arath-At5g14930

Arabidopsis thaliana (Mouse-ear cress) At5g14930 sag101 AtSAG101

Comment

The Arabidopsis EDS1 (arath-eds1) and PAD4 (arath-pad4 F22O6.190) genes encode lipase-like proteins that function in resistance (R) gene-mediated and basal plant disease resistance.EDS1 can dimerize and interact with PAD4 or with SAG101 (arath-At5g14930). Plants utilise intracellular nucleotide-binding, leucine-rich repeat (NLR) immune receptors to detect pathogen effectors and activate local and systemic defence. NRG1 and ADR1 'helper' NLRs (RNLs) cooperate with enhanced disease susceptibility 1 (EDS1), senescence-associated gene 101 (SAG101) and phytoalexin-deficient 4 (PAD4) lipase-like proteins to mediate signalling from TIR domain NLR receptors (TNLs). Two distinct modules (NRG1\/EDS1\/SAG101 and ADR1\/EDS1\/PAD4) mediate TNL receptor defence signalling.

Relationship

Family : Plant_lipase_EDS1-like

Block : L

Position in NCBI Life Tree : Arabidopsis thaliana

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Viridiplantae N E > Streptophyta N E > Streptophytina N E > Embryophyta N E > Tracheophyta N E > Euphyllophyta N E > Spermatophyta N E > Magnoliophyta N E > Mesangiospermae N E > eudicotyledons N E > Gunneridae N E > Pentapetalae N E > rosids N E > malvids N E > Brassicales N E > Brassicaceae N E > Camelineae N E > Arabidopsis N E > Arabidopsis thaliana N E

Molecular evidence

No mutation

4NFU - Structure of the central plant immunity signaling node Arabidopsis thaliana EDS1 in complex with its interaction partner SAG101 7XJP - Cryo-EM structure of Arabidopsis thaliana EDS1 and SAG101 with ATP-APDR 8YL6 - Arabidopsis thaliana EDS1-SAG101-NRG1.1 L134E heterotrimer 8YL7 - Arabidopsis thaliana EDS1-SAG101-NRG1.3 E heterotrimer 8YN0 - Crystal structure of NRG1C (Probable disease resistance protein At5g66890: not a\/b hydrolase) in complex with EDS1-SAG101-(ADPr-ATP) 8YN1 - Cryo-EM structure of NRG1A(LRR) (Probable disease resistance protein At5g66890: not a\/b hydrolase) in complex with EDS1-SAG101-(ADPr-ATP)

No kinetic

No disease

No substrate

No inhibitor

Database

AF239887 AF239888 AL391146 DQ103714

Q4F883 Q9LL47 Q9LL48

Sequence

Peptide

MIRVYKFQKK KDSGLEFQIH REEKFTLVVF SAPPICRSSS SDSTLLHVKD KENPFPFLCS ENNPSFSLHT PAFNLFTSAP TSLTYLKSEL LQTLKSEKPV IITGAALGGS VASLYTLWLL ETIEPTLKRP LCITFGSPLI GDASLQQILE NSVRNSCFLH VVSAQTRIKM DFFKPFGTFL ICFDSGCVCI EDHVAVTELL NGVHDSGLVD YSQVLNRLDQ SMLSLADSRL IPEDVIKGIE KRAEMKNLRF DMMFKKLNDM KISMAYIEWY KKKCKEVKIG YYDRFKTQLA FPSKEFDINI KNHHKSELNR FWKSVVEEVE RRPQSDASIL KRRFLFSGNN YRRMIEPLDI AEYYLEGRKE YRTMGRSHHY VMLEKWFGME SILIEKERCK KRDLSDLLTF DSCFWAEVED SLIVINQLNT TVGMRDDERE VLTRKLVEFE GYVWEIITKR EVSPEIFLEE SSFMKWWKEY KKIKGFNSSY LTEFMNTRKY ESYGKSQ

References (9)

Title : Plant Toll\/interleukin-1 receptor\/resistance protein domains physically associate with enhanced disease susceptibility1 family proteins in immune signaling - Chen_2024_iScience_27_108817

Author(s) : Chen J , Zhang X , Bernoux M , Rathjen JP , Dodds PN

Ref : iScience , 27 :108817 , 2024

Abstract :

PubMedSearch : Chen_2024_iScience_27_108817

PubMedID: 38533452

Gene_locus related to this paper: arath-At5g14930 , arath-eds1

Title : Cavity surface residues of PAD4 and SAG101 contribute to EDS1 dimer signaling specificity in plant immunity - Dongus_2022_Plant.J__

Author(s) : Dongus JA , Bhandari DD , Penner E , Lapin D , Stolze SC , Harzen A , Patel M , Archer L , Dijkgraaf L , Shah J , Nakagami H , Parker JE

Ref : Plant J , : , 2022

Abstract :

PubMedSearch : Dongus_2022_Plant.J__

PubMedID: 35324052

Gene_locus related to this paper: arath-At5g14930 , arath-eds1 , arath-PAD4

Title : Pathogen effector recognition-dependent association of NRG1 with EDS1 and SAG101 in TNL receptor immunity - Sun_2021_Nat.Commun_12_3335

Author(s) : Sun X , Lapin D , Feehan JM , Stolze SC , Kramer K , Dongus JA , Rzemieniewski J , Blanvillain-Baufume S , Harzen A , Bautor J , Derbyshire P , Menke FLH , Finkemeier I , Nakagami H , Jones JDG , Parker JE

Ref : Nat Commun , 12 :3335 , 2021

Abstract :

