bioorg.Chem_168_109336 |
| Author(s) : Song ZL , Osama A , Ji M , He Q , Zhang B , Zhao H , Hu Y , Cai W , Fang J |
| Ref : Bioorg Chem , 168 :109336 , 2025 |
| Abstract : |
| PubMedSearch : Song_2025_Bioorg.Chem_168_109336 |
| PubMedID: 41353931 |