ADPr-ATP
TIR-encoded nicotinamide adenine dinucleotide hydrolase (NADase) produces signaling molecules to promote exclusive EDS1-PAD4 and EDS1-SAG101 interactions with helper NLR subclasses. TIR-containing proteins catalyze adenosine diphosphate (ADP)-ribosylation of adenosine triphosphate (ATP) and ADP ribose (ADPR) through ADPR polymerase-like and NADase activity, forming ADP-ribosylated ATP (ADPr-ATP) and ADPr-ADPR (di-ADPR), respectively. Specific binding of ADPr-ATP or di-ADPR allosterically promotes EDS1-SAG101 interaction with helper NLR N requirement gene 1A (NRG1A) in vitro and in planta. Enzymatic activity of TIRs enables specific activation of the EDS1-SAG101-NRG1 immunity branch.
General
Type : Aminopurin, Purine, Ribose
Chemical_Nomenclature : [[(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-[(2~{S},3~{R},4~{S},5~{R})-5-[[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxymethyl]-3,4-bis(oxidanyl)oxolan-2-yl]oxy-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate
Canonical SMILES : c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O)OP(=O)(O)OC[C@@H]4[C@H]([C@H]([C@@H](O4)O[C@@H]5[C@@H]([C@H](O[C@H]5n6cnc7c6ncnc7N)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)O)O)O)N
InChI : InChI=1S\/C25H37N10O26P5\/c26-19-11-21(30-4-28-19)34(6-32-11)23-16(39)13(36)8(55-23)1-52-63(44,45)60-64(46,47)53-2-9-14(37)17(40)25(57-9)58-18-15(38)10(3-54-65(48,49)61-66(50,51)59-62(41,42)43)56-24(18)35-7-33-12-20(27)29-5-31-22(12)35\/h4-10,13-18,23-25,36-40H,1-3H2,(H,44,45)(H,46,47)(H,48,49)(H,50,51)(H2,26,28,30)(H2,27,29,31)(H2,41,42,43)\/t8-,9-,10-,13-,14-,15-,16-,17-,18-,23-,24-,25+\/m1\/s1
InChIKey : BLHBPWIRUPJXKW-VIUUMBSUSA-N
Other name(s) : A1L15
Target
Families : ADPr-ATP ligand of proteins in family
Plant_lipase_EDS1-like
Protein :
arath-eds1
References (2)
| Title : TIR-catalyzed ADP-ribosylation reactions produce signaling molecules for plant immunity - Jia_2022_Science_377_eabq8180 |
| Author(s) : Jia A , Huang S , Song W , Wang J , Meng Y , Sun Y , Xu L , Laessle H , Jirschitzka J , Hou J , Zhang T , Yu W , Hessler G , Li E , Ma S , Yu D , Gebauer J , Baumann U , Liu X , Han Z , Chang J , Parker JE , Chai J |
| Ref : Science , 377 :eabq8180 , 2022 |
| Abstract : |
| PubMedSearch : Jia_2022_Science_377_eabq8180 |
| PubMedID: 35857644 |
| Title : EDS1 modules as two-tiered receptor complexes for TIR-catalyzed signaling molecules to activate plant immunity - Li_2022_Stress.Biol_2_30 |
| Author(s) : Li J , Tao X |
| Ref : Stress Biol , 2 :30 , 2022 |
| Abstract : |
| PubMedSearch : Li_2022_Stress.Biol_2_30 |
| PubMedID: 37676367 |