PubMedSearch : Sun_2021_Nat.Commun_12_3335

PubMedID: 34099661

Gene_locus related to this paper: arath-At5g14930 , arath-eds1 , arath-PAD4

Title : A Coevolved EDS1-SAG101-NRG1 Module Mediates Cell Death Signaling by TIR-Domain Immune Receptors - Lapin_2019_Plant.Cell_31_2430

Author(s) : Lapin D , Kovacova V , Sun X , Dongus JA , Bhandari D , von Born P , Bautor J , Guarneri N , Rzemieniewski J , Stuttmann J , Beyer A , Parker JE

Ref : Plant Cell , 31 :2430 , 2019

Abstract :

PubMedSearch : Lapin_2019_Plant.Cell_31_2430

PubMedID: 31311833

Gene_locus related to this paper: arath-At5g14930 , arath-eds1 , arath-PAD4

Title : Structural Basis for Signaling by Exclusive EDS1 Heteromeric Complexes with SAG101 or PAD4 in Plant Innate Immunity - Wagner_2013_Cell.Host.Microbe_14_619

Author(s) : Wagner S , Stuttmann J , Rietz S , Guerois R , Brunstein E , Bautor J , Niefind K , Parker JE

Ref : Cell Host Microbe , 14 :619 , 2013

Abstract :

PubMedSearch : Wagner_2013_Cell.Host.Microbe_14_619

PubMedID: 24331460

Gene_locus related to this paper: arath-At5g14930 , arath-eds1 , arath-PAD4

Title : Crystallization and preliminary crystallographic analysis of Arabidopsis thaliana EDS1, a key component of plant immunity, in complex with its signalling partner SAG101 - Wagner_2011_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_67_245

Author(s) : Wagner S , Rietz S , Parker JE , Niefind K

Ref : Acta Crystallographica Sect F Struct Biol Cryst Commun , 67 :245 , 2011

Abstract :

PubMedSearch : Wagner_2011_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_67_245

PubMedID: 21301097

Gene_locus related to this paper: arath-At5g14930 , arath-eds1 , arath-PAD4

Title : Arabidopsis SENESCENCE-ASSOCIATED GENE101 stabilizes and signals within an ENHANCED DISEASE SUSCEPTIBILITY1 complex in plant innate immunity - Feys_2005_Plant.Cell_17_2601

Author(s) : Feys BJ , Wiermer M , Bhat RA , Moisan LJ , Medina-Escobar N , Neu C , Cabral A , Parker JE

Ref : Plant Cell , 17 :2601 , 2005

Abstract :

PubMedSearch : Feys_2005_Plant.Cell_17_2601

PubMedID: 16040633

Gene_locus related to this paper: arath-At5g14930 , arath-eds1 , arath-PAD4 , arath-T17F15.50

Title : A gene encoding an acyl hydrolase is involved in leaf senescence in Arabidopsis - He_2002_Plant.Cell_14_805

Author(s) : He Y , Gan S

Ref : Plant Cell , 14 :805 , 2002

Abstract :

PubMedSearch : He_2002_Plant.Cell_14_805

PubMedID: 11971136

Gene_locus related to this paper: arath-At5g14930

Title : Structural analysis of Arabidopsis thaliana chromosome 5. VIII. Sequence features of the regions of 1,081,958 bp covered by seventeen physically assigned P1 and TAC clones. -

Author(s) : Asamizu E , Sato S , Kaneko T , Nakamura Y , Kotani H , Miyajima N , Tabata S

Ref : DNA Research , 5 :379 , 1998

PubMedID: 10048488

Gene_locus related to this paper: arath-At5g14930 , arath-at5g18630 , arath-AT5G19050 , arath-At5g24180 , arath-AT5G24190 , arath-At5g24200 , arath-F2G14.100 , arath-F6H11.120 , arath-F9G14.280 , arath-F14F8.240 , arath-HNL , arath-At5g14310

arath-At5g14930

Comment

Relationship

Molecular evidence

Mutation (0)

Structure (6)

Kinetic (0)

Disease (0)

Substrate (0)

Inhibitor (0)

Database

Genbank (4)

Interpro (3)

Pfam (3)

UniProt (3)

PIRSF (3)

SUPERFAM (3)

Sequence

Peptide

References (9)

1. Plant Toll\/interleukin-1 receptor\/resistance protein domains physically associate with enhanced disease susceptibility1 family proteins in immune signaling - Chen_2024_iScience_27_108817

2. Cavity surface residues of PAD4 and SAG101 contribute to EDS1 dimer signaling specificity in plant immunity - Dongus_2022_Plant.J__

3. Pathogen effector recognition-dependent association of NRG1 with EDS1 and SAG101 in TNL receptor immunity - Sun_2021_Nat.Commun_12_3335

4. A Coevolved EDS1-SAG101-NRG1 Module Mediates Cell Death Signaling by TIR-Domain Immune Receptors - Lapin_2019_Plant.Cell_31_2430

5. Structural Basis for Signaling by Exclusive EDS1 Heteromeric Complexes with SAG101 or PAD4 in Plant Innate Immunity - Wagner_2013_Cell.Host.Microbe_14_619

6. Crystallization and preliminary crystallographic analysis of Arabidopsis thaliana EDS1, a key component of plant immunity, in complex with its signalling partner SAG101 - Wagner_2011_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_67_245

7. Arabidopsis SENESCENCE-ASSOCIATED GENE101 stabilizes and signals within an ENHANCED DISEASE SUSCEPTIBILITY1 complex in plant innate immunity - Feys_2005_Plant.Cell_17_2601

8. A gene encoding an acyl hydrolase is involved in leaf senescence in Arabidopsis - He_2002_Plant.Cell_14_805

9. Structural analysis of Arabidopsis thaliana chromosome 5. VIII. Sequence features of the regions of 1,081,958 bp covered by seventeen physically assigned P1 and TAC clones. -