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Nrf2 modulator

General

An Nrf2 modulator activates or inhibits the Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) pathway, controlling antioxidant and detoxification genes, with applications in treating chronic diseases like neurodegeneration, metabolic disorders, and potentially cancer. These modulators include natural compounds (like sulforaphane, curcumin, quercetin) and synthetic drugs (like omaveloxolone), working to promote redox balance and cellular protection. Used as building blocks of Multi-target drug ligand MTDL
Inhibitor Main targeted enzyme families Type Structure
AChE-Nrf2modulator-Cpd32 Chromen Nrf2 modulator Derivative of Donepezil Multitarget Flavonoid
AChE-Nrf2modulator-1 ACHE Pyridine Oxadiazol Nrf2 modulator Derivative of Donepezil Multitarget
4c2-AChE-IN-24 ACHE Sulfur Compound Multitarget Piperidine Nrf2 modulator
Tacrine-Melatonin-Feruloyl-5c BCHE ACHE Derivative of Tacrine Acridine Derivative of Tryptamine Indole Multitarget Feruloyl Acrylate Antioxidant Hydroxycinnamic-ester Alkyl linked bis-ligand Nrf2 modulator
AChE-Nrf2modulator-Cpd32 Chromen Nrf2 modulator Derivative of Donepezil Multitarget Flavonoid
AChE-Nrf2modulator-1 ACHE Pyridine Oxadiazol Nrf2 modulator Derivative of Donepezil Multitarget
4c2-AChE-IN-24 ACHE Sulfur compound Multitarget Piperidine Nrf2 modulator
Tacrine-Melatonin-Feruloyl-5c BCHE ACHE Derivative of Tacrine Acridine Derivative of Tryptamine Indole Multitarget Feruloyl Acrylate Antioxidant Hydroxycinnamic-ester Alkyl linked bis-ligand Nrf2 modulator
AChE-Nrf2modulator-Cpd32 Chromen Nrf2 modulator Derivative of Donepezil Multitarget Flavonoid
AChE-Nrf2modulator-1 ACHE Pyridine Oxadiazol Nrf2 modulator Derivative of Donepezil Multitarget
4c2-AChE-IN-24 ACHE Sulfur compound Multitarget Piperidine Nrf2 modulator
Tacrine-Melatonin-Feruloyl-5c BCHE ACHE Derivative of Tacrine Acridine Derivative of Tryptamine Indole Multitarget Feruloyl Acrylate Antioxidant Hydroxycinnamic-ester Alkyl linked bis-ligand Nrf2 modulator