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arath-At5g14930

Arabidopsis thaliana (Mouse-ear cress) At5g14930 sag101 AtSAG101

Comment

The Arabidopsis EDS1 (arath-eds1) and PAD4 (arath-pad4 F22O6.190) genes encode lipase-like proteins that function in resistance (R) gene-mediated and basal plant disease resistance.EDS1 can dimerize and interact with PAD4 or with SAG101 (arath-At5g14930). Plants utilise intracellular nucleotide-binding, leucine-rich repeat (NLR) immune receptors to detect pathogen effectors and activate local and systemic defence. NRG1 and ADR1 'helper' NLRs (RNLs) cooperate with enhanced disease susceptibility 1 (EDS1), senescence-associated gene 101 (SAG101) and phytoalexin-deficient 4 (PAD4) lipase-like proteins to mediate signalling from TIR domain NLR receptors (TNLs). Two distinct modules (NRG1\/EDS1\/SAG101 and ADR1\/EDS1\/PAD4) mediate TNL receptor defence signalling.

Relationship

Family : Plant_lipase_EDS1-like

Block : L

Position in NCBI Life Tree : Arabidopsis thaliana

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Viridiplantae N E > Streptophyta N E > Streptophytina N E > Embryophyta N E > Tracheophyta N E > Euphyllophyta N E > Spermatophyta N E > Magnoliophyta N E > Mesangiospermae N E > eudicotyledons N E > Gunneridae N E > Pentapetalae N E > rosids N E > malvids N E > Brassicales N E > Brassicaceae N E > Camelineae N E > Arabidopsis N E > Arabidopsis thaliana N E

Molecular evidence

Database

Sequence

Peptide

MIRVYKFQKK KDSGLEFQIH REEKFTLVVF SAPPICRSSS SDSTLLHVKD KENPFPFLCS ENNPSFSLHT PAFNLFTSAP TSLTYLKSEL LQTLKSEKPV IITGAALGGS VASLYTLWLL ETIEPTLKRP LCITFGSPLI GDASLQQILE NSVRNSCFLH VVSAQTRIKM DFFKPFGTFL ICFDSGCVCI EDHVAVTELL NGVHDSGLVD YSQVLNRLDQ SMLSLADSRL IPEDVIKGIE KRAEMKNLRF DMMFKKLNDM KISMAYIEWY KKKCKEVKIG YYDRFKTQLA FPSKEFDINI KNHHKSELNR FWKSVVEEVE RRPQSDASIL KRRFLFSGNN YRRMIEPLDI AEYYLEGRKE YRTMGRSHHY VMLEKWFGME SILIEKERCK KRDLSDLLTF DSCFWAEVED SLIVINQLNT TVGMRDDERE VLTRKLVEFE GYVWEIITKR EVSPEIFLEE SSFMKWWKEY KKIKGFNSSY LTEFMNTRKY ESYGKSQ

References (8)

Title : Cavity surface residues of PAD4 and SAG101 contribute to EDS1 dimer signaling specificity in plant immunity - Dongus_2022_Plant.J__
Author(s) : Dongus JA , Bhandari DD , Penner E , Lapin D , Stolze SC , Harzen A , Patel M , Archer L , Dijkgraaf L , Shah J , Nakagami H , Parker JE
Ref : Plant J , : , 2022
Abstract :
PubMedSearch : Dongus_2022_Plant.J__
PubMedID: 35324052
Gene_locus related to this paper: arath-At5g14930 , arath-eds1 , arath-PAD4

Title : Pathogen effector recognition-dependent association of NRG1 with EDS1 and SAG101 in TNL receptor immunity - Sun_2021_Nat.Commun_12_3335
Author(s) : Sun X , Lapin D , Feehan JM , Stolze SC , Kramer K , Dongus JA , Rzemieniewski J , Blanvillain-Baufume S , Harzen A , Bautor J , Derbyshire P , Menke FLH , Finkemeier I , Nakagami H , Jones JDG , Parker JE
Ref : Nat Commun , 12 :3335 , 2021
Abstract :
PubMedSearch : Sun_2021_Nat.Commun_12_3335
PubMedID: 34099661
Gene_locus related to this paper: arath-At5g14930 , arath-eds1 , arath-PAD4

Title : A Coevolved EDS1-SAG101-NRG1 Module Mediates Cell Death Signaling by TIR-Domain Immune Receptors - Lapin_2019_Plant.Cell_31_2430
Author(s) : Lapin D , Kovacova V , Sun X , Dongus JA , Bhandari D , von Born P , Bautor J , Guarneri N , Rzemieniewski J , Stuttmann J , Beyer A , Parker JE
Ref : Plant Cell , 31 :2430 , 2019
Abstract :
PubMedSearch : Lapin_2019_Plant.Cell_31_2430
PubMedID: 31311833
Gene_locus related to this paper: arath-At5g14930 , arath-eds1 , arath-PAD4

Title : Structural Basis for Signaling by Exclusive EDS1 Heteromeric Complexes with SAG101 or PAD4 in Plant Innate Immunity - Wagner_2013_Cell.Host.Microbe_14_619
Author(s) : Wagner S , Stuttmann J , Rietz S , Guerois R , Brunstein E , Bautor J , Niefind K , Parker JE
Ref : Cell Host Microbe , 14 :619 , 2013
Abstract :
PubMedSearch : Wagner_2013_Cell.Host.Microbe_14_619
PubMedID: 24331460
Gene_locus related to this paper: arath-At5g14930 , arath-eds1 , arath-PAD4

Title : Crystallization and preliminary crystallographic analysis of Arabidopsis thaliana EDS1, a key component of plant immunity, in complex with its signalling partner SAG101 - Wagner_2011_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_67_245
Author(s) : Wagner S , Rietz S , Parker JE , Niefind K
Ref : Acta Crystallographica Sect F Struct Biol Cryst Commun , 67 :245 , 2011
Abstract :
PubMedSearch : Wagner_2011_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_67_245
PubMedID: 21301097
Gene_locus related to this paper: arath-At5g14930 , arath-eds1 , arath-PAD4

Title : Arabidopsis SENESCENCE-ASSOCIATED GENE101 stabilizes and signals within an ENHANCED DISEASE SUSCEPTIBILITY1 complex in plant innate immunity - Feys_2005_Plant.Cell_17_2601
Author(s) : Feys BJ , Wiermer M , Bhat RA , Moisan LJ , Medina-Escobar N , Neu C , Cabral A , Parker JE
Ref : Plant Cell , 17 :2601 , 2005
Abstract :
PubMedSearch : Feys_2005_Plant.Cell_17_2601
PubMedID: 16040633
Gene_locus related to this paper: arath-At5g14930 , arath-eds1 , arath-PAD4 , arath-T17F15.50

Title : A gene encoding an acyl hydrolase is involved in leaf senescence in Arabidopsis - He_2002_Plant.Cell_14_805
Author(s) : He Y , Gan S
Ref : Plant Cell , 14 :805 , 2002
Abstract :
PubMedSearch : He_2002_Plant.Cell_14_805
PubMedID: 11971136
Gene_locus related to this paper: arath-At5g14930

Title : Structural analysis of Arabidopsis thaliana chromosome 5. VIII. Sequence features of the regions of 1,081,958 bp covered by seventeen physically assigned P1 and TAC clones. -
Author(s) : Asamizu E , Sato S , Kaneko T , Nakamura Y , Kotani H , Miyajima N , Tabata S
Ref : DNA Research , 5 :379 , 1998
PubMedID: 10048488
Gene_locus related to this paper: arath-At5g14930 , arath-at5g18630 , arath-AT5G19050 , arath-At5g24180 , arath-AT5G24190 , arath-At5g24200 , arath-F2G14.100 , arath-F6H11.120 , arath-F9G14.280 , arath-F14F8.240 , arath-HNL , arath-At5g14